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This meeting took place in 2018



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State of the Brain: Genetic Dissection of Brain Circuits and Behavior in Health and Disease (A2)


Organizer(s) Sean Hill, Hongkui Zeng, Z. Josh Huang and György Buzsáki
January 14—18, 2018
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Sep 21, 2017
Abstract Deadline: Oct 19, 2017
Scholarship Deadline: Sep 21, 2017
Discounted Registration Deadline: Nov 20, 2017

Lead Sponsor: Allen Institute for Brain Science

Summary of Meeting:
Identifying and understanding the building blocks of the nervous system and how they interact is a central focus of international efforts to understand the brain. Modern genetic approaches hold the promise of establishing an inventory of cell types, exploring mechanisms of cellular identity, developing tools for experimental manipulations, building a brain-wide cell type atlas, and providing the basis of establishing brain-wide connectivity atlases at cellular resolution. Understanding how diseases and disorders impact cells, synapses and circuitry is essential to guide the development of treatments and therapies. Creating such an atlas of genetically identified cell types and their connectivity will provide key data and knowledge for developing in silico reconstructions of brain circuitry and developing theories of brain structure and function. This conference brings together leading scientists from around the world to present the latest tools, techniques and discoveries in using genetic approaches to understand the cell types of the brain and their role in cognition, behavior and brain diseases and disorders.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, January 14 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 18 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, January 19 in order to fully experience the meeting.

SUNDAY, JANUARY 14

4:00—8:00 PM
Arrival and Registration

Longs Peak Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Longs Peak Foyer

MONDAY, JANUARY 15

7:00—8:00 AM
Breakfast

Longs Peak
8:00—9:30 AM
Welcome and Keynote Session
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Sean Hill, Center for Addiction and Mental Health, Canada

Catherine C. Dulac, Harvard University, USA
Molecular and Cellular Architecture of Social Behavior Circuits

Walter J. Koroshetz, NINDS, National Institutes of Health, USA
From Genetic Dissection to Neuromodulation: The Promise of the BRAIN Initiative

Coffee Break

9:50—11:45 AM
Tools and Techniques for Genetic Dissection
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Edward S. Boyden, Massachusetts Institute of Technology, USA

Anthony Zador, Cold Spring Harbor Laboratory, USA
Sequencing the Connectome

Qingming Luo, Huazhong University of Science and Technology, China
Brainsmatics: Deciphering Brain Function with Brain-Wide Genetically Defined Networks

Viviana Gradinaru, California Institute of Technology, USA
Gene Delivery Across the Blood-Brain-Barrier, Whole-Body Tissue Clearing, and Optogenetics to Understand and Influence Physiology and Behavior

Alan R. Mardinly, University of California, Berkeley, USA
Short Talk: Precise Holographic Manipulation of Neural Ensembles in Behaving Animals

11:45 AM—5:00 PM
On Own for Lunch

11:45 AM—1:00 PM
Poster Setup

Longs Peak
1:00—10:00 PM
Poster Viewing

Longs Peak
4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—7:00 PM
Towards a Census of Cell Types
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Walter J. Koroshetz, NINDS, National Institutes of Health, USA

Hongkui Zeng, Allen Institute for Brain Science, USA
Building a Cell Type Taxonomy for Mouse Cortical Neurons

Sten Linnarsson, Karolinska Institutet, Sweden
Brain Cell Types and Lineages from Transcriptomes

Hideyuki Okano, Keio University School of Medicine, Japan
Disease Modeling and Brain Mapping using Genetically Modified Marmosets

Kee Wui Huang, Harvard Medical School, USA
Short Talk: Single-Cell Transcriptomic Profiling with Spatial Mapping Reveals Distinct 5-HT Neuron Subtypes in the Dorsal Raphe Nucleus

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs Peak Foyer
7:30—10:00 PM
Poster Session 1

Longs Peak

TUESDAY, JANUARY 16

7:00—8:00 AM
Breakfast

Longs Peak
8:00—11:15 AM
Genetic Dissection of Microcircuitry
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Karel Svoboda, Janelia Research Campus & Cold Spring Harbor Laboratory, USA

