Whistler Conference Centre Floorplan

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Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

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Long Noncoding RNAs: From Molecular Mechanism to Functional Genetics (X2)

joint with the meeting on RNA-Protein Interactions (X1)

Scientific Organizers: Saba Valadkhan and Piero Carninci


February 24—28, 2019

Whistler Conference Centre, Whistler, British Columbia, Canada


Sponsored by Cell Research and Ionis Pharmaceuticals, Inc.


Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.
BEWARE of booking lodging through companies unaffiliated with Keystone Symposia. Click here for more details.

Keystone Symposia is committed to maintaining a positive and respectful environment at its meetings. To this end, please review and comply with our policies.

Registered attendees of one meeting in a joint pair may participate in sessions of the other, pending space availability.

DEADLINES:
*All deadlines end at 11:59 PM US Mountain Standard Time
Scholarship Deadline: Oct 25, 2018 [details]
Discounted Abstract Deadline: Oct 25, 2018 [details]
Abstract Deadline: Nov 29, 2018 [details]
Discounted Registration Deadline: Jan 10, 2019 [details]

If you have missed a deadline due to the US government shutdown, please contact our office.

Click here to view Cancellation Policy

Register Yourself Deadlines and Fees

Rates and Deadlines listed below are for the 2019-X2 "Long Noncoding RNAs: From Molecular Mechanism to Functional Genetics" conference only.

*All deadlines end at 11:59 PM US Mountain Standard Time

Deadline Date Cost
Discounted Abstract Deadline
More details
Before and On October 25, 2018 100.00 USD*
- 50.00 USD discount
Abstract Deadline
More details
After October 25, 2018 until January 13, 2019 100.00 USD*
* 50.00 USD of Abstract fee deducted from your registration fee when you register for this meeting
Scholarship
More details
October 25, 2018 n/a
Discounted NON-STUDENT Registration
More details
Before and On January 10, 2019 945.00 USD
(includes 200.00 discount)
Regular NON-STUDENT Registration
More details
After January 10, 2019 1145.00 USD
Discounted STUDENT Registration
More details
Before and On January 10, 2019 720.00 USD
(includes 200.00 discount)
Regular STUDENT Registration
More details
After January 10, 2019 920.00 USD

* Changes in payment type that result in a refund are subject to a processing fee.
* Currency exchange gains/losses are the responsibility of the registrant and the Keystone Symposia will accept no liability for money loss through bank charges, transfers or currency fluctuations.




Discounted Abstract Deadline: October 25, 2018

*All deadlines end at 11:59 PM US Mountain Standard Time

Abstract Submission Fee: 100.00 USD*
Submission by this date receives 50.00 USD discount.
*50.00 USD will be applied to Registration Fee when you register

Abstract Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadlines. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract early allows us to:
  • submit your abstract to organizers to be considered for a short talk
  • accept your abstract online
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
(The Abstract Deadline: is November 29, 2018)

Global Health Travel Award Deadline:

*All deadlines end at 11:59 PM US Mountain Standard Time


Global Health Travel Award Details: You MUST complete your Global Health Travel Award appplication by the Global Health Travel Award Deadline and complete the other required steps (verify your contact information and submit a recommendation letter) to be considered for a travel award.


Click here to learn more about Global Health Travel Awards.

Scholarship Deadline: October 25, 2018

*All deadlines end at 11:59 PM US Mountain Standard Time


Scholarship Details: You MUST submit your abstract by the Scholarship Deadline and complete the other required steps (submit a scholarship application and submit a mentor letter) to be considered for a scholarship.

Click here to learn more about Scholarships.

Abstract Deadline: November 29, 2018

*All deadlines end at 11:59 PM US Mountain Standard Time


Abstract Submission Fee: 100.00 USD*
*50.00 USD will be applied to Registration Fee when you register

Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadline. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract by the Abstract Deadline allows us to:

  • submit your abstract to organizers to be considered for a short talk
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
Abstracts submitted after the Abstract Deadline will NOT be considered for a short talk.

(Discounted Abstract Deadline: is October 25, 2018)

Discounted Registration Deadline: January 10, 2019

*All deadlines end at 11:59 PM US Mountain Standard Time


Registration Fee: 945.00 USD* (includes 200.00 USD discount)
Student Registration Fee: 720.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

After the Discounted Registration Deadline:


Registration Fee: 1145.00 USD*
Student Registration Fee: 920.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

Registration spaces are limited and may fill prior to discounted registration deadline.

