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Fairmont Banff Springs Floorplan
This meeting took place in 2013
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Meeting Details
Neuronal Control of Appetite, Metabolism and Weight (C6)
Organizer(s) Tony K.T. Lam and Matthias H. Tschöp
March 17 - March 22, 2013
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: November 14, 2012
Late Abstract Deadline: December 19, 2012
Scholarship Deadline: November 14, 2012
Early Registration Deadline: January 17, 2013
Sponsored by AVEO Oncology
CME Information
Summary of Meeting:
Obesity and Type 2 diabetes are associated with a disruption in energy, glucose and lipid homeostasis. Exciting new developments indicate a key role for the central nervous system in the homeostatic control of systemic metabolic processes. A goal of the Keystone Symposia meeting on Neuronal Control of Appetite, Metabolism and Weight is to bring together basic and clinical scientists from academia and the pharmaceutical industry studying neuronal control of appetite, metabolism and body weight or related complementary fields (such as addiction/reward, cellular stress, and inflammation) to share novel and relevant insights with relevance for human obesity, diabetes and metabolic disease. The meeting seeks to integrate existing knowledge with novel discoveries on central nervous system mechanisms activated by hormones or nutrients that regulate systemic metabolism. Meeting participants will discuss the latest research in this field along with future directions and perspectives that are relevant for both basic science and clinical research.
CME Information
Obesity and Type 2 diabetes are associated with a disruption in energy, glucose and lipid homeostasis. Exciting new developments indicate a key role for the central nervous system in the homeostatic control of systemic metabolic processes. A goal of the Keystone Symposia meeting on Neuronal Control of Appetite, Metabolism and Weight is to bring together basic and clinical scientists from academia and the pharmaceutical industry studying neuronal control of appetite, metabolism and body weight or related complementary fields (such as addiction/reward, cellular stress, and inflammation) to share novel and relevant insights with relevance for human obesity, diabetes and metabolic disease. The meeting seeks to integrate existing knowledge with novel discoveries on central nervous system mechanisms activated by hormones or nutrients that regulate systemic metabolism. Meeting participants will discuss the latest research in this field along with future directions and perspectives that are relevant for both basic science and clinical research.
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, MARCH 17
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Matthias H. Tschöp,
HelmholtzZentrum München, Germany
Richard D. Palmiter,
HHMI/University of Washington, USA
Deciphering Neural Circuits Controlling Appetite
Deciphering Neural Circuits Controlling Appetite
09:00—12:00
Hypothalamic Inflammation, ER Stress and Mitochondrial Function
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Tony K.T. Lam,
University of Toronto, Canada
Dongsheng Cai,
Albert Einstein College of Medicine, USA
Hypothalamic Autophagy, Inflammation and Neurodegeneration in Obesity and Diabetes
Hypothalamic Autophagy, Inflammation and Neurodegeneration in Obesity and Diabetes
Umut Ozcan,
Children's Hospital Boston, Harvard Medical School, USA
Hypothalamic Inflammation, ER Stress and Metabolic Control
Hypothalamic Inflammation, ER Stress and Metabolic Control
Jens C. Brüning,
Institute for Genetics, University of Cologne, Germany
Insulin Receptors in the Brain: Where Do They Matter?
Insulin Receptors in the Brain: Where Do They Matter?
Eleftheria Maratos-Flier,
Beth Israel Deaconess Medical Center, USA
Central Actions of FGF21
Central Actions of FGF21
Eduardo A. Nillni,
Brown University, Rhode Island Hospital, USA
Short Talk: Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-Translational Processing
Short Talk: Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-Translational Processing
14:30—16:30
Workshop 1: Is the CNS Still a Relevant Pharmaceutical Target for Metabolic Disease?
