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This meeting took place in 2013


Here are the related meetings in 2015:
Obesity and the Metabolic Syndrome: Mitochondria and Energy Expenditure (X7)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Adipose Tissue Biology (J5)


Organizer(s) Susan K. Fried and Anthony W. Ferrante
January 27—February 1, 2013
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 27, 2012
Late Abstract Deadline: Oct 29, 2012
Scholarship Deadline: Sep 27, 2012
Early Registration Deadline: Nov 28, 2012

Supported by the Directors' Fund


Summary of Meeting:
Adipocytes are central players in the development of obesity and associated metabolic syndromes. Key areas of ongoing research in this field focus on basic mechanisms that modulate the lifespan of adipocytes, explain how resident and recruited immune cell populations influence adipose tissue remodeling and metabolic function, contribute to the functional heterogeneity of white as well as brown adipose tissue depots, and link alterations in adipocyte function to disease risk. The next few years will bring the application of new technologies and nextgen sequencing, and will likely yield unanticipated insights into developmental and functional aspects of adipocyte biology. Thus, an important goal of the meeting is to engage researchers from diverse fields to take basic discoveries in adipocyte biology to the next level, including a deepening understanding the etiology of type 2 diabetes through our joint meeting, as well as correlated diseases such as cancer, dementia and asthma. The meeting goals are: 1) to foster cross-talk between basic researchers working on model systems with those studying mammalian models and clinical/translational aspects; 2) to integrate emerging knowledge of the myriad roles of adipose tissue in understanding mechanisms linking the degree of adiposity and adipose tissue distribution to disease; and 3) to disseminate knowledge of new technologies that can deepen and broaden knowledge of adipocyte biology in vivo and in vitro. Attendees will take away a more diverse knowledge of the field and an awareness of potential new mechanistic connections and therapeutic opportunities.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 27

16:00—20:00
Arrival and Registration


MONDAY, JANUARY 28

07:00—08:00
Breakfast

08:00—09:00
Welcome and Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Susan K. Fried, Boston University School of Medicine, USA

* C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA

Craig B. Thompson, Memorial Sloan-Kettering Cancer Center, USA
Metabolic Regulation in Cancer Biology

09:00—11:00
Mechanisms of Metabolic Dysfunction and New Therapeutic Targets for Diabetes and Obesity (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* David E. Kelley, Merck & Co., Inc., USA

* David E. Moller, Eli Lilly and Company, USA

Bruce M. Spiegelman, Harvard Medical School, USA
Control of Beige Fat Thermogenesis: Toward a New Generation of Therapeutics

David J. Mangelsdorf, HHMI/University of Texas Southwestern Medical Center, USA
Journal of Lipid Research Lectureship Award Presented by Kathryn Moore: Regulation of Nutrient Metabolism by FGF21

Philippe Froguel, Imperial College of London, UK
Germline and Somatic Clonal Genomic Structure Events in Diabetes and Obesity and their Relation with Associated Diseases

09:40—10:00
Coffee Break

11:00—12:00
APSA Panel on Career Development (Joint)

Jennifer M. Kwan, APSA Policy Chair and Vice President of External Affairs, and Laina King, Director, Diversity in Life Science Programs at Keystone Symposia, will lead a discussion on ways early-career investigators can enhance their professional development skills, particularly in the areas of translational research and biomedical discovery.

* Jennifer M. Kwan, University of Illinois, Chicago, USA

* Laina King, Keystone Symposia, USA

C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA

David E. Kelley, Merck & Co., Inc., USA

Anne C. Ferguson-Smith, University of Cambridge, UK

Randy S. Levinson, Nature Publishing Group, USA

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: 8 Shades of Brown

* Sheila Collins, Sanford-Burnham Medical Research Institute, USA

* Jan Nedergaard, Stockholm University, Sweden

* Barbara Cannon, Stockholm University, Sweden
Introduction and Overview

Nicholas Douris, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
FGF21 Stimulates Browning of White Adipose Tissue via Direct Action on the Brain

