Fairmont Banff Springs Floorplan

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This meeting took place in 2018


Here are the related meetings in 2019:
Microbiome: Chemical Mechanisms and Biological Consequences (C3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Manipulation of the Gut Microbiota for Metabolic Health (X3)


Organizer(s) Nathalie Delzenne and Liping Zhao
March 4—8, 2018
Fairmont Banff Springs • Banff, Alberta Canada
Discounted Abstract Deadline: Nov 1, 2017
Abstract Deadline: Dec 1, 2017
Scholarship Deadline: Nov 1, 2017
Discounted Registration Deadline: Jan 9, 2018

Sponsored by Merck & Co., Inc. and Takeda Pharmaceutical Company Limited


Summary of Meeting:
The main objective of this Keystone Symposia conference is to evaluate the contribution of the gut microbiota to diseases characterized by alterations of host energy metabolism, and to highlight development of new therapeutic and nutritional approaches. Innovative models allow us to better elaborate the link between gut microbiota, the environment (including nutrition and xenobiotics – drugs, contaminants, additives) and host physiology, namely by focusing on specific metabolites produced by the gut microbes. As compared to previous meetings organized in the same field, additional metabolic disorders will be covered, including undernutrition and cachexia, disturbances of gut-muscle axis and cardiovascular dysfunction. Special attention will be brought to innovative tools to manipulate the gut microbiota, implicating both academic and industry research. The symposium will bring together a multidisciplinary audience to explore the vast amount of existing data (metagenomics and metabolomics dataset) that can be leveraged to elaborate novel tools to modulate the gut microbiota for host health.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, March 4 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 8 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 9 in order to fully experience the meeting.

SUNDAY, MARCH 4

4:00—8:00 PM
Arrival and Registration

Van Horne Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Van Horne Foyer

MONDAY, MARCH 5

7:00—8:00 AM
Breakfast

Mezzanine 2
8:00—9:00 AM
Welcome and Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Yasmine Belkaid, NIAID, National Institutes of Health, USA

* Janelle S. Ayres, The Salk Institute for Biological Studies, USA

* Nathalie Delzenne, Université Catholique de Louvain, Belgium

* Liping Zhao, Shanghai Jiao Tong University, China and Rutgers University, USA

Andreas J. Bäumler, University of California, Davis, USA
Healthy Guts Exclude Oxygen

9:00—11:30 AM
Microbiota and Cardio­vascular-Metabolic Health (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Lora V. Hooper, University of Texas Southwestern Medical Center, USA

* Fredrik Bäckhed, University of Gothenburg, Sweden
Mechanistic Studies of the Impact of the Gut Microbiome on Obesity and Type 2 Diabetes

Coffee Break

Liping Zhao, Shanghai Jiao Tong University, China and Rutgers University, USA
Ecological Understanding of the Causative Role of Gut Microbiota in Human Metabolic Health

Julia H. Kreznar, University of Wisconsin-Madison, USA
Short Talk: Identifying the Genetic Determinants of Gut Microbiome Composition on a Western Diet

Amy McMillan, Cleveland Clinic, USA
Short Talk: The Gut Microbe-Dependent Metabolite Trimethylamine N-oxide (TMAO) Is Associated with Multiple Measures of Periodontal Disease and Cardiovascular Disease Risk