*
Mads Tang-Christensen,
Novo Nordisk, Denmark
*
Ruth E. Gimeno,
Eli Lilly & Company, USA
Targeting TrkB/BDNF for the Treatment of Metabolic Disorders
Targeting TrkB/BDNF for the Treatment of Metabolic Disorders
Birgitte S. Wulff,
Novo Nordisk, Denmark
Safety and Efficacy of a Long Acting alpha-MSH Analogue, MC4-NN2-0453, in Overweight to Obese But Otherwise Healthy Subjects
Safety and Efficacy of a Long Acting alpha-MSH Analogue, MC4-NN2-0453, in Overweight to Obese But Otherwise Healthy Subjects
Andrew C. Adams,
Eli Lilly & Company, USA
FGF21: From the Brain to Adipose and Back Again
FGF21: From the Brain to Adipose and Back Again
Lora K. Heisler,
University of Cambridge, UK
5-HT2C Receptor Agonist: a New Obesity Treatment
5-HT2C Receptor Agonist: a New Obesity Treatment
17:00—19:00
Addiction and Reward in the CNS Control of Metabolism
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Kevin L. Grove,
Oregon National Primate Research Center, USA
Harvey J. Grill,
University of Pennsylvania, USA
Do Separate Sets of Neurons Control for the Satiation, the Motivational, and the Association-Based Preference Effects of Leptin?
Do Separate Sets of Neurons Control for the Satiation, the Motivational, and the Association-Based Preference Effects of Leptin?
Tamas L. Horvath,
Yale University School of Medicine, USA
A Role for the Arcute Nucleus in Reward and Complex Behaviors
A Role for the Arcute Nucleus in Reward and Complex Behaviors
Dana M. Small,
Yale University School of Medicine, USA
Metabolic Control of Neural Circuits Underlying Food Reward Learning in Humans
Metabolic Control of Neural Circuits Underlying Food Reward Learning in Humans
Sandeep Sharma,
Montreal Diabetes Research Center, University de Montreal, Canada
Short Talk: Saturated High-Fat Diets Are Anxiogenic and Elicit Pro-Inflammatory Signaling in Brain Reward Circuitry
Short Talk: Saturated High-Fat Diets Are Anxiogenic and Elicit Pro-Inflammatory Signaling in Brain Reward Circuitry
08:00—11:15
Nutrient Sensing and the Brain
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Robert H. Eckel,
University of Colorado Denver, Anschutz Medical Campus, USA
Daniele Piomelli,
University of California, Irvine, USA
Lipid Sensing and the Gut-Brain Axis
Lipid Sensing and the Gut-Brain Axis
Tony K.T. Lam,
University of Toronto, Canada
Nutrient Sensing in the Gut and the Brain
Nutrient Sensing in the Gut and the Brain
Bradford B. Lowell,
Beth Israel Deaconess Medical Center, USA
Neurocircuits Regulating Energy Balance
Neurocircuits Regulating Energy Balance
Sabrina Diano,
Yale University School of Medicine, USA
Glucose Sensing and Hypothalamic Neuropeptide Processing
Glucose Sensing and Hypothalamic Neuropeptide Processing
Eglantine Balland,
INSERM, France
Short Talk: Tanycytes of the Median Eminence Gate Leptin Transport into the Hypothalamus
Short Talk: Tanycytes of the Median Eminence Gate Leptin Transport into the Hypothalamus
Raj Kamal Srivastava,
Institute of Physiological Chemistry, Germany
Short Talk: Genetic Deletion of the CB1 Receptor from Dopamine-beta-Hydroxylase Expressing Cells Makes Mice Sensitive to Stress-Induced Obesity
Short Talk: Genetic Deletion of the CB1 Receptor from Dopamine-beta-Hydroxylase Expressing Cells Makes Mice Sensitive to Stress-Induced Obesity
15:00—16:30
Workshop 2: Challenges of the Publishing Process: How to Write a Scientific Masterpiece
*
Ushma Savla Neill,
Journal of Clinical Investigation & Molecular Metabolism, USA
Iain Patten,
Scientific Writing Consultant, Spain
Randy S. Levinson,
Nature Publishing Group, USA
Nikla Emambokus,
Cell Press, USA
17:00—19:00
