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This meeting took place in 2013
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Meeting Details
Diabetes — New Insights into Mechanism of Disease and its Treatment (J6)
Organizer(s) C. Ronald Kahn, Jens C. Brüning and Gerald I. Shulman
January 27 - February 1, 2013
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: September 27, 2012
Late Abstract Deadline: October 29, 2012
Scholarship Deadline: September 27, 2012
Early Registration Deadline: November 28, 2012
Sponsored by EMD Millipore, MedImmune and Nestlé Institute of Health Sciences
CME Information
Joint Meeting:
Adipose Tissue Biology (J5)
Summary of Meeting:
We are in the midst of an epidemic of type 2 diabetes and the closely related metabolic syndrome. These disorders come from a complete interaction between genes and environment which is not fully understood. The goals of this meeting are to address important new areas of research into the primary pathogenesis of these disorders and especially focus on those that might lead to new therapies. The major topics of the meeting are: 1) Mechanisms of metabolic dysfunction and new therapeutic targets for diabetes and obesity; 2) miRNAs in control of metabolism; 3) Aging, mitochondria, and control of metabolism; 4) Epigenetics and perinatal imprinting in diabetes and obesity; 5) CNS control of metabolism; 6) Gastric bypass surgery and the gut in control of metabolism; 7) Metabolic mediators of insulin resistance; and 8) Signaling defects and inflammation in insulin resistance. The major goals of this meeting are to: 1) Make investigators of aware of important new advances in the field of diabetes research; 2) Bring new topics of research from outside the field to the diabetes research community; 3) Stimulate interactions and potential collaborations between participants; and 4) Bring lessons from clinical practice back to the bench. The program should bring new scientific knowledge, new methods and new insights from clinical practice together to stimulate interchange of ideas and even collaborations. Although this meeting has been a regular annual event in the Keystone Symposia series, many of the topics and speakers are new and thus will enrich the field in new ways. The Keystone Symposia Diabetes meeting remains the most important forum for new basic science presentations in the field of diabetes. By bringing it together with the conference on Adipocyte Biology and having multiple joint sessions, this meeting fill a need in the scientific community that is not filled by other conferences. The meeting has novel content that will inform and challenge the attendees and brings many new research paradigms, as well as novel approaches and methods to the scientific community. The meeting is truly interdisciplinary, with not only basic scientists and clinical scientists, but those from many disciplines outside the fields of endocrinology and metabolism, including gastroenterology, neuroscience, innate immunity and genetics.
CME Information
We are in the midst of an epidemic of type 2 diabetes and the closely related metabolic syndrome. These disorders come from a complete interaction between genes and environment which is not fully understood. The goals of this meeting are to address important new areas of research into the primary pathogenesis of these disorders and especially focus on those that might lead to new therapies. The major topics of the meeting are: 1) Mechanisms of metabolic dysfunction and new therapeutic targets for diabetes and obesity; 2) miRNAs in control of metabolism; 3) Aging, mitochondria, and control of metabolism; 4) Epigenetics and perinatal imprinting in diabetes and obesity; 5) CNS control of metabolism; 6) Gastric bypass surgery and the gut in control of metabolism; 7) Metabolic mediators of insulin resistance; and 8) Signaling defects and inflammation in insulin resistance. The major goals of this meeting are to: 1) Make investigators of aware of important new advances in the field of diabetes research; 2) Bring new topics of research from outside the field to the diabetes research community; 3) Stimulate interactions and potential collaborations between participants; and 4) Bring lessons from clinical practice back to the bench. The program should bring new scientific knowledge, new methods and new insights from clinical practice together to stimulate interchange of ideas and even collaborations. Although this meeting has been a regular annual event in the Keystone Symposia series, many of the topics and speakers are new and thus will enrich the field in new ways. The Keystone Symposia Diabetes meeting remains the most important forum for new basic science presentations in the field of diabetes. By bringing it together with the conference on Adipocyte Biology and having multiple joint sessions, this meeting fill a need in the scientific community that is not filled by other conferences. The meeting has novel content that will inform and challenge the attendees and brings many new research paradigms, as well as novel approaches and methods to the scientific community. The meeting is truly interdisciplinary, with not only basic scientists and clinical scientists, but those from many disciplines outside the fields of endocrinology and metabolism, including gastroenterology, neuroscience, innate immunity and genetics.
