Whistler Conference Centre Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

Gene Control in Development and Disease (X6)

joint with the meeting on Chromatin Architecture and Chromosome Organization (X5)

Scientific Organizers: Richard A. Young, Joanna Wysocka and Phillip A. Sharp


March 23—27, 2018

Whistler Conference Centre, Whistler, British Columbia, Canada


Sponsored by Novartis Institutes for BioMedical Research


Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.
BEWARE of booking lodging through companies unaffiliated with Keystone Symposia. Click here for more details.

Keystone Symposia is committed to maintaining a positive and respectful environment at its meetings. To this end, please review and comply with our policies.

Registered attendees of one meeting in a joint pair may participate in sessions of the other, pending space availability.

DEADLINES:
*All deadlines end at 11:59 PM US Mountain Standard Time
Scholarship Deadline: Nov 28, 2017 [details]
Discounted Abstract Deadline: Nov 28, 2017 [details]
Abstract Deadline: Dec 20, 2017 [details]
Discounted Registration Deadline: Jan 17, 2018 [details]

Click here to view Cancellation Policy

Register Yourself Deadlines and Fees

Rates and Deadlines listed below are for the 2018-X6 "Gene Control in Development and Disease" conference only.

*All deadlines end at 11:59 PM US Mountain Standard Time

Deadline Date Cost
Discounted Abstract Deadline
More details
Before and On November 28, 2017 100.00 USD*
- 50.00 USD discount
Abstract Deadline
More details
After November 28, 2017 until February 9, 2018 100.00 USD*
* 50.00 USD of Abstract fee deducted from your registration fee when you register for this meeting
Scholarship
More details
November 28, 2017 n/a
Discounted NON-STUDENT Registration
More details
Before and On January 17, 2018 920.00 USD
(includes 200.00 discount)
Regular NON-STUDENT Registration
More details
After January 17, 2018 1120.00 USD
Discounted STUDENT Registration
More details
Before and On January 17, 2018 695.00 USD
(includes 200.00 discount)
Regular STUDENT Registration
More details
After January 17, 2018 895.00 USD

* Changes in payment type that result in a refund are subject to a processing fee.
* Currency exchange gains/losses are the responsibility of the registrant and the Keystone Symposia will accept no liability for money loss through bank charges, transfers or currency fluctuations.




Discounted Abstract Deadline: November 28, 2017

*All deadlines end at 11:59 PM US Mountain Standard Time

Abstract Submission Fee: 100.00 USD*
Submission by this date receives 50.00 USD discount.
*50.00 USD will be applied to Registration Fee when you register

Abstract Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadlines. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract early allows us to:
  • submit your abstract to organizers to be considered for a short talk
  • accept your abstract online
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
(The Abstract Deadline: is December 20, 2017)

Global Health Travel Award Deadline:

*All deadlines end at 11:59 PM US Mountain Standard Time


Global Health Travel Award Details: You MUST complete your Global Health Travel Award appplication by the Global Health Travel Award Deadline and complete the other required steps (verify your contact information and submit a recommendation letter) to be considered for a travel award.


Click here to learn more about Global Health Travel Awards.

Scholarship Deadline: November 28, 2017

*All deadlines end at 11:59 PM US Mountain Standard Time


Scholarship Details: You MUST submit your abstract by the Scholarship Deadline and complete the other required steps (submit a scholarship application and submit a mentor letter) to be considered for a scholarship.

Click here to learn more about Scholarships.

Abstract Deadline: December 20, 2017

*All deadlines end at 11:59 PM US Mountain Standard Time


Abstract Submission Fee: 100.00 USD*
*50.00 USD will be applied to Registration Fee when you register

Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadline. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract by the Abstract Deadline allows us to:

  • submit your abstract to organizers to be considered for a short talk
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
Abstracts submitted after the Abstract Deadline will NOT be considered for a short talk.