Dissecting CNS Control of Metabolism I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Gregory James Morton,
University of Washington, USA
Kendra K. Bence,
University of Pennsylvania, USA
The Role of Protein Tyrosine Phosphatases in Neuronal Control of Energy Balance
The Role of Protein Tyrosine Phosphatases in Neuronal Control of Energy Balance
Christoph Buettner,
Mount Sinai School of Medicine, USA
Novel Roles of Brain Insulin Signaling in Regulating Whole Body Nutrient Partitioning and Innate Immunity
Novel Roles of Brain Insulin Signaling in Regulating Whole Body Nutrient Partitioning and Innate Immunity
Domenico Accili,
Columbia University, USA
FoxO1 Targets Regulating Energy Balance in the Central Nervous System
FoxO1 Targets Regulating Energy Balance in the Central Nervous System
Toshiya Kojima,
University of Tokyo, Japan
Short Talk: SUMOylation of Krüppel-Like Factor 5 Controls Food Intake by Suppressing AgRP Expression on Contact with FoxO1 in Hypothalamic Neurons
Short Talk: SUMOylation of Krüppel-Like Factor 5 Controls Food Intake by Suppressing AgRP Expression on Contact with FoxO1 in Hypothalamic Neurons
08:00—11:15
Gut-Brain Interactions in the Control of Systemic Metabolism
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*
Darleen A. Sandoval,
University of Cincinnati, USA
Daniel J. Drucker,
Samuel Lunenfeld Research Institute, Canada
The Biology of Incretins: Gut-Brain-Cardiovascular Connections
The Biology of Incretins: Gut-Brain-Cardiovascular Connections
Remy G. Burcelin,
Institute of Molecular Medicine, France
The Role of GLP-1 on the Gut-Brain Axis
The Role of GLP-1 on the Gut-Brain Axis
Hans-Rudolf Berthoud,
Pennington Biomedical Research Center, USA
Bariatric Surgery on CNS Control of Metabolism
Bariatric Surgery on CNS Control of Metabolism
Chen Liu,
University of Texas Southwestern Medical Center, USA
Short Talk: PPARgamma Signaling in Vagal Sensory Neurons Regulates Energy Balance
Short Talk: PPARgamma Signaling in Vagal Sensory Neurons Regulates Energy Balance
Gary J. Schwartz,
Albert Einstein College of Medicine, USA
Short Talk: Mediobasal Hypothalamic beta-3 Adrenergic Receptor Signaling Regulates Energy Intake and Utilization
Short Talk: Mediobasal Hypothalamic beta-3 Adrenergic Receptor Signaling Regulates Energy Intake and Utilization
14:30—16:30
Workshop 3: CNS Control of Metabolism: Hot Topics
*
Thierry Alquier,
University of Montreal-Montreal Diabetes Research Center, Canada
*
Diego Perez-Tilve,
University of Cincinnati, USA
Pawan Gulati,
University of Cambridge, UK
Novel Function for FTO in Cell Growth and Translational Control
Novel Function for FTO in Cell Growth and Translational Control
Martin Heni,
Eberhard Karls University Tübingen, Germany
Variation in the Obesity Risk Gene FTO Determines the Postprandial Cerebral Processing of Food Stimuli
Variation in the Obesity Risk Gene FTO Determines the Postprandial Cerebral Processing of Food Stimuli
Roger D. Cone,
Vanderbilt University, USA
Developmental Control of the Pharmacological Function of the Melanocortin-4 Receptor by MRAP2 Proteins
Developmental Control of the Pharmacological Function of the Melanocortin-4 Receptor by MRAP2 Proteins
Qingchun Tong,
University of Texas, Houston, USA
Disruption of Glutamate Release from Leptin Receptor-Expressing Neurons Results in Torpor-Like Behavior
Disruption of Glutamate Release from Leptin Receptor-Expressing Neurons Results in Torpor-Like Behavior
Lei Zhang,
Garvan Institute of Medical Research, Australia
Gender Specific Role of Neuropeptide FF Receptor 2 in the Regulation of Energy Balance and Glucose Homeostasis