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, JANUARY 27
08:00—09:00
Welcome and Keynote Address (Joint)
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Susan K. Fried,
Boston University School of Medicine, USA
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C. Ronald Kahn,
Joslin Diabetes Center and Harvard Medical School, USA
Craig B. Thompson,
Memorial Sloan-Kettering Cancer Center, USA
Metabolic Regulation in Cancer Biology
Metabolic Regulation in Cancer Biology
09:00—11:00
Mechanisms of Metabolic Dysfunction and New Therapeutic Targets for Diabetes and Obesity (Joint)
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David E. Kelley,
Merck & Co., Inc., USA
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David E. Moller,
Eli Lilly and Company, USA
Bruce M. Spiegelman,
Harvard Medical School, USA
Control of Beige Fat Thermogenesis: Toward a New Generation of Therapeutics
Control of Beige Fat Thermogenesis: Toward a New Generation of Therapeutics
David J. Mangelsdorf,
HHMI/University of Texas Southwestern Medical Center, USA
Journal of Lipid Research Lectureship Award Presented by Kathryn Moore: Regulation of Nutrient Metabolism by FGF21
Journal of Lipid Research Lectureship Award Presented by Kathryn Moore: Regulation of Nutrient Metabolism by FGF21
Philippe Froguel,
Imperial College of London, UK
Germline and Somatic Clonal Genomic Structure Events in Diabetes and Obesity and their Relation with Associated Diseases
Germline and Somatic Clonal Genomic Structure Events in Diabetes and Obesity and their Relation with Associated Diseases
11:00—12:00
APSA Panel on Career Development (Joint)
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Jennifer M. Kwan,
University of Illinois at Chicago, USA
*
Laina King,
Keystone Symposia, USA
C. Ronald Kahn,
Joslin Diabetes Center and Harvard Medical School, USA
David E. Kelley,
Merck & Co., Inc., USA
Anne C. Ferguson-Smith,
University of Cambridge, UK
Randy S. Levinson,
Nature Publishing Group, USA
14:30—16:30
Workshop 1: New Aspects of Insulin Signaling and Insulin Resistance
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Domenico Accili,
Columbia University, USA
Utpal B. Pajvani,
Columbia University Medical Center, USA
Inhibition of Notch Uncouples Akt Activation from Hepatic Lipid Accumulation by Decreasing mTorc1 Stability
Inhibition of Notch Uncouples Akt Activation from Hepatic Lipid Accumulation by Decreasing mTorc1 Stability
Rebecca A. Haeusler,
Columbia University, USA
FoxOs Regulate Liver Metabolic Fluxes
FoxOs Regulate Liver Metabolic Fluxes
Ana Paula Arruda,
Harvard School of Public Health, USA
Altered Mitochondria-Associated ER Membranes (MAMs) Links ER Stress to Mitochondrial Dysfunction in Obesity
Altered Mitochondria-Associated ER Membranes (MAMs) Links ER Stress to Mitochondrial Dysfunction in Obesity
Mads Fuglsang Kjolby,
Aarhus University, Denmark
The Ectodomain of SorCS1 Increases Peripheral Insulin Sensitivity and Lowers Plasma Glucose Levels in Mice
The Ectodomain of SorCS1 Increases Peripheral Insulin Sensitivity and Lowers Plasma Glucose Levels in Mice
Jeremie Boucher,
Joslin Diabetes Center, USA
A Novel Role for Insulin and IGF-1 Receptors in Control of Genomic Imprinting
A Novel Role for Insulin and IGF-1 Receptors in Control of Genomic Imprinting
Yingfeng Deng,
University of Texas Southwestern Medical Center, USA
Revisiting the Leloir Pathway: A Novel Connection between ER Stress and Insulin Sensitivity
Revisiting the Leloir Pathway: A Novel Connection between ER Stress and Insulin Sensitivity
Esther Phielix,
German Diabetes Center, Germany
Reduction of Free Fatty Acids Lowers H2O2 Production But Does Not Restore Insulin-Stimulated Oxidative Capacity in Type 2 Diabetes