(Discounted Abstract Deadline: is November 28, 2017)

Discounted Registration Deadline: January 17, 2018

*All deadlines end at 11:59 PM US Mountain Standard Time


Registration Fee: 920.00 USD* (includes 200.00 USD discount)
Student Registration Fee: 695.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

After the Discounted Registration Deadline:


Registration Fee: 1120.00 USD*
Student Registration Fee: 895.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

Registration spaces are limited and may fill prior to discounted registration deadline.

Please be advised that a few meeting participants have received calls and emails from a number of different housing services - "Exhibitors Housing Services", "Global Housing", etc. THESE COMPANIES ARE NOT AFFILIATED WITH KEYSTONE SYMPOSIA and are not authorized by Keystone Symposia to contact you. These companies may tell you that the meeting is filling and seek to take your lodging reservation and obtain your credit card number. We highly recommend that you not make a reservation with these companies or any other housing service! These companies' representations to participants have been misleading. Please report to Keystone Symposia any calls or correspondence you might have received and book only through the lodging link on our website, an established travel agency, or directly with the hotel.
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Friday, March 23 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Tuesday, March 27 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Wednesday, March 28 in order to fully experience the meeting.

FRIDAY, MARCH 23

4:00—8:00 PM
Arrival and Registration

Grand Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Grand Foyer

SATURDAY, MARCH 24

7:00—8:00 AM
Breakfast

Sea to Sky A
8:00—9:00 AM
Welcome and Keynote Address
Registered attendees can view abstracts starting on 02/23/2018

Sea to Sky B
* Richard A. Young, Whitehead Institute for Biomedical Research, USA

* Joanna Wysocka, Stanford University School of Medicine, USA

* Phillip A. Sharp, Massachusetts Institute of Technology, USA

Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
Unexpected Activities of RNA-Guided CRISPR Enzymes

8:00—9:00 AM
Welcome and Keynote Address
Registered attendees can view abstracts starting on 02/23/2018

Sea to Sky C
* Edith Heard, Institut Curie, France

* Peter Fraser, Florida State University, USA

Job Dekker, University of Massachusetts Medical School, USA
Folding, Unfolding and Refolding of Genomes

9:00—11:30 AM
Basics
Registered attendees can view abstracts starting on 02/23/2018

Sea to Sky B
* Jennifer A. Doudna, HHMI/University of California, Berkeley, USA

* Michael S. Levine, Princeton University, USA

Patrick Cramer, Max Planck Institute for Biophysical Chemistry, Germany
Integrated Structural Biology of Gene Transcription

Coffee Break

Karen Adelman, Harvard Medical School, USA
Pause Control in Development and Disease

Ronald M. Evans, HHMI/The Salk Institute, USA
Vitamin D and Dysregulated Transcription

Xiong Ji, Peking University, China
Short Talk: RNAPII Elimination Reveals Transcriptional-dependent Three Dimensional Chromatin Landscape

Diego Villar Lozano, University of Cambridge, UK
Short Talk: The Gene Expression Consequences of Mammalian Regulatory Evolution

9:00—11:30 AM
Chromosome Architecture
Registered attendees can view abstracts starting on 02/23/2018

Sea to Sky C
* Wendy A. Bickmore, University of Edinburgh, UK

* William Stafford Noble, University of Washington, USA

Carlo Vermeulen, Hubrecht Institute, Netherlands
Locus-Specific Enhancer Hubs and Architectural Loop Collisions Uncovered From Single Allele DNA Topologies

Coffee Break

Peter Fraser, Florida State University, USA
Chromosome Architecture Dynamics Using Single Cell HiC

Suzana Hadjur, University College London, UK
Role of Cohesin Complex Diversity in Genome Organization and Cell Fate Determination

Maciej Piotr Zaczek, Institute of Molecular Pathology, Austria
Short Talk: CTCF Constrains Cohesin Translocation along DNA

Elphège P. Nora, Gladstone Institute, USA
Short Talk: Dissecting the Molecular Connection between CTCF and Cohesin

