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This meeting took place in 2014



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Innate Immunity, Metabolism and Vascular Injury (X8)


Organizer(s) Ajay Chawla, Peter Tontonoz and Gwendalyn J. Randolph
March 23—28, 2014
Whistler Conference Centre • Whistler, British Columbia Canada
Discounted Abstract Deadline: Nov 21, 2013
Abstract Deadline: Dec 19, 2013
Scholarship Deadline: Nov 21, 2013
Discounted Registration Deadline: Jan 23, 2014

Supported by an educational donation provided by Amgen


Summary of Meeting:
A chronic low-grade inflammatory response is a defining feature of various metabolic diseases, including atherosclerosis, obesity, and type 2 diabetes. This smoldering inflammation in tissues, whether it is in the vascular bed, white adipose tissue or perivascular fat, is primarily mediated by the innate immune system. Consequently, this Keystone Symposium on Innate Immunity, Metabolism and Vascular Injury will bring together leading investigators in areas of macrophage biology, vascular inflammation, atherosclerosis, and obesity-induced metabolic disease. Sessions will encompass a broad range of topics highlighting the importance of and mechanisms by which innate immunity contributes to progression of metabolic diseases, including monocyte development and trafficking, macrophage activation in vascular bed and adipose tissues, and systems biology of myeloid cells. Exciting new developments in sensing of metabolic stress by inflammasomes, clearance of apoptotic cells by macrophages, and initiation of necrotic cell death programs will also be discussed. These basic studies will be complemented by talks discussing new strategies for promoting plaque regression, and targeting innate inflammation to treat insulin resistance, type 2 diabetes, and coronary artery disease.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 23

16:00—20:00
Arrival and Registration

Grand Foyer
18:00—20:00
Welcome Mixer

Grand Foyer

MONDAY, MARCH 24

07:00—08:00
Breakfast

Sea to Sky A
08:00—09:00
Opening Remarks
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
Ajay Chawla, University of California, San Francisco, USA

Peter Tontonoz, University of California, Los Angeles, USA

Gwendalyn J. Randolph, Washington University, USA


Following Session is for Complications of Diabetes (X7)

08:00—08:15
Opening Remarks
Meeting has ended...abstracts no longer viewable online.

Michael A. Brownlee, Albert Einstein College of Medicine, USA


Following Session is for Complications of Diabetes (X7)

08:15—09:15
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* Susan Quaggin, Northwestern University, USA

Michael A. Brownlee, Albert Einstein College of Medicine, USA
The Molecular Basis of Diabetic Complications

08:15—10:45
Monocytes: Development and Disease
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Gwendalyn J. Randolph, Washington University, USA

Frederic Geissmann, Memorial Sloan Kettering Cancer Center, USA
Developmental and Functional Heterogeneity of Macrophages

Filip K. Swirski, Massachusetts General Hospital, USA
The Monocyte Lineage in Atherosclerosis

Alan R. Tall, Columbia University, USA
Regulation of Hematopoiesis by Cholesterol

Tiffany Horng, ShanghaiTech University, China
Short Talk: The TSC-mTOR Pathway Regulates Macrophage Polarization

Partha Dutta, Massachusetts General Hospital Harvard Medical School, USA
Short Talk: Activation of CCR2+ Hematopoietic Stem Cells after Myocardial Infarction


Following Session is for Complications of Diabetes (X7)

09:15—11:30
Metabolic Dysregulation and the Pathogenesis of Diabetic Cardiovascular Disease
Meeting has ended...abstracts no longer viewable online.
Dysreguation of metabolism and impaired heart and vascular function. Defining the pathways contributing to impaired cardiovascular function and opportinuties to correct this will be the focus of this session.

