Keystone Resort Floorplan

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This meeting took place in 2018


Here are the related meetings in 2019:
Genome Engineering: From Mechanisms to Therapies (B4)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Precision Genome Editing with Programmable Nucleases (B1)


Organizer(s) Jin-Soo Kim, Feng Zhang and Daniel F. Voytas
January 28—February 1, 2018
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Oct 3, 2017
Abstract Deadline: Nov 1, 2017
Scholarship Deadline: Oct 3, 2017
Discounted Registration Deadline: Dec 5, 2017

Sponsored by Editas Medicine, Regeneron Pharmaceuticals, Inc., Sangamo Therapeutics, Inc. and Vertex Pharmaceuticals Incorporated

Summary of Meeting:
Genome editing refers to the use of programmable DNA-targeting platforms to manipulate genetic and epigenetic information in living cells and organisms. Genome editing has been recently democratized by the development of RNA-guided endonucleases repurposed from CRISPR-Cas microbial defense systems against viruses or plasmids. Whereas novel tools such as Cpf1 and RNA-guided deaminases are being developed to expand the scope of genome editing, old tools such as ZFNs and TALENs are likely to undergo innovations as well. These tools enable genome-wide genetic screens in cell lines and genetic studies in both model and non-model organisms. Furthermore, genome editing holds great promise for broad applications in medicine and biotechnology, raising public interest and concerns. Yet genome editing is still limited by many factors such as inefficient delivery in vivo, off-target effects, and unwanted, alternative DNA repair. This conference offers opportunities to learn about new developments, advancements and applications in the field.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, January 28 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 1 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 2 in order to fully experience the meeting.

SUNDAY, JANUARY 28

4:00—8:00 PM
Arrival and Registration

Longs Peak Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Longs Peak Foyer

MONDAY, JANUARY 29

7:00—8:00 AM
Breakfast

Shavano/Torreys
8:00—9:00 AM
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Jin-Soo Kim, Institute for Basic Science, South Korea

Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
CRISPR Systems: Nature’s Toolkit for Genome Editing

9:00—11:30 AM
DNA Repair and Genome Editing
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Jacob E. Corn, ETH in Zurich, Switzerland

Maria Jasin, Memorial Sloan Kettering Cancer Center, USA
Protecting the Genome by Homologous Recombination

Coffee Break

Eric A. Hendrickson, University of Minnesota Medical School, USA
The Mechanisms of Precise Genome Editing Using Oligonucleotide Donors

Eugene V. Koonin, National Institutes of Health, USA
CRISPRICITY: A Metric for Measuring CRISPR Association and a Comprehensive Census of Cas Proteins

Chance Meers, Georgia Institute of Technology, USA
Short Talk: Transcript-RNA from an Actively Transcribed Gene Accurately Repairs a DNA Double-Strand Break via a Homology- Driven Mechanism

Anastasia Lomova, University of California, Los Angeles, USA
Short Talk: Improving Gene Editing by Temporal Control of DNA Repair

11:30—11:45 AM
NIH Somatic Cell Genome Editing Program: Overview
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Elizabeth Wilder, National Institutes of Health, USA

11:30 AM—5:00 PM
On Own for Lunch

11:30 AM—1:00 PM
Poster Setup

Shavano/Torreys
1:00—10:00 PM
Poster Viewing

Shavano/Torreys
2:30—4:30 PM
Workshop: Easi-CRISPR: CRISPRing Made Easier
The workshop is based on Easi (Efficient additions with ssDNA inserts)-CRISPR, a recently developed method at the laboratories of Drs. Masato Ohtsuka (Tokai Univeristy, Japan) and C.B. Gurumurthy, which is now becoming a widely used approach for achieving higher knock-in efficiencies via homology directed repair. The workshop will cover: 1) General introduction to animal model generation; 2) Overview of animal model generation methods during pre- and post-CRISPR era; 3) Introduction to Easi-CRISPR and its applications; 4) Examples (case studies) of Easi-CRISPR animal model designs; 5) Hands-on workshop on Easi-CRISPR animal model designs; and 6) Demonstration of animal model designing using participant’s projects (time permitting).
Relevant publications on Easi-CRISPR: https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1220-4 https://www.nature.com/articles/nprot.2017.153
Pre-prints of Easi-CRISPR: https://www.biorxiv.org/content/early/2017/05/23/141424 https://www.biorxiv.org/content/early/2016/08/17/069963