11:30 AM—5:00 PM
On Own for Lunch

11:30 AM—1:00 PM
Poster Setup

Sea to Sky A
1:00—10:00 PM
Poster Viewing

Sea to Sky A
2:30—4:30 PM
Workshop 1: Transcription and Development

Sea to Sky B
* Karen Adelman, Harvard Medical School, USA

* Patrick Cramer, Max Planck Institute for Biophysical Chemistry, Germany

Richard G. Jenner, University College London, UK
RNA Antagonizes the Interaction of PRC2 and Other Epigenetic Modifiers with Chromatin

Natalia B. Ivanova, Yale University School of Medicine, USA
Chromatin-Associated Factors Dppa2 and Dppa4 Guide Epigenetic Remodeling during Cellular Reprogramming

Ido Sagi, Hebrew University of Jerusalem, Israel
Studying Haploidy and Parental Imprinting in Human Pluripotent Stem Cells

Aydan Bulut-Karslioglu, University of California, San Francisco, USA
Chd1-Mediated Repair of Physiological DNA Breaks Sustains Hypertranscription and Proliferation of ES Cells

Ruben Esse, Boston University, USA
DOT1L in Enhancer Regulation

Sudhir Thakurela, Harvard University, USA
Genetic Determinants and Epigenetic Effects of Pioneer Factor Occupancy during Development

Elodie Emilie Thierion, University of Cambridge, UK
Gene Regulation Dynamics and Evolution in Somites

2:30—4:30 PM
Workshop 1: 4DN

Sea to Sky C
* Job Dekker, University of Massachusetts Medical School, USA

* Thoru Pederson, University of Massachusetts Medical School, USA
CRISPR Barcoding Reveals Changes in Interphase Chromosome Conformation and Dynamics in Human Cells

Josef Redolfi, Friedrich Miescher Institute for Biomedical Research, Switzerland
Crosslinking- and Ligation-Free Detection of Chromosomal Interactions using DamID and Physical Modeling

Kerstin Bystricky, University of Toulouse, France
Chromatin Dynamics in Real-Time and at Nanoscale Resolution Reveal Transcription Dependent Long Range Correlation

Saumya Agrawal, RIKEN, Yokohama Campus, Japan
Association between Three-Dimensional Localization and Function of Long Non-Coding RNAs

Sofia Quinodoz, California Institute of Technology, USA
Higher-Order Inter-Chromosomal Hubs Shape 3-Dimensional Genome Organization in the Nucleus

Valerio Orlando, King Abdullah University of Science and Technology, Saudi Arabia
Ago1 in Association with NEAT1 lncRNA Contributes to Nuclear and 3D Chromatin Architecture in Human Cells

Alice Sherrard, University of Bristol, UK
Imaging Chromatin Dynamics Reveals a Novel Mechanism for Nuclear Organization after Cell Division

Marlies E. Oomen, University of Massachusetts Medical School, USA
Cell Cycle Dynamics of CTCF Binding and its Relation to Chromosome Organization

4:30—5:00 PM
Coffee Available

Grand Foyer
5:00—7:15 PM
Control Elements (Joint)
Registered attendees can view abstracts starting on 02/23/2018

Sea to Sky B/C
* Bing Ren, Ludwig Institute for Cancer Research, USA

* Mikhail Spivakov, Babraham Institute, UK

Eileen E.M. Furlong, European Molecular Biology Laboratory, Germany
Functional Insights into Genome Topology and Enhancer Function during Embryonic Development

Michael S. Levine, Princeton University, USA
Transcriptional Bursting

Joanna Wysocka, Stanford University School of Medicine, USA
Enhancers in Development

Rajat Gupta, Massachusetts General Hospital, USA
Short Talk: A Genetic Variant Associated with Five Vascular Diseases Distally Regulates Gene Expression Via Long-Range Enhancer Interactions

Jeff Alexander, University of California, San Francisco, USA
Short Talk: Live-Cell Imaging Reveals Enhancer-Dependent Sox2 Transcription Is Not Associated with Enhancer Proximity

7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
7:30—10:00 PM
Poster Session 1

