Pacifico Yokohama Floorplan
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This meeting took place in 2017
Here are the related meetings in 2020:
Intra- and Intercellular Mechanisms of Aging (B2)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Aging and Mechanisms of Aging-Related Disease (E2)
Organizer(s) Kazuo Tsubota, Shin-ichiro Imai, Matt Kaeberlein and Joan Mannick
May 15—19, 2017
Pacifico Yokohama • Yokohama, Japan
Discounted Abstract Deadline: Jan 17, 2017
Abstract Deadline: Feb 15, 2017
Scholarship Deadline: Jan 17, 2017
Discounted Registration Deadline: Mar 15, 2017
Sponsored by Astellas Pharma Inc., Journal of Molecular Cell Biology (JMCB) and Nestlé Institute of Health Sciences. Special scholarship support provided by the Japanese Society of Anti-Aging Medicine.
Summary of Meeting:
Populations are aging rapidly worldwide, particularly in Asia, driving a strong interest in aging/longevity research. This Keystone Symposia meeting will capture the cutting-edge front of this exciting field of science, covering essential aspects of aging/longevity research, including critical signaling pathways and regulators, inter-tissue communication, stem cells, stress and damage responses, cellular senescence, physiological rhythms, human genetics and mental well-being (happiness). Because aging is a systemic phenomenon, it is important to address various layers of the aging/longevity-controlling hierarchy, particularly focusing on metabolic regulation, including mitochondria, NAD+, oxidative stress, inflammation, protein homeostasis, autophagy and many other age-associated pathophysiologies. The outcome of these studies needs to be translated to resolve social and economic issues caused by rapidly aging societies. Novel therapeutic and preventive interventions have been explored and developed as a growing attempt to meet the unmet needs of our aging societies, and these new aspects of aging/longevity research and the gaps in knowledge between the basic science and practical applications will also be covered in the meeting. There is a growing body of evidence that our modern lifestyle, such as the heavy use of blue light in smart phones and tablet computers, affects physiological rhythms and metabolism, promoting age-associated diseases such as obesity, diabetes, cancer and depression. Therefore, it is now time to think differently about what we can do to deal with all these problems in light of recent progress in this exciting field of science.
View Scholarships/Awards
Populations are aging rapidly worldwide, particularly in Asia, driving a strong interest in aging/longevity research. This Keystone Symposia meeting will capture the cutting-edge front of this exciting field of science, covering essential aspects of aging/longevity research, including critical signaling pathways and regulators, inter-tissue communication, stem cells, stress and damage responses, cellular senescence, physiological rhythms, human genetics and mental well-being (happiness). Because aging is a systemic phenomenon, it is important to address various layers of the aging/longevity-controlling hierarchy, particularly focusing on metabolic regulation, including mitochondria, NAD+, oxidative stress, inflammation, protein homeostasis, autophagy and many other age-associated pathophysiologies. The outcome of these studies needs to be translated to resolve social and economic issues caused by rapidly aging societies. Novel therapeutic and preventive interventions have been explored and developed as a growing attempt to meet the unmet needs of our aging societies, and these new aspects of aging/longevity research and the gaps in knowledge between the basic science and practical applications will also be covered in the meeting. There is a growing body of evidence that our modern lifestyle, such as the heavy use of blue light in smart phones and tablet computers, affects physiological rhythms and metabolism, promoting age-associated diseases such as obesity, diabetes, cancer and depression. Therefore, it is now time to think differently about what we can do to deal with all these problems in light of recent progress in this exciting field of science.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Monday, May 15 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Friday, May 19 with a closing plenary session from 16:30 to 18:45, followed by a social hour and entertainment. We recommend return travel on Saturday, May 20 in order to fully experience the meeting.
MONDAY, MAY 15
TUESDAY, MAY 16
WEDNESDAY, MAY 17
THURSDAY, MAY 18
FRIDAY, MAY 19
SATURDAY, MAY 20
Conference Program Print | View meeting in 24 hr (international) time
The meeting will begin on Monday, May 15 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Friday, May 19 with a closing plenary session from 16:30 to 18:45, followed by a social hour and entertainment. We recommend return travel on Saturday, May 20 in order to fully experience the meeting.