* Gurumurthy B. Channabasavaiah, University of Nebraska Omaha, USA

4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—7:00 PM
Genome Editing Methods and Novel Tools I
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
Jonathan Samuel Gootenberg, Harvard University, USA
Expanding the Genome Editing Toolbox by Harnessing Microbial Diversity

David R. Liu, Broad Institute, HHMI, and Harvard University, USA
Base Editing: Chemistry on a Target Nucleotide in the Genome of Living Cells

J. Keith Joung, Massachusetts General Hospital, USA
Efficient Gene Editing and Gene Regulation Using CRISPR-Cpf1 Nuclease Technology

Evan August Boyle, Stanford University, USA
Short Talk: High-Throughput Biochemical Profiling of dCas9 Association and Dissociation Kinetics Uncovers New Rules for Off-Target Binding

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
7:30—10:00 PM
Poster Session 1

Shavano/Torreys

TUESDAY, JANUARY 30

7:00—8:00 AM
Breakfast

Shavano/Torreys
8:00—11:15 AM
Genome Editing Methods and Novel Tools II
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Charles Gersbach, Duke University, USA

Scot A. Wolfe, University of Massachusetts Medical School, USA
Orthogonal Cas9-Cas9 Fusions Provide a Versatile Platform for Precise Genome Editing

Jin-Soo Kim, Institute for Basic Science, South Korea
Genome-Wide Target Specificities of CRISPR Nucleases and Deaminases

Coffee Break

Jacob E. Corn, ETH in Zurich, Switzerland
Discovery of Stimulation-Responsive Immune Enhancers with CRISPR Activation

Keiji Nishida, Kobe University, Japan
Genome Editing with Non-Nuclease Editors from Bacteria to Plants

Alister Funnell, Altius Institute for Biomedical Sciences, USA
Short Talk: High-Scale in situ Functional Mapping and Quantitative Engineering of Regulatory DNA

Omar Abudayyeh, Massachusetts Institute of Technology, USA
Short Talk: Harnessing RNA Targeting CRISPR Systems for Transcriptome Engineering and Human Health

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Shavano/Torreys
1:00—10:00 PM
Poster Viewing

Shavano/Torreys
4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—7:00 PM
Epigenome Editing and Gene Regulation
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Scot A. Wolfe, University of Massachusetts Medical School, USA

Charles Gersbach, Duke University, USA
Epigenome Editing for Gene Therapy, Cell Programming and Functional Epigenomics

Jennifer Mitchell, University of Toronto, Canada
Uncovering Distal Regulatory Element Function Using CRISPR Genome Engineering

Joseph M. Miano, University of Rochester, USA
Short Talk: CRISPR Interrogation of Regulatory Sequence Function in Mice

Chris Richardson, University of California, Berkeley, USA
Short Talk: The Fanconi Anemia Pathway Plays a Key Role in Templated Repair at CRISPR-Cas9 Cut Sites

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
7:30—10:00 PM
Poster Session 2

Shavano/Torreys

WEDNESDAY, JANUARY 31

7:00—8:00 AM
Breakfast

Shavano/Torreys
8:00—11:15 AM
Genetic Screening via CRISPR
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Edward J. Rebar, Sangamo Therapeutics, Inc., USA

Randall J. Platt, ETH Zurich, Switzerland
CRISPR Screening Directly in vivo

Reuven Agami, Netherlands Cancer Institute, Netherlands
Functional Genetic Screens of Regulatory DNA Elements

Coffee Break

Neville Sanjana, New York Genome Center & NYU, USA
New Frontiers for Pooled Screens: Finding Regulatory Elements in the Noncoding Genome and Capturing Multi-Cell Interactions