Reduction of Free Fatty Acids Lowers H2O2 Production But Does Not Restore Insulin-Stimulated Oxidative Capacity in Type 2 Diabetes
Darcy L. Johannsen,
Pennington Biomedical Research Center, USA
Insulin Resistance Driven by High-Fat Overfeeding Is Not Mediated by Muscular Lipid Accumulation
Insulin Resistance Driven by High-Fat Overfeeding Is Not Mediated by Muscular Lipid Accumulation
14:30—16:30
Workshop 1: 8 Shades of Brown
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Sheila Collins,
Sanford-Burnham Medical Research Institute, USA
*
Jan Nedergaard,
Stockholm University, Sweden
*
Barbara Cannon,
Stockholm University, Sweden
Introduction and Overview
Introduction and Overview
Nicholas Douris,
Beth Israel Deaconess Medical Center, Harvard Medical School, USA
FGF21 Stimulates Browning of White Adipose Tissue via Direct Action on the Brain
FGF21 Stimulates Browning of White Adipose Tissue via Direct Action on the Brain
Shingo Kajimura,
University of California, San Francisco, USA
Molecular Control of Brown Adipose Cell Fate and Energy Homeostasis through a PRDM16 Transcriptional Complex
Molecular Control of Brown Adipose Cell Fate and Energy Homeostasis through a PRDM16 Transcriptional Complex
Therese J. Larsen,
Rigshospitalet, University of Copenhagen, Denmark
Supraclavicular Adipocytes from Adult Humans, Display a mRNA Signature that Partly Overlaps with both Brown and Brite/Beige Murine Expression Profiles
Supraclavicular Adipocytes from Adult Humans, Display a mRNA Signature that Partly Overlaps with both Brown and Brite/Beige Murine Expression Profiles
Annie Moisan,
Roche Pharmaceuticals, Switzerland
A Screening Platform to Identify Regulators of Human Adipocyte Cell Fate
A Screening Platform to Identify Regulators of Human Adipocyte Cell Fate
Kathleen Ogilvie,
Pfizer, USA
Do Adipocyte Cell Lines Reliably Respond to Pharmacological Agents which Recruit a Beige-Cell Gene Signature in Vivo?
Do Adipocyte Cell Lines Reliably Respond to Pharmacological Agents which Recruit a Beige-Cell Gene Signature in Vivo?
Hai-Bin Ruan,
Yale University School of Medicine, USA
Nutrient-Sensitive O-GlcNAc Signaling in AgRP Neurons Regulates Adipocyte Browning and Energy Homeostasis
Nutrient-Sensitive O-GlcNAc Signaling in AgRP Neurons Regulates Adipocyte Browning and Energy Homeostasis
Courtney M. Anderson,
University of California, Berkeley, USA
Requirement of the Scavenger Receptor CD36 for Brown Adipose Tissue Mitochondrial Function
Requirement of the Scavenger Receptor CD36 for Brown Adipose Tissue Mitochondrial Function
17:00—19:00
miRNAs and Metabolic Disease
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*
Silvia Corvera,
University of Massachusetts Medical School, USA
Markus Stoffel,
Institute of Molecular Health Science, Switzerland
miRNAs in Control of beta-Cell Function
miRNAs in Control of beta-Cell Function
Jens C. Brüning,
Institute for Genetics, University of Cologne, Germany
miRNAs in Control of Liver Metabolism
miRNAs in Control of Liver Metabolism
Anna Krook,
Karolinska Institutet, Sweden
Role of miRNA Let7 in Diabetes-Related Inflammation
Role of miRNA Let7 in Diabetes-Related Inflammation
Thaís Amaral e Sousa,
University of São Paulo, Brazil
Short Talk: Deregulation of microRNAs Let-7b and miR-696 in Mice Insulin Resistant Skeletal Muscle
Short Talk: Deregulation of microRNAs Let-7b and miR-696 in Mice Insulin Resistant Skeletal Muscle
17:00—19:00
Losing Fat: Dynamics of Adipocyte Lipid Turnover
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*
Susan K. Fried,
Boston University School of Medicine, USA
Rudolf Zechner,
University of Graz, Austria
Lypolysis and Thermogenesis
Lypolysis and Thermogenesis
Paul F. Pilch,
Boston University School of Medicine, USA
Pleiotropic Effects of Cavin-1 Deficiency on in vivo and in vitro Lipid Metabolism