Sea to Sky A

SUNDAY, MARCH 25

7:00—8:00 AM
Breakfast

Sea to Sky A
8:00—11:00 AM
Genome Structure (Joint)
Registered attendees can view abstracts starting on 02/23/2018

Sea to Sky B/C
* Suzana Hadjur, University College London, UK

* Stavros Lomvardas, Columbia University, USA

Juanma Vaquerizas, Max Planck Institute for Molecular Biomedicine, Germany
Chromatin Architecture during Early Development

Bing Ren, Ludwig Institute for Cancer Research, USA
Regulation of Lineage-specific Chromatin Organization at Enhancers

Coffee Break

Wendy A. Bickmore, University of Edinburgh, UK
The Remote Control of Gene Expression

Mitchell Guttman, California Institute of Technology, USA
Functional Noncoding RNA

Julie Ahringer, University of Cambridge, UK
Short Talk: ARC-C for Genome-Wide Analysis of Regulatory Element Interactions at High-Resolution

11:00 AM—12:00 PM
Meet the Editors Panel (Joint)

Sea to Sky B/C
* Edith Heard, Institut Curie, France

* Richard A. Young, Whitehead Institute for Biomedical Research, USA

Sharon Ahmad, Journal of Cell Science, UK

Marie Bao, Cell Press, USA

Katherine Brown, Development, UK

Melina Casadio, Rockefeller University Press, USA

Alex Eccleston, Nature, UK, UK

Markus Elsner, Nature Biotechnology, Germany

Tiago Faial, Nature Genetics, USA

Sarah Geisler, Cell, USA

Di Jiang, PLOS Biology, USA

Steve Mao, Science, AAAS, USA

Carolina Perdigoto, Nature Communications, UK

Nicole Rusk, Nature Methods, USA

Rupa Sarkar, Nature Protocols, UK

Esther Schnapp, EMBO, Germany

Julie Sollier, Cell Press, USA

Anke Sparmann, Nature Structural and Molecular Biology, UK

Ruth Zearfoss, Cell Press, USA

Eytan Zlotorynski, Nature Reviews Molecular Cell Biology, UK

11:00 AM—5:00 PM
On Own for Lunch

11:00 AM—1:00 PM
Poster Setup

Sea to Sky A
1:00—10:00 PM
Poster Viewing

Sea to Sky A
4:30—5:00 PM
Coffee Available

Grand Foyer
5:00—7:00 PM
Epigenetics
Registered attendees can view abstracts starting on 02/23/2018

Sea to Sky B
* Geeta J. Narlikar, University of California, San Francisco, USA

* Joseph R. Ecker, The Salk Institute for Biological Studies, USA

Leonard I. Zon, HHMI/Boston Children's Hospital, USA
Epigenetic Pathways Regulating Cell Fate

Oliver J. Rando, University of Massachusetts Medical School, USA
Small RNA Trafficking during Sperm Epididymal Maturation is Essential for Early Development in Mammals

Edith Heard, Institut Curie, France
Developmental Dynamics of X-Chromosome Structure

Zachary Hugh Harvey, Stanford University, USA
Short Talk: A Prion That Mediates Meiotic Inheritances of Activated Chromatin States

5:00—7:00 PM
Spatio-Temporal Dynamics of Chromatin
Registered attendees can view abstracts starting on 02/23/2018

Sea to Sky C
* Eileen E.M. Furlong, European Molecular Biology Laboratory, Germany

* Juanma Vaquerizas, Max Planck Institute for Molecular Biomedicine, Germany

Stavros Lomvardas, Columbia University, USA
Interchromosomal Interactions Regulate Singular Olfactory Receptor Choice

Victor G. Corces, Emory University, USA
Mechanisms of Transgenerational Inheritance

Amos Tanay, Weizmann Institute, Israel
Single Cell Approaches in Epigenomics and 3D Chromosome Organization

Yong Hoon Kim, University of Pennsylvania School of Medicine, USA
Short Talk: Rev-erb alpha Dynamically Modulates Chromatin Looping to Control Circadian Gene Transcription

