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This meeting took place in 2019



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DNA Replication and Genome Instability: From Mechanism to Disease (A1)


Organizer(s) Karlene A. Cimprich, Mark J. O'Connor and Johannes C. Walter
January 13—17, 2019
Snowbird Resort • Snowbird, Utah USA
Discounted Abstract Deadline: Oct 4, 2018
Abstract Deadline: Oct 16, 2018
Scholarship Deadline: Oct 4, 2018
Discounted Registration Deadline: Nov 13, 2018

Organized in collaboration with Cancer Research UK

This activity is supported by an educational grant from Celgene Corporation

Sponsored by Editas Medicine, EMD Serono Research and Development Institute, Inc. and TESARO, Inc.

Summary of Meeting:
This conference will bring together scientists studying the most fundamental aspects of DNA replication and recombination, the organization and regulation of these processes at the cellular and molecular level, and their links to human disease. The aim is to disseminate the latest progress in this area, provide young scientists with the opportunity to present their work in a short talk or poster format, discuss the challenges and opportunities in developing basic research knowledge for the treatment of disease, and discuss the relevance of emerging work in other fields to genome instability and replication stress. Through talks and specialized workshops led by leaders in the field, the conference will cover single-molecule to cellular and genome-level studies, providing an integrated view of the relationship between DNA replication, recombination and genome instability.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, January 13 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 17 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, January 18 in order to fully experience the meeting.

SUNDAY, JANUARY 13

4:00—8:00 PM
Arrival and Registration

Ballroom Lobby
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Ballroom Lobby

MONDAY, JANUARY 14

7:00—8:00 AM
Breakfast

Golden Cliff/Eagles
8:00—9:30 AM
Welcome and Keynote Session
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Karlene A. Cimprich, Stanford University, USA

* Johannes C. Walter, Harvard Medical School, USA

David Cortez, Vanderbilt University School of Medicine, USA
Replication Fork Proteomes: How Many Proteins Are Needed?

Eric C. Greene, Columbia University, USA
Single Molecule Analysis of Recombination

Coffee Break

9:50—11:30 AM
The Influence of Chromatin on Replication and Repair
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Karlene A. Cimprich, Stanford University, USA

* Johannes C. Walter, Harvard Medical School, USA

Iestyn Whitehouse, Memorial Sloan Kettering Cancer Center, USA
Coordination of Transcription and DNA Replication during Embryogenesis

Gaelle Legube, Center for Integrative Biology, France
Chromatin and Chromosome Dynamics during DNA Double-Strand Break Repair

Andrew N. Blackford, University of Oxford, UK
Short Talk: How Cells Respond to DNA Double-Strand Breaks in Mitosis

Philipp Oberdoerffer, NCI, National Institutes of Health, USA
Short Talk: Epigenetic Control of Genome Stability at the Inactive X Chromosome

11:30 AM—5:00 PM
On Own for Lunch

11:30 AM—1:00 PM
Poster Setup

Superior/Superior Lobby/Wasatch
1:00—10:00 PM
Poster Viewing

Superior/Superior Lobby/Wasatch
2:30—4:30 PM
Workshop 1: Basic Mechanisms of Replication

Ballroom 2
* Joseph Yeeles, MRC Laboratory of Molecular Biology, UK

Bik Kwoon Tye, Hong Kong University of Science and Technology, Hong Kong
Selectivity for Replication Origins by the Origin Recognition Complex

Nynke H. Dekker, Delft University of Technology, Netherlands
In vitro Single-Molecule Fluorescence Studies of Yeast Replication

Neha Puri, Johns Hopkins University School of Medicine, USA
Structural and Functional Coupling of ATP Turnover to Replicative Helicase Loading and Activation

Conrad A. Nieduszynski, University of Oxford, UK
Capturing the Dynamics of DNA Replication on Individual Ultra-Long Nanopore Sequencing Reads

Marko Lõoke, Massachusetts Institute of Technology, USA
Life without Mcm10: Identification and Characterization of Mcm2-7 Mutations that Fully Bypass Mcm10 Function

Nicholas E. Dixon, University of Wollongong, Australia
A Primase-Induced Conformational Switch Controls Polymerase Exchange in the Bacterial Replisome

Tatiana Moiseeva, University of Pittsburgh, USA
ATR/Chk1-Dependent Replication Initiation Control in Undamaged Cells