Pleiotropic Effects of Cavin-1 Deficiency on in vivo and in vitro Lipid Metabolism
Richard N. Bergman,
Cedars-Sinai Medical Center, USA
Role of Free Fatty Acids in the Insulin Resistance Syndrome
Role of Free Fatty Acids in the Insulin Resistance Syndrome
Irfan J. Lodhi,
Washington University School of Medicine, USA
Short Talk: Peroxisomal Lipid Synthesis Programs Adipose Tissue Development through PPAR Signaling
Short Talk: Peroxisomal Lipid Synthesis Programs Adipose Tissue Development through PPAR Signaling
08:00—11:00
Aging, Mitochondria and Control of Metabolism
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*
Gerald I. Shulman,
HHMI/Yale University School of Medicine, USA
Andrew G. Dillin,
University of California, Berkeley, USA
Humoral Control of Mitochondrial Form and Function
Humoral Control of Mitochondrial Form and Function
Kitt F. Petersen,
Yale University School of Medicine, USA
Mitochondrial Function in Humans and its Relationship with Ectopic Lipid, Insulin Resistance and the Metabolic Syndrome
Mitochondrial Function in Humans and its Relationship with Ectopic Lipid, Insulin Resistance and the Metabolic Syndrome
Eric M. Verdin,
University of California, San Francisco, USA
Reversible Acetylation in Regulation of Mitochondrial Function and Aging
Reversible Acetylation in Regulation of Mitochondrial Function and Aging
Dudley W. Lamming,
Whitehead Institute for Biomedical Research, USA
Short Talk: Depletion of mTORC2 Impairs the Health and Longevity of Mice Independently of Effects on Hepatic Glucose Output
Short Talk: Depletion of mTORC2 Impairs the Health and Longevity of Mice Independently of Effects on Hepatic Glucose Output
08:00—11:00
Remodeling a Healthy Adipose Tissue
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*
Stephen R. Farmer,
Boston University School of Medicine, USA
Silvia Corvera,
University of Massachusetts Medical School, USA
Metabolic Control of Adipose Tissue Angiogenesis
Metabolic Control of Adipose Tissue Angiogenesis
Rajat Singh,
Albert Einstein College of Medicine, USA
When Fat Is Self-Absorbed – Autophagy and Lipid Metabolism
When Fat Is Self-Absorbed – Autophagy and Lipid Metabolism
Chad A. Cowan,
Harvard University, USA
Genome Editing to Generate Human Cellular Models of Metabolic Disease
Genome Editing to Generate Human Cellular Models of Metabolic Disease
Yun-Hee Lee,
Wayne State University, USA
Short Talk: Identification of an Adipogenic Niche for Adipose Tissue Remodeling and Restoration
Short Talk: Identification of an Adipogenic Niche for Adipose Tissue Remodeling and Restoration
Carolyn S. Hudak,
University of California, Berkeley, USA
Short Talk: Development of Adipose Tissue
Short Talk: Development of Adipose Tissue
Li Qiang,
Columbia University Medical Center, USA
Short Talk: Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of PPARgamma
Short Talk: Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of PPARgamma
17:00—19:00
Epigenetics and Perinatal Imprinting in Diabetes and Obesity (Joint)
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*
Philippe Froguel,
Imperial College of London, UK
C. Ronald Kahn,
Joslin Diabetes Center and Harvard Medical School, USA
Diabetes and Obesity - Nature versus Nurture
Diabetes and Obesity - Nature versus Nurture
Anne C. Ferguson-Smith,
University of Cambridge, UK
Intergenerational Epigenetic Programming of Metabolic Defects in a Mouse Model of Undernutrition
Intergenerational Epigenetic Programming of Metabolic Defects in a Mouse Model of Undernutrition
Paolo Sassone-Corsi,
University of California, Irvine, USA
Epigenetic Control of Circadian Rhythms and Metabolism
Epigenetic Control of Circadian Rhythms and Metabolism
08:00—11:00
Signaling Defects and Inflammation in Insulin Resistance (Joint)
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*