Sea to Sky B
* Susan Quaggin, Northwestern University, USA

Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Adipocyte Origin of Insulin Resistance, Chronic Inflammation and Lipotoxicity

Richard J.M. Coward, University of Bristol, UK
Insulin Resistance and the Kidney

Christopher B. Newgard, Duke University Medical Center, USA
Metabolomics and Cardiometabolic Disease Mechanisms

Kyoungmin Park, Joslin Diabetes Center, USA
Short Talk: Direct Demonstration that Overexpression of IRS1 and Enhanced Insulin Actions in Vascular Endothelial Cells Can Reduce Atherosclerosis via a Novel Pathway to Activate eNOS

09:40—10:00
Coffee Break

Grand Foyer
11:45—13:00
Poster Setup

Sea to Sky A
13:00—22:00
Poster Viewing

Sea to Sky A
11:45—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 1

Sea to Sky C
* Ichiro Manabe, Chiba University, Japan

Miyako Tanaka, Nagoya University, Japan
Mincle, a Novel Pathogen Sensor in Macrophages, Underlies Obesity-Induced Adipose Tissue Fibrosis in Mice

Joel D. Schilling, Washington University School of Medicine, USA
Inflammatory-Metabolic Crosstalk in Macrophages: The Role of the Lysosome

Bruno M. Carvalho, University of Pernambuco, Brazil
Splenic Monocytes and Macrophages Mediate Insulin Resistance in Obesity

Dario A. Gutierrez, Merck Research Labs Cambridge Exploratory Science Center, USA
Kit Deficiency, But Not Lack of Mast Cells, Has a Profound Effect on Adiposity and Obesity-Induced Insulin Resistance

Anca Dana E. Dobrian, Eastern Virginia Medical School, USA
Signal Transducer and Activator 4 (STAT4) Deficiency in Subsets of Hematopoietic Cells Improves Metabolic Phenotype by Reducing Adipose Tissue and Islet Inflammation in Obesity and Insulin Resistance

Jonathan R. Brestoff, Perelman School of Medicine, University of Pennsylvania, USA
Group 2 Innate Lymphoid Cell Responses in White Adipose Tissue Are Conserved in Mice and Humans

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Genomics of Myeloid Cells
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Alan R. Tall, Columbia University, USA

Christopher K. Glass, University of California, San Diego, USA
A Genome-Wide View of Macrophage Activation

Laszlo Nagy, Sanford-Burnham Medical Research Institute at Lake Nona, USA
The Genomic Basis of a Retinoid X Receptor-Induced Angiogenic Macrophage Phenotype

Chih-Hao Lee, Harvard University School of Public Health, USA
Serum Lipidome in Metabolic and Immune Functions

Ekaterina K. Koltsova, Fox Chase Cancer Center, USA
Short Talk: Interleukin-27 Signaling Curbs Inflammation in Atherosclerosis


Following Session is for Complications of Diabetes (X7)

17:00—19:00
Stem Cells in Diabetic Tissue Repair I
Meeting has ended...abstracts no longer viewable online.
Impaired tissues repair is a hallmark of the diabetic state. Recent studies suggest impaired stem cell mobilization may contribute. This session overview the contribution of stem-cell "opathy" to diabetic complications.

Sea to Sky B
* Michael A. Brownlee, Albert Einstein College of Medicine, USA

Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA
Using iPS Cells to Investigate Complications in Type 1 Diabetes

Geoffrey C. Gurtner, Stanford University, USA
Stem Cell Defects and Impaired Diabetic Wound Healing

Andras Nagy, Mount Sinai Hospital, University of Toronto, Canada
Alternative Sources of Stem Cells for Tissue Repair

Mattia Albiero, Venetian Institute of Molecular Medicine, Italy
Short Talk: Diabetes Causes Bone Marrow Autonomic Neuropathy and Impairs Stem Cell Mobilization via Dysregulated p66Shc and Sirt1

19:00—20:00
Social Hour with Lite Bites

Sea to Sky A
19:30—22:00
Poster Session 1

Sea to Sky A

TUESDAY, MARCH 25

07:00—08:00
Breakfast

Sea to Sky A
08:00—11:15
Macrophages and Vascular Inflammation (Joint)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Christopher K. Glass, University of California, San Diego, USA