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
7:30—10:00 PM
Poster Session 2

Sea to Sky A

MONDAY, MARCH 26

7:00—8:00 AM
Breakfast

Sea to Sky A
8:00—11:30 AM
New Models
Registered attendees can view abstracts starting on 02/23/2018

Sea to Sky B
* Magdalena D. Zernicka-Goetz, University of Cambridge, UK

* Yonatan Stelzer, Weizmann Institute of Science, Israel

Phillip A. Sharp, Massachusetts Institute of Technology, USA
Phase Separation in Transcription Control

Ibrahim Cissé, Massachusetts Institute of Technology, USA
Super-Resolution Imaging of Transcription in Live Mammalian Cells

Coffee Break

Geeta J. Narlikar, University of California, San Francisco, USA
Phase-Separation in Heterochromatin Formation

Ankur Jain, University of California, San Francisco, USA
RNA Phase Separation and Neurodegenerative Disease

Sheila Teves, University of California Berkeley, USA
Short Talk: A Stable Mode of Bookmarking by TBP Recruits RNA Polymerase II to Mitotic Chromosomes

Mounia Lagha, Centre National de la Recherche Scientifique, France
Short Talk: Zelda and Transcriptional Memory in Drosophila Embryos

Yuelin Song, Massachusetts Institute of Technology, USA
Short Talk: Dynamic DNA Methylation Heterogeneity at Super-Enhancers in Single-Cells

8:00—11:15 AM
Chromatin Architecture, Development and Disease
Registered attendees can view abstracts starting on 02/23/2018

Sea to Sky C
* Karen L. Reddy, Johns Hopkins University, USA

* Leonid Mirny, Massachusetts Institute of Technology, USA

Jane A. Skok, New York University School of Medicine, USA
The mechanisms underlying the impact of MMSET overexpression on gene regulation in multiple myeloma

Ana Pombo, Max-Delbrück-Centrum für Molekulare Medizin, Germany
Genome Architecture Mapping: Exploring Mechanisms of 3D Chromatin Folding in Rare Cell Types

Coffee Break

Mikhail Spivakov, Babraham Institute, UK
Mapping Genomic Regulatory Architecture and Interpreting Non-coding Variation with Promoter Capture Hi-C

Kevin G. Monahan, Columbia University, USA
Short Talk: Ldb1 is Required for the Formation of a Multi-Chromosomal Enhancer Hub that Governs Singular Olfactory Receptor Transcription

Alistair Boettiger, Stanford University, USA
Short Talk: Nanoscale Visualization of cis-Regulation in Development using ORCA

Jean J. Gautier, Columbia University, College of Physicians and Surgeons, USA
Short Talk: Nuclear Actin Polymerization Drives DNA Double-Strand Break Mobility and Clustering for Homology-Directed Repair

Rani E. George, Dana-Farber Cancer Institute, USA
Short Talk: The CTCF Paralog BORIS Promotes Novel Chromatin Regulatory Interactions in Cancer Cells

11:30 AM—5:00 PM
On Own for Lunch

11:30 AM—1:00 PM
Poster Setup

Sea to Sky A
1:00—10:00 PM
Poster Viewing

Sea to Sky A
4:30—5:00 PM
Coffee Available

Grand Foyer
5:00—7:00 PM
Development
Registered attendees can view abstracts starting on 02/23/2018

Sea to Sky B
* Natalia B. Ivanova, Yale University School of Medicine, USA

* Peter C. Scacheri, Case Western Reserve University, USA

Eliezer Calo, Massachusetts Institute of Technology, USA
Tissue Selective Effects of Nucleolar Stress and rDNA Damage in Developmental Disorders

Magdalena D. Zernicka-Goetz, University of Cambridge, UK
Building the Mammalian Embryo in vivo and in vitro

Joseph R. Ecker, The Salk Institute for Biological Studies, USA
Single Cell Methylomes Reveal Neuronal Populations and Regulatory Elements in the Mammalian Brain