Gökhan S. Hotamisligil,
Harvard University, USA
Diane J. Mathis,
Harvard Medical School, USA
Regulatory T Cells Residing in Adipose Tissue
Regulatory T Cells Residing in Adipose Tissue
Anthony W. Ferrante,
Columbia University, USA
Eating Fat: Non-Inflammatory Functions of Adipose Tissue Macrophages
Eating Fat: Non-Inflammatory Functions of Adipose Tissue Macrophages
Alan R. Saltiel,
University of Michigan, USA
Inflammatory Links between Obesity, Diabetes and Energy Expenditure
Inflammatory Links between Obesity, Diabetes and Energy Expenditure
Ajay Chawla,
University of California, San Francisco, USA
Innate Control of Metabolism
Innate Control of Metabolism
Jan Mauer,
Max Planck Institute for Neurological Research, Germany
Short Talk: IL-6 Signaling in Myeloid Cells Limits High Fat Diet-Induced Insulin Resistance
Short Talk: IL-6 Signaling in Myeloid Cells Limits High Fat Diet-Induced Insulin Resistance
14:30—15:30
Workshop 2A: Islet Pathophysiology
*
Markus Stoffel,
Institute of Molecular Health Science, Switzerland
Nicole Ehrhardt,
Cedars-Sinai Medical Center, USA
Lipase Maturation Factor 1 (LMF1): A New Player in ER-Stress and beta Cell Function
Lipase Maturation Factor 1 (LMF1): A New Player in ER-Stress and beta Cell Function
Yun Sok Lee,
University of California, San Deigo, USA
A Novel Pathway for Regulation of Insulin Secretion by Fractalkine and CX3CR1 System
A Novel Pathway for Regulation of Insulin Secretion by Fractalkine and CX3CR1 System
Jean-Sébastien Annicotte,
EGID CNRS UMR 8199, France
The P300/CBP-Associated Factor (PCAF) Is a Histone Acetyl Transferase that Controls beta-Cell Function
The P300/CBP-Associated Factor (PCAF) Is a Histone Acetyl Transferase that Controls beta-Cell Function
Veronika Leiss,
Institute of Experimental and Clinical Pharmacology and Toxicology, Germany
Role of Islet Galphai2 in the Regulation of Glucose Homeostasis
Role of Islet Galphai2 in the Regulation of Glucose Homeostasis
15:30—16:30
Workshop 2B: New Drugs for Diabetes
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Hans Ulrich Stilz,
Sanofi-Aventis Deutschland GmbH, Germany
Annelie Falkevall,
Karolinska Institutet, Sweden
Targeting VEGF-B as a Novel Treatment for Insulin Resistance and Type 2 Diabetes
Targeting VEGF-B as a Novel Treatment for Insulin Resistance and Type 2 Diabetes
James D. Dunbar,
Eli Lilly & Company, USA
Comparison of the in vitro and in vivo Actions of FGF19 and FGF21
Comparison of the in vitro and in vivo Actions of FGF19 and FGF21
Derek M. Erion,
Pfizer, USA
Hepato-Selective Glucokinase Activators Reduce Fasting and Postprandial Hyperglycemia in Rats without Inducing Hypoglycemia or Increasing Hepatic Lipids
Hepato-Selective Glucokinase Activators Reduce Fasting and Postprandial Hyperglycemia in Rats without Inducing Hypoglycemia or Increasing Hepatic Lipids
Safina Ali,
Samuel Lunenfeld Research Institute, Canada
Disruption of Cardiomyocyte Glucagon Receptor Signaling Decreases Flux through Fatty Acid Oxidation and Enhances Survival Following Ischemic Injury
Disruption of Cardiomyocyte Glucagon Receptor Signaling Decreases Flux through Fatty Acid Oxidation and Enhances Survival Following Ischemic Injury
17:00—19:00
Gastric Bypass Surgery and the Gut in Control of Metabolism
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*
Mary-Elizabeth Patti,
Joslin Diabetes Center, USA
David E. Cummings,
University of Washington, USA
Metabolic Surgery: Endocrine Mechanisms of Diabetes Remission after "Bariatric" Operations
Metabolic Surgery: Endocrine Mechanisms of Diabetes Remission after "Bariatric" Operations
Lee M. Kaplan,
Massachusetts General Hospital, USA
Physiological Responses to Bariatric Surgery
Physiological Responses to Bariatric Surgery
Line V. Kristensen,
University of Copenhagen, Denmark
