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Alpbach Congress Centrum Floorplan
This meeting took place in 2013
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Meeting Details
Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic Dysfunction (D3)
Organizer(s) Antonio J. Vidal-Puig, Antonio Moschetta and Anastasia Kralli
April 3 - April 8, 2013
Alpbach Congress Centrum • Alpbach, Austria
Abstract Deadline: December 4, 2012
Late Abstract Deadline: January 4, 2013
Scholarship Deadline: December 4, 2012
Early Registration Deadline: January 31, 2013
Supported by the Directors' Fund
CME Information
Summary of Meeting:
This meeting brings fundamental cellular and physiological principles involving nuclear receptors and other transcription factors to the boundaries between physiology and disease oriented research. As evidenced by the session titles, the organizers have developed a program that covers the involvement of nuclear receptors (NR) and other transcription factors (TFs) regulating energy balance (food intake, energy expenditure and fat deposition), and their pathophysiological dysregulation leading to obesity associated cardiometabolic complications. The program has been configured to bring together diverse, sometimes conflicting ideas, and novel approaches to investigate the involvement of NR and TFs that may help to elucidate them. A primary goal is to gather junior and senior investigators who study transcriptional mechanisms controlling different aspects of energy homeostasis and metabolic adaptation, and thereby stimulate new ideas on how transcriptional networks could be targeted therapeutically in the context of metabolic disease. Taken together, the program design will provide an interdisciplinary integration of multiple organs and systems regulating energy homeostasis. Thus, this meeting is highly likely to attract a wide variety of investigators, many of whom might not otherwise interact.
CME Information
This meeting brings fundamental cellular and physiological principles involving nuclear receptors and other transcription factors to the boundaries between physiology and disease oriented research. As evidenced by the session titles, the organizers have developed a program that covers the involvement of nuclear receptors (NR) and other transcription factors (TFs) regulating energy balance (food intake, energy expenditure and fat deposition), and their pathophysiological dysregulation leading to obesity associated cardiometabolic complications. The program has been configured to bring together diverse, sometimes conflicting ideas, and novel approaches to investigate the involvement of NR and TFs that may help to elucidate them. A primary goal is to gather junior and senior investigators who study transcriptional mechanisms controlling different aspects of energy homeostasis and metabolic adaptation, and thereby stimulate new ideas on how transcriptional networks could be targeted therapeutically in the context of metabolic disease. Taken together, the program design will provide an interdisciplinary integration of multiple organs and systems regulating energy homeostasis. Thus, this meeting is highly likely to attract a wide variety of investigators, many of whom might not otherwise interact.
Conference Program Print | View meeting in 12 hr (am/pm) time
WEDNESDAY, APRIL 3
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Antonio J. Vidal-Puig,
University of Cambridge, UK
Welcoming Remarks
Welcoming Remarks
*
Antonio Moschetta,
Consorzio Mario Negri Sud, Italy
Helen H. Hobbs,
University of Texas Southwestern Medical Center, USA
ABCG5/ABCG8: A Sterol Selectivity Filter for Cholesterol Homeostasis
ABCG5/ABCG8: A Sterol Selectivity Filter for Cholesterol Homeostasis
09:00—12:00
Nuclear Receptors and Metabolism: Liver and Gut Pathways
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*
Michael Trauner,
Medical University of Vienna, Austria
David D. Moore,
