Granlibakken Tahoe Floorplan

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This meeting took place in 2017



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Lipidomics and Bioactive Lipids in Metabolism and Disease (B6)


Organizer(s) Alfred H. Merrill, Walter Allen Shaw, Sarah Spiegel and Michael J.O.Wakelam
February 26—March 2, 2017
Granlibakken Tahoe • Tahoe City, California USA
Discounted Abstract Deadline: Oct 26, 2016
Abstract Deadline: Dec 12, 2016
Scholarship Deadline: Oct 26, 2016
Discounted Registration Deadline: Jan 9, 2017

Sponsored by Abide Therapeutics Inc.

Summary of Meeting:
The ability to analyze large numbers of lipids from different categories (e.g., fatty acyls, glycerolipids, sphingolipids and sterols) has greatly advanced our understanding of their biochemical functions and roles in disease, but has also created challenges of scale. This Keystone Symposia meeting will cover areas of lipid research that have been particularly impacted by these technologies. It will specifically address the challenge of managing the large data sets generated by lipidomic technologies and conceptually studying them given how interconnected and cross-regulated lipid metabolic pathways are. Bringing together an outstanding group of scientists with expertise in the lipid categories as well as in lipidomic approaches, it will summarize recent findings for the major lipid categories from state-of-the-art technologies and lay the foundation for a broader understanding of new methods and the technical capabilities and limitations of these methods, as well as where better approaches are needed.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, February 26 with registration from 16:00 to 20:00 and a welcome mixer and light meal from 18:00 to 20:00. Conference events conclude on Thursday, March 2 with a closing plenary session from 17:00 to 19:00, followed by dinner and entertainment. We recommend return travel on Friday, March 3 in order to fully experience the meeting.

SUNDAY, FEBRUARY 26

4:00—8:00 PM
Arrival and Registration

Pre Function
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Granhall
6:00—8:00 PM
Light Meal - Provided by Granlibakken

Granhall

MONDAY, FEBRUARY 27

7:00—8:00 AM
Breakfast

Granhall
8:00—9:00 AM
Welcome and Keynote Address (Organizers)
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
Edward A. Dennis, University of California, San Diego, USA
Lipidomics Highlights Infection and Inflammation Progression

9:00—11:30 AM
Lipidomics in Inflammation
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Sarah Spiegel, Virginia Commonwealth University, USA

* Alfred H. Merrill, Jr., Georgia Institute of Technology, USA

Garret A. FitzGerald, University of Pennsylvania, USA
Prostaglandins and Their Inhibitors

Coffee Break

Valerie B. O'Donnell, Cardiff University, UK
Lipidomics Characterization of Oxidation during Platelet Activation and Physiological Blood Clotting

Richard L. Proia, National Institutes of Health, USA
Visualizing Sphingosine-1-Phosphate G Protein-Coupled Receptor Signaling in Living Animals

Charles E. Chalfant, Virginia Commonwealth University, School of Medicine, USA
Short Talk: The Lipidome in Inflammation, Wound Healing, and Pre-Eclampsia

Veronica G. Anania, Genentech, Inc., USA
Short Talk: Bioactive Lipids as Pharmacodynamic Biomarkers of Mast Cell Activity in the Clinic

11:30—11:45 AM
Description of LIPID MAPS and Website Tools
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Valerie B. O'Donnell, Cardiff University, UK

Eoin Fahy, University of California, San Diego, USA

11:45 AM—5:00 PM
On Own for Lunch

11:30 AM—1:00 PM
Poster Setup

Bay
1:00—10:00 PM
Poster Viewing

Bay
4:30—5:00 PM
Coffee Available

Pre Function
5:00—7:00 PM
Lipidomics and Infection
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Charles R. Brown, University of Missouri, USA

Markus R. Wenk, National University of Singapore, Singapore
Natural Variation of Blood Plasma Lipids in Healthy Asian Individuals

Dennis R. Voelker, National Jewish Health, USA
Journal of Lipid Research Lectureship: Pulmonary Surfactant Phospholipids Regulate Innate Immunity

Frances Platt, University of Oxford, UK
The Niemann-Pick Type C Disease Pathway and its Unanticipated Role in Infection

7:15—8:15 PM
Dinner
No registration fees are used to fund alcohol served at this function.