MONDAY, MAY 15
8:30—9:30 AM
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.
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Joan Mannick,
resTORbio, USA
Johan Auwerx,
École Polytechnique Fédérale de Lausanne, Switzerland
Cross-species Genetic Mapping of Targets in Mitochondria, Metabolism and Aging
Cross-species Genetic Mapping of Targets in Mitochondria, Metabolism and Aging
9:30 AM—12:00 PM
Signal Transduction I – Evolutionarily Conserved Players
Meeting has ended...abstracts no longer viewable online.
*
Shin-ichiro Imai,
Washington University School of Medicine, USA
Leonard P. Guarente,
Massachusetts Institute of Technology, USA
The Role of Sirtuins in Aging and Age-Associated Diseases
The Role of Sirtuins in Aging and Age-Associated Diseases
Coffee Break
Joan Mannick,
resTORbio, USA
Is mTOR an Evolutionarily Conserved Pathway that Regulates Aging?
Is mTOR an Evolutionarily Conserved Pathway that Regulates Aging?
Noboru Mizushima,
University of Tokyo, Japan
Autophagy in Intracellular Quality Control
Autophagy in Intracellular Quality Control
Motoshi Hayano,
Harvard Medical School, USA
Short Talk: Do Epigenetic Changes Cause Aging in Animals?
Short Talk: Do Epigenetic Changes Cause Aging in Animals?
Louis R. Lapierre,
Brown University, USA
Short Talk: Blocking Lipid Secretion Promotes Lipophagy and Longevity
Short Talk: Blocking Lipid Secretion Promotes Lipophagy and Longevity
2:00—4:00 PM
Workshop 1: Cutting-Edge Front of Aging/Longevity Science
*
Kazuo Tsubota,
Keio University School of Medicine, Japan
Naoko Ohtani,
Osaka City University Graduate School of Medicine, Japan
Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity
Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity
Mark S. Lucanic,
Buck Institute for Research on Aging, USA
Caenorhabditis Intervention Testing Program: Screening Pro-Longevity Chemicals for Reproducible and Robust Positive Effects across Diverse Genetic Backgrounds
Caenorhabditis Intervention Testing Program: Screening Pro-Longevity Chemicals for Reproducible and Robust Positive Effects across Diverse Genetic Backgrounds
Shuhei Nakamura,
Osaka University, Japan
Rubicon Regulates Lifespan via Modulating Autophagy Activity
Rubicon Regulates Lifespan via Modulating Autophagy Activity
Kazuto Kawamura,
Okinawa Institute of Science and Technology, Japan
Forward Genetic Screen for Adult-Onset Motor Deficits in C. elegans
Forward Genetic Screen for Adult-Onset Motor Deficits in C. elegans
Hiromi Rakugi,
Osaka University, Japan
From Bench to Society in Geriatric Medicine
From Bench to Society in Geriatric Medicine
Hiroshi Itoh,
Keio University School of Medicine, Japan
Application of NMN (Nicotinamide Mononucleotide) to Anti-Aging in Humans
Application of NMN (Nicotinamide Mononucleotide) to Anti-Aging in Humans
4:30—7:00 PM
Signal Transduction II – Mitochondria
Meeting has ended...abstracts no longer viewable online.
*
Ana Maria Cuervo,
Albert Einstein College of Medicine, USA
Marcia C. Haigis,
Harvard Medical School, USA
The Function of Mitochondrial Sirtuins in Metabolism and Aging
The Function of Mitochondrial Sirtuins in Metabolism and Aging
Matt Kaeberlein,
University of Washington, USA
The Importance of mTOR Signaling in Aging and Longevity Control
The Importance of mTOR Signaling in Aging and Longevity Control
Michael Ristow,
Swiss Federal Institute of Technology Zurich - ETH, Switzerland
Mitochondrial Control of Healthy Aging
Mitochondrial Control of Healthy Aging
Takashi Kadowaki,
University of Tokyo, Japan
Adiponectin as an Anti-Aging Regulation
Adiponectin as an Anti-Aging Regulation
Nicholas L. Bentley,
University of New South Wales, Australia
Short Talk: Elevating Mitochondrial NAD Biosynthesis Enhances Hepatic Energy Metabolism, and Improves Glucose Tolerance in Aged Mice
Short Talk: Elevating Mitochondrial NAD Biosynthesis Enhances Hepatic Energy Metabolism, and Improves Glucose Tolerance in Aged Mice
8:30—11:30 AM
Stem Cell Aging and Humoral Factors
Meeting has ended...abstracts no longer viewable online.