Baylor College of Medicine, USA
LRH1, the Gut and the Liver
LRH1, the Gut and the Liver
David Shapiro,
Intercept Pharmaceuticals Inc., USA
FXR Agonism – From Theory to Practice
FXR Agonism – From Theory to Practice
Michela Plateroti,
Université Claude Bernard Lyon 1, France
Thyroid Hormone Receptor and Intestinal Epithelium Stemness
Thyroid Hormone Receptor and Intestinal Epithelium Stemness
17:00—19:00
Nuclear Receptors and Control of Food Intake
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*
Beatrice Desvergne,
University of Lausanne, Switzerland
Joel K. Elmquist,
University of Texas Southwestern Medical Center, USA
SF-1: A Molecular Link between Coordinated Energy Balance and Mood
SF-1: A Molecular Link between Coordinated Energy Balance and Mood
Miguel López,
Universidad de Santiago de Compostela, Spain
Central Actions of Estrogens on Energy Balance
Central Actions of Estrogens on Energy Balance
Tony K.T. Lam,
University of Toronto, Canada
Nutrient and Hypothalamus Sensing
Nutrient and Hypothalamus Sensing
Brian Finan,
Helmholtz Center Munich, Germany
Short Talk: Targeted Nuclear Hormone Delivery Using Natural Peptides
Short Talk: Targeted Nuclear Hormone Delivery Using Natural Peptides
08:00—11:15
Nuclear Receptors and Energy Expenditure Pathways
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*
Daniel P. Kelly,
Sanford-Burnham Medical Research Institute, USA
Anastasia Kralli,
The Scripps Research Institute, USA
Estrogen-Related Receptors (ERRs) and ERR Coregulators: Pathways Regulating Energy Expenditure in Brown Adipose Tissue
Estrogen-Related Receptors (ERRs) and ERR Coregulators: Pathways Regulating Energy Expenditure in Brown Adipose Tissue
Krishna Chatterjee,
University of Cambridge, UK
Nuclear Receptors and Metabolic Dysfunction: Insights from Human Genetics
Nuclear Receptors and Metabolic Dysfunction: Insights from Human Genetics
Beatrice Desvergne,
University of Lausanne, Switzerland
Too Much or Too Little Fat: Same Metabolic Consequences, Same Mechanisms?
Too Much or Too Little Fat: Same Metabolic Consequences, Same Mechanisms?
Alessandra Ferrari,
Università degli Studi di Milano, Italy
Short Talk: Key Role of Class I Histone Deacetylases in Energy Metabolism via Regulation of Pgc-1alpha and PPARgamma
Short Talk: Key Role of Class I Histone Deacetylases in Energy Metabolism via Regulation of Pgc-1alpha and PPARgamma
Juliane G. Bogner-Strauss,
Graz University of Technology, Institute for Genomics and Bioinformatics, Austria
Short Talk: N-Acetyltransferase 8-Like: New Implications in Brown Adipocyte Metabolism through PPARalpha Signaling
Short Talk: N-Acetyltransferase 8-Like: New Implications in Brown Adipocyte Metabolism through PPARalpha Signaling
14:30—16:30
Workshop and Round-Table Discussion: Targeting NRs for the Treatment of Metabolic Disease
*
Peter Tontonoz,
HHMI/University of California, Los Angeles, USA
C. Daniel De Magalhaes Filho,
The Salk Institute for Biological Studies, USA
The Effects of Overactivating a Fat Burning Pathway Upon Systemic Aging and Age-Related Cardiac Health
The Effects of Overactivating a Fat Burning Pathway Upon Systemic Aging and Age-Related Cardiac Health
David P. Marciano,
The Scripps Research Institute, USA
Modulating the PPARgamma Paradigm: Structural Insights into a Novel Class of Functional Selective Ligands
Modulating the PPARgamma Paradigm: Structural Insights into a Novel Class of Functional Selective Ligands
Knut R. Steffensen,
Karolinska Institute, Sweden
The Anti-inflammatory Roles of the Liver X Receptors in Colon
The Anti-inflammatory Roles of the Liver X Receptors in Colon
Constance Maria Voss,
University of Vienna, Austria
Identification and Investigation of Novel LXR Modulators
Identification and Investigation of Novel LXR Modulators
15:30—16:30
Round-Table Discussion
*
David J. Mangelsdorf,
HHMI/University of Texas Southwestern Medical Center, USA
Krishna Chatterjee,
University of Cambridge, UK
David Shapiro,