Botond Roska, Friedrich Miescher Institute, Switzerland
Genetic Dissection of the Retina

Liqun Luo, Stanford University, USA
TRAPing Active Neurons

Coffee Break

Andreas Tolias, Baylor College of Medicine, USA
The Fabric of the Neocortex

Z. Josh Huang, Cold Spring Harbor Laboratory, USA
Cortical Interneuron Types, Subtypes and Connection Specificity

Seung-Hee Lee, Korea Advanced Institutes of Science and Technology, KAIST, South Korea
Short Talk: Locomotion Modulates Audiovisual Integration in the Posterior Parietal Cortex

Balázs József Rózsa, Hungarian Academy of Sciences, Hungary
Short Talk: Fast 3D Imaging and Re-Activation of Neuronal Networks, Dendrites, and Spines in Several Cubic Millimeter Volumes in Behaving Animals to Understand Visual Representation

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Longs Peak
1:00—10:00 PM
Poster Viewing

Longs Peak
2:30—4:30 PM
Workshop 1: Cell Type Discovery using Single-Cell Transcriptomics

Grays Peak
* Sten Linnarsson, Karolinska Institutet, Sweden

Ariel Levine, NINDS, National Institutes of Health, USA
Large-Scale Single Nucleus Transcriptional Profiling Defines Spinal Cord Cell Types and Their Activity during Behavior

Shristi Pandey, Harvard University, USA
Spatial Mapping of Cell Types in the Zebrafish Habenula using Single-Cell RNAseq

Damon Polioudakis, University of California, Los Angeles, USA
A Molecular Taxonomy of Cell Types in Developing Human Cortex

Marie Aare Bentsen, University of Washington School of Medicine, USA
A Single-Cell Transcriptomics Roadmap to Investigate Type 2 Diabetes Remission Induced by the Action of Fibroblast Growth Factor 1 in the Brain

Lisa Topolnik, CRCHUQ, Canada
Transcriptomic Profiling, Connectivity and Network State-Dependent Recruitment of Long-Range VIP-GABAergic Neurons in the Mouse Hippocampus

Zhuzhu Zhang, The Salk Institute for Biological Studies, USA
Single-Nucleus Methylome and Transcriptome Sequencing Reveals Molecular Differences between Identified Cortical Projection Cell Types

4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—7:00 PM
Genetic Dissection of Meso and Macrocircuitry
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Z. Josh Huang, Cold Spring Harbor Laboratory, USA

Ann-Shyn Chiang, National Tsing Hua University, Taiwan
Multiscale Anatomy of Drosophila Connectome

Attila Losonczy, Columbia University, USA
Dissecting Hippocampal Circuit Dynamics during Temporal Associative Learning

Suzana Herculano-Houzel, Vanderbilt University, USA
It Takes Three Variables to Build a Cortex (and the Human Cortex Is Not Special): Lessons from Comparative Neuroanatomy

Johannes Passecker, Medical University Vienna, Austria
Short Talk: Activity of Prefrontal Neurons Predict Future Choices during Gambling

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs Peak Foyer
7:30—10:00 PM
Poster Session 2

Longs Peak

WEDNESDAY, JANUARY 17

7:00—8:00 AM
Breakfast

Longs Peak
8:00—11:15 AM
Data, Modeling, Informatics
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Hongkui Zeng, Allen Institute for Brain Science, USA

Kenneth Harris, University College London, UK
High-Dimensional Geometry of the Cortical Population Code as Revealed by 10,000-Cell Recordings

Sean Hill, Center for Addiction and Mental Health, Canada
A Digital Reconstruction of Cortical Microcircuitry: From Gene Expression to Emergent Network Activity

Coffee Break

Surya Ganguli, Stanford University, USA
Cell Classification as a Computational Problem

György Buzsáki, New York University, Langone Medical Center, USA
How Does Circuit Modification Support Learning?