Please be advised that some meeting participants have received calls and emails from a number of different housing services, including "Exhibitors Housing Services," “Expo Housing Services,” "Global Housing," etc. THESE COMPANIES ARE NOT AFFILIATED WITH KEYSTONE SYMPOSIA and are not authorized by Keystone Symposia to contact you. These companies may tell you that the meeting is filling, without any actual knowledge to that effect, and pressure you into giving them your credit card number to make a lodging reservation with them.

We highly recommend that you not make a reservation with these companies or any other housing service! These companies' representations to participants have been misleading. Please report any calls or correspondence you might have received to Keystone Symposia and book only through lodging links in your Keystone Symposia account, an established travel agency or directly with the hotel(s) listed on our website.
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, February 24 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 28 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 1 in order to fully experience the meeting.

SUNDAY, FEBRUARY 24

4:00—8:00 PM
Arrival and Registration

Grand Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Grand Foyer

MONDAY, FEBRUARY 25

7:00—8:00 AM
Breakfast

Sea to Sky A
8:00—9:30 AM
Welcome and Keynote Session (Joint)
Registered attendees can view abstracts starting on 01/24/2019

Sea to Sky B/C
* Douglas L. Black, University of California, Los Angeles, USA

* Anne Ephrussi, European Molecular Biology Laboratory, Germany

* Saba Valadkhan, Case Western Reserve University, USA

* Piero Carninci, RIKEN Center for Integrative Medical Sciences, Japan

Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
New Genome Editors and Inhibitors from the CRISPR Family Tree

John S. Mattick, University of Oxford, UK
The New World of RNA Biology

Coffee Break

9:50 AM—12:30 PM
Functional RNA Elements in Mammalian Genomes (Joint)
Registered attendees can view abstracts starting on 01/24/2019

Sea to Sky B/C
* Danesh Moazed, Harvard Medical School, USA

* Howard Y. Chang, Stanford University, USA

Xiang-Dong Fu, University of California, San Diego, USA
Broad Roles of RNA-Binding Proteins in Regulated Gene Expression

Thomas R. Cech, HHMI/University of Colorado, USA
RNA-Protein Interactions Regulate Epigenetic Silencing

Chris B. Burge, Massachusetts Institute of Technology, USA
Patterns in the Recognition of RNAs by RBPs

Maiwen Caudron-Herger, German Cancer Research Center, Germany
Short Talk: Proteome-Wide and Quantitative Identification of RNA-Dependent Protein Complexes

Mario A. Flores, NCBI, National Institutes of Health, USA
Short Talk: Dissecting the Characteristics and Functions of Transcribed Enhancers

Yoav Lubelsky, Weizmann Institute of Science, Israel
Short Talk: Elucidating the Crosstalk between hnRNPK Binding and Nuclear Retention of Long RNAs

Yoko Matsuno, Niigata University, Japan
Short Talk: Characteristic Convergent Variation in LINE-1 Nucleotides Can Benefit Redundantly Forming Triplexes with lncRNA in Mammalian X-Chromosome Inactivation

12:30—5:00 PM
On Own for Lunch

12:30—1:00 PM
Poster Setup

Sea to Sky A
1:00—10:00 PM
Poster Viewing

Sea to Sky A
2:30—4:30 PM
Workshop 1: lncRNAs: Diversity of Function

Sea to Sky C
* Lingling Chen, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China

* Susan B. Carpenter, University of California, Santa Cruz, USA

Thomas C. Brodnicki, St Vincent's Institute, Australia
A Long Noncoding RNA Attenuates Dendritic Cell Function and Decreases Autoimmune Disease Susceptibility

Ousman Tamgue, University of Douala, Cameroon and University of Cape Town, IDM, South Africa
Long Non-Coding RNA-26 Promotes Intracellular Mycobacterium tuberculosis Growth through Inhibition of Pro-Inflammatory Genes Expression and Macrophage Activation

Fabio Desideri, Sapienza University of Rome, Italy
Charme Long Noncoding RNA Shapes the 3D Nuclear Structure by its Close Cooperation with Chromatin

