Lee Shau Kee Lecture Centre, Centennial Campus, The University of Hong Kong Floorplan

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This meeting took place in 2017



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Regenerative Biology and Applications: Cell Differentiation, Tissue Organization and Biomedical Engineering (T3)


Organizer(s) Paul K.H. Tam, Urban Lendahl and Freda D. Miller
October 15—19, 2017
Lee Shau Kee Lecture Centre, Centennial Campus, The University of Hong Kong • Pok Fu Lam, Hong Kong
Discounted Abstract Deadline: Jun 15, 2017
Abstract Deadline: Jul 24, 2017
Scholarship Deadline: Jun 15, 2017
Discounted Registration Deadline: Aug 15, 2017

Organized in collaboration with the Croucher Foundation and The University of Hong Kong; Held in honor of the 130th Anniversary of The University of Hong Kong Li Ka Shing Faculty of Medicine

Summary of Meeting:
This four-day Keystone Symposia conference focuses on three important aspects of the rapidly developing area of regenerative biology: 1) The biology of the stem cell, with a focus on single-cell transcriptomics, deduction of cell lineage, pluripotency control and epigenetic regulation; 2) The tissue level, including the stem cell niche, organ generation, organoids and dysregulation of these processes in disease; and 3) Biomedical engineering and various types of disease modeling. Focusing on these three particular areas will prevent the meeting from being spread too thin over the entire realm of regenerative medicine, but will at the same time provide insights into research fields where progress currently occurs at blistering speed. The overall goal of the conference is to provide both late-breaking data for the experts in the fields as well as overviews in areas that will interest a broad scientific community. Across the three main themes, the aim is to blend discussions on a range of organs, such as liver, heart, bone and skin, with talks that cover novel tissue engineering and organoid biology principles. Speakers from both academia and industry who are at the forefront in disease modeling, organs-on-chips and drug discovery will present. With this three-pronged thematic approach, the conference will be focused, yet broad enough to foster an exciting cross-disciplinary discussion among speakers and attendees, which will be highly stimulating for the regenerative medicine community in Hong Kong and the rest of the world. This is vital for training the next-generation stem cell biologists and clinicians and to accelerate the pace at which basic science discoveries can be converted into clinical applications.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, October 15 with registration from 18:00 to 20:00. Conference events conclude on Thursday, October 19 with a closing plenary session from 15:30 to 19:30, followed by dinner. We recommend return travel on Friday, October 20 in order to fully experience the meeting.

SUNDAY, OCTOBER 15

6:00—8:00 PM
Arrival and Registration
Time and location changed from HKU to Hotel Jen due to weather. Registration will also be available tomorrow in the Grand Hall Foyer Monday from 7:30am.

Hotel Jen Foyer

MONDAY, OCTOBER 16

7:30 AM
Arrival and Registration

Grand Hall Foyer, Lee Shau Kee Lecture Centre, HKU
9:00—9:15 AM
Welcoming Remarks
Peter Mathieson, President and Vice-Chancellor, University of Hong Kong, Hong Kong
Sophia Chan Siu-chee, Secretary for Food and Health, Hong Kong
Nicolas W. Yang, Secretary for Innovation and Technology, Hong Kong

9:15—10:15 AM
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grand Hall
* Freda D. Miller, Hospital for Sick Children, Canada

Robin H. Lovell-Badge, Francis Crick Institute, UK
Regulation, Sex, and Stem Cells

10:15 AM—12:45 PM
Pluripotency and Differentiation of Stem Cells
Meeting has ended...abstracts no longer viewable online.