Shingo Kajimura, University of California, San Francisco, USA
Molecular Control of Brown Adipose Cell Fate and Energy Homeostasis through a PRDM16 Transcriptional Complex

Therese J. Larsen, Rigshospitalet, University of Copenhagen, Denmark
Adipose Tissue from Supraclavicular Region of Adult Humans Display Classical Brown Fat Signature

Annie Moisan, Roche Pharmaceuticals, Switzerland
A Screening Platform to Identify Regulators of Human Adipocyte Cell Fate

Kathleen Ogilvie, aTyr Pharma, USA
Do Adipocyte Cell Lines Reliably Respond to Pharmacological Agents which Recruit a Beige-Cell Gene Signature in Vivo?

Hai-Bin Ruan, Yale University School of Medicine, USA
Nutrient-Sensitive O-GlcNAc Signaling in AgRP Neurons Regulates Adipocyte Browning and Energy Homeostasis

Courtney M. Anderson, University of California, Berkeley, USA
Requirement of the Scavenger Receptor CD36 for Brown Adipose Tissue Mitochondrial Function

14:30—16:30
Workshop 1: New Aspects of Insulin Signaling and Insulin Resistance

* Domenico Accili, Columbia University, USA

Utpal B. Pajvani, Columbia University Medical Center, USA
Inhibition of Notch Uncouples Akt Activation from Hepatic Lipid Accumulation by Decreasing mTorc1 Stability

Rebecca A. Haeusler, Columbia University, USA
FoxOs Regulate Liver Metabolic Fluxes

Ana Paula Arruda, Harvard School of Public Health, USA
Altered Mitochondria-Associated ER Membranes (MAMs) Links ER Stress to Mitochondrial Dysfunction in Obesity

Mads Fuglsang Kjolby, Aarhus University, Denmark
The Ectodomain of SorCS1 Increases Peripheral Insulin Sensitivity and Lowers Plasma Glucose Levels in Mice

Jeremie Boucher, Joslin Diabetes Center, USA
A Novel Role for Insulin and IGF-1 Receptors in Control of Genomic Imprinting

Yingfeng Deng, University of Texas Southwestern Medical Center, USA
Revisiting the Leloir Pathway: A Novel Connection between ER Stress and Insulin Sensitivity

Esther Phielix, German Diabetes Center, Germany
Reduction of Free Fatty Acids Lowers H2O2 Production But Does Not Restore Insulin-Stimulated Oxidative Capacity in Type 2 Diabetes

Darcy L. Johannsen, Pennington Biomedical Research Center, USA
Insulin Resistance Driven by High-Fat Overfeeding Is Not Mediated by Muscular Lipid Accumulation

16:30—17:00
Coffee Available

17:00—19:00
Losing Fat: Dynamics of Adipocyte Lipid Turnover
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Susan K. Fried, Boston University School of Medicine, USA

Rudolf Zechner, University of Graz, Austria
Lipolysis: A Drug Target for Metabolic Disease?

Paul F. Pilch, Boston University School of Medicine, USA
Consequences of Cav(e)lin/Caveolae Deficiency on Lipid Metabolism

Richard N. Bergman, Cedars-Sinai Medical Center, USA
Role of Free Fatty Acids in the Insulin Resistance Syndrome

Irfan J. Lodhi, Washington University School of Medicine, USA
Short Talk: Peroxisomal Lipid Synthesis Programs Adipose Tissue Development through PPAR Signaling

17:00—19:00
miRNAs and Metabolic Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Silvia Corvera, University of Massachusetts Medical School, USA

Markus Stoffel, ETH Zürich, Switzerland
miRNAs in Control of beta-Cell Function

Jens C. Brüning, Max Planck Institute for Metabolism Research, Germany
miRNAs in Control of Liver Metabolism

Anna Krook, Karolinska Institutet, Sweden
Role of miRNA Let7 in Diabetes-Related Inflammation

