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Alpbach Congress Centrum Floorplan

Alpbach Congress Centrum Floorplan

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This meeting took place in 2013



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Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic Dysfunction (D3)


Organizer(s) Antonio J. Vidal-Puig, Antonio Moschetta and Anastasia Kralli
April 3—8, 2013
Alpbach Congress Centrum • Alpbach, Austria
Abstract Deadline: Dec 4, 2012
Late Abstract Deadline: Jan 4, 2013
Scholarship Deadline: Dec 4, 2012
Early Registration Deadline: Jan 31, 2013

Supported by the Directors' Fund

Summary of Meeting:
This meeting brings fundamental cellular and physiological principles involving nuclear receptors and other transcription factors to the boundaries between physiology and disease oriented research. As evidenced by the session titles, the organizers have developed a program that covers the involvement of nuclear receptors (NR) and other transcription factors (TFs) regulating energy balance (food intake, energy expenditure and fat deposition), and their pathophysiological dysregulation leading to obesity associated cardiometabolic complications. The program has been configured to bring together diverse, sometimes conflicting ideas, and novel approaches to investigate the involvement of NR and TFs that may help to elucidate them. A primary goal is to gather junior and senior investigators who study transcriptional mechanisms controlling different aspects of energy homeostasis and metabolic adaptation, and thereby stimulate new ideas on how transcriptional networks could be targeted therapeutically in the context of metabolic disease. Taken together, the program design will provide an interdisciplinary integration of multiple organs and systems regulating energy homeostasis. Thus, this meeting is highly likely to attract a wide variety of investigators, many of whom might not otherwise interact.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, APRIL 3

16:00—20:00
Arrival and Registration


THURSDAY, APRIL 4

07:00—08:00
Breakfast

08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Antonio J. Vidal-Puig, University of Cambridge, UK
Welcoming Remarks

* Antonio Moschetta, Consorzio Mario Negri Sud, Italy

Helen H. Hobbs, University of Texas Southwestern Medical Center, USA
ABCG5/ABCG8: A Sterol Selectivity Filter for Cholesterol Homeostasis

09:00—12:00
Nuclear Receptors and Metabolism: Liver and Gut Pathways
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Michael Trauner, Medical University of Vienna, Austria

David D. Moore, Baylor College of Medicine, USA
Nutrient Sensing Nuclear Receptors REgulat Autophagy

David Shapiro, Intercept Pharmaceuticals Inc., USA
FXR Agonism – From Theory to Practice

Antonio Moschetta, Consorzio Mario Negri Sud, Italy
FXR in the Gut-Liver Axis

Michela Plateroti, Université Claude Bernard Lyon 1, France
Thyroid Hormone Receptor and Intestinal Epithelium Stemness

09:40—10:00
Coffee Break

12:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

12:00—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Nuclear Receptors and Control of Food Intake
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Beatrice Desvergne, University of Lausanne, Switzerland

Joel K. Elmquist, University of Texas Southwestern Medical Center, USA
SF-1: A Molecular Link between Coordinated Energy Balance and Mood

Miguel López, Universidad de Santiago de Compostela, Spain
Central Actions of Estrogens on Energy Balance

Tony K.T. Lam, University of Toronto, Canada
CNS Action of Insulin and Glucagon

Brian Finan, Helmholtz Center Munich, Germany
Short Talk: Targeted Nuclear Hormone Delivery Using Natural Peptides

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


FRIDAY, APRIL 5

07:00—08:00
Breakfast

08:00—11:15
Nuclear Receptors and Energy Expenditure Pathways
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Daniel P. Kelly, Sanford-Burnham Medical Research Institute, USA

Anastasia Kralli, The Scripps Research Institute, USA
Estrogen-Related Receptors (ERRs) and ERR Coregulators: Pathways Regulating Energy Expenditure in Brown Adipose Tissue

Antonio J. Vidal-Puig, University of Cambridge, UK
Brown Fat Activity Modulators

Krishna Chatterjee, University of Cambridge, UK
Nuclear Receptors and Metabolic Dysfunction: Insights from Human Genetics

Beatrice Desvergne, University of Lausanne, Switzerland
Too Much or Too Little Fat: Same Metabolic Consequences, Same Mechanisms?