Grand Hall
* Patrick P.L. Tam, Children's Medical Research Institute, Australia

* Elly S.W. Ngan, University of Hong Kong, Hong Kong

Andrew Hutchins, Southern University of Science and Technology, China
The Use of Gene Modification Technologies and the Potential Use in Humans

Coffee Break

Pentao Liu, Wellcome Trust Sanger Institute, UK
Establishment of Cultures of Mammalian Expanded Potential Stem Cells

Huck-Hui Ng, Genome Institute of Singapore, Singapore
Systems Biology of Stem Cells

Michelle M.W. Chan, University of California, San Francisco, USA
Short Talk: Assembling Cell Lineages Using an Evolvable Barcoding Strategy to Probe Mammalian Development

David R. Hyde, University of Notre Dame, USA
Short Talk: Transcriptomic and Epigenomic Changes during Müller Glia Reprogramming in the Regenerating Zebrafish Retina

12:45—2:00 PM
Networking Lunch

Lecture Hall LG 2
2:00—4:15 PM
Molecular Regulation of Stem Cells
Meeting has ended...abstracts no longer viewable online.

Grand Hall
* David R. Kaplan, Hospital for Sick Children, Canada

* Wood Yee Chan, Chinese University of Hong Kong, Hong Kong

Urban Lendahl, Karolinska Institutet, Sweden
Notch Signaling and Vascular Differentiation

Ana Martin-Villalba, DKFZ German Cancer Research Center, Germany
Chromatin as a Hub Integrating Environmental Signals and Fate Decisions in Adult Neural Stem Cells

Timm Schroeder, ETH Zürich, Switzerland
Long-Term Single Cell Quantification: New Tools for Old Questions

András Simon, Karolinska Institutet, Sweden
Short Talk: Reading and Editing a Salamander Genome Reveals Novel Features of Tetrapod Regeneration

Jan Kaslin, Australian Regenerative Medicine Institute, Australia
Short Talk: Make Do and Make New: How Zebrafish Rapidly Regenerates CNS Injury

4:15—4:45 PM
Poster Teasers for Poster Session 1
3-minute poster teaser talks

Lecture Hall LG 2
* David R. Kaplan, Hospital for Sick Children, Canada

* Wood Yee Chan, Chinese University of Hong Kong, Hong Kong

Shermaine Eng, Agency for Science Technology and Research A-STAR, Singapore
Investigating the Human Teashirt Genes TSHZ2 and TSHZ3 in Pancreatic and Endocrine Lineage Commitment Using Genome-Modified Human Embryonic Stem Cells (hESC)

Suji Kim, Yeungnam University College of Medicine, South Korea
The Role of p90RSK in Pulmonary Fibrosis

Anil Chandrashekran, King's College London, UK
Characterizing a Liver-Organoid System for the Treatment of Acute Live Failure

Paschalis Efstathopoulos, Karolinska Institutet, Sweden
A Novel Method to Increase Reproducibility of Ventral Midbrain Organoids Derived from Human Pluripotent Stem Cells

Wenqiang Fan, University of Mainz, Germany
Role of Hippo Signaling in Adult Neural Stem Cell Homeostasis

Jie Shi Chua, University of Utah, USA
Manipulating GAG Biosynthesis to Guide the Fate and Growth of Neuronal Progenitors

Dmitry Penkov, Russian Cardiological Institute, Russia
Prep1 Is a New Player in Adipogenic Differentiation of Mesenchymal Progenitors

6:00—10:00 PM
Optional Dinner Gathering

Jumbo Kingdom

TUESDAY, OCTOBER 17

8:30—9:00 AM
Poster Setup

Lecture Hall LG 2
9:00 AM—7:30 PM
Poster Viewing

Lecture Hall LG 2
9:00 AM—12:00 PM
Tissue Organization (The Stem Cell Niche)
Meeting has ended...abstracts no longer viewable online.

Grand Hall
* Ronald A. Li, University of Hong Kong, Hong Kong

* Martin C.H. Cheung, University of Hong Kong, Hong Kong

Yechiel Elkabetz, Max Planck Institute for Molecular Genetics, Germany
Neural Stem Cells/Epigenetics

Michael Rudnicki, Ottawa Hospital Research Institute, Canada
Molecular Regulation of Muscle Stem Cell Function

Coffee Break

Guo-li Ming, University of Pennsylvania, USA
Engineering Brain-Region-Specific Organoids for Neural Development and Brain Disease Modeling

Christopher S. Chen, Boston University, USA
Engineering 3D Culture Models of Physiology and Disease

12:00—1:30 PM
Networking Lunch

Lecture Hall LG 2
12:30—3:30 PM
Poster Session 1
Organizer judges panel will browse the posters for Poster Prize consideration.