Gender Specific Role of Neuropeptide FF Receptor 2 in the Regulation of Energy Balance and Glucose Homeostasis
17:00—19:00
Dissecting CNS Control of Metabolism II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Scott Waddell,
University of Oxford, UK
Scott Sternson,
HHMI/Janelia Farm Research Campus, USA
Neural Circuits and Motivational Processes Underlying Hunger
Neural Circuits and Motivational Processes Underlying Hunger
Lora K. Heisler,
University of Cambridge, UK
CNS Integration of Metabolic Signals
CNS Integration of Metabolic Signals
Vishwa Deep Dixit,
Pennington Biomedical Research Center
Inflammasomes and Astrogliosis
Inflammasomes and Astrogliosis
Daniel D. Lam,
University of Michigan, USA
Short Talk: A Dual Enhancer Complex Controls Neuronal Pomc Expression and Body Weight
Short Talk: A Dual Enhancer Complex Controls Neuronal Pomc Expression and Body Weight
08:00—11:15
Neurocircuitry and Systemic Control of Metabolism
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*
William F. Colmers,
University of Alberta, Canada
Lori M. Zeltser,
Columbia University, USA
Plasticity in Developing Circuits Regulating Energy Homeostasis
Plasticity in Developing Circuits Regulating Energy Homeostasis
Martin G. Myers, Jr.,
University of Michigan, USA
Leptin Receptors in the Brain: Where Do They Matter?
Leptin Receptors in the Brain: Where Do They Matter?
Michael A. Cowley,
Monash University, Australia
Leptin Modulation of DMH Circuits Controlling the Sympathetic Nervous System
Leptin Modulation of DMH Circuits Controlling the Sympathetic Nervous System
Roberto Coppari,
University of Genève, Switzerland
Metabolic Actions of Hypothalamic SIRT1
Metabolic Actions of Hypothalamic SIRT1
Stephanie M. Correa,
University of California, San Francisco, USA
Short Talk: A Population of Estrogen-Responsive Nkx2-1 Neurons in the Ventromedial Hypothalamus (VMH) Mediates Sex-Specific Obesity in Mice
Short Talk: A Population of Estrogen-Responsive Nkx2-1 Neurons in the Ventromedial Hypothalamus (VMH) Mediates Sex-Specific Obesity in Mice
Barbora Doslikova,
University of Cambridge, UK
Short Talk: 5-HT2C Receptor Agonist Anorectic Efficacy Potentiated by 5-HT1B Receptor Agonist Co-Application; an Effect Mediated via Augmented Pro-Opiomelanocortin Neuron Activation
Short Talk: 5-HT2C Receptor Agonist Anorectic Efficacy Potentiated by 5-HT1B Receptor Agonist Co-Application; an Effect Mediated via Augmented Pro-Opiomelanocortin Neuron Activation
17:00—18:30
Glia Cells and CNS Control of Metabolism
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Serge Luquet,
Université Paris Diderot, Sorbonne Paris Cité, France
Matthias H. Tschöp,
HelmholtzZentrum München, Germany
Hypothalamic Inflammatory Processes in Diabetes and Obesity
Hypothalamic Inflammatory Processes in Diabetes and Obesity
Licio A. Velloso,
University of Campinas, Brazil
A Role for Hypothalamic Microglia in Obesity and Diabetes
A Role for Hypothalamic Microglia in Obesity and Diabetes
Darya Kryzskaya,
McGill University, Canada
Short Talk: A Role for Hypothalamic NG2-glia in Energy Homeostasis
Short Talk: A Role for Hypothalamic NG2-glia in Energy Homeostasis
18:30—19:15
Closing Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Matthias H. Tschöp,
HelmholtzZentrum München, Germany
Michael W. Schwartz,
University of Washington, USA
Brain Mechanisms Governing Glucose Homeostasis: Implications for Diabetes Pathogenesis and Treatment
Brain Mechanisms Governing Glucose Homeostasis: Implications for Diabetes Pathogenesis and Treatment
*Session Chair †Speaker invited, not yet responded.
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