Alessandra Ferrari, Università degli Studi di Milano, Italy
Short Talk: Key Role of Class I Histone Deacetylases in Energy Metabolism via Regulation of Pgc-1alpha and PPARgamma

Juliane G. Bogner-Strauss, Graz University of Technology, Institute for Genomics and Bioinformatics, Austria
Short Talk: N-Acetyltransferase 8-Like: New Implications in Brown Adipocyte Metabolism through PPARalpha Signaling

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—16:30
On Own for Lunch and Recreation

14:30—16:30
Workshop and Round-Table Discussion: Targeting NRs for the Treatment of Metabolic Disease

* Peter Tontonoz, HHMI/University of California, Los Angeles, USA

C. Daniel De Magalhaes Filho, The Salk Institute for Biological Studies, USA
The Effects of Overactivating a Fat Burning Pathway Upon Systemic Aging and Age-Related Cardiac Health

David P. Marciano, The Scripps Research Institute, USA
Modulating the PPARgamma Paradigm: Structural Insights into a Novel Class of Functional Selective Ligands

Knut R. Steffensen, Karolinska Institute, Sweden
The Anti-inflammatory Roles of the Liver X Receptors in Colon

Constance Maria Voss, University of Vienna, Austria
Identification and Investigation of Novel LXR Modulators

15:30—16:30
Round-Table Discussion

* David J. Mangelsdorf, HHMI/University of Texas Southwestern Medical Center, USA

Krishna Chatterjee, University of Cambridge, UK

David Shapiro, Intercept Pharmaceuticals Inc., USA

16:30—17:00
Coffee Available

17:00—19:15
Adipogenesis and Energy Storage
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Karen Reue, University of California, Los Angeles, USA

Evan D. Rosen, Beth Israel Deaconess Medical Center, Harvard University, USA
Epigenomic Approaches to Target Identification in Adipose Biology

Juro Sakai, University of Tokyo, Japan
Epigenomic Regulation of Energy Metabolism in Brown Adipocytes

Lluis Fajas, Université de Lausanne, Switzerland
Cell Cycle Regulators Control Energy Homeostasis

Amit R. Majithia, Massachusetts General Hospital, USA
Short Talk: High Throughput Functional Analysis of Coding Variants Identified in Population Scale Genome Sequencing: A Paradigm for Mapping Genes Underlying Human Metabolic Diseases

Ralf Kittler, University of Texas Southwestern Medical Center, USA
Short Talk: Pyruvate Dehydrogenase Kinase 4 Is a Key Metabolic Regulator of PPARgamma-Mediated Cell Cycle Arrest

19:15—20:15
Social Hour with Lite Bites

19:45—22:00
Poster Session 2


SATURDAY, APRIL 6

07:00—08:00
Breakfast

08:00—11:15
Nutrient Challenges and Lipid Homeostasis
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Helen H. Hobbs, University of Texas Southwestern Medical Center, USA

David J. Mangelsdorf, HHMI/University of Texas Southwestern Medical Center, USA
A Survivor’s Guide to the Hunger Games: FGF21

Peter Tontonoz, HHMI/University of California, Los Angeles, USA
Nuclear Receptor Regulation of Lipid Metabolism and Inflammation

Ronald M. Evans, HHMI/The Salk Institute, USA
Catching Fire with FGF1: The Hunger Games Sequel

Jaemyoung Suh, The Salk Institute for Biological Studies, USA
Catching Fire with FGF1: The Hunger Games Sequel

Karen Reue, University of California, Los Angeles, USA
Reflections on Lipin Proteins, Lipid Storage, and Lipid Intermediates

Federica Gilardi, University of Lausanne, Switzerland
Short Talk: Dynamics of SREBP1 DNA Binding in Mouse Liver

Pedro F. Marrero, University of Barcelona, Spain
Short Talk: FSP27 Expression Regulates Liver PPARalpha Signaling Activity

09:20—09:40
Coffee Break

11:15—12:30
Editors' Round-Table

Randy S. Levinson, Nature Publishing Group, USA

Effie Tzameli, Cell Press, USA

Esther Schnapp, EMBO, Germany

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

12:30—16:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 2

* George E.O. Muscat, University of Queensland, Australia

Elnaz Karimian Azari, ETH-IFNH, Switzerland
Possible Role of Intestinal Fatty Acid Oxidation (FAO) in the Peroxisome Proliferator Receptor-alpha (PPAR-alpha) Agonist Wy-14643-Induced Hypophagia