*
Thomas A. Rando,
Stanford University School of Medicine, USA
Heinrich Jasper,
Genentech, Inc. & Buck Institute for Research on Aging, USA
Inflammation and Immune Modulation: Tackling Age-related Stem Cell Dysfunction
Inflammation and Immune Modulation: Tackling Age-related Stem Cell Dysfunction
Rajendra S. Apte,
Washington University School of Medicine, USA
Photoreceptor Metabolism in the Aging Eye
Photoreceptor Metabolism in the Aging Eye
Coffee Break
Emi K. Nishimura,
Tokyo Medical and Dental University, Japan
Stem Cells Orchestrate Hair Follicle Aging Program
Stem Cells Orchestrate Hair Follicle Aging Program
Tapash Jay Sarkar,
Stanford University, USA
Short Talk: Scalable Rejuvenation through Transient Reprogramming
Short Talk: Scalable Rejuvenation through Transient Reprogramming
Yaisa Andrews-Zwilling,
SanBio, Inc., USA
Short Talk: Transplanted Modified Bone Marrow-Derived Mesenchymal Stem Cells, SB623, Ameliorate Chronic Behavioral and Pathological Deficits in Stroke Rats
Short Talk: Transplanted Modified Bone Marrow-Derived Mesenchymal Stem Cells, SB623, Ameliorate Chronic Behavioral and Pathological Deficits in Stroke Rats
2:00—4:00 PM
Workshop 2: Mitochondria and NAD Metabolism
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Johan Auwerx,
École Polytechnique Fédérale de Lausanne, Switzerland
Mitsukuni Yoshida,
Washington University in St. Louis, USA
eNAMPT as an Adipose-Derived NAD+ Biosynthetic Enzyme that Systemically Regulates Aging
eNAMPT as an Adipose-Derived NAD+ Biosynthetic Enzyme that Systemically Regulates Aging
Emi Inagaki,
Keio University, Japan
NAD-Related Metabolites and their Possible Application for Corneal Disease
NAD-Related Metabolites and their Possible Application for Corneal Disease
Anthony Joseph Covarrubias,
Buck Institute, USA
The Role of Macrophages in NAD+ Homeostasis during Aging
The Role of Macrophages in NAD+ Homeostasis during Aging
Masakatsu Yamashita,
Ehime University School of Medicine, Japan
Metabolic Regulation of T Cell Senescence by Menin
Metabolic Regulation of T Cell Senescence by Menin
Pénélope Andreux,
Amazentis, Switzerland
Translation of Urolithin A Effects on Mitochondria and Muscle from Worms to Rodents to Humans
Translation of Urolithin A Effects on Mitochondria and Muscle from Worms to Rodents to Humans
Caroline C. Escoubas,
Harvard School of Public Health, USA
The Role of Mitochondrial Dynamics in AMPK-Mediated Learning and Memory
The Role of Mitochondrial Dynamics in AMPK-Mediated Learning and Memory
4:30—6:30 PM
Intertissue Communication and Rhythm
Meeting has ended...abstracts no longer viewable online.