Marine Gautier, Centre National de la Recherche Scientifique, France
Functional Characterization of Hypoxia-Regulated lncRNAs in Non-Small Cell Lung Carcinomas

Paras Sehgal, Institute of Genomics and Integrative Biology, India
Regulation of Diacyl Glycerol-Mediated Protein Kinase C-Beta Activation by Vascular Endothelial -Associated Long Noncoding RNA 2 Modulates Endothelial Permeability

Roberto Vendramin, VIB-KU Leuven, Belgium
SAMMSON Fosters Cancer Cell Fitness by Concertedly Enhancing Mitochondrial and Cytosolic Translation

Tan Phat Pham, Amsterdam University Medical Center, Netherlands
The Age and Shear Regulated Long Non-Coding RNA Aerrie Controls Endothelial Cell Function

Laura Stanicek, Amsterdam University Medical Center, Netherlands
The Shear Stress-Induced Long Non-Coding RNA LASSIE as a Regulator of Endothelial Cell Junctions


Following Session is for RNA-Protein Interactions (X1)

2:30—4:30 PM
Workshop 1: New RNA Technologies

Sea to Sky B
Daniel Benhalevy, NIAMS, National Institutes of Health, USA
Proximity-CLIP Provides a Snapshot of Protein-Occupied RNA Elements in Sub-Cellular Compartments

* Kevin Drew, University of Texas at Austin, USA
Systematic Discovery of Endogenous Human Ribonucleoprotein Complexes

Hong Han, University of Toronto, Canada
An Integrated High-Throughput Chemical Screening Platform for RNA Splicing Modulators

Sudhakar Jha, National University of Singapore, Singapore
Utilization of a Novel Technique to Identify RNA-Binding Proteins

Jakob Trendel, European Molecular Biology Laboratory, Germany
Protein Half-Lives on RNA Reveal Human Ribosome Maintenance Independent of Ribosome Biogenesis

Marta Gabryelska, University of Edinburgh, UK
Probing Ribosome Assembly Dynamics with CLASH

* Alena Shkumatava, Institut Curie-Centre de Recherche, France
Systematic Identification and Quantitative Measurement of RNA-Protein Interactions by incPRINT

4:30—5:00 PM
Coffee Available

Grand Foyer
5:00—7:00 PM
lncRNAs, Transposons and Evolution of the Genome
Registered attendees can view abstracts starting on 01/24/2019

Sea to Sky C
* John L. Rinn, University of Colorado Boulder, USA

Igor Ulitsky, Weizmann Institute of Science, Israel
Functions, Modes of Action and Localization of Long Noncoding RNAs in Mammalian Cells

Lynne E. Maquat, University of Rochester Medical Center, USA
Role of Retrotransposon Elements within Cellular RNAs

Paulo P. Amaral, University of Cambridge, UK
Defining the Landscape of Covalent Modifications in Conserved Noncoding RNAs using Direct-RNA Sequencing

Paolo Gandellini, Fondazione IRCCS Istituto Nazionale dei Tumori, Italy
Short Talk: LEADeR Role of miR-205 Host Gene as Long Non-Coding RNA in Prostate Basal Cell Differentiation

Giovanni Pascarella, RIKEN CLST Yokohama Institute, Japan
Short Talk: Somatic Retrotransoposons-Associated Structural Variants in Health and Neurodegeneration


Following Session is for RNA-Protein Interactions (X1)

5:00—7:00 PM
RNP in Phase Transition
Registered attendees can view abstracts starting on 01/24/2019

Sea to Sky B
* Kristen W. Lynch, University of Pennsylvania, USA

Kathrin Plath, University of California, Los Angeles, USA
A New Mode of Xist Action

Roy R. Parker, HHMI/University of Colorado, USA
RNP Granules in Health and Disease

Kimberly L. Mowry, Brown University, USA
Large RNP Transport Granules Drive mRNA Localization

Joseph Lobel, University of California, San Francisco, USA
Short Talk: Pat1 Activates Late Steps in mRNA Decay by Multiple Mechanisms

Xiong Ji, Peking University, China
Short Talk: RNAPII Condensates Connect Genome Organization and Gene Regulation

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
7:30—10:00 PM
Poster Session 1