Intercept Pharmaceuticals Inc., USA
17:00—19:15
Adipogenesis and Energy Storage
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Karen Reue,
University of California, Los Angeles, USA
Evan D. Rosen,
Beth Israel Deaconess Medical Center, Harvard University, USA
Epigenomic Aspects of Adipose Biology
Epigenomic Aspects of Adipose Biology
Juro Sakai,
University of Tokyo, Japan
Epigenomic Regulation of Energy Metabolism in Brown Adipocytes
Epigenomic Regulation of Energy Metabolism in Brown Adipocytes
Amit R. Majithia,
Massachusetts General Hospital, USA
Short Talk: High Throughput Functional Analysis of Coding Variants Identified in Population Scale Genome Sequencing: A Paradigm for Mapping Genes Underlying Human Metabolic Diseases
Short Talk: High Throughput Functional Analysis of Coding Variants Identified in Population Scale Genome Sequencing: A Paradigm for Mapping Genes Underlying Human Metabolic Diseases
Ralf Kittler,
University of Texas Southwestern Medical Center, USA
Short Talk: Pyruvate Dehydrogenase Kinase 4 Is a Key Metabolic Regulator of PPARgamma-Mediated Cell Cycle Arrest
Short Talk: Pyruvate Dehydrogenase Kinase 4 Is a Key Metabolic Regulator of PPARgamma-Mediated Cell Cycle Arrest
08:00—11:15
Nutrient Challenges and Lipid Homeostasis
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*
Helen H. Hobbs,
University of Texas Southwestern Medical Center, USA
David J. Mangelsdorf,
HHMI/University of Texas Southwestern Medical Center, USA
The Hunger Games and FGF21: A Survivor's Guide
The Hunger Games and FGF21: A Survivor's Guide
Jaemyoung Suh,
The Salk Institute, USA
Catching Fire with FGF1: The Hunger Games Sequel
Catching Fire with FGF1: The Hunger Games Sequel
Peter Tontonoz,
HHMI/University of California, Los Angeles, USA
Nuclear Receptor Regulation of Lipid Metabolism and Inflammation
Nuclear Receptor Regulation of Lipid Metabolism and Inflammation
Karen Reue,
University of California, Los Angeles, USA
Lipin Proteins as Modulators of Cellular Lipid Storage and Bioactive Lipid Intermediates
Lipin Proteins as Modulators of Cellular Lipid Storage and Bioactive Lipid Intermediates
Federica Gilardi,
University of Lausanne, Switzerland
Short Talk: Dynamics of SREBP1 DNA Binding in Mouse Liver
Short Talk: Dynamics of SREBP1 DNA Binding in Mouse Liver
Pedro F. Marrero,
University of Barcelona, Spain
Short Talk: FSP27 Expression Regulates Liver PPARalpha Signaling Activity
Short Talk: FSP27 Expression Regulates Liver PPARalpha Signaling Activity
11:15—12:30
Editors' Round-Table
Randy S. Levinson,
Nature Publishing Group, USA
Effie Tzameli,
Cell Press, USA
Esther Schnapp,
EMBO, Germany
14:30—16:30
Workshop 2
*
George E.O. Muscat,
University of Queensland, Australia
Elnaz Karimian Azari,
Institute of Food, Nutrition and Health (IFNH), Switzerland
Possible Role of Intestinal Fatty Acid Oxidation (FAO) in the Peroxisome Proliferator Receptor-alpha (PPAR-alpha) Agonist Wy-14643-Induced Hypophagia
Possible Role of Intestinal Fatty Acid Oxidation (FAO) in the Peroxisome Proliferator Receptor-alpha (PPAR-alpha) Agonist Wy-14643-Induced Hypophagia
Pooja Jha,
Medical University of Vienna, Austria
Adipose Triglyceride Lipase Critically Determines Hepatic Inflammation and Steatohepatitis via PPARalpha Signaling
Adipose Triglyceride Lipase Critically Determines Hepatic Inflammation and Steatohepatitis via PPARalpha Signaling
Michele Vacca,
Consorzio Mario Negri Sud, Italy
Neuron-Derived Orphan Receptor 1 Acts as a Switch that Allows Proliferation in Quiescent Hepatocytes
Neuron-Derived Orphan Receptor 1 Acts as a Switch that Allows Proliferation in Quiescent Hepatocytes
Carmine Settembre,
Telethon Institute of Genetics and Medicine (TIGEM), Italy
TFEB Controls Cellular Lipid Metabolism through a Starvation-Induced Autoregulatory Loop
TFEB Controls Cellular Lipid Metabolism through a Starvation-Induced Autoregulatory Loop
Kai Ge,
NIDDK, National Institutes of Health, USA
Epigenetic Regulation of Adipogenesis by Histone Methylation