2:30—4:30 PM
Workshop 2: Basic Mechanisms of Recombination

Ballroom 3
* Sharon B. Cantor, University of Massachusetts Medical School, USA

Wolf-Dietrich Heyer, University of California, Davis, USA
Mechanisms of Recombination: D-loop Reversal and Pathway Control

Akira Shinohara, Osaka University, Japan
Human RAD51 Paralog, SWSAP1, Promotes RAD51 Assembly by Regulating the Anti-Recombinase, FIGNL1 AAA+ATPase

Yizhou Joseph He, Dana-Farber Cancer Institute, USA
DYNLL1 Binds MRE11 to Limit DNA End Resection in BRCA1-Deficient Cells

Jordan Becker, University of Oxford, UK
The ASCIZ-DYNLL1 Axis Promotes 53BP1-Dependent Non-Homologous End-Joining and PARP Inhibitor Sensitivity

Yang Yu, Baylor College of Medicine, USA
Dna2 Nuclease Deficiency Results in Large and Complex DNA Insertions at Chromosomal Breaks

Dongyi Xu, Peking University, China
NAIF1-Constituted Nucleoskeleton Suppresses Chromosome Translocation and Tumorigenesis

Abigail Shea, CRUK Cambridge Institute, UK
A Co-Clinical Trial Investigating Targeted Agents in Breast Cancer Using Patient-Derived Tumour Xenograft Models

4:30—5:00 PM
Coffee Available

Ballroom Lobby
5:00—7:00 PM
Mechanisms of DNA Replication
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Bik Kwoon Tye, Hong Kong University of Science and Technology, Hong Kong

John F.X. Diffley, Francis Crick Institute, UK
Chromosome Replication: From Mechanism to Misregulation in Cancer

Joseph Yeeles, MRC Laboratory of Molecular Biology, UK
Short Talk: Cryo-EM Structures of a 1.4 MDa Eukaryotic Replisome Progression Complex

James M. Dewar, Vanderbilt University, USA
Short Talk: Multiple Roles for Topoisomerase IIα during Termination of Vertebrate DNA Replication

Johannes C. Walter, Harvard Medical School, USA
TRAIP: Master Regulator of ICL Repair and CMG Unloading

Kathleen Collins, University of California, Berkeley, USA
Telomerase Assembly and Action at Telomeres

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
7:30—10:00 PM
Poster Session 1

Superior/Superior Lobby/Wasatch

TUESDAY, JANUARY 15

7:00—8:00 AM
Breakfast

Golden Cliff/Eagles
8:00—11:00 AM
Mechanisms of Recombination and Repair
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Wolf-Dietrich Heyer, University of California, Davis, USA

Stephen C. West, Francis Crick Institute, UK
MutSβ Stimulates Holliday Junction Resolution by the SMX Tri-Nuclease

Anna Malkova, University of Iowa, USA
In Search for the Link between Alternative Lengthening of Telomeres and the Mode of Telomere Erosion

Aparna Gorthi, University of Texas Health at San Antonio, USA
Short Talk: Role of STAG2 in R-Loop Processing, Replication and Recombinational Repair

Coffee Break

Joseph J. Loparo, Harvard Medical School, USA
How Non-homologous End-Joining Avoids Mistakes

Agnel Sfeir, New York University School of Medicine, USA
Mechanism of Alternative End-Joining

Chao Dong, University of Hong Kong, China
Short Talk: Fine-Tuning of Transcriptional Activities at DSBs by the DYRK1 Kinases

11:00 AM—5:00 PM
On Own for Lunch

11:00 AM—1:00 PM
Poster Setup

Superior/Superior Lobby/Wasatch
1:00—10:00 PM
Poster Viewing

Superior/Superior Lobby/Wasatch
4:30—5:00 PM
Coffee Available

Ballroom Lobby
5:00—7:00 PM
Understanding and Exploiting Replication Stress
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* David Cortez, Vanderbilt University School of Medicine, USA

Massimo Lopes, University of Zürich, Switzerland
Replication Fork Remodeling upon Cancer-Relevant Replication Stress

Sharon B. Cantor, University of Massachusetts Medical School, USA
Short Talk: Defining Mechanisms that Subvert the Replication Stress Response in Cancer