Thaís Amaral e Sousa, University of São Paulo, Brazil
Short Talk: Deregulation of microRNAs Let-7b and miR-696 in Mice Insulin Resistant Skeletal Muscle

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, JANUARY 29

07:00—08:00
Breakfast

08:00—11:00
Remodeling a Healthy Adipose Tissue
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Stephen R. Farmer, Boston University School of Medicine, USA

Silvia Corvera, University of Massachusetts Medical School, USA
Metabolic Control of Adipose Tissue Angiogenesis

Rajat Singh, Albert Einstein College of Medicine, USA
Autophagy and Lipid Metabolism

Chad A. Cowan, Harvard University, USA
Genome Editing to Generate Human Cellular Models of Metabolic Disease

Yun-Hee Lee, Wayne State University, USA
Short Talk: Identification of an Adipogenic Niche for Adipose Tissue Remodeling and Restoration

Carolyn S. Hudak, Harvard University, USA
Short Talk: Pref-1 Expressing Cells are the Adipose Precursors

Li Qiang, Columbia University Medical Center, USA
Short Talk: Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of PPARgamma

08:00—11:00
Aging, Mitochondria and Control of Metabolism
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Gerald I. Shulman, HHMI/Yale University School of Medicine, USA

Andrew G. Dillin, University of California, Berkeley, USA
Humoral Control of Mitochondrial Form and Function

Kitt F. Petersen, Yale University School of Medicine, USA
Mitochondrial Function in Humans and its Relationship with Ectopic Lipid, Insulin Resistance and the Metabolic Syndrome

Eric M. Verdin, University of California, San Francisco, USA
Reversible Acetylation in Regulation of Mitochondrial Function and Aging

Domenico Accili, Columbia University, USA
Foxo2013: Can we Leverage some of its Properties to Treat Type 2 Diabetes

Dudley W. Lamming, Whitehead Institute for Biomedical Research, USA
Short Talk: Depletion of mTORC2 Impairs the Health and Longevity of Mice Independently of Effects on Hepatic Glucose Output

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Epigenetics and Perinatal Imprinting in Diabetes and Obesity (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Philippe Froguel, Imperial College of London, UK

C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Diabetes and Obesity - Nature or Nurture

Anne C. Ferguson-Smith, University of Cambridge, UK
Intergenerational Epigenetic Programming of Metabolic Defects in a Mouse Model of Undernutrition

Paolo Sassone-Corsi, University of California, Irvine, USA
Joining the Dots: Epigenetics, Metabolism and the Circadian Clock

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, JANUARY 30

07:00—08:00
Breakfast

08:00—11:00
Signaling Defects and Inflammation in Insulin Resistance (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Gökhan S. Hotamisligil, Harvard University, USA

Diane J. Mathis, Harvard Medical School, USA
Regulatory T Cells Residing in Adipose Tissue

Anthony W. Ferrante, Columbia University, USA
Non-Inflammatory Functions of Adipose Tissue Macrophages

Alan R. Saltiel, University of Michigan, USA
Inflammatory Links between Obesity, Diabetes and Energy Expenditure

Ajay Chawla, University of California, San Francisco, USA
Innate Control of Metabolism

Jan Mauer, Max Planck Institute for Neurological Research, Germany
Short Talk: IL-6 Signaling in Myeloid Cells Limits Obesity-Induced Insulin Resistance

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

14:30—15:30
Workshop 2A: Islet Pathophysiology

* Markus Stoffel, ETH Zürich, Switzerland

Nicole Ehrhardt, Cedars-Sinai Medical Center, USA
Lipase Maturation Factor 1 (LMF1): A New Player in ER-Stress and beta Cell Function

Yun Sok Lee, University of California, San Deigo, USA
A Novel Pathway for Regulation of Insulin Secretion by Fractalkine and CX3CR1 System