Epigenetic Regulation of Adipogenesis by Histone Methylation
Andrea L. Hevener,
University of California, Los Angeles, USA
Skeletal Muscle-Specific ERalpha Deficiency Impairs Mitochondrial Quality Control and Promotes Features of the Metabolic Syndrome
Skeletal Muscle-Specific ERalpha Deficiency Impairs Mitochondrial Quality Control and Promotes Features of the Metabolic Syndrome
Lily C. Chao,
Children's Hospital Los Angeles, USA
NR4A1 Regulation of Fbp2 Promotes Muscle Growth
NR4A1 Regulation of Fbp2 Promotes Muscle Growth
17:00—19:00
Immune System and Metabolism
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Thomas P. Burris,
The Scripps Research Institute, USA
Mercedes Ricote,
Centro Nacional de Investigaciones Cardiovasculares, Spain
Emerging Roles of RXRs in Macrophage Biology
Emerging Roles of RXRs in Macrophage Biology
Ajay Chawla,
University of California, San Francisco, USA
Innate Immunity and Metabolism
Innate Immunity and Metabolism
Inez Rogatsky,
Weill Medical College of Cornell University, USA
A Transcriptional Coregulator GRIP1 at the Intersection of Pro- and Anti-Inflammatory Pathways
A Transcriptional Coregulator GRIP1 at the Intersection of Pro- and Anti-Inflammatory Pathways
Eckardt Treuter,
Karolinska Institutet, Sweden
Short Talk: Dysregulation of a GPS2/SMRT Corepressor Pathway Coincides with Adipocyte Inflammation in Human Obesity
Short Talk: Dysregulation of a GPS2/SMRT Corepressor Pathway Coincides with Adipocyte Inflammation in Human Obesity
08:00—11:15
Skeletal Muscle, Exercise and Diet
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Andrea L. Hevener,
University of California, Los Angeles, USA
Daniel P. Kelly,
Sanford-Burnham Medical Research Institute, USA
Nuclear Receptor-miRNA Regulatory Networks
Nuclear Receptor-miRNA Regulatory Networks
Juleen R. Zierath,
Karolinska Institutet, Sweden
Epigenetic Regulation in Response to Exercise: Impact on Diabetes and Obesity
Epigenetic Regulation in Response to Exercise: Impact on Diabetes and Obesity
Carl S. Thummel,
University of Utah School of Medicine, USA
Regulation of Metabolism by Drosophila Nuclear Receptors
Regulation of Metabolism by Drosophila Nuclear Receptors
George E.O. Muscat,
University of Queensland, Australia
Short Talk: Transgenic Nor-1/NR4A3 Expression Decreases Adiposity: Resistance to (High Fat) Diet Induced Obesity in a Background of Insulin Resistance
Short Talk: Transgenic Nor-1/NR4A3 Expression Decreases Adiposity: Resistance to (High Fat) Diet Induced Obesity in a Background of Insulin Resistance
Noriaki Shimizu,
University of Tokyo, Japan
Short Talk: Physiological Regulation of Skeletal Muscle Mass via Glucocorticoid Receptor
Short Talk: Physiological Regulation of Skeletal Muscle Mass via Glucocorticoid Receptor
17:00—19:00
Circadian Clock and Metabolism
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*
Vincent Giguère,
McGill University, Canada
Kenneth A. Dyar,
Venetian Institute of Molecular Medicine, Italy
Short Talk: The Skeletal Muscle Circadian Clock Controls Insulin Sensitivity and Metabolic Flexibility
Short Talk: The Skeletal Muscle Circadian Clock Controls Insulin Sensitivity and Metabolic Flexibility
Thomas P. Burris,
The Scripps Research Institute, USA
ROR and REV-ERB Regulation of Immune Function and Metabolism
ROR and REV-ERB Regulation of Immune Function and Metabolism
Paolo Sassone-Corsi,
University of California, Irvine, USA
Metabolism Control of the Circadian Clock
Metabolism Control of the Circadian Clock
Erin Stashi,
Baylor College of Medicine, USA
Short Talk: SRC-2 Is Essential for Orchestrating Circadian Rhythm and Metabolism
Short Talk: SRC-2 Is Essential for Orchestrating Circadian Rhythm and Metabolism
19:00—19:10
Closing Remarks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Anastasia Kralli,
The Scripps Research Institute, USA
*Session Chair †Speaker invited, not yet responded.
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