Kathryn J. Moore, New York University Medical Center, USA
The NLRP3 Inflammasome in Atherosclerosis and Diabetes: Activation from Within

Christoph J. Binder, Medical University of Vienna, Austria
Innate Sensors of Oxidative Stress

Ira Tabas, Columbia University, USA
Defective Inflammation Resolution in Atherosclerosis: Mechanisms and Therapeutic Opportunities

Peter Tontonoz, University of California, Los Angeles, USA
Integration of Metabolism and Inflammation by LXRs

Qian Li, Joslin Diabetes Center, USA
Short Talk: Acceleration of Atherosclerosis by Specific Deletion of Protein Kinase C Isoform in Macrophages: An Anti-Atherosclerotic Role for its Activation in Diabetes

José J. Fuster, Boston University School of Medicine, USA
Short Talk: Non-Canonical Wnt Signaling Promotes Inflammatory Abdominal Aortic Aneurysm Formation

09:20—09:40
Coffee Break

Grand Foyer
11:15—13:00
Poster Setup

Sea to Sky A
13:00—22:00
Poster Viewing

Sea to Sky A
11:15—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Inflammasomes in Metabolic Disease
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Kathryn J. Moore, New York University Medical Center, USA

Jorge Henao-Mejia, University of Pennsylvania and Children's Hospital of Philadelphia, USA
Talk Title to be Announced

Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
Fatty Acid Activation of the Inflammasomes

Vishva M. Dixit, Genentech, Inc., USA
The Inflammasome

Jon A. Hagar, University of North Carolina at Chapel Hill, USA
Short Talk: Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock


Following Session is for Complications of Diabetes (X7)

17:00—19:00
Emerging Targets for the Treatment of Diabetic Complications
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* Karl Tryggvason, Karolinska Institutet, Sweden

Susan Quaggin, Northwestern University, USA
Targeting the Tie2 Pathway for Diabetic Nephropathy

Dean Li, University of Utah, USA
Vascular Inflammation

Martin Friedlander, The Scripps Research Institute, USA
Endothelial Progenitor Cells and Diabetic Retinopathy

Ulf P.E. Eriksson, Karolinska Institutet, Sweden
Short Talk: Targeting VEGF-B as a Treatment of Insulin Resistance, Type 2 Diabetes and Diabetic Co-Morbidities

19:00—20:00
Social Hour with Lite Bites

Sea to Sky A
19:30—22:00
Poster Session 2

Sea to Sky A

WEDNESDAY, MARCH 26

07:00—08:00
Breakfast

Sea to Sky A
08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Ajay Chawla, University of California, San Francisco, USA

Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Inflammation and Diseases of Homeostasis

09:00—11:30
Innate Inflammation and Insulin Resistance
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Ira Tabas, Columbia University, USA

Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Targeting Inflammation to Treat Metabolic Disease

Richard M. Locksley, HHMI/University of California, San Francisco, USA
Innate Helper Type 2 Cells (ILC2) and Metabolic Homeostasis

Ajay Chawla, University of California, San Francisco, USA
Anticipatory Inflammation: Physiologic Functions and Pathologic Consequences

Dayoung Oh, University of Texas Southwestern Medical Center, USA
Short Talk: LTB4 Causes Macrophage-Mediated Inflammation and Directly Induces Insulin Resistance

James C. Lo, Weill Cornell Medicine, USA
Short Talk: Adipsin Is an Adipokine that Improves beta Cell Function in Diabetes


Following Session is for Complications of Diabetes (X7)

08:00—11:00
Clinical Therapies on the Horizon for Diabetic Complications
Meeting has ended...abstracts no longer viewable online.
Several novel therapeutics are in phase 2 clinical trials. These trials should be completed by 2014 or earlier. This session will overview the rationale for and results of these trials.