Mark J. O'Connor, AstraZeneca, UK
Reversing PARP Inhibitor Resistance by Targeting the Replication Stress Response

Giorgia Federico, University of Naples Federico II, Italy
Short Talk: NCOA4 Protein Couples Iron Availability to DNA Replication

Sarah A.E. Lambert, Institute Curie, France
Nuclear Spatial Organization of Replication Fork Processing in Fission Yeast

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
7:30—10:00 PM
Poster Session 2

Superior/Superior Lobby/Wasatch

WEDNESDAY, JANUARY 16

7:00—8:00 AM
Breakfast

Golden Cliff/Eagles
8:00—11:00 AM
Overcoming Replication Fork Obstacles
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Catherine H. Freudenreich, Tufts University, USA

Karim Labib, University of Dundee, UK
The Mechanism of CMG Helicase Ubiquitylation and Disassembly

Ralph Scully, Beth Israel Deaconess Medical Center, USA
Recombination and Repair at Stalled Mammalian Replication Forks

Boris Pfander, Max Planck Institute of Biochemistry, Germany
Short Talk: Cell Cycle Phase-Specific Recognition and Processing of DNA Over-Replication Forks

Coffee Break

David Gallo, University of Toronto, Canada
Short Talk: Rad5 Recruits Error-Prone DNA Polymerases for Mutagenic Repair of ssDNA Gaps on Undamaged Templates

Alessandro Vindigni, St. Louis University, USA
PrimPol-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA1-Deficient Tumors

Wojciech Niedzwiedz, Institute of Cancer Research, UK
Short Talk: EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2

Sriram Sridharan, Center for Cancer Research, USA
Short Talk: Landscape of Replication Stress Induced DNA Damage Sites

11:00 AM—5:00 PM
On Own for Lunch

11:00 AM—1:00 PM
Poster Setup

Superior/Superior Lobby/Wasatch
1:00—10:00 PM
Poster Viewing

Superior/Superior Lobby/Wasatch
2:30—4:30 PM
Workshop/Panel Discussion 3: Translating Basic Science to the Clinic

Ballroom 2-3
* Mark J. O'Connor, AstraZeneca, UK

* Daniel Durocher, Lunenfeld-Tanenbaum Research Institute, Canada

Yves G. Pommier, NCI, National Institutes of Health, USA
Schlafen 11 (SLFN11), Replication Stress Executioner and its Potential Translation to the Clinic

Alan D. D'Andrea, Dana-Farber Cancer Institute, USA
PARP Inhibitor Resistance and Acquired Vulnerability

Lauren A. Byers, MD Anderson Cancer Center, USA
Targeting DNA Damage Response (DDR) in Lung Cancer

4:30—5:00 PM
Coffee Available

Ballroom Lobby
5:00—7:00 PM
RNA-Induced Genome Instability
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Gaelle Legube, Center for Integrative Biology, France

Karlene A. Cimprich, Stanford University, USA
The Causes and Consequences of Replication Stress

Andrew Jackson, University of Edinburgh, UK
The Fifth Element: Genomic Consequences of Embedded Ribonucleotides

Peter C. Stirling, University of British Columbia, Canada
Short Talk: Nuclease-Independent Functions of Mre11-Rad50-Nbs1 Coordinate Cellular R-Loop Tolerance

Jan-Gert Brüning, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Investigation of Replication-Transcription Collisions in vitro

Houra Merrikh, Vanderbilt University, USA
The Impact of DNA Topology on Replication-Transcription Conflicts

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
7:30—10:00 PM
Poster Session 3

Superior/Superior Lobby/Wasatch

THURSDAY, JANUARY 17

7:00—8:00 AM
Breakfast

Golden Cliff/Eagles
8:00—11:00 AM
Genomic Drivers of Tumorigenesis and Drug Resistance
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Agnel Sfeir, New York University School of Medicine, USA

Daniel Durocher, Lunenfeld-Tanenbaum Research Institute, Canada
Mapping DNA Damage Networks with CRISPR-Based Genetic Screens

Christopher Lord, Institute of Cancer Research, UK
Using Genetics to Understand Synthetic Lethal Sensitivity and Resistance to DDR Inhibitors