Sea to Sky A

TUESDAY, FEBRUARY 26

7:00—8:00 AM
Breakfast

Sea to Sky A
8:00—11:30 AM
Coding and Noncoding RNAs on Chromatin (Joint)
Registered attendees can view abstracts starting on 01/24/2019

Sea to Sky B/C
* Kathrin Plath, University of California, Los Angeles, USA

* Igor Ulitsky, Weizmann Institute of Science, Israel

Danesh Moazed, Harvard Medical School, USA
RNAi in Chromatin Remodeling

Yijun Ruan, University of Connecticut, USA
Protein-RNA-Chromatin Interactions

Coffee Break

Jeannie T. Lee, Massachusetts General Hospital, USA
Xist RNA Antagonizes the Chromatin Remodeler, BRG1, on the Inactive X Chromosome

Valerio Orlando, King Abdullah University of Science and Technology, Saudi Arabia
RNAi Component Ago1 Interacts with lncRNAs to Regulate Nuclear Architecture and Cell Differentiation

Ryan Alexander Flynn, Stanford University, USA
Short Talk: DNA-PK Leverages Non-Coding RNA Binding to Regulate Nucleolar Functions

Riki Kurokawa, Saitama Medical University, Japan
Short Talk: Arginine Methylation of RNA Binding Protein TLS Inhibits Binding to Long Noncoding RNA, Repressing the Histone Acetyltransferase Activity

Saigopal Somasundaram, Case Western Reserve University, USA
Short Talk: The DNMT1-Associated lincRNA DACOR1 Reprograms Genome-Wide DNA Methylation in Colon Cancer

Eric James de Bony de Lavergne, Ghent University, Belgium
Short Talk: NESPR Long Non-Coding RNA, a New Neuroblastoma-Specific Oncogene

11:30 AM—5:00 PM
On Own for Lunch

11:30 AM—1:00 PM
Poster Setup

Sea to Sky A
1:00—10:00 PM
Poster Viewing

Sea to Sky A
4:30—5:00 PM
Coffee Available

Grand Foyer
5:00—7:00 PM
Regulation of Differentiation and Development by lncRNAs
Registered attendees can view abstracts starting on 01/24/2019

Sea to Sky C
* Lynne E. Maquat, University of Rochester Medical Center, USA

Saba Valadkhan, Case Western Reserve University, USA
Regulation of Cellular Quiescence by lncRNAs

Joshua T. Mendell, HHMI/University of Texas Southwestern Medical Center, USA
lncRNAs in Mammalian Physiology and Disease

Susan B. Carpenter, University of California, Santa Cruz, USA
Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2

Gaultier Hericher, Université Laval – CRCHU de Québec, Canada
Short Talk: Novel Tuna Isoforms Define the Pluripotent Stem Cell State

Varune Rohan Ramnarine, University of British Columbia, Canada
Short Talk: The Long Noncoding RNA Landscape of Neuroendocrine Prostate Cancer and its Clinical Implications


Following Session is for RNA-Protein Interactions (X1)

5:00—7:00 PM
Dissecting RNP Functions in vivo
Registered attendees can view abstracts starting on 01/24/2019

Sea to Sky B
* V. Narry Kim, Institute for Basic Science, South Korea

Joan A. Steitz, Yale University, USA
Target-Directed miRNA Decay: Yet Another Function of Ago Proteins

Susan L. Ackerman, University of California, San Diego, USA
tRNAs and Neuron Function

Kristen W. Lynch, University of Pennsylvania, USA
CELF2 Regulation of Splicing and Polyadenylation in Activated T Cells

Danielle Widner, Yale University, USA
Short Talk: RNA-Protein Complex Formation in a Mysterious Large ncRNA

Qingqing Wang, University of California, Berkeley, USA
Short Talk: Decipering the Splicing Code of Coordinated RN- Binding Proteins PSI and hrp48 in Sculpting the Drosophila Transcriptome

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
7:30—10:00 PM
Poster Session 2

Sea to Sky A

WEDNESDAY, FEBRUARY 27

7:00—8:00 AM
Breakfast

Sea to Sky A
8:00—11:15 AM
lncRNAs in Disease: Tools for Discovery
Registered attendees can view abstracts starting on 01/24/2019

Sea to Sky C
* Fabrizio d'Adda di Fagagna, IFOM, The FIRC Institute of Molecular Oncology, Italy

