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This meeting took place in 2018



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Organs- and Tissues-on-Chips (D1)


Organizer(s) Christopher P. Austin, Danilo Tagle, Christine L. Mummery and Brian R. Berridge
April 8—12, 2018
Big Sky Resort • Big Sky, Montana USA
Discounted Abstract Deadline: Dec 6, 2017
Abstract Deadline: Jan 9, 2018
Scholarship Deadline: Dec 6, 2017
Discounted Registration Deadline: Feb 6, 2018

Sponsored by Merck & Co., Inc.

Summary of Meeting:
More than 30% of promising medications have failed in human clinical trials because they are determined to be toxic despite promising pre-clinical studies in 2-D cell culture and animal models. Another 60% fail due to lack of efficacy. Consequently, though several thousand diseases affect humans, only about 500 have approved treatments. However, with the growing understanding of human biology, along with increased availability of innovative technologies, there is now an unprecedented opportunity to translate scientific discoveries more efficiently into new, more effective and safer health interventions. Organs- or Tissues-on-Chips are innovative, alternative approaches that would enable early indications and potentially more reliable readouts of toxicity and efficacy. These microfabricated devices recapitulate the multicellular architectures, tissue-tissue interfaces, physicochemical microenvironments, vascular perfusion and innervation, producing in essence microphysiological systems that mimic human tissue and organ functionality not possible with conventional 2D or 3D culture systems. Through innovative biosensing and readout approaches, these devices employ high-resolution, real-time imaging and non-invasive analysis of biochemical, genetic and metabolic activities of living cells in a functional tissue and organ context. This technology has great potential to advance the study of tissue development, organ physiology and disease etiology. In the context of drug discovery and development, it should be especially valuable for the study of molecular mechanisms of action, prioritization of lead candidates, toxicity testing and biomarker identification. These microfabricated devices have also proven to be useful for modeling human diseases. This conference will touch on ongoing efforts and various applications of tissue-on-chips technology to studies in precision medicine, environmental exposures, reproduction and development, cancer and for use at the International Space Station.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, April 8 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 12 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, April 13 in order to fully experience the meeting.

SUNDAY, APRIL 8

4:00—8:00 PM
Arrival and Registration

Lower Atrium
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Jefferson

MONDAY, APRIL 9

7:00—8:00 AM
Breakfast

Gallatin
8:00—9:00 AM
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Danilo A. Tagle, NCATS, National Institutes of Health, USA

* Christine L. Mummery, Leiden University Medical Center, Netherlands

* Brian R. Berridge, National Institute of Environmental Health Sciences, NIH, USA

* Christopher P. Austin, National Institutes of Health, USA
Overview of Organs-on-Chips in Drug Development for Safety, Toxicity and Efficacy Testing

9:00—11:15 AM
Organs-on-Chips in Drug Development
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Brian R. Berridge, National Institute of Environmental Health Sciences, NIH, USA

* Kevin Kit Parker, Harvard University, USA

D. Lansing Taylor, University of Pittsburgh Drug Discovery Institute, USA
Role of a Human Liver Microphysiology System as a Key Component of a Quantitative Systems Pharmacology Platform for Investigating Liver Disease Progression and Drug Discovery and Development

Coffee Break

Christine L. Mummery, Leiden University Medical Center, Netherlands
Cardiovascular Diseases and Drugs in Organ-on-Chip hiPSC Models

Misti Ushio, TARA Biosystems, USA
Short Talk: BiowireTM II: A Commercial Platform for the Production and Functional Assessment of Adult-Like Engineered Human Cardiac Tissue

Jonathan Himmelfarb, University of Washington, USA
A Human Kidney on a Chip for Disease Modeling and Toxicity Testing

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Gallatin
1:00—10:00 PM
Poster Viewing

Gallatin
4:30—5:00 PM
Coffee Available

Lower Atrium
5:00—7:00 PM
Integrated Organs-on-Chips
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Jason Ekert, GlaxoSmithKline, USA

* Christopher P. Austin, National Institutes of Health, USA

Gordana V. Vunjak-Novakovic, Columbia University, USA
Human Multi-Tissue Platforms with Perfusable Vasculature

Donald E. Ingber, Wyss Institute for Biologically Inspired Engineering at Harvard, USA
DARPA Integrated 10-Organ System Using Microfluidic Platform

Linda G. Griffith, Massachusetts Institute of Technology, USA
DARPA Integrated 10-Organ System Using a Microwell System

Olivier Frey, InSphero, Switzerland
Short Talk: Automating Multi-Tissue Microphysiological Systems Based on 3D Microtissues

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Gallatin
7:30—10:00 PM
Poster Session 1

Gallatin

TUESDAY, APRIL 10

7:00—8:00 AM
Breakfast

Gallatin
8:00—11:15 AM
Organs-on-Chips for Disease Modeling I
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Christine L. Mummery, Leiden University Medical Center, Netherlands

* Bruce R. Conklin, Gladstone Institutes, USA

Kevin Kit Parker, Harvard University, USA
Cardiomyocytes-on-Chips as Models for Barth Syndrome and Long QT