Short Talk: GPR40, GPR120 and GPR119 Act in Concert as Enteroendocrine Sensors for Dietary Fat
Short Talk: GPR40, GPR120 and GPR119 Act in Concert as Enteroendocrine Sensors for Dietary Fat
17:00—19:00
Variation in the Biology of Adipose Depots
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*
Jacqueline M. Stephens,
Louisiana State University, USA
Susan K. Fried,
Boston University School of Medicine, USA
Fat Distribution in Men and Women: The Biology of Pear Shape
Fat Distribution in Men and Women: The Biology of Pear Shape
James L. Kirkland,
Mayo Clinic, USA
Cellular Senescence and Adipose Tissue
Cellular Senescence and Adipose Tissue
Elise C. Jeffery,
Yale University, USA
Short Talk: High-Fat Diet Induces Depot- and Sex-Specific Adipocyte Hyperplasia
Short Talk: High-Fat Diet Induces Depot- and Sex-Specific Adipocyte Hyperplasia
Sagar P. Bapat,
The Salk Institute for Biological Studies, USA
Short Talk: Male-Specific Enrichment of Fat-Resident Regulatory T Cells Is Linked to the Insulin Sensitizing Effect of TZDs
Short Talk: Male-Specific Enrichment of Fat-Resident Regulatory T Cells Is Linked to the Insulin Sensitizing Effect of TZDs
08:00—11:00
Metabolic Mediators of Insulin Resistance
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*
Jeffrey Flier,
Harvard University, USA
*
Barbara C. Hansen,
University of South Florida, Tampa, USA
Philipp E. Scherer,
University of Texas Southwestern Medical Center, USA
Inflammation, UPR and Lipids: All about Stress and Toxicity?
Inflammation, UPR and Lipids: All about Stress and Toxicity?
Gerald I. Shulman,
HHMI/Yale University School of Medicine, USA
Novel PKCs as Mediators of Liver and Muscle Insulin Resistance in Humans
Novel PKCs as Mediators of Liver and Muscle Insulin Resistance in Humans
Gökhan S. Hotamisligil,
Harvard University, USA
Endoplasmic Reticulum Stress as a Mediator of Insulin Resistance
Endoplasmic Reticulum Stress as a Mediator of Insulin Resistance
Greg R. Steinberg,
McMaster University, Canada
AMP-Activated Protein Kinase (AMPK) Regulation of Lipid Metabolism and Insulin Sensitivity
AMP-Activated Protein Kinase (AMPK) Regulation of Lipid Metabolism and Insulin Sensitivity
Alexei Kharitonenkov,
Eli Lilly and Company, USA
Short Talk: Rational Design and Efficacy of LY2405319, an FGF21-Based Clinical Candidate
Short Talk: Rational Design and Efficacy of LY2405319, an FGF21-Based Clinical Candidate
08:00—11:00
Brown Adipose Tissue: Where There Is Smoke...
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*
Eleftheria Maratos-Flier,
Beth Israel Deaconess Medical Center, USA
Stephen R. Farmer,
Boston University School of Medicine, USA
Progenitor Morphology and Development of Beige/Brite Adipocytes
Progenitor Morphology and Development of Beige/Brite Adipocytes
Sheila Collins,
Sanford-Burnham Medical Research Institute, USA
Converging Hormonal Signals that 'Spark' the Brown-in-White Adipocyte Transformation
Converging Hormonal Signals that 'Spark' the Brown-in-White Adipocyte Transformation
Yu-Hua Tseng,
Joslin Diabetes Center/Harvard Medical School, USA
Cross Talk between Constitutive and Recruitable Brown Adipose Tissues for Thermoregulation and Energy Homeostasis
Cross Talk between Constitutive and Recruitable Brown Adipose Tissues for Thermoregulation and Energy Homeostasis
Sona Rajakumari,
University of Pennsylvania, USA
Short Talk: EBF2 Determines and Maintains Brown Adipocyte Identity
Short Talk: EBF2 Determines and Maintains Brown Adipocyte Identity
Xingxing Kong,
Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Short Talk: Thermogenic Actions of the Immune Transcription Factor IRF4
Short Talk: Thermogenic Actions of the Immune Transcription Factor IRF4
14:30—16:30
Workshop 2: Assessing Immune Cell Populations in Adipose Tissue: What Are the FACS?