Yonatan Stelzer, Weizmann Institute of Science, Israel
Short Talk: Parent- and Sex-Specific DNA Methylation Dynamics during Mouse Development

5:00—7:00 PM
Integrating Chromatin States and Genome Architecture to Understand Genome Function
Registered attendees can view abstracts starting on 02/23/2018

Sea to Sky C
* Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland

* Giacomo Cavalli, Institute of Human Genetics, France

John A. Stamatoyannopoulos, Altius Institute for Biomedical Sciences, USA
Transcriptional Circuitry and Regulatory Landscapes

Richard A. Young, Whitehead Institute for Biomedical Research, USA
Phase Separation and Genome Architecture

William J. Greenleaf, Stanford University, USA
Understanding the Physical Genome

Jiao Sima, Florida State University, USA
Short Talk: CRISPR Dissection of a Replication Domain Reveals Discrete Internal cis Elements Regulating Replication Timing and Chromatin Compartment

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
7:30—10:00 PM
Poster Session 3

Sea to Sky A

TUESDAY, MARCH 27

7:00—8:00 AM
Breakfast

Sea to Sky A
7:30—8:00 AM
Poster Setup

Sea to Sky A
8:00 AM—5:00 PM
Poster Viewing

Sea to Sky A
8:00—11:00 AM
Disease
Registered attendees can view abstracts starting on 02/23/2018

Sea to Sky B
* Richard A. Young, Whitehead Institute for Biomedical Research, USA

* Cheryl Arrowsmith, University of Toronto, Canada

Peter C. Scacheri, Case Western Reserve University, USA
Mechanisms of Aberrant Enhancer Activation in Cancer

Manolis Kellis, Massachusetts Institute of Technology, Broad Institute, USA
Functional Dissection of Disease-Associated Variation

Coffee Break

Matthias Merkenschlager, Imperial College London, UK
Cohesin Links Inflammation and Cancer

Chao Lu, Columbia University, USA
Short Talk: Reprogramming of Chromatin Organization by Cancer-Associated Histone H3 Mutations

Michele Gabriele, University of Milan, European Institute of Oncology, Italy
Short Talk: YY1 Haploinsufficiency Disrupts Histone Acetylation in Gabriele-De Vries Neurodevelopmental Syndrome

Jesse M. Engreitz, Broad Institute of Harvard and MIT, USA
Short Talk: Principles of Enhancer Function from Thousands of CRISPR Perturbations

8:00—11:15 AM
Chromatin Architecture and the Nuclear Positioning
Registered attendees can view abstracts starting on 02/23/2018

Sea to Sky C
* Ana Pombo, Max-Delbrück-Centrum für Molekulare Medizin, Germany

* Jane A. Skok, New York University School of Medicine, USA

Karen L. Reddy, Johns Hopkins University, USA
The Nuclear Lamina and the Shifting Shape of Epigenomes

Bas van Steensel, Netherlands Cancer Institute, Netherlands
Mechanisms of Gene Regulation in Lamina - Associated Domains

Coffee Break

Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland
Histone H3K9me Mediates Heterochromatin Sequestration and Stabilizes Repeat Elements with BRCA1

Giacomo Cavalli, Institute of Human Genetics, France
Polycomb Proteins and 3D Genome Folding in the Epigenetic Regulation of Development

Robert Johnston, Johns Hopkins University, USA
Short Talk: Pairing TADs (PairiTs) Drive Homologous Chromosomes Together to Promote Interchromosomal Gene Regulation

Wei Xie, Tsinghua University, China
Short Talk: Dynamic Epigenetic Landscapes during Early Lineage Specification in Mouse Embryos

11:00 AM—12:00 PM
Lunch

Sea to Sky A
12:00—2:30 PM
Poster Session 4

Sea to Sky A
2:30—4:30 PM
Workshop 2: Disease Connections

Sea to Sky B
* Ross L. Levine, Memorial Sloan Kettering Cancer Center, USA

* Manolis Kellis, Massachusetts Institute of Technology, Broad Institute, USA

Zuzana Tothova, Dana Farber Cancer Institute, USA
STAG2 Mutations Alter Cohesin Ring Structure and Function and Provide Therapeutic Vulnerabilities in Acute Myeloid Leukemia