Steven C. George, University of California, Davis, USA
3D “Organ-on-a-Chip” Models of Atrial Conduction and Primary Human Cancer

Megan Laura McCain, University of Southern California, USA
Short Talk: Engineering µMyocardium with Tunable Cell-Matrix and Cell-Cell Interactions for Cardiac Disease Modeling

Coffee Break

George Truskey, Duke University, USA
Microphysiological Systems Vascular Model of Progeria

Nancy L. Allbritton, University of North Carolina at Chapel Hill and North Carolina State University, USA
Intestinal Simulacra on a Microscale

Robert Barrett, Cedars-Sinai Medical Center, USA
Short Talk: Intestine-Chip: A New Model to Understand the Role of the Intestinal Epithelium in IBD by Combining Microengineering Technology and iPSC-Derived Human Intestinal Organoids

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Gallatin
1:00—10:00 PM
Poster Viewing

Gallatin
4:30—5:00 PM
Coffee Available

Lower Atrium
5:00—7:00 PM
Organs-on-Chips for Disease Modeling II
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Danilo A. Tagle, NCATS, National Institutes of Health, USA

* Clive N. Svendsen, Cedars-Sinai Regenerative Medicine Institute, USA

Helena Therese Hogberg, Johns Hopkins Bloomberg School of Public Health, USA
3D Neuronal Microphysiology Systems and Neuronal Disease Models

Samuel Sances, Cedars-Sinai Medical Center, USA
Short Talk: Microphysiological Systems to Study Human Neurodegenerative Disease

Kevin E. Healy, University of California, Berkeley, USA
Microphysiological Systems for Drug Discovery, Disease Modeling, and Precision Medicine

Joanna Burdette, University of Illinois at Chicago, USA
Reproductive Cycles in a Dish Engineered to Model PCOS

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Gallatin
7:30—10:00 PM
Poster Session 2

Gallatin

WEDNESDAY, APRIL 11

7:00—8:00 AM
Breakfast

Gallatin
8:00—11:00 AM
Other Opportunities: 1) Tissue-on-Chips for Translational Research in Space 2) Environmental Health
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Gordana V. Vunjak-Novakovic, Columbia University, USA

* Liz Warren, CASIS, USA

Bruce R. Conklin, Gladstone Institutes, USA
CRISPR and Stem Cells: Disease Mechanism and Genome Surgery

Rocky S. Tuan, University of Pittsburgh School of Medicine, USA
Tissue Chip Modeling of Synovial Joint Physiology and Pathologies

Coffee Break

Warren M. Casey, NIEHS, National Institutes of Health, USA
Tissue Chips for Chemical Safety Testing: “Build it and They Will Come” Is Not a Viable Strategy

Richard S. Paules, NIEHS, National Institutes of Health, USA
Tox21 Efforts in Improving Toxicology and Human Safety Assessment

Sreenivasa Ramaiahgari, National Toxicology Program of NIEHS, USA
Short Talk: Functional Characterization of Microplate Cultured Human and Rat 3D Hepatocyte Spheroids and Their Use with High-Throughput Transcriptomics (S1500+) in Toxicology Screening

11:00 AM—5:00 PM
On Own for Lunch

11:00 AM—1:00 PM
Poster Setup

Gallatin
1:00—10:00 PM
Poster Viewing

Gallatin
2:30—4:30 PM
Workshop 1: Innovative Approaches, Designs, Readouts

Jefferson/Madison
* Lorna Ewart, AstraZeneca, UK

* Steven C. George, University of California, Davis, USA

Riccardo Barrile, Emulate Inc., USA
Organ-on-Chip Technology Recapitulates Thrombosis Induced by an Anti-CD154 Candidate Therapeutic Monoclonal Antibody

Stefano Da Sacco, University of Southern California, USA
Development of a Barrier-Free Glomerulus-on-a-Chip System as a Model to Study the Glomerular Filtration Barrier in vitro

Viktoras Frismantas, Wyss Institute for Biologically Inspired Engineering at Harvard University, USA
Modeling Drug- and Radiation-Induced Myelosuppression in a Vascularized Human Bone Marrow-on-a-Chip

Dhvanit I. Shah, Nationwide Children's Hospital, USA
Development of a Bioreactor Simulating Mechanosensation to Stimulate Hematopoietic Stem Cell Formation

Berend J. van Meer, Leiden University Medical Center, Netherlands
Generic and Simultaneous Optical Measurement Method of Electrophysiology, Calcium and Contractility for Heart-on-Chips in Response to Drugs and Disease

Remi Villenave, Emulate Inc., USA
A Micro-Engineered Airway Lung-Chip that Recapitulates Unique Features of Human Viral-Induced Exacerbation of Asthma

Ashutosh Agarwal, University of Miami, USA
Resealable, Optically Accessible, PDMS-Free Fluidic Platforms for Organs on Chips

4:30—5:00 PM
Coffee Available

Lower Atrium
5:00—7:00 PM
Commercializing Tissue Chip Technologies
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Ivan Rusyn, Texas A&M University, USA