Howard Y. Chang, Stanford University, USA
Genome Regulation by Long Noncoding RNAs

Joakim Lundeberg, KTH-Royal Institute of Technology, Sweden
Spatial Transcriptome Analysis and Disease

Coffee Break

Nicholas J. Proudfoot, University of Oxford, UK
Different Mechanisms Define lncRNA and Protein Coding Gene Transcription Units in Mammalian Cells

Jin Chen, University of California, San Francisco, USA
Systematic Discovery of Novel Peptides from the Noncanonical Translation of Non-Coding Regions

Per Johnsson, Karolinska Institutet, Sweden
Short Talk: Functional Prediction and Validation of lncRNAs using Allele-Sensitive Single-Cell RNA-Sequencing

Lydia M. Contreras, University of Texas at Austin, USA
Short Talk: Novel High-Throughput Tools for in vivo Functional Characterization of Regulatory RNAs

Bojan Losic, Icahn School of Medicine at Sinai, USA
Short Talk: Circular RNA Mediate IBD Genetic Risk


Following Session is for RNA-Protein Interactions (X1)

8:00—11:15 AM
RNA Transport and Localization
Registered attendees can view abstracts starting on 01/24/2019

Sea to Sky B
* Kimberly L. Mowry, Brown University, USA

* Erik Sontheimer, University of Massachusetts Medical School, USA

Anne Ephrussi, European Molecular Biology Laboratory, Germany
Motor-Mediated RNA Transport and Localization

Robert H. Singer, Albert Einstein College of Medicine, USA
Neuronal Targets for RNA Binding Proteins

Coffee Break

Dierk Niessing, Ulm University, Germany
Molecular Architecture and Dynamics of mRNA Transport Complexes

Anob Chakrabarti, Francis Crick Institute, UK
Short Talk: Exploring the Characteristics and Functions of RNA Secondary Structures Bound in vivo by Staufen

Hong Cheng, Shanghai Institute of Biological Science, Chinese Academy of Sciences, China
Short Talk: NRDE2 Negatively Regulates Nuclear Exosome Functions and Controls Embryonic Stem Cell Self-Renewal

Mehdi Pirouz, Boston Children's Hospital, USA
Short Talk: The Perlman Syndrome Dis3l2 Exonuclease as Guardian of ER-associated Translation

Dhara Patel, Universite de Montreal, Canada
Short Talk: Complementary 3’UTRs Derived from Overlapping Genes can Promote Cytoplasmic Co-Localization of Distinct mRNAs

Jernej Murn, University of California, Riverside, USA
Short Talk: Transcriptional Control of Neuronal Differentiation by an RNA-Binding Protein

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Sea to Sky A
1:00—10:00 PM
Poster Viewing

Sea to Sky A
4:30—5:00 PM
Coffee Available

Grand Foyer
5:00—7:00 PM
Novel Insights into Functional Mechanism of lncRNAs
Registered attendees can view abstracts starting on 01/24/2019

Sea to Sky C
* Joshua T. Mendell, HHMI/University of Texas Southwestern Medical Center, USA

Piero Carninci, RIKEN Center for Integrative Medical Sciences, Japan
Functional Genomics of lncRNAs

Michael G. Rosenfeld, University of California, San Diego, USA
eRNAs Mediate Phase Separation of Ligand-Activated Enhancers to License Cooperative Chromosomal Enhancer Assembly

John L. Rinn, University of Colorado Boulder, USA
The Firre Locus Produces a Trans-Acting RNA Molecule that Functions in Hematopoiesis

Kaveh Daneshvar, Harvard Medical School, USA
Short Talk: lncRNA DIGIT and BRD3 Protein Form Phase-Separated Condensates and Regulate Endoderm Differentiation.