Granhall
7:30—10:00 PM
Poster Session 1

Bay
8:00—9:00 PM
Social Hour
No registration fees are used to fund alcohol served at this function.

Bay

TUESDAY, FEBRUARY 28

7:00—8:00 AM
Breakfast

Granhall
8:00—11:15 AM
Cancer Lipidomics
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Markus R. Wenk, National University of Singapore, Singapore

* Andrew J. Morris, University of Kentucky, USA

Sarah Spiegel, Virginia Commonwealth University, USA
Targeting the Sphingosine-1-Phosphate Axis and Development of a Novel Therapy for Endocrine-Resistant Breast Cancer

Tony Futerman, Weizmann Institute of Science, Israel
Ceramide Synthases and Cellular Function

Coffee Break

Michael J.O. Wakelam, Babraham Institute, UK
Lipidomic Changes Predict Novel Therapeutic Targets in Colorectal Cancer and Other Diseases

Christian Metallo, University of California, San Diego, USA
Understanding the Interplay between Amino Acid and Lipid Metabolism

Tzipora Goldkorn, University of California, Davis, USA
Short Talk: nSMase2 Conveys Oncogenic Advantages to Tumors of Lung Adenocarcinoma in Smokers via SphK1

David A. Potter, University of Minnesota, USA
Short Talk: Heme Binding Biguanides Target Cytochrome P450 Dependent Cancer Cell Mitochondria

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Bay
1:00—10:00 PM
Poster Viewing

Bay
4:30—5:00 PM
Coffee Available

Pre Function
5:00—7:15 PM
Cardiovascular Lipidomics
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Julian L. Griffin, University of Cambridge, UK

William Griffiths, Swansea University, UK
Oxysterol Lipidomics in Mouse and Man

L. Ashley Cowart, Medical University of South Carolina, USA
Advances in Understanding the Roles of Ceramide Synthase Isoforms in the Cardiac Response to Dyslipidemia

Jeffrey G. McDonald, University of Texas Southwestern Medical Center, USA
Analysis of ELOVL Enzyme Activity by Infusion-Based Lipidomics Using MS/MSALL

Andrew J. Morris, University of Kentucky, USA
Short Talk: Lysophosphatidic Acid Metabolism and Signaling in Atherosclerosis

Rheem A. Totah, University of Washington, USA
Short Talk: cis- and trans-Epoxyeicosatrienoic Acids in Patients with Cardiovascular Disease

7:15—7:30 PM
Recognition of Scholarship Awardees
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Alfred H. Merrill, Jr., Georgia Institute of Technology, USA

Patricia Rodrigues, Cardiff University, UK
GATA6 Transcription Factor Regulates Lipid Metabolism in Tissue Resident Macrophages

Opeyemi Stella Ademowo, Aston University, UK
Phospholipid Oxidation and Carotenoid Supplementation in Alzheimer’s Disease Patients

7:30—8:30 PM
Dinner
No registration fees are used to fund alcohol served at this function.

Granhall
7:30—10:00 PM
Poster Session 2

Bay
8:00—9:00 PM
Social Hour
No registration fees are used to fund alcohol served at this function.

Bay

WEDNESDAY, MARCH 1

7:00—8:00 AM
Breakfast

Granhall
8:00—9:00 AM
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Michael J.O. Wakelam, Babraham Institute, UK

Vytas A. Bankaitis, Texas A&M University, USA
Phosphatidylinositol Transfer Protein-Dependent Golgi Positioning Controls Cell Polarity in Neural Stem Cells and Projection Neurons in Developing Mammalian Forebrain

9:00—11:30 AM
Lipid Localization and Implications for Cell Regulation
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA

* Junken Aoki, Tohoku University, Japan

Per Haberkant, European Molecular Biology Laboratory, Germany
A Quantitative Map of Cellular Protein-Sphingolipid Complexes and their Lipid-Binding Profile

Coffee Break

Erwin London, SUNY Stony Brook, USA
Using Cyclodextrins to Control the Lipid Composition, Lipid Asymmetry, and Membrane Properties of Artificial Vesicles and Living Cells

John Katsaras, Oak Ridge National Laboratory, USA
Model Membranes, Bacteria and Lateral Membrane Organization