Jean-Sébastien Annicotte, EGID CNRS UMR 8199, France
The P300/CBP-Associated Factor (PCAF) Is a Histone Acetyl Transferase that Controls beta-Cell Function

Veronika Leiss, Institute of Experimental and Clinical Pharmacology and Toxicology, Germany
Role of Islet Galphai2 in the Regulation of Glucose Homeostasis

15:30—16:30
Workshop 2B: New Drugs for Diabetes

* Haus Ulrich Stilz, Novo Nordisk A/S, Denmark

Annelie Falkevall, Karolinska Institutet, Sweden
Targeting VEGF-B as a Novel Treatment for Insulin Resistance and Type 2 Diabetes

James D. Dunbar, Eli Lilly & Company, USA
Comparison of the in vitro and in vivo Actions of FGF19 and FGF21

Derek M. Erion, Pfizer, USA
Hepato-Selective Glucokinase Activators Reduce Fasting and Postprandial Hyperglycemia in Rats without Inducing Hypoglycemia or Increasing Hepatic Lipids

Safina Ali, Samuel Lunenfeld Research Institute, Canada
Disruption of Cardiomyocyte Glucagon Receptor Signaling Decreases Flux through Fatty Acid Oxidation and Enhances Survival Following Ischemic Injury

16:30—17:00
Coffee Available

17:00—19:00
Variation in the Biology of Adipose Depots
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jacqueline M. Stephens, Louisiana State University, USA

Susan K. Fried, Boston University School of Medicine, USA
Fat Distribution in Men and Women: The Biology of Pear Shape

James L. Kirkland, Mayo Clinic, USA
Cellular Senescence and Adipose Tissue

Elise C. Jeffery, Yale University, USA
Short Talk: Regulation of Adipocyte Precursor Cells in Obesity

Sagar P. Bapat, The Salk Institute for Biological Studies, USA
Short Talk: Sexually Dimorphic Properties of Fat Resident Regulatory T Cells

17:00—19:00
Gastric Bypass Surgery and the Gut in Control of Metabolism
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Mary-Elizabeth Patti, Joslin Diabetes Center, USA

David E. Cummings, University of Washington, USA
Metabolic Surgery: Endocrine Mechanisms of Diabetes Remission after "Bariatric" Operations

Daniel D. Kaplan, NGM Biopharmaceuticals, Inc., USA
New Gut Mediators of Bypass Surgery

Lee M. Kaplan, Massachusetts General Hospital, USA
Contributions of the Gut Microbiota to the Physiological Response to Geriatric Bypass

Line V. Kristensen, University of Copenhagen, Denmark
Short Talk: GPR40, GPR120 and GPR119 Act in Concert as Enteroendocrine Sensors for Dietary Fat

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


THURSDAY, JANUARY 31

07:00—08:00
Breakfast

08:00—11:00
Brown Adipose Tissue: Where There Is Smoke...
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Eleftheria Maratos-Flier, Beth Israel Deaconess Medical Center, USA

Stephen R. Farmer, Boston University School of Medicine, USA
Progenitor Morphology and Development of Beige Adipocytes

Sheila Collins, Sanford-Burnham Medical Research Institute, USA
Converging Hormonal Signals that 'Spark' the Brown-in-White Adipocyte Expansion

Yu-Hua Tseng, Joslin Diabetes Center/Harvard Medical School, USA
Cross Talk between Constitutive and Recruitable Brown Adipose Tissues for Thermoregulation and Energy Homeostasis

Sona Rajakumari, University of Pennsylvania, USA
Short Talk: EBF2 Determines and Maintains Brown Adipocyte Identity

Xingxing Kong, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Short Talk: Thermogenic Actions of Interferon Regulatory Factor 4 (IRF4)

08:00—11:00
Metabolic Mediators of Insulin Resistance
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jeffrey Flier, Harvard University, USA

* Barbara C. Hansen, University of South Florida, Tampa, USA

Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Inflammation, UPR and Lipids: All about Stress and Toxicity?