*
Anthony W. Ferrante,
Columbia University, USA
Yoshihiro Ogawa,
Tokyo Medical and Dental University, Japan
Role of Macrophage-Inducible C-Type Lectin in Obesity-Induced Adipose Tissue Inflammation
Role of Macrophage-Inducible C-Type Lectin in Obesity-Induced Adipose Tissue Inflammation
Dwight J. Klemm,
University of Colorado Denver Anschutz Medical Center, USA
Soluble Adipose Tissue Factors Stimulate de Novo Differentiation of Bona Fide Adipocytes from Bone Marrow Myeloid Cells
Soluble Adipose Tissue Factors Stimulate de Novo Differentiation of Bona Fide Adipocytes from Bone Marrow Myeloid Cells
John S. Parks,
Wake Forest University School of Medicine, USA
Dietary Cholesterol Promotes Adipocyte Hypertrophy and Inflammation in Visceral, But Not Subcutaneous, Fat in Non-Human Primates
Dietary Cholesterol Promotes Adipocyte Hypertrophy and Inflammation in Visceral, But Not Subcutaneous, Fat in Non-Human Primates
Tal Pecht,
Ben-Gurion University of the Negev, Israel
Adipose Tissue Foam Cells in Human Obesity
Adipose Tissue Foam Cells in Human Obesity
Marek Wagner,
University of Bergen, Norway
Adipose Tissue-Derived Macrophages, Endothelial Cells and Cancer
Adipose Tissue-Derived Macrophages, Endothelial Cells and Cancer
Nicolas Venteclef,
Institute of Cardiometabolism and Nutrition, France
Dysregulation of a GPS2/SMRT Corepressor Pathway in Adipocytes Coincides with Adipose Tissue Inflammation in Human Obesity
Dysregulation of a GPS2/SMRT Corepressor Pathway in Adipocytes Coincides with Adipose Tissue Inflammation in Human Obesity
Maryam Rakhshandehroo,
Utrecht Medical Center, Netherlands
Natural Killer T Cells in Adipose Tissue Prevent Insulin Resistance
Natural Killer T Cells in Adipose Tissue Prevent Insulin Resistance
17:00—19:00
CNS Control of Metabolism
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*
Jens C. Brüning,
Institute for Genetics, University of Cologne, Germany
Joel K. Elmquist,
University of Texas Southwestern Medical Center, USA
Investigating Autonomic Regulatory Networks Controlling Energy Balance and Glucose Homeostasis
Investigating Autonomic Regulatory Networks Controlling Energy Balance and Glucose Homeostasis
Christoph Buettner,
Mount Sinai School of Medicine, USA
CNS Control of Adipose Tissue Functionality
CNS Control of Adipose Tissue Functionality
Richard M. Caprioli,
Vanderbilt University Medical Center, USA
Imaging Mass Spectrometry: A New Technology for the Direct Mapping of Endogenous Compounds in Tissue
Imaging Mass Spectrometry: A New Technology for the Direct Mapping of Endogenous Compounds in Tissue
Céline E. Riera,
The Salk Institute for Biological Studies, USA
Short Talk: Neuroendocrine Regulation of the Calcineurin/CRTC1 Longevity Circuit in C. elegans and Mice
Short Talk: Neuroendocrine Regulation of the Calcineurin/CRTC1 Longevity Circuit in C. elegans and Mice
17:00—19:00
Beyond Diabetes - Complications of Obesity
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*
Ira J. Goldberg,
Columbia University, USA
Kathryn J. Moore,
New York University Medical Center, USA
Mechanisms of Macrophage Retention in Metabolic Diseases
Mechanisms of Macrophage Retention in Metabolic Diseases
Scott A. Small,
Columbia University, USA
Leucine Elevations Cause Retromer Deficiency: A Possible Link between Obesity/Diabetes and Alzheimer’s Disease
Leucine Elevations Cause Retromer Deficiency: A Possible Link between Obesity/Diabetes and Alzheimer’s Disease
Roberta Goncalves Marangoni,
Northwestern University, USA
Short Talk: Aberrant Adipogenesis in the Pathogenesis of Scleroderma
Short Talk: Aberrant Adipogenesis in the Pathogenesis of Scleroderma
*Session Chair †Speaker invited, not yet responded.
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