* Murat Cirit, Massachusetts Institute of Technology, USA

Geraldine A. Hamilton, Emulate Inc., USA
Organs-on-Chips Technology: A Platform for Advancing Efficacy and Safety Testing in Drug Discovery and Development

Thomas Neumann, Nortis, Inc., USA
How Organ-on-Chip Technologies Will Revolutionize in-vitro Methods

Uwe Marx, TissUse GmbH and Technische Universitat Berlin, Germany
Commercializing Integrated Multi-Organ Tissue Chips

Jos Joore, Mimetas, Netherlands
Short Talk: Commercializing High-Throughput Organ-on-a-Chip Systems for Early Implementation into Therapeutic Development

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Gallatin
7:30—10:00 PM
Poster Session 3

Gallatin

THURSDAY, APRIL 12

7:00—8:00 AM
Breakfast

Gallatin
8:00—11:15 AM
Perspectives from Regulatory Agencies and the Pharmaceutical Industry
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Mark E. Schurdak, University of Pittsburgh, USA

* Tracy C. MacGill, U.S. Food and Drug Administration, USA

Donna Mendrick, Food and Drug Administration, USA
FDA Perspectives on Tissues-on-Chips

Adrian Roth, F. Hoffmann-La Roche Ltd., Switzerland
Industry Perspective on Organ-on-Chip Technology

Coffee Break

Brian R. Berridge, National Institute of Environmental Health Sciences, NIH, USA
Tissue Chips to Improve Clinical Translation and Reduce Late-Stage Drug Development Attrition

Amy Pointon, AstraZeneca, UK
Short Talk: The Value of Functional Multi-Organ Microphysiological Systems to Cardiovascular Safety

Andrew Schwab, Environmental Protection Agency, USA
Short Talk: Development of a Human Neurovascular Unit Organotypic Systems Model

Elizabeth Baker, Physicians Committee for Responsible Medicine, USA
Short Talk: Preclinical Innovation and Patient Safety: Supporting Human-Based Science Through Advances in Law, Policy, Education and Training

Lorna Ewart, AstraZeneca, UK
Short Talk: Liver-Chip and Spheroids as Systems to Determine Hepatic Safety and Metabolism

11:15 AM—5:00 PM
On Own for Lunch

2:30—4:30 PM
Workshop 2: Tissue Chips for Personalized Medicine

Jefferson/Madison
* Kevin E. Healy, University of California, Berkeley, USA

* Donald E. Ingber, Wyss Institute for Biologically Inspired Engineering at Harvard, USA

Zongyou Guo, Columbia University, USA
Atopic Cytokines IL4/13 Perturb iPSC-Derived Itch-Specific Sensory Neurons

Peter Loskill, Fraunhofer Institute for Interfacial Engineering and Biotechnology, Germany
Merging High-Content and High-Throughput Screening: Microphysiological Organ-on-a-Chip Systems Integrating Human Retinal, Cardiac and Adipose Tissue

Chris P. Miller, University of Washington, USA
A 3D Human Renal Cell Carcinoma on a Chip for the Study of Tumor Angiogenesis

Kasper Renggli, ETH Zürich, Switzerland
Leukemia on Chip – Flow- and Metabolism-Based Microphysiological Multi-Tissue System for Patient-Derived Liquid Biopsies

Gad David Vatine, Ben Gurion University, Israel
Microphysiological Human iPSC-Based Isogenic Blood Brain Barrier-on-Chip Platform for Personalized Predictive Medicine

Hee-Gyeong Yi, POSTECH, South Korea
3D Cell-Printed Glioblastoma-on-a-Chip for Personalized Medicine

Leigh Joan Atchison, Duke University, USA
An Induced Pluripotent Stem Cell-Derived Tissue-Engineered Blood Vessel to Study Hutchinson-Gilford Progeria Syndrome

4:30—5:00 PM
Coffee Available

Lower Atrium
5:00—6:45 PM
Validating Tissue Chips
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Peter Loskill, Fraunhofer Institute for Interfacial Engineering and Biotechnology, Germany

* Lucie Low, National Institutes of Health, USA

Ivan Rusyn, Texas A&M University, USA
Tissue Chip Validation Center at Texas A&M University (TEX-VAL Center)

Murat Cirit, Massachusetts Institute of Technology, USA
Quantitative Assessment of Tissue Chip Technologies

Mark E. Schurdak, University of Pittsburgh, USA
The Microphysiology Systems Database for Validation of Tissue Chip Organ Models

6:45—7:00 PM
Meeting Wrap-Up
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
Danilo A. Tagle, NCATS, National Institutes of Health, USA
The NIH Tissue Chips for Drug Screening Program: Current and Future Directions

7:00—8:00 PM
Social Hour with Lite Bites

Gallatin
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Gallatin

FRIDAY, APRIL 13

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Merck & Co., Inc.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13EB026338-01

Funding for this conference was made possible (in part) by 1R13EB026338-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

InSphero Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676