Gerald I. Shulman, HHMI/Yale University School of Medicine, USA
Novel PKCs as Mediators of Liver and Muscle Insulin Resistance in Humans

Gökhan S. Hotamisligil, Harvard University, USA
Endoplasmic Reticulum Stress as a Mediator of Insulin Resistance

Greg R. Steinberg, McMaster University, Canada
AMP-Activated Protein Kinase (AMPK) Regulation of Lipid Metabolism and Insulin Sensitivity

Alexei Kharitonenkov, Eli Lilly and Company, USA
Short Talk: Rational Design and Efficacy of LY2405319, an FGF21-Based Clinical Candidate

09:00—09:20
Coffee Break

 
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Assessing Immune Cell Populations in Adipose Tissue: What Are the FACS?

* Anthony W. Ferrante, Columbia University, USA

Yoshihiro Ogawa, Tokyo Medical and Dental University, Japan
Role of Macrophage-Inducible C-Type Lectin in Obesity-Induced Adipose Tissue Inflammation

Dwight J. Klemm, University of Colorado Denver Anschutz Medical Center, USA
Soluble Adipose Tissue Factors Stimulate de Novo Differentiation of Bona Fide Adipocytes from Bone Marrow Myeloid Cells

John S. Parks, Wake Forest University School of Medicine, USA
Dietary Cholesterol Promotes Adipocyte Hypertrophy and Inflammation in Visceral, But Not Subcutaneous, Fat in Non-Human Primates

Tal Pecht, Ben-Gurion University of the Negev, Israel
Adipose Tissue Foam Cells in Human Obesity

Marek Wagner, University of Bergen, Norway
Adipose Tissue-Derived Macrophages, Endothelial Cells and Cancer

Nicolas Venteclef, Institute of Cardiometabolism and Nutrition, France
Dysregulation of a GPS2/SMRT Corepressor Pathway in Adipocytes Coincides with Adipose Tissue Inflammation in Human Obesity

Maryam Rakhshandehroo, Utrecht Medical Center, Netherlands
iNKTs in Adipose Tissue Prevent Insulin Resistance

16:30—17:00
Coffee Available

17:00—19:00
Beyond Diabetes - Complications of Obesity
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Ira J. Goldberg, NYU Langone Medical Center, USA

Kathryn J. Moore, New York University Medical Center, USA
Mechanisms of Macrophage Retention in Metabolic Diseases

Mikhail G. Kolonin, University of Texas, USA
Regulation of Tumor Progression by Adipose Tissue

Scott A. Small, Columbia University, USA
Branch-Chained Amino Acids Link Obesity/T2DM and Alzheimer’s Disease through Retromer Deficiency

Roberta Goncalves Marangoni, Northwestern University, USA
Short Talk: Aberrant Adipogenesis in the Pathogenesis of Scleroderma

17:00—19:00
CNS Control of Metabolism
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jens C. Brüning, Max Planck Institute for Metabolism Research, Germany

Joel K. Elmquist, University of Texas Southwestern Medical Center, USA
Investigating Autonomic Regulatory Networks Controlling Energy Balance and Glucose Homeostasis

Christoph Buettner, Mount Sinai School of Medicine, USA
CNS Control of Adipose Tissue Functionality

Richard M. Caprioli, Vanderbilt University Medical Center, USA
Imaging Mass Spectrometry: A New Technology for the Direct Mapping of Endogenous Compounds in Tissue

Céline E. Riera, The Salk Institute for Biological Studies, USA
Short Talk: Neuroendocrine Regulation of the Calcineurin/CRTC1 Longevity Circuit in C. elegans and Mice

19:00—20:00
Social Hour with Lite Bites

20:00—23:00
Entertainment


FRIDAY, FEBRUARY 1

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge additional support for this conference from:


Journal of Lipid Research

AdipoGen International ALPCO Diagnostics
CEDARLANE Novus Biologicals, Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK084688-04

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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