Violeta Serra, Vall d'Hebron Institute of Oncology, Spain
Short Talk: Lack of RAD51 Nuclear Foci Formation Identifies Homologous Recombination Repair (HRR)-Deficient,PARPi-Sensitive Tumors Beyond Germline BRCA1/BRCA2 Mutation

Coffee Break

Lee Zou, Harvard Medical School, USA
Roles of ATR in Countering APOBECs in Cancer Cells

Domenic Pilger, Sidney Sussex College, UK
Short Talk: ATM Orchestrates the DNA-Damage Response to Counter Toxic Non-Homologous End-Joining at Broken Replication Forks

Zachary Mirman, Rockefeller University, USA
53BP1/Rif1/Shieldin Counteract DSB Resection through CST/Pol Alpha-Dependent Fill-in

11:00 AM—5:00 PM
On Own for Lunch

2:30—4:30 PM
Workshop 4: Chromatin, Replication and Repair

Ballroom 2
* Evi Soutoglou, Institute of Genetics and Molecular and Cellular Biology, France
Double-Strand Break Relocation Correlates with Heterochromatic Repeat Clustering

Dominika T. Gruszka, Francis Crick Institute, UK
Replication-Coupled Parental Histone Dynamics Probed at Single Molecule Level

John K. Barrows, Medical University of South Carolina, USA
Establishing an in vitro System for Regulated Transcription and mRNA Processing

Caitlin Purman, Washington University in St. Louis, USA
Determining the Local Transcriptional Response to DNA Double-Strand Breaks in G1 Phase

Nataliia Serbyn, University of Geneva, Switzerland
The Aspartic Protease Ddi1 Contributes to DPC Repair in Yeast

Diana E. Libuda, University of Oregon, USA
Temperature Increases Cause Transposon-Associated DNA Damage Specific to Spermatocytes and Not Oocytes

Mihaela Todorova Peycheva, IMP - Research Institute of Molecular Pathology, Austria
DNA Replication Is Critical for the Genesis of AID-Dependent Chromosomal Translocations in B Cells

2:30—4:30 PM
Workshop 5: Replication Stress and DNA Damage Signaling

Ballroom 3
* Niels Mailand, University of Copenhagen, Denmark
Profiling Cellular Signaling Responses to DNA-Protein Crosslinks

Kristijan Ramadan, University of Oxford, UK
SPRTN Protease and Checkpoint Kinase 1 Cross-Activation Loop Safeguards DNA Replication

Ya-Chu Chang, University of Minnesota, USA
Uncovering the Molecular Dynamics Upon Replication Fork Stalling using Proteomics

Claus Sørensen, University of Copenhagen, Denmark
CtIP Variants Associated with Early-Onset Breast Cancer Compromise Replication Fork Stability

Sarem Hailemariam, Washington University, USA
Rif2 Inhibits the MRX-Dependent Activation of Tel1 Kinase

Robin van Schendel, Leiden University Medical Center, Netherlands
Okazaki Fragment Deposition Dictates Deletion Mutagenesis at Persistent Replication Fork Barriers

Catherine H. Freudenreich, Tufts University, USA
Collapsed Forks Caused by Expanded CAG Repeats Relocate to the Nuclear Pore in a Manner Dependent on SUMOylation of Repair Proteins

4:30—5:00 PM
Coffee Available

Ballroom Lobby
5:00—6:45 PM
Linking DNA Damage Response to the Immune Response
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Andrew Jackson, University of Edinburgh, UK

Roger A. Greenberg, University of Pennsylvania, USA
DNA Damage Signaling to the Immune System

Alberto Bardelli, University of Torino, Italy
Inactivation of DNA Repair to Improve Immune Surveillance

Sophie Postel-Vinay, Gustave Roussy Cancer Campus, France
Combining DNA Damage Response (DDR) Inhibitors with Immunotherapy: The Next Step Change in Cancer Therapy?

Timo Reislander, University of Oxford, UK
Short Talk: PARP Inhibitors Potentiate Cell-Intrinsic Immune Responses Triggered by BRCA2 Inactivation

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ballroom 1-2
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Ballroom 1-2

FRIDAY, JANUARY 18

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Organized in collaboration with Cancer Research UK This activity was supported by an educational grant from Celgene Corporation.
Editas Medicine EMD Serono Research and Development Institute, Inc.
TESARO, Inc.
 

We gratefully acknowledge additional support for this conference from:

AstraZeneca

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676