Karan Joshua Abraham, University of Toronto, Canada
Short Talk: Intergenic Non-Coding RNA-DNA Hybrids Maintain Nucleolar Biomolecular Condensates and Ribosome Biogenesis


Following Session is for RNA-Protein Interactions (X1)

5:00—7:00 PM
Structure and Function of RBPs
Registered attendees can view abstracts starting on 01/24/2019

Sea to Sky B
* Rui Zhao, University of Colorado, USA

Douglas L. Black, University of California, Los Angeles, USA
Splicing Activation by Rbfox Requires Self-Aggregation of its Tyrosine-Rich Domain

Frédéric H.T. Allain, ETH Zurich, Switzerland
Interaction of U1snRNP with Drugs and RNA-Binding Proteins in Splicing Regulation

Traci M.T. Hall, NIEHS, National Institutes of Health, USA
Collaborative RNA Recognition Specificity by PUF Proteins

Andreas Schlundt, Goethe University Frankfurt, Germany
Short Talk: The Individual Contributions of Single IMP3 RNA-Binding Domains to the Recognition of Clustered Sequences in Target mRNAs

Janosch Hennig, European Molecular Biology Laboratory, Germany
Short Talk: Structural Insights into MLE-Unr-roX2 Complex Assembly during Early Steps of Drosophila Dosage Compensation

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
7:30—10:00 PM
Poster Session 3

Sea to Sky A

THURSDAY, FEBRUARY 28

7:00—8:00 AM
Breakfast

Sea to Sky A
8:00—11:30 AM
lncRNAs: Diversity in Form and Function
Registered attendees can view abstracts starting on 01/24/2019

Sea to Sky C
* Jeannie T. Lee, Massachusetts General Hospital, USA

Karissa Y. Sanbonmatsu, Los Alamos National Laboratory, USA
Two-Dimensional and Three-Dimensional Structure-Function Relationships for Individual Long Noncoding RNAs

Jay W. Shin, RIKEN Yokohama, Japan
Functional Elucidation of Long Noncoding RNAs

Coffee Break

Lingling Chen, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
lncRNAs of Novel Origin

Xiao Liu, Yale University, USA
Short Talk: A ncRNA Derived from xbp-1 mRNA Cleavage Promotes Axon Regeneration

Yoo Jane Han, University of Chicago, USA
Short Talk: Circular RNAs Expressed from the BRCA1 Pseudogene Regulates Antiviral Immune Signaling in Breast Cancer Cells

Prasanth Kannanganattu, University of Illinois, USA
Short Talk: Nucleolus-Enriched Repeat-Containing Noncoding RNA Regulates rDNA Transcription.

Filipp Frank, Emory University, USA
Short Talk: SHAPE-MaP Identifies Two Structural Modules with Distinct Function in the lncRNA Growth Arrest Specific 5 (Gas5)

Haobo Li, Massachusetts General Hospital, USA
Short Talk: Inhibition of Novel Long Noncoding RNA lncExACT1 Induces Physiological Cardiac Hypertrophy

Fu-Kai Hsieh, Massachusetts General Hospital, USA
Short Talk: The lncRNA HERVH Negatively Regulates Chromatin Targeting and Remodeling Mediated by CHD7


Following Session is for RNA-Protein Interactions (X1)

8:00—11:15 AM
RNP Machines and Regulation
Registered attendees can view abstracts starting on 01/24/2019

Sea to Sky B
* Eric Lecuyer, Institut de Recherches Cliniques de Montreal, Canada Joint Institute, Canada

V. Narry Kim, Institute for Basic Science, South Korea
The Barricade Complex as A Rate-Limiting Blockade against mRNA Deadenylation

Rui Zhao, University of Colorado, USA
Structure and Function of the Spliceosome

Coffee Break

Yanli Wang, Chinese Academy of Sciences, China
CRISPR-Cas Mediated Cleavage of Invading RNAs

Erik Sontheimer, University of Massachusetts Medical School, USA
Enhancing Genome Editing with New Cas9s and Fully Stabilized Guides

Huating Wang, Chinese University of Hong Kong, China
Short Talk: MyoD-Induced Enhancer RNA Interacts with hnRNPL Protein via CAAA Motif to Activate Target Gene Transcription during Myogenic Differentiation

Simone Hoefler, Leibniz University Hanover, Germany
Short Talk: Structural and Functional Dissection of Eukaryotic snoRNP Complexes Catalyzing rRNA 2'-O-Ribose Methylations

Jiarui Song, Texas A&M University, USA
Short Talk: A Novel Plant-Specific Structural Element within the Arabidopsis Telomerase RNA

11:30 AM—5:00 PM
On Own for Lunch

2:30—4:30 PM
Workshop 2: Mechanistic Diversity of lncRNA

Sea to Sky C
* Jay W. Shin, RIKEN Yokohama, Japan

* Paulo P. Amaral, University of Cambridge, UK

Gabrijela Dumbovic, University of Colorado Boulder, USA
The Tug1 lncRNA Locus Is Essential for Male Fertility and Harbors a Tripartite DNA, lncRNA and Protein Functionality