*
Matt Kaeberlein,
University of Washington, USA
Shin-ichiro Imai,
Washington University School of Medicine, USA
Nicotinamide Mononucleotide, a Key Systemic NAD+ Intermediate in Mammalian Aging and Longevity Control
Nicotinamide Mononucleotide, a Key Systemic NAD+ Intermediate in Mammalian Aging and Longevity Control
Satchidananda Panda,
The Salk Institute for Biological Studies, USA
Circadian Regulation for the Prevention and Treatment of Metabolic Diseases
Circadian Regulation for the Prevention and Treatment of Metabolic Diseases
Francisca O. Peixoto,
IRB Barcelona, Spain
Short Talk: Aged Stem Cells Reprogram their Daily Rhythmic Functions to Adapt to Tissue-Specific Stress
Short Talk: Aged Stem Cells Reprogram their Daily Rhythmic Functions to Adapt to Tissue-Specific Stress
Victoria A. Acosta Rodriguez,
University of Texas Southwestern Medical Center, USA
Short Talk: Calorically Restricted Mice Self-Impose a Temporal Pattern of Food Intake
Short Talk: Calorically Restricted Mice Self-Impose a Temporal Pattern of Food Intake
8:30—11:30 AM
Cellular Senescence
Meeting has ended...abstracts no longer viewable online.
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Eisuke Nishida,
Kyoto University, Japan
John Sedivy,
Brown University, USA
Activation of Somatic Retrotransposition in Cellular Senescence and Aging
Activation of Somatic Retrotransposition in Cellular Senescence and Aging
Jan M. van Deursen,
Mayo Clinic, USA
How Senescent Cells Contribute to Aging and Disease
How Senescent Cells Contribute to Aging and Disease
Coffee Break
Tohru Minamino,
Niigata University Graduate School of Medical and Dental Sciences, Japan
Cellular Senescence and Age-Associated Diseases
Cellular Senescence and Age-Associated Diseases
Yun-Chen Chiang,
University of North Carolina at Chapel Hill, USA
Short Talk: The Role of p16INK4a in Shaping the T Cell Receptor Repertoire Diversity
Short Talk: The Role of p16INK4a in Shaping the T Cell Receptor Repertoire Diversity
Kyoko Miura,
Hokkaido University, Japan
Short Talk: Unique Response of Cancer- and Senescence-Resistant Rodent “Naked Mole-Rat” to Cellular Senescence Induction
Short Talk: Unique Response of Cancer- and Senescence-Resistant Rodent “Naked Mole-Rat” to Cellular Senescence Induction
4:30—6:30 PM
Stress, Damage and Epigenetic Changes
Meeting has ended...abstracts no longer viewable online.
*
Emi K. Nishimura,
Tokyo Medical and Dental University, Japan
Rochelle Buffenstein,
Calico Life Sciences LLC, USA
Sustained Maintenance of Proteostasis in the Long-Lived Naked Mole-Rat
Sustained Maintenance of Proteostasis in the Long-Lived Naked Mole-Rat
Jan H. J. Hoeijmakers,
Erasmus MC, Netherlands
DNA Damage, Aging and Nutritional Interventions
DNA Damage, Aging and Nutritional Interventions
Jing-Dong Jackie Han,
Shanghai Institutes of Biological Sciences, China
Integrative Data Analysis for Development and Aging
Integrative Data Analysis for Development and Aging
6:30—7:30 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:30—9:15 AM
Keynote Address
Meeting has ended...abstracts no longer viewable online.
*
Leonard P. Guarente,
Massachusetts Institute of Technology, USA
Thomas A. Rando,
Stanford University School of Medicine, USA
Epigenetic Regulation of Stem Cell Aging
Epigenetic Regulation of Stem Cell Aging
9:15 AM—12:30 PM
Age-Associated Complications
Meeting has ended...abstracts no longer viewable online.