Lecture Hall LG 2
3:00—3:30 PM
Coffee Available

Lecture Hall LG 2
3:30—5:30 PM
Tissue Organization (Generating Tissue-Specific Cells)
Meeting has ended...abstracts no longer viewable online.

Grand Hall
* Edwin H. Chan, Chinese University of Hong Kong, Hong Kong

* Stephanie K.Y. Ma, University of Hong Kong, Hong Kong

Kristin J. Hope, McMaster Stem Cell and Cancer Research Institute, Canada
Molecular Mechanisms that Regulate Hematopoietic Stem Cell Expansion

David Piper, Thermo Fisher Scientific, USA
Improvements in the Genome Engineering of iPSCs to Build Disease Models for Screening

Mahendra S. Rao, New York Stem Cell Foundation, USA
Generation of Clinical-Grade Pluripotent Stem Cells

5:30—7:30 PM
Reception
No registration fees are used to fund alcohol served at this function.

Lecture Hall LG 2

WEDNESDAY, OCTOBER 18

9:00 AM—12:00 PM
Tissue Organization (Physiological and Pathophysiological Development of Organ Systems) I
Meeting has ended...abstracts no longer viewable online.

Grand Hall
* Hsiao-Yuan Lee, Academia Sinica, Taiwan

* Kathryn S.E. Cheah, University of Hong Kong, Hong Kong

Berthold Göttgens, Cambridge Institute for Medical Research, UK
Cellular States and Regulatory Networks of Normal and Leukaemic Blood Cell Development

Freda D. Miller, Hospital for Sick Children, Canada
Cellular Mechanisms Underlying Adult Mammalian Digit Tip Regeneration

Coffee Break

Yukiko Gotoh, University of Tokyo, Japan
Regulation of Embryonic and Adult Neural Stem Cell Fate

Paul K.H. Tam, University of Hong Kong, Hong Kong
Neural Crest Stem Cells and Hirschsprung Disease

10:20 AM—12:00 PM
Poster Setup

Lecture Hall LG 2
12:00—4:30 PM
Poster Viewing

Lecture Hall LG 2
12:00—2:00 PM
Networking Lunch

Lecture Hall LG 2
2:00—4:00 PM
Tissue Organization (Physiological and Pathophysiological Development of Organ Systems) II
Meeting has ended...abstracts no longer viewable online.

Grand Hall
* Ola Hermanson, Karolinska Institutet, Sweden

* Danny Chan, University of Hong Kong, Hong Kong

Hongkui Deng, Peking University, China
Small Molecule-Induced Cell Fate Reprogramming

Benedikt Berninger, University Medical Center Johannes Gutenberg University Mainz, Germany
Unfolding of a Developmental Program during Lineage Conversion of Human Brain Pericytes into Neurons by Synergistic Ascl1 and Sox2

Jessica Lehoczky, Brigham and Women's Hospital, Harvard Medical School, USA
Short Talk: A Role for Lgr6 in Mouse Digit Tip Regeneration

Carmine Gentile, University of Sydney, Australia
Short Talk: Cardiac Spheroid Co-Cultures as Novel in vitro Models to Study the Human Heart Microenvironment

4:00—4:30 PM
Poster Teasers for Poster Session 2
3-minute poster teaser talks

Lecture Hall LG 2
* Hsiao-Yuan Lee, Academia Sinica, Taiwan

* Kathryn S.E. Cheah, University of Hong Kong, Hong Kong

Allan Patrick Stephane Renom, Hong Kong University of Science and Technology, Hong Kong
Investigating the Role of Ca2+ Signaling during Zebrafish Embryonic Heart Development