11:30 AM—5:00 PM
On Own for Lunch

11:30 AM—1:00 PM
Poster Setup

Mezzanine 2
1:00—10:00 PM
Poster Viewing

Mezzanine 2
2:30—4:30 PM
Workshop: Metagenomic, Metatranscriptomic and Multi’Omic Microbiome Analyses (Joint)
This workshop will provide an introduction to study design tools and analysis methods for emerging molecular tools in human microbiome population studies, integrating detailed metagenomic, metatranscriptomic, and other culture-independent molecular methods. Alternating between lecture content and hands-on activities, tutorial presentations will walk attendees through the typical steps in a meta’omic study design and analysis workflow: 1) integration of multiple molecular techniques within a study, 2) bioinformatics for metagenomes and metatranscriptomes, 3) and profiling of microbial community features (taxa, strains, pathways, genes, small molecules, and others). The hands-on components of the tutorial will introduce the bioBakery suite of meta’omic analysis methods, which are publicly available and will be used online through a cloud interface during the workshop. Attendees will work on their personal laptops and interact with their instances through a web browser-based graphical interface (https://bitbucket.org/biobakery/biobakery/wiki/biobakery_workshop).
Tutorial Schedule:
Multi’omics for human microbiome studies (20 minutes, Curtis Huttenhower)
Tutorial setup (15 minutes, Melanie Schirmer)
Metagenome taxonomic and strain profiling (20 minutes, Kevin Bonham)
Lab: StrainPhlAn (25 minutes, Kevin Bonham)
Meta’omic functional profiling (15 minutes, Eric Franzosa)
Lab: HUMAnN2 (25 minutes, Eric Franzosa)

Van Horne A/B
* Curtis Huttenhower, Harvard School of Public Health, USA

4:30—5:00 PM
Coffee Available

Van Horne Foyer
5:00—7:15 PM
The Gut Microbiome in the Control of Fat Metabolism (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Fredrik Bäckhed, University of Gothenburg, Sweden

* Anna Mae Diehl, Duke University Medical Center, USA
The Gut Microbiome and NAFLD Pathogenesis

Mirko Trajkovski, University of Geneva - CMU, Switzerland
The Microbiota and the Browning of Adipose Tissue

Patrice D. Cani, UCLouvain, Belgium
Intestinal Endocannabinoids, Gut Microbes and Adiposity: Novel Mechanisms

Kelsey E. Huus, University of British Columbia, Canada
Short Talk: The Development of IgA-Lactobacillus Interactions Is Disrupted during Malnutrition and Environmental Enteropathy

Philippe Gerard, INRA, France
Short Talk: A Bacterial Species Isolated from an Obese Human Gut Triggers Non-Alcoholic Fatty Liver Disease in Germ-Free Mice through Lps-Dependent Mechanism

7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
7:30—10:00 PM
Poster Session 1

Mezzanine 2-Cascade Room

TUESDAY, MARCH 6

7:00—8:00 AM
Breakfast

Mezzanine 2
8:00—11:15 AM
Microbiota and Metabolic Disorders
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Ruth E. Ley, Max Planck Institute for Developmental Biology, Germany

Emily P. Balskus, Harvard University, USA
Deciphering Gut Microbiota-Drug Interactions with Chemistry

François Leulier, Institut de Génomique Fonctionnelle de Lyon, France
Host-Microbiota Mutualism upon Chronic Undernutrition: Lessons from Gnotobiotic Animal Models

Coffee Break

Herbert Tilg, Medical University Innsbruck, Austria
Microbiome and Liver Diseases

Eran Elinav, Weizmann Institute of Science, Israel
Host Microbiome Interactions in Health and Disease

Chenhong Zhang, Shanghai Jiao Tong University, China
Short Talk: Predominant Gut Lactobacillus murinus Strain Mediates the Anti-Inflammaging Effects in Calorie-Restricted Mice

Tim Hendrikx, University of California, San Diego, USA
Short Talk: Engineered Lactobacillus reuteri that Secretes IL-22 in the Gut Ameliorates Alcohol-Induced Liver Damage in Mice by Inducing Antimicrobial Molecules Reg3β and Reg3γ

8:00—11:15 AM
The Microbiota of Early Life and Developmental Immunology
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
Maria G. Dominguez-Bello, Rutgers University, USA
Effect of C-Section on the Microbiota and Host Phenotype

* Andrew J.S. Macpherson, University of Bern, Switzerland
The Maternal Microbiota and Early Postnatal Innate Immune Development