Karen Wing Yee Yuen, University of Hong Kong, Hong Kong
Point Centromere Activity Requires an Optimal Level of Centromeric Non-Coding RNA

Thomas Alan Dixon-McDougall, University of British Columbia, Canada
Point Centromere Activity Requires an Optimal Level of Centromeric Non-Coding RNA

Jin-Wu Nam, Hanyang University, South Korea
En Bloc and Segmental Deletions of Human XIST Reveal X Chromosome Inactivation-Involving RNA Elements

Eddie Grinman, The Scripps Research Institute – Florida, USA
Investigating the Role of a Synaptically Targeted Intronic lncRNA in Memory Storage

Rotem Ben Tov Perry, Weizmann Institute of Science, Israel
Regulation of Neuroregeneration by Long Noncoding RNAs

Qing Lyu, University of Rochester, USA
B2M RNA Facilitates HSV-1 Gene Expression via Interacting with ASH2L and VP16

Karoline Kragh Ebbesen, Aarhus University, Denmark
Unraveling the Biogenesis and Function of the Circular RNA ciRS-7


Following Session is for RNA-Protein Interactions (X1)

2:30—4:30 PM
Workshop 2: RNA Modifications and Regulated RNA Processing

Sea to Sky B
Erin K. Borchardt, Yale University, USA
Investigating RNA Pseudouridylation Patterns in Viral Infection

Marisa J. L. Aitken, MD Anderson Cancer Center, USA
hnRNP K Overexpression Drives Myeloid Malignancy via Interaction with RUNX1

Alexander M. Price, Children's Hospital of Philadelphia, USA
Adenovirus Co-Opts Cellular m6A Modification Machinery to Facilitate Viral RNA Splicing and Protein Production

* Ramesh S. Pillai, University of Geneva, Switzerland
RNA Modifications and Regulation of Gene Expression

Sushant Bangru, University of Illinois, Urbana-Champaign, USA
Temporal Control of ESRP2 Licenses Fetal-to-Adult Switch in Alternative Splicing Required for Hepatocyte Maturation

* Bobby J. Hogg, NHLBI, National Institutes of Health, USA
hnRNP L-Dependent Protection of Normal mRNAs from NMD Subverts Quality Control in B Cell Lymphoma

Eleonora D'Ambra, Sapienza University of Rome, Italy
Study of FUS-Dependent circRNAs Function and Localization in Murine Motor Neurons

Xiao Song, Northwestern University, USA
SRSF3 Promotes Glioblastoma Progression Via Splicing Regulation of Alternative Exons

4:30—5:00 PM
Coffee Available

Grand Foyer
5:00—6:45 PM
RNA and RBP in Disease (Joint)
Registered attendees can view abstracts starting on 01/24/2019

Sea to Sky B/C
* Susan L. Ackerman, University of California, San Diego, USA

* Joakim Lundeberg, KTH-Royal Institute of Technology, Sweden

Fabrizio d'Adda di Fagagna, IFOM, The FIRC Institute of Molecular Oncology, Italy
Sequence-Specific Inhibition of Noncoding RNA Generated at Dysfunctional Telomeres Improves Progeric Phenotypes and Extends Lifespan in two Animal Species

Mofang Liu, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, China
A Novel Function of MIWI/piRNA in Activating Translation of Spermiogenic mRNAs during Spermiogenesis

Frank W. Rigo, Ionis Pharmaceuticals, USA
Targeting RNA with Antisense Oligonucleotides to Treat Disease

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Joint)
Registered attendees can view abstracts starting on 01/24/2019

Sea to Sky B/C
* Xiang-Dong Fu, University of California, San Diego, USA

* Saba Valadkhan, Case Western Reserve University, USA

* Piero Carninci, RIKEN Center for Integrative Medical Sciences, Japan

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Sea to Sky A

FRIDAY, MARCH 1

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Cell Research Ionis Pharmaceuticals, Inc.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 HG010292-01

Funding for this conference was made possible (in part) by 1 R13 HG010292-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Arraystar Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Ionis Pharmaceuticals, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676