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This meeting took place in 2001



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Molecular and Cellular Aspects of Tuberculosis Research in the Post Genome Era (B1)


Organizer(s) Gilla Kaplan, Stewart T. Cole, and Patrick J. Brennan
January 25—30, 2001
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Sep 25, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 27, 2000

Summary of Meeting:
Tuberculosis is of epidemic proportions in vast areas of Africa, Asia, Eastern Europe and South and Central America. In 1997 there were 3 million deaths due to tuberculosis. This disease is the leading infectious cause of death in the world today. In the absence of any effective control, the projected number of deaths will reach 4 million by the year 2004. Drug-resistant strains are emerging, and are a major public health problem in the developing world, as well as in Europe and the U.S.A. Despite recent knowledge of mechanisms of drug activity and drug resistance, few new effective drugs have been developed. With the completion of the genome sequence for M. tuberculosis, new avenues of research are possible, including targeted drug development, identification and characterization of antigens for vaccine and diagnostic studies, and the definition of those factors which render the bacilli virulent and pathogenic. Therefore, the aims of this meeting are: to review the latest knowledge obtained from the genome sequence of M. tuberculosis; to dissect the cell biology of M. tuberculosis interaction within the host cell; to understand the molecular basis of strain differences and patterns of transmission; to explore mechanisms of pathogenesis and protective immunity; to understand how the immune response may be manipulated to enhance the host defense against TB. The exchange of knowledge among epidemiologists, cell biologists, immunologists, biochemists, microbial geneticists, and biotechnology scientists will define the direction of new therapies, diagnostics and vaccines.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


THURSDAY, JANUARY 25

2:00—7:00 PM
Registration

Chamisa Lobby
6:15—7:15 PM
Welcome

Chamisa Lobby
7:15—7:30 PM
Orientation

Chamisa Ballroom 2
7:30—8:30 PM
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2

FRIDAY, JANUARY 26

7:00—8:00 AM
Breakfast

Los Vaqueros
8:00—11:00 AM
Genomics/Post-Genomics
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
Stewart T. Cole, École Polytechnique Fédérale de Lausanne, Switzerland
Comparative Mycobacterial Genomics

Peter R. Jungblut, Max-Planck Institute for Infection Biology, Germany
Proteomics of the M. tuberculosis Complex

Brigitte C. Gicquel, Institut Pasteur, France
Functional genomics of M. tuberculosis

Marcel A. Behr, McGill University, Canada
On the Origin of BCG

9:20—9:40 AM
Coffee Break

11:00 AM—1:00 PM
Poster Setup

Chamisa Ballroom 1
2:30—4:30 PM
Workshop 1: TB Structural Genomics

2:30—4:30 PM
Workship 4: Immunodiagnosis of Tuberculosis

4:30—6:30 PM
POSTER SESSION 1: Advances in Colorectal Cancer Screening/Novel Mechanisms

Chamisa Ballroom 1
5:30—6:30 PM
Social Hour

Chamisa Ballroom 1
7:50—8:10 PM
Coffee Break

Chamisa Lobby
6:30—9:30 PM
Genetic Diversity of M. tuberculosis
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
Graham F. Hatfull, University of Pittsburgh, USA
MycobacterioPhages: Novel Systems of Gene Regulation

Peter M. Small, Bill & Melinda Gates Foundation, USA
comparing Genomes Within the Species Mycobacterium tuberculosis


SATURDAY, JANUARY 27

7:00—8:00 AM
Breakfast

Los Vaqueros
8:00—11:00 AM
Tumor Markers
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
Douglas B. Young, Imperial College London, UK
Reporting on Host Cell Interactions

David G. Russell, Cornell University, USA
Mycobacterium and the Environment Within the Phagocyte

Alan Aderem, Center for Infectious Disease Research, USA
Macrophage Phagocytosis of Pathogens: From Genes to Function

Samuel M. Behar, University of Massachusetts Medical School, USA
The role of CD1 and NKT Cells in tuberculosis

9:20—9:40 AM
Coffee Break

Chamisa Lobby
11:00 AM—1:00 PM
Poster Setup

Chamisa Ballroom 1
2:30—4:30 PM
Workshop 2: The Antigen-85 Complex of M. tuberculosis: Structure, Function and Immunogenicity

4:30—6:30 PM
POSTER SESSION 2: Tumor Markers/Tumor Vaccines and Other Novel Therapies

Chamisa Ballroom 1
5:30—6:30 PM
Social Hour

Chamisa Ballroom 1
7:50—8:10 PM
Coffee Break

Chamisa Lobby
6:30—9:30 PM
Tumor Vaccines and Other Novel Therapies. Session Sponsored by Pharmacia Corporation.
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
Clifton E. Barry III, NIAID, National Institutes of Health, USA
Deveopment of a Second-Generation Ethambutol

Mamadou Daffé, Centre National de la Recherche Scientifique, France
Deciphering the Lipid Partners of the Cell Wall Diffusion Barrier of Mycobactera

James C. Sacchettini, Texas A & M University, USA
Structure-based Design of Novel Anti-tuberculars

Patrick J. Brennan, College of Veterinary Medicine, Colorado State University, USA
Aspects of Biosynthesis of Mycobacterial Cell Walls


SUNDAY, JANUARY 28

7:00—8:00 AM
Breakfast

Los Vaqueros
8:00—11:30 AM
Chemoprevention. Session Sponsored by Merck & Co., Inc.
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
Gilla Kaplan, Bill & Melinda Gates Foundation, USA
The Regulation of Host Protective Immunity to M. tuberculosis Infection

M. Joseph Colston, Medical Research Council,
Activation of Dendritic Cells and Priming of Immune Responses by Mycobacterium tuberculosis

Tom H. M. Ottenhoff, Leiden University Medical Center, Netherlands
Role of Type-1 Cytokines and T Cells in Human Mycobacterial Infectious Diseases

Paul Fine, London School Hygiene and Tropical Medicine, UK
BCG: Efficacy and Immunity

9:20—9:40 AM
Coffee Break

Chamisa Lobby
11:00 AM—1:00 PM
Poster Setup

Chamisa Ballroom 1
2:30—4:30 PM
Workshop 3: The Academic-Industrial Interface: Research RFunding and Product