Coffee Break

Gregory M. Barton, University of California, Berkeley, USA
Determinants of CD4 T Cell Responses to the Microbiota

Michael D. Rosenblum, University of California, San Francisco, USA
Neonatal Regulatory T Cells and Immune Tolerance to Skin Commensals

Brittany Needham, California Institute of Technology, USA
Short Talk: Gut Bacterial Production of a Single Metabolite Causes Behavioral Abnormalities Related to Anxiety and Autism Spectrum Disorder

Michael G. Constantinides, NIAID, National Institutes of Health, USA
Short Talk: Mucosal-Associated Invariant T Cells Respond to Cutaneous Microbiota

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Mezzanine 2
1:00—10:00 PM
Poster Viewing

Mezzanine 2
2:30—4:30 PM
Workshop and Panel: Discovery, Translation and Commercialization in Microbiome Research and Development: Opportunities and Challenges

Van Horne A/B
David N. Cook, Seres Therapeutics, Inc., USA
Treating IBD with Multi-Species Bacterial Consortia

Henry J. Haiser, Novartis Institutes for BioMedical Research, USA
Facing the Challenges and Opportunities of Microbiome Research—a Big Pharma Perspective

* Thomas Gajewski, University of Chicago, USA
Prospect of Manipulating the Microbiota as a Cancer Immunotherapeutic

Maria G. Dominguez-Bello, Rutgers University, USA
Challenges in Translation of Microbiome Research

4:30—5:00 PM
Coffee Available

Van Horne Foyer
5:00—7:00 PM
Gut Barrier Alterations and Host Metabolic Disorders
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Robert W. Karp, National Institutes of Health, USA

Lora V. Hooper, University of Texas Southwestern Medical Center, USA
How the Microbiota, the Immune System and the Circadian Clock Interact to Regulate Metabolism

Philippe Langella, Institut National de la Recherche Agronomique, France
Microbial Bioactive Metabolites and Gut Function

Michiel Kleerebezem, Wageningen University, Netherlands
Small Intestine Microbiota and Host Metabolism

Jun Sun, University of Illinois at Chicago, USA
Short Talk: Vitamin D Receptor Regulation of Microbiome in Inflammation and Obesity

5:00—7:00 PM
Mechanistics Microbiome Function in Physiology and Aging
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Janelle S. Ayres, The Salk Institute for Biological Studies, USA

Meghan A. Koch, University of California, Berkeley, USA
Maternal Antibodies Regulate Neonatal Health

Sarkis K. Mazmanian, California Institute of Technology, USA
Gut Microbiomes from Human Autism Spectrum Disorder Alter Behaviors in Mice

Nicholas Bessman, Weill Cornell Medicine, USA
Short Talk: A Dendritic Cell-Derived Hormone Regulates Microbiome Colonization and Repair in the Intestine

Rachel R. Caspi, NEI, National Institutes of Health, USA
Short Talk: The Good and The Bad: Two Faces of an Ocular Surface Commensal

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
7:30—10:00 PM
Poster Session 2

Mezzanine 2-Cascade Room

WEDNESDAY, MARCH 7

7:00—8:00 AM
Breakfast

Mezzanine 2
8:00—11:15 AM
Feeding the Gut Microbiota for Health
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Liping Zhao, Shanghai Jiao Tong University, China and Rutgers University, USA

Jens Walter, University of Alberta, Canada
Modulation of the Human Gut Microbiota with Non-Digestible Carbohydrates – An Ecological Perspective

Nathalie Delzenne, Université Catholique de Louvain, Belgium
Feeding the Gut Microbiota with Prebiotics: Which Consequence for Host Health?