Damien Downes, University of Oxford, UK
Systematic Dissection of GWAS loci using Chromatin Conformation and NG Sequencing Approaches

Elliott C. Ferris†, University of Utah, USA
Convergent Patterns of Accelerated Evolution in Hibernating Mammals May Elucidate New Regulatory Mechanisms Shaping Human Metabolic Disease

Nicholas Gomez, Rockefeller University, USA
Stem Cell Reprogramming during Oncogenesis and Development

Kai Ge, NIDDK, National Institutes of Health, USA
Enhancer Epigenomic Regulation in Differentiation, Development and Cancer

Debora R. Sobreira, University of Chicago, USA
Obesity-Associated Variants within FTO are Functionally Connected to the Coordinated Expression of IRX3 and IRX5 in Brain and Adipose Tissue

Rajesh C. Rao, University of Michigan, USA
Wdr5 Acts as a Temporal Rheostat to Control Retinal Neuroectoderm Versus Mesoderm Fate Choice

2:30—4:30 PM
Workshop 2: Modeling and Simulations

Sea to Sky C
* Geoffrey Fudenberg, University of California, San Francisco, USA

* Marc A. Marti-Renom, CNAG-CRG, Spain

Kristin Abramo, University of Massachusetts Medical School, USA
Building an Interphase Nucleus

Annaelle Brunet, University of Oslo, Norway
Lamina-Associated Domains as Tuning Actors Configuring the Mechanical Constraints of the Chromatin Domain at Nuclear Periphery

Nick Gilbert, University of Edinburgh, UK
Chromatin-Associated RNA Recycling by XRN2 Regulates Transcription and Chromosome Structure

Kohta Ikegami, University of Chicago, USA
Phospho-Lamin A Binding at Enhancers Coordinates Nuclear Envelope Breakdown with Mitotic Transcriptional Quiescence

Michele Di Pierro, Rice University, USA
De Novo Prediction of Human Chromosome Structures: Epigenetic Marking Patterns Encode Genome Architecture

Jie Liang, University of Illinois at Chicago, USA
Deep Sampling to Reconstruct Large 3D Ensembles of Chromatin Chains from 2D Heatmaps of Captured Conformations

4:30—5:00 PM
Coffee Available

Grand Foyer
5:00—6:45 PM
Therapeutics
Registered attendees can view abstracts starting on 02/23/2018

Sea to Sky B
* Leonard I. Zon, HHMI/Boston Children's Hospital, USA

* Zuzana Tothova, Dana Farber Cancer Institute, USA

James E. Bradner, Novartis Institutes for BioMedical Research, USA
Transcription and Drug Discovery

Cheryl Arrowsmith, University of Toronto, Canada
Probing the Epigenome using Chemical Biology

Ross L. Levine, Memorial Sloan Kettering Cancer Center, USA
Mutations in Epigenetic Regulators in the Biology and Therapy of Myeloid Malignancies

5:00—6:45 PM
Physical Modeling of Chromatin and Chromosomes
Registered attendees can view abstracts starting on 02/23/2018

Sea to Sky C
* William J. Greenleaf, Stanford University, USA

William Stafford Noble, University of Washington, USA
Modeling the 3D Architecture of the Genome

Leonid Mirny, Massachusetts Institute of Technology, USA
Biophysical Models of Chromatin (re)Organization

Marc A. Marti-Renom, CNAG-CRG, Spain
Structure Determination of Genomes and Genomic Domains by Satisfaction of Spatial Restraints

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Registered attendees can view abstracts starting on 02/23/2018

Sea to Sky B
6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Registered attendees can view abstracts starting on 02/23/2018

Sea to Sky C
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Sea to Sky A

WEDNESDAY, MARCH 28

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Novartis Institutes for BioMedical Research

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676