Marcelo J. Salierno, University Medical Center Johannes Gutenberg University Mainz, Germany
Controlling Somal Translocation of Embryonic Cortical Neurons

Natalia Soshnikova, Institute of Molecular Biology, Germany
Defining Lgr5+ Embryonic Intestinal Progenitor Niche Using Single Cell Transcriptomics

Nam Myeong-Ok, CHA University, South Korea
Effects of a Small Molecule R-Spondin-1 Substitute RS-246204 on a Mouse Intestinal Organoid Culture

Chia-Ning Shen, Academia Sinica, Taiwan
ABCG2 Deficiency in Hepatocytes Disrupts Mitochondrial Fusion/Fission Balance and Impairs Reprogramming-Mediated Liver Repairing

Sharon W.S. Tan, National University of Singapore, Singapore
Redox Homeostasis Is Essential for the Maintenance of the Drosophila Testis Germline Stem Cells

Hannah M. Thomas, University of South Australia, Australia
Flightless I Regulation of Pericyte Function in Diabetic Wounds

4:30 PM
On Own for Dinner


THURSDAY, OCTOBER 19

9:00 AM—3:30 PM
Poster Viewing

Lecture Hall LG 2
9:00—10:00 AM
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grand Hall
* Urban Lendahl, Karolinska Institutet, Sweden

Hans C. Clevers, Hubrecht Institute, Netherlands
Lgr5 Stem Cell-Based Organoids in Human Disease

10:00 AM—12:30 PM
Stem Cells for Biomedical Engineering
Meeting has ended...abstracts no longer viewable online.

Grand Hall
* Xian-Jie Yang, University of California, Los Angeles, USA

* Mai Har Sham, University of Hong Kong, Hong Kong

Lorenz Studer, Memorial Sloan Kettering Cancer Center, USA
Parkinson's Disease

Coffee Break

Himanshu Kaul, University of Toronto, Canada
Engineering Early Human Development

Molly S. Shoichet, University of Toronto, Canada
Using Biomimetic Strategies to Design Hydrogels for 3D Cell Culture

Sunny S.K. Chan, University of Minnesota, USA
Short Talk: Teratomas Harbor Skeletal Muscle Stem Cells with Extremely High Functional Regenerative Potency

Dhvanit I. Shah, Brigham and Women's Hospital, Harvard Medical School, USA
Short Talk: Bioreactor Simulating Mechanosensation Stimulates Hematopoietic Stem Cell Formation

12:30—1:30 PM
Networking Lunch

Lecture Hall LG 2
12:30—3:30 PM
Poster Session 2
Organizer judges panel will browse the posters for Poster Prize consideration.

Lecture Hall LG 2
3:00—3:30 PM
Coffee Available

Lecture Hall LG 2
3:30—5:30 PM
Biomedical Engineering for Stem Cells
Meeting has ended...abstracts no longer viewable online.

Grand Hall
* Hans C. Clevers, Hubrecht Institute, Netherlands

* Dong Sun, City University of Hong Kong, Hong Kong

Benjamin F. L. Lai, University of Toronto, Canada
Short Talk: Perfusable Vascularized Tissues for Drug Testing and Modeling Inter-Organ Biological Events on a Microfluidic Plate

Lee L. Rubin, Harvard University, USA
Improving Neural Function

Paolo De Coppi, University College London, UK
Engineering Gut Tissue: A Step-by-Step Approach

5:30—5:45 PM
Meeting Wrap-Up: Outcomes and Future Directions
Meeting has ended...abstracts no longer viewable online.

Grand Hall
* Paul K.H. Tam, University of Hong Kong, Hong Kong

6:30—7:30 PM
Social Hour
No registration fees are used to fund alcohol served at this function.

Café Malacca, Hotel Jen
7:30—9:00 PM
Buffet Dinner
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Café Malacca

FRIDAY, OCTOBER 20

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Croucher Foundation The University of Hong Kong

We gratefully acknowledge additional support for this conference from:

Oncotarget

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Thermo Fisher Scientific Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676