Alexander Kros, Leiden Institute of Chemistry, Leiden University, Netherlands
Short Talk: Quantifying Membrane Compound Exchange Between Live Mammalian Cells

Kuniyuki Kano, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan
Short Talk: Imaging MS Analysis of Lysophospholipids using AP-MALDI-MS

11:30 AM—5:00 PM
On Own for Lunch

11:30 AM—1:00 PM
Poster Setup

Bay
1:00—10:00 PM
Poster Viewing

Bay
3:30—4:30 PM
Workshop: LIPID MAPS Tools

Mountain/Lake
* Eoin Fahy, University of California, San Diego, USA
The LIPID MAPS Lipidomics Gateway

4:30—5:00 PM
Coffee Available

Pre Function
5:00—7:00 PM
Lipidomics
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Valerie B. O'Donnell, Cardiff University, UK

* Friedrich Spener, University of Graz, Austria

Walter Allen Shaw, Avanti Polar Lipids, Inc., USA
When Bad Things Happen to Good Samples: The Good, the Bad, and the Scary of Lipid Mass Spectrometry

Kim Ekroos, University of Southern Denmark, Denmark
High-Definition FLUX Lipidomics

Toyoshi Fujimoto, Nagoya University Graduate School of Medicine, Japan
Freeze-fracture Electron Microscopy to Define Distribution of Lipids and Lipid Domains at the Nanoscale

Roger Sandhoff, German Cancer Research Center, Germany
Short Talk: Stereoisomer-Specific Quantification of Simple Bioactive Glycosphingolipids from Bacteria and Mammals

7:00—8:00 PM
Dinner
No registration fees are used to fund alcohol served at this function.

Granhall
7:30—10:00 PM
Poster Session 3

Bay
8:00—9:00 PM
Social Hour
No registration fees are used to fund alcohol served at this function.

Bay

THURSDAY, MARCH 2

7:00—8:00 AM
Breakfast

Granhall
8:00—11:00 AM
Neurological Lipidomics
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* William Griffiths, Swansea University, UK

* Tony Futerman, Weizmann Institute of Science, Israel

Robert C. Murphy, University of Colorado Denver, USA
High-Throughput Lipidomic Analysis the CTS Method: Application to Neuronal Tissue

Maria Fuller, SA Pathology, University of Adelaide, Australia
The Brain Lipidome: A Therapeutic Target for Neurodegenerative Disorders

Coffee Break

Steffany A.L. Bennett, University of Ottawa, Canada
Translational Lipidomics: Can Patients with DLB, AD or MCI be Stratified by Interrogating their Plasma Lipidomes?

Janet E. Deane, University of Cambridge, UK
Short Talk: Aberrant Glycosphingolipid Processing in a Lysosomal Storage Disease

Patricia C. Kane, NeuroLipid Research Foundation, USA
Short Talk: Addressing Neurological Disorders by Clearing Epigenetics and Stabilizing Membranes and Cardiolipin with Bioactive Lipids

11:00 AM—5:00 PM
On Own for Lunch

4:30—5:00 PM
Coffee Available

Pre Function
5:00—6:45 PM
Metabolism
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Dennis R. Voelker, National Jewish Health, USA

* L. Ashley Cowart, Medical University of South Carolina, USA

Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA
Acyl-CoA Metabolism and Partitioning

James Mukasa Ntambi, University of Wisconsin-Madison, USA
Regulation of Adipose Tissue Lipogenesis and Fatty Acid Oxidation

Nicholas O. Davidson, Washington University School of Medicine, USA
Fatty Acid Flux and Hepatic Fibrosis: Pathways Linking Lipid Metabolism and Liver Injury

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
7:00—8:00 PM
Dinner
No registration fees are used to fund alcohol served at this function.

Granhall
7:00—8:00 PM
Social Hour
No registration fees are used to fund alcohol served at this function.

Granhall
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Granhall

FRIDAY, MARCH 3

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Abide Therapeutics Inc.

We gratefully acknowledge additional support for this conference from:

Avanti Polar Lipids, Inc. Cayman Chemical Company
Journal of Lipid Research Lipotype GmbH

SCIEX, LLC
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Avanti Polar Lipids, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676