Sea to Sky B
* David E. Kelley, Merck & Co., Inc., USA

Daniel J. Drucker, Lunenfeld-Tanenbaum Research Institute, Canada
Cardiovascular Effects of GLP1R Agonists

Matthew D. Breyer, Janssen Pharmaceutical Company, USA
Discovery of Novel Treatments for Diabetic Nephropathy

James W. Russell, University of Maryland, USA
Nicotinamide Precursors as a Treatment in the Diabetic Nervous System

Edward P. Feener, KalVista Pharmaceuticals, USA
Plasma Kallikrein Inhibitors for Diabetic Macular Edema

Kevin G. Peters, Aerpio Pharmaceuticals, USA
Short Talk: Novel Approach to Treatment of Diabetic Macular Edema: Activating Tie2 by Inhibition of Vascular Endothelial Protein Tyrosine Phosphatase (VE-PTP)

09:20—09:40
Coffee Break

Grand Foyer
11:30—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Apoptosis and Necrosis
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Peter Tontonoz, University of California, Los Angeles, USA

Yoshihiro Ogawa, Kyushu University, Japan
Role of Parenchymal-Stromal Cell Interaction in Metabolic Diseases

Shigekazu Nagata, IFReC, Osaka University, Japan
Exposure of Phosphatidylserine and Phosphatidylserine-Dependent Engulfment of Apoptotic Cells

Andrés Hidalgo, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Spain
Clearance of Aged Neutrophils

A. Phillip West, Yale University School of Medicine, USA
Short Talk: Altered Mitochondrial DNA Dynamics Elicit a Cell-Intrinsic Antiviral Signaling Program


Following Session is for Complications of Diabetes (X7)

17:00—18:25
Mitochondrial Biology
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* James W. Russell, University of Maryland, USA

Navdeep S. Chandel, Northwestern University, USA
Physiological Roles of Mitochondrial Reactive Oxygen Species

Melinda T. Coughlan, Baker IDI Heart & Diabetes Institute, Australia
Impaired Mitophagy Activity in Diabetic Nephropathy

Moshe Levi, Georgetown University, USA
Short Talk: G Protein Coupled Receptor TGR5 Activation Prevents Kidney Disease in Mice with Obesity and Diabetes

19:00—20:00
Social Hour with Lite Bites

Sea to Sky A

THURSDAY, MARCH 27

07:00—08:00
Breakfast

Sea to Sky A
08:00—11:15
Where Are the Missing Genetics in Diabetic Complications? (Joint)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Karl Tryggvason, Karolinska Institutet, Sweden
Search for Diabetic Nephropathy Susceptibility Genes

Caroline S. Fox, Merck Research Labs, USA
Using GWAS, Exome ChIP and Exome Sequencing as Tools for Understanding Kidney Disease

Michael G. Rosenfeld, University of California, San Diego, USA
Enhancer Codes and Regulated Gene Transcription in Development and Disease

Fredrik Bäckhed, University of Gothenburg, Sweden
Altered Gut Metagenome in Diabetes - Cause or Consequence

Claudiu V. Komorowsky, University Clinic Erlangen, Germany
Short Talk: Systems Genetics Facilitates Driver Identification in Human Diabetic Kidney Disease

Alexandre Stewart, University of Ottawa Heart Institute, Canada
Short Talk: IRF2BP2, A Novel Transcriptional Regulator of Innate Immunity and Cholesterol Metabolism

09:20—09:40
Coffee Break

Grand Foyer
11:15—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 2

Sea to Sky C
* Christoph J. Binder, Medical University of Vienna, Austria

Xin Rong, HHMI/University of California, Los Angeles, USA
LXRs Regulate ER Stress and Inflammation through Dynamic Modulation of Membrane Phospholipid Composition

Mark A. Gillespie, Institute for Systems Biology, USA
A Systems Approach to Identifying Promoter-Bound LXR Coregulators in Atherosclerosis

Siroon Bekkering, Radboud UMC, Netherlands
oxLDL Augments Long-Term Pro-Inflammatory Cytokine Production and Foam Cell Formation via Epigenetic Histone Modifications of Monocytes

Suneil K. Koliwad, University of California, San Francisco, USA
Saturated Fats Engage an IRE1 alpha-Dependent Pathway to Activate the NLRP3 Inflammasome in Murine Myeloid Cells