Coffee Break

André Marette, Laval University Hospital Research Center, Canada
Exploring the Interaction between Dietary Polyphenols and the Gut Microbiota to Alleviate Obesity-Linked Diseases

Maria Carmen Collado, Institute of Agrochemistry and Food Technology-Spanish National Research Council, Spain
Maternal Microbiome and its Role in Infant Health

Long H. Nguyen, Massachusetts General Hospital, USA
Short Talk: The Influence of Dietary Patterns and Intake of Sulfur on Sulfate-Reducing Bacteria Abundance and Function

Jared D. Hoffman, University of Kentucky, USA
Short Talk: Prebiotics for the Gut Microbiota as an Intervention for Alzheimer's Disease Prevention in APOE4 Carriers

8:00—11:15 AM
The Microbiota and Resistance to Infectious Diseases
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Sara R. Cherry, University of Pennsylvania School of Medicine, USA
Defining the Inter-Kingdom Interactions that Impact Enteric Viral Infections

Howard C. Hang, Rockefeller University, USA
Chemical Dissection of Gut Bacteria Protection Mechanisms

Coffee Break

Kerwyn Casey Huang, Stanford University, USA
Resilience of the Gut Microbiota to Perturbations

Ken H. Cadwell, New York University School of Medicine, USA
Transkingdom Interactions and Colonization Resistance

Jeffrey R. Singer, University of Alabama at Birmingham, USA
Short Talk: Intestinal Oxygen Regulates Primary Succession and Opportunistic Overgrowth in a Murine Model of Late-Onset Sepsis

Shai Bel, Bar-Ilan University, Israel
Short Talk: Paneth Cells Secrete Lysozyme via Secretory Autophagy during Bacterial Infection of the Intestine

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Mezzanine 2
1:00—10:00 PM
Poster Viewing

Mezzanine 2
4:30—5:00 PM
Coffee Available

Van Horne Foyer
5:00—7:00 PM
Xenobiotics-Microbiota Interactions in Metabolic Diseases
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Nathalie Delzenne, Université Catholique de Louvain, Belgium

Mark R. Charbonneau, Synlogic, USA
A Genetically Engineered E. coli Nissle to Prevent Hyperammonemia in Urea Cycle Disorders (UCDs)

Leah Guthrie, Albert Einstein College of Medicine, USA
Short Talk: Human Microbiome Signatures of Differential Colorectal Cancer Drug Metabolism

Silke S. Heinzmann, Helmholtz Centre Munich, Germany
Short Talk: Endogenous and Host-Microbial Co-Metabolites in Human Biofluids to Investigate Gut Microbiome Functionality

James R. Brown, GlaxoSmithKline, USA
Short Talk: A Chemogenomics Approach for the Discovery of Human Host Receptor Interactions with Endogenous Microbial Metabolites

Leyuan Li, University of Ottawa, Canada
Short Talk: Rapid Assay of Individuals' Microbiome (RapidAIM) for Understanding Drug-Microbiome Interaction and High-Throughput Drug Screening

5:00—7:00 PM
Disease Tolerance, Pathology and the Microbiome
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
Yasmine Belkaid, NIAID, National Institutes of Health, USA
Control of Tissue Immunity and Repair by the Microbiota

Janelle S. Ayres, The Salk Institute for Biological Studies, USA
Micronutrient Metabolism Mediates Healthy Host-Pathogen Interactions

* Denise M. Monack, Stanford University, USA
Microbiota Regulation of Salmonella Persistence and Disease Transmission

Zhenrun Jerry Zhang, Rockefeller University, USA
Short Talk: Control of Salmonella Virulence by Microbiota-Derived Short-Chain Fatty Acids

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
7:30—10:00 PM
Poster Session 3

Mezzanine 2-Cascade Room

THURSDAY, MARCH 8

7:00—8:00 AM
Breakfast

Mezzanine 2
8:00—11:15 AM
Dealing with Microbiome Complexity
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Joël Doré, INRA / MetaGenoPolis, France

Ruth E. Ley, Max Planck Institute for Developmental Biology, Germany
Sphingolipid Production by Gut Microbes Impacts Host Metabolism