Danwei Huangfu, Memorial Sloan Kettering Cancer Institute, USA
Human Development and Disease through the Lens of Pluripotent Stem Cells

Bushra Raj, Harvard University, USA
Short Talk: Single-Cell Transcriptional Profiling Coupled with Lineage Tracing via Mutable Barcodes in the Vertebrate Brain

Jason D. Arroyo, Pfizer, USA
Short Talk: Using Human Genetics and Functional Genomics for a Locus-to-Gene Approach to Drug Target Validation

11:15 AM—12:15 PM
Panel: Somatic Cell Genome Editing Program: Discussion with NIH

Grays/Longs Peak
* Timothy LaVaute, NINDS, National Institutes of Health, USA

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Shavano/Torreys
1:00—10:00 PM
Poster Viewing

Shavano/Torreys
4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—7:00 PM
Therapeutic Genome Editing
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Randall J. Platt, ETH Zurich, Switzerland

Edward J. Rebar, Sangamo Therapeutics, Inc., USA
Therapeutic Genome Editing and Gene Regulation Using Designed Zinc Finger Proteins

Amy J. Wagers, Harvard University, USA
In vivo Gene Editing in Muscle and Muscle Stem Cells

Charles F. Albright, Editas Medicine, USA
Development of a Subretinally-Delivered, CEP290-Specific CRISPR Medicine for the Treatment of Leber Congenital Amaurosis 10 (LCA10)

Pavitra Roychoudhury, University of Washington, USA
Short Talk: Rational Design and Evaluation of CRISPR/Cas9 Strategies for HIV Cure

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
7:30—10:00 PM
Poster Session 3

Shavano/Torreys

THURSDAY, FEBRUARY 1

7:00—8:00 AM
Breakfast

Shavano/Torreys
8:00—11:15 AM
Plant and Animal Biotechnology
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Daniel F. Voytas, University of Minnesota, USA

Dan Carlson, Recombinetics, Inc., USA
Large Animal Genome Editing for Agriculture and Biomedicine

Caixia Gao, Chinese Academy of Sciences, China
Genome Editing with Programmable Nucleases in Crop Plants

Coffee Break

Daniel F. Voytas, University of Minnesota, USA
Editing the Plant Genome

Weizhi Ji, Kunming University of Science and Technology, China
Primate Gene Editing and Human Complex Disease Study

Mariette E.S. Andersson, Swedish University of Agricultural Sciences, Sweden
Short Talk: CRISPR-Cas9 Takes Several Bites in the Potato Genome- Efficient Targeted Multiallelic Mutagenesis in Tetraploid Solanum tuberosum

Asim Ahmad Beg, University of Michigan, USA
Short Talk: A Rapid and Facile C. elegans Genome Engineering Pipeline Using CRISPR/Cas9 Ribonucleoproteins

11:15 AM—5:00 PM
On Own for Lunch

4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—6:45 PM
Human Germline Editing and ELSI
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Jin-Soo Kim, Institute for Basic Science, South Korea

Kathy K. Niakan, Francis Crick Institute, UK
Genome Editing Reveals a Role for OCT4 in Human Embryogenesis

Shoukrat Mitalipov, Oregon Health & Science University, USA
Human Germline Gene Correction

Tetsuya Ishii, Hokkaido University, Japan
The Potential Guidelines for Germline Genome Editing in Clinics

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Shavano/Torreys

FRIDAY, FEBRUARY 2

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Editas Medicine Regeneron Pharmaceuticals, Inc.
Sangamo Therapeutics, Inc. Vertex Pharmaceuticals Incorporated

We gratefully acknowledge additional support from these exhibitors at this conference:

Agilent Technologies, Inc. Dharmacon, a Horizon Discovery Group Company
Synthego
 
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge additional support for this conference from:

American Society of Gene & Cell Therapy (ASGCT) Integrated DNA Technologies

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Editas Medicine


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676