*
Satchidananda Panda,
The Salk Institute for Biological Studies, USA
Yousin Suh,
Albert Einstein College of Medicine, USA
Enhancer Mechanisms in Human Aging and Aging-Related Disease
Enhancer Mechanisms in Human Aging and Aging-Related Disease
Coffee Break
Kazuo Tsubota,
Keio University School of Medicine, Japan
Age-Associated Eye Diseases and their Treatment
Age-Associated Eye Diseases and their Treatment
Masashi Yanagisawa,
University of Tsukuba, Japan
Towards the Mysteries of Sleep
Towards the Mysteries of Sleep
Ana Maria Cuervo,
Albert Einstein College of Medicine, USA
Selective autophagy and age-associated diseases
Selective autophagy and age-associated diseases
Liang Dai,
L’Oreal Research and Innovation, Singapore
Short Talk: The Role of Pre-LaminA in Skin Aging
Short Talk: The Role of Pre-LaminA in Skin Aging
Lauren Tindale,
BC Cancer Agency, Canada
Short Talk: Lipid and Alzheimer’s Disease Genes Associated with Healthy Aging and Longevity in Healthy Oldest-Old
Short Talk: Lipid and Alzheimer’s Disease Genes Associated with Healthy Aging and Longevity in Healthy Oldest-Old
2:00—4:00 PM
Workshop 3: Epigenetics and Stress Response
*
Jing-Dong Jackie Han,
Shanghai Institutes of Biological Sciences, China
Clea Barcena,
University of Oviedo, Spain
Methionine Restriction Extends Mouse Lifespan by Modulating Bile Acid Signaling
Methionine Restriction Extends Mouse Lifespan by Modulating Bile Acid Signaling
Chung-Yi Liang,
National Yang-Ming University, Taiwan
Functional Regulation of the DAF-16/FoxO Transcription Factor by Acetylation in Stress Responses and Longevity
Functional Regulation of the DAF-16/FoxO Transcription Factor by Acetylation in Stress Responses and Longevity
Nitish Mittal,
Biozentrum, University of Basel, Switzerland
The Gcn4 Transcription Factor Reduces Protein Synthesis Capacity to Extend Lifespan
The Gcn4 Transcription Factor Reduces Protein Synthesis Capacity to Extend Lifespan
Claire H. Wilson,
University of South Australia, Australia
Caspase-2, a Regulator of Metabolic and Stress Response Pathways during Aging
Caspase-2, a Regulator of Metabolic and Stress Response Pathways during Aging
Harumi Fujita,
Keio University School of Medicine, Japan
Genetic Characterization of a Patient with a Progeroid Phenotype and Mosaic Variegated Aneuploidy
Genetic Characterization of a Patient with a Progeroid Phenotype and Mosaic Variegated Aneuploidy
Min-Hao Kuo,
Michigan State University, USA
Intracellular Triacylglycerol Promotes Longevity Independently of Energy Expenditure
Intracellular Triacylglycerol Promotes Longevity Independently of Energy Expenditure
Parag Kundu,
Nanyang Technological University, Singapore
Gut Microbiome of Aging-Host: Friend or Foe?
Gut Microbiome of Aging-Host: Friend or Foe?
4:30—6:30 PM
Interventions for Aging and Longevity
Meeting has ended...abstracts no longer viewable online.
*
Masashi Yanagisawa,
University of Tsukuba, Japan
Eisuke Nishida,
Kyoto University, Japan
Life-Span Regulation by Environmental Stresses in C. elegans
Life-Span Regulation by Environmental Stresses in C. elegans
Hideyuki Okano,
Keio University School of Medicine, Japan
Preemptive Medicine for Dementia and Neurodegenerative Diseases using iPSC-Technologies and Genetically Modified Non-human Primates
Preemptive Medicine for Dementia and Neurodegenerative Diseases using iPSC-Technologies and Genetically Modified Non-human Primates
Gary Krishnan,
Eli Lilly and Company, USA
Short Talk: Changes in Human Skeletal Muscle Transcriptome after Exercise Provides a Guide-Post for the Identification of Novel Exercise Mimetic Therapies to Treat Aging-Related Loss in Muscle Function
Short Talk: Changes in Human Skeletal Muscle Transcriptome after Exercise Provides a Guide-Post for the Identification of Novel Exercise Mimetic Therapies to Treat Aging-Related Loss in Muscle Function
Arya Biragyn,
NIA, National Institutes of Health, USA
Short Talk: Aging Microbiota Change in Primates and Mice Converts Innate B1a Cells into Pathogenic 4BL Cells that Induce Cytolytic CD8+T Cells
Short Talk: Aging Microbiota Change in Primates and Mice Converts Innate B1a Cells into Pathogenic 4BL Cells that Induce Cytolytic CD8+T Cells
6:30—6:45 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.
6:45—7:45 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
7:45—8:45 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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