Ryan Snodgrass, Goethe University Frankfurt, Germany
Hypoxia Augments Palmitate-Induced Proinflammatory Activation of Primary Human Macrophages

Joseph J. Boyle, Imperial College London, UK
AMPK-ATF1 Regulated Transcription Integrates Iron and Lipid Metabolism in Mhem Macrophages in Vascular Self-Protection from Hemorrhage and Pharmacological Protection with Metformin

Maroof Hasan, Novartis Institutes for BioMedical Research, Switzerland
The Role of Trex1 in Immunometabolism and Autoimmune Disease


Following Session is for Complications of Diabetes (X7)

14:30—16:30
Workshop: External Funding for Diabetes Complications Research

Sea to Sky B
Teresa Jones, NIDDK, National Institutes of Health, USA

Christian Ketchum, NIDDK, National Institutes of Health, USA
Diabetic Complications Consortium (DiaComp)

Tracy Rankin, NIDDK, National Institutes of Health, USA

Helen D. Nickerson, Juvenile Diabetes Research Foundation, USA
JDRF Strategy and Priorities in Diabetic Complications

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Progressing Fat and Regressing Cholesterol
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Ajay Chawla, University of California, San Francisco, USA

Karine Clément, INSERM/Sorbonne Universite, France
Extracellular Matrix Remodeling of Adipose Tissue and Metabolic Homeostasis

Edward A. Fisher, New York University School of Medicine, USA
HDL and Atherosclerosis Regression: Getting Rid of Cholesterol and Macrophages from the Plaque

Gwendalyn J. Randolph, Washington University, USA
Blood and Lymphatic Vasculature Inflammation in Crohn's Disease

Rachel J. Roth-Flach, Pfizer Inc., USA
Short Talk: Endothelial MAP4K4 Is a Novel Regulator of Vascular Inflammation and Atherosclerosis


Following Session is for Complications of Diabetes (X7)

17:00—19:00
Model Systems for Diabetic Complications
Meeting has ended...abstracts no longer viewable online.
The complexity of the systemic effects of chronic hyperglycemia on the organism cannot be reproduced by cell culture. This session will review novel biological systems that can faciliate the study of diabetic complications.

Sea to Sky B
* Matthew D. Breyer, Janssen Pharmaceutical Company, USA

Ross L. Cagan, Mount Sinai School of Medicine, USA
Modeling Diabetic Complications in Drosophila

Jens Kroll, Medical Faculty Mannheim, Heidelberg University and DKFZ-ZMBH Alliance, Germany
Modeling Diabetic Complications in Zebrafish

Thomas M. Coffman, NUS Duke Singapore, Singapore
Humanized Mouse Models of Diabetic Nephropathy

Hermann Haller, Hannover Medical School, Germany
Short Talk: A Novel Rapid Animal Model in Zebrafish to Analyse Molecular Mechanisms of Proteinuria and to Identify and to Evaluate Drugs for CKD and Diabetic Nephropathy

19:00—19:15
Concluding Remarks
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
Ajay Chawla, University of California, San Francisco, USA

Peter Tontonoz, University of California, Los Angeles, USA

Gwendalyn J. Randolph, Washington University, USA


Following Session is for Complications of Diabetes (X7)

19:00—19:15
Concluding Remarks
Meeting has ended...abstracts no longer viewable online.

Michael A. Brownlee, Albert Einstein College of Medicine, USA

Matthew D. Breyer, Janssen Pharmaceutical Company, USA

Susan Quaggin, Northwestern University, USA

19:15—20:15
Social Hour with Lite Bites

Sea to Sky A
20:00—23:00
Entertainment

Sea to Sky A

FRIDAY, MARCH 28

 
Departure


*Session Chair †Invited, not yet responded.


We gratefully acknowledge support for this conference from:


Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Educational donation provided by Amgen.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HL121792-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

S. Karger AG - Journal of Innate Immunity

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations

If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676