Pooja Jha, Medical University of Vienna, Austria
Adipose Triglyceride Lipase Critically Determines Hepatic Inflammation and Steatohepatitis via PPARalpha Signaling

Michele Vacca, Consorzio Mario Negri Sud, Italy
Neuron-Derived Orphan Receptor 1 Acts as a Switch that Allows Proliferation in Quiescent Hepatocytes

Carmine Settembre, Telethon Institute of Genetics and Medicine (TIGEM), Italy
TFEB Controls Cellular Lipid Metabolism through a Starvation-Induced Autoregulatory Loop

Kai Ge, NIDDK, National Institutes of Health, USA
Epigenetic Regulation of Adipogenesis by Histone Methylation

Andrea L. Hevener, University of California, Los Angeles, USA
Skeletal Muscle-Specific ERalpha Deficiency Impairs Mitochondrial Quality Control and Promotes Features of the Metabolic Syndrome

Lily C. Chao, Children's Hospital Los Angeles, USA
NR4A1 Regulation of Fbp2 Promotes Muscle Growth

16:30—17:00
Coffee Available

17:00—19:00
Immune System and Metabolism
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Thomas P. Burris, The Scripps Research Institute, USA

Mercedes Ricote, Centro Nacional de Investigaciones Cardiovasculares, Spain
Emerging Roles of RXRs in Macrophage Biology

Ajay Chawla, University of California, San Francisco, USA
Type 2 Immunity at the Crossroads of Metabolism and Regeneration

Inez Rogatsky, Weill Medical College of Cornell University, USA
Anti-Inflammatory Actions of Glucocorticoids: New Players and Mechanisms

Eckardt Treuter, Karolinska Institutet, Sweden
Short Talk: Dysregulation of a GPS2/SMRT Corepressor Pathway Coincides with Adipocyte Inflammation in Human Obesity

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


SUNDAY, APRIL 7

07:00—08:00
Breakfast

08:00—11:15
Skeletal Muscle, Exercise and Diet
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Andrea L. Hevener, University of California, Los Angeles, USA

Daniel P. Kelly, Sanford-Burnham Medical Research Institute, USA
Nuclear Receptor-miRNA Regulatory Networks

Juleen R. Zierath, Karolinska Institutet, Sweden
Epigenetic Regulation in Response to Exercise: Impact on Diabetes and Obesity

Vincent Giguère, McGill University, Canada
mTOR: A New Friend of the Estrogen Related Receptor alpha

Carl S. Thummel, University of Utah School of Medicine, USA
Regulation of Carbohydrate Metabolism by ERR and HNF4 in Drosophila

George E.O. Muscat, University of Queensland, Australia
Short Talk: Transgenic Nor-1/NR4A3 Expression Decreases Adiposity: Resistance to (High Fat) Diet Induced Obesity in a Background of Insulin Resistance

Noriaki Shimizu, University of Tokyo, Japan
Short Talk: Physiological Regulation of Skeletal Muscle Mass via Glucocorticoid Receptor

09:20—09:40
Coffee Break

11:15—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Circadian Clock and Metabolism
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Vincent Giguère, McGill University, Canada

Paolo Sassone-Corsi, University of California, Irvine, USA
Metabolism Control of the Circadian Clock

Thomas P. Burris, The Scripps Research Institute, USA
ROR and REV-ERB Regulation of Immune Function and Metabolism

Kenneth A. Dyar, Venetian Institute of Molecular Medicine, Italy
Short Talk: The Skeletal Muscle Circadian Clock Controls Insulin Sensitivity and Metabolic Flexibility

Erin Stashi, Baylor College of Medicine, USA
Short Talk: SRC-2 Is Essential for Orchestrating Circadian Rhythm and Metabolism

19:00—19:10
Closing Remarks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Anastasia Kralli, The Scripps Research Institute, USA

19:10—20:10
Social Hour with Lite Bites

20:00—23:00
Entertainment


MONDAY, APRIL 8

 
Departure


*Session Chair †Speaker invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Intercept Pharmaceuticals Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676