Natalia Shulzhenko, Oregon State University, USA
Transkingdom Networks Uncovering Host-Microbiota Interactions

Coffee Break

Peter J. Turnbaugh, University of California, San Francisco, USA
Editing the Microbiome for Precision Medicine

Colin Hill, University College Cork, Ireland
Phage - Drivers of Microbiome Structure

Abigail J. Johnson, University of Minnesota, USA
Short Talk: Daily Microbiome-Diet Correspondence in Healthy Individuals

Penny Oh, Nanyang Technlogical University, Singapore
Short Talk: Friends with Benefits: Gram-Positive Bacteria Keeping Hepatic Clock in Sync

8:00—11:15 AM
Cancer, Metabolism and the Microbiome
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
Laure Bindels, Université Catholique de Louvain, Belgium
The Gut Microbiota in Cancer Cachexia

* Ravid Straussman, Weizmann Institute of Science, Israel
The Tumor Microbiome and its Effect on Chemoresistance

Coffee Break

Dimitra Lamprinaki, Quadram Institute Bioscience, UK
Short Talk: Fusobacterium Nucleatum Is Involved in Tumor Progression through Interaction with Lectins Expressed by Myeloid Cells

Clarissa Campbell, Memorial Sloan Ketttering Cancer Center, USA
Short Talk: Extrathymically-Generated Regulatory T Cells Shape the Metabolic Function of the Intestinal Microbiota

Marc A. Sze, University of Michigan, USA
Short Talk: The Relationship between the Microbiota and Short-Chain Fatty Acid Levels in Individuals with and without Colorectal Lesion

Andriy Morgun, Oregon State University, USA
Short Talk: Transkingdom Network Reveals Bacterial Players Associated with Cervical Cancer Gene Expression Program

Stephanie A. Cevallos, University of California, Davis, USA
Short Talk: Investigating a Mechanistic Link Between ER Stress and Colorectal Cancer

Yan Yan, Harvard University, USA
Short Talk: Metagenomics of the Mucosal and Stool Microbiome in Lynch Syndrome

11:15 AM—5:00 PM
On Own for Lunch

4:30—5:00 PM
Coffee Available

Van Horne Foyer
5:00—6:45 PM
Panel: Faculty and Industry Working Together for Innovation

Van Horne C
* Nathalie Delzenne, Université Catholique de Louvain, Belgium

Matthew Henn, Seres Therapeutics, USA
Bugs as Drugs

Henry J. Haiser, Novartis Institutes for BioMedical Research, USA
Microbiome Research at NIBR—Microbial Metabolites that Modulate Host Functions

Joël Doré, INRA / MetaGenoPolis, France
Preserving and Restoring Man-Microbes Symbiosis

5:00—6:45 PM
The Microbiota in Cancer Treatment Toxicities and Immune Response
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Matthew R. Redinbo, University of North Carolina at Chapel Hill, USA
Targeted Inhibitors for the Gut Microbiome

Kristen M. Larsen, University of South Carolina, USA
Short Talk: The Role of the Microbiome in Colorectal Cancer Development and Response to 5-Fluoruracil (5-FU) in ApcMin/+ Mice

Thomas Gajewski, University of Chicago, USA
Anti-Tumor Immune Responses and the Commensal Microbiota

Patricia Diaz, University of Connecticut Health Center, USA
Short Talk: Disruption of Oral Homeostasis by Chemotherapeutic Cancer Treatment

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Van Horne C
6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Mezzanine 2

FRIDAY, MARCH 9

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Merck & Co., Inc. Takeda Pharmaceutical Company Limited

We gratefully acknowledge additional support from these exhibitors at this conference:

Anaerobe Systems
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 DK116615-01

Funding for this conference was made possible (in part) by 1 R13 DK116615-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

eLife Mercodia, Inc.
Research Diets, Inc. Zymo Research Corporation
Seres Therapeutics
 

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676