Michael Kunst, Max Planck Institute of Neurobiology, Germany
Short Talk: A Cellular-Resolution Atlas of the Larval Zebrafish Brain

Eilif Muller, EPFL, Switzerland
Short Talk: Recent Advances in Data-Driven Brain Region Reconstruction and Simulation in the Human Brain Project

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Longs Peak
1:00—10:00 PM
Poster Viewing

Longs Peak
4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—7:00 PM
Genetic Dissection of Behavior
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* György Buzsáki, New York University, Langone Medical Center, USA

Yang Dan, University of California, Berkeley, USA
Neural Circuits Controlling Sleep

Karel Svoboda, Janelia Research Campus & Cold Spring Harbor Laboratory, USA
Cell Type-Specific Analysis of the Cortical Circuits for Motor Planning and Movement Initiation

Marion Ponserre, Max Planck Institute of Neurobiology, Germany
Short Talk: Organization of Central Amygdala Circuits that Regulate Appetitive Behavior

Scott Waddell, University of Oxford, UK
Short Talk: Competition between Memories of Opposite Valence Underlies Memory Extinction in Drosophila

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs Peak Foyer
7:30—10:00 PM
Poster Session 3

Longs Peak

THURSDAY, JANUARY 18

7:00—8:00 AM
Breakfast

Longs Peak
8:00—11:00 AM
Genetic Dissection of Brain Disorders and Diseases
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Yang Dan, University of California, Berkeley, USA

Freda D. Miller, Hospital for Sick Children, Canada
Extrinsic Regulation of Cellular Genesis during Normal and Pathological Cortex Development

Lorna W. Role, Stony Brook University, USA
Genetic Dissection of Cholinergic Signaling in Memory Disorders

Coffee Break

Khalil Ramadi, Massachusetts Institute of Technology, USA
Short Talk: A Chronically Implanted, Remotely-Controlled, Drug Delivery System to Deep Brain Microstructures Elicits Repeatable Behavioral Modulation in a Volume-Dependent Manner

Noam D. Beckmann, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Multiscale Causal Networks Integrating DNA, RNA, and Proteomic Data Identify VGF as a Novel Key Driver of Alzheimer's Disease

Summer Thyme, Harvard University, USA
Short Talk: Shared Neurobiological Roles of Schizophrenia-Associated Genes

11:00 AM—5:00 PM
On Own for Lunch

2:30—4:30 PM
Workshop 2: Genetic Dissection of Circuits and Behavior

Grays Peak
* Lorna W. Role, Stony Brook University, USA

Yoav Adam, Harvard University, USA
All-Optical Electrophysiology in Behaving Mice with Enhanced Near Infrared Voltage Sensors

Nikolaos Balaskas, Columbia University, USA
Defining the Genetic Diversity of Spinal Presynaptic Inhibitory Interneurons

Takaaki Miyazaki, National Institute of Genetics, Japan
Anatomical Screening and Live Imaging of Gustatory 2nd-Order Neurons that Link Sugar Detection and Feeding/Reward Systems

Jean-Francois Poulin, Northwestern University, USA
Mapping Projections of Dopamine Neuron Subtypes using Intersectional Genetic Strategies

Kazuki Katori, University of Tokyo, Japan
Sharp Wave-Associated Activity Pattern of Olfactory Cortical Neurons in the Mouse Piriform Cortex

Taehong Yang, Stanford University, USA
Social Control of Hypothalamus-Mediated Male Aggression

4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—6:45 PM
From Genetic Dissection to the Clinic
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Freda D. Miller, Hospital for Sick Children, Canada

Thomas Portmann, Circuit Therapeutics, Inc., USA
A Circuit-Based Approach to CNS Drug Discovery: Integrating Optogenetics and Single-Cell Genomics

Edward S. Boyden, Massachusetts Institute of Technology, USA
Technologies for Analyzing and Controlling Neural Circuits

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Grays Peak
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs Peak Foyer
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Longs Peak

FRIDAY, JANUARY 19

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Lead Sponsor for generously supporting this meeting:

Allen Institute for Brain Science
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Chroma Technology Corporation The Kavli Foundation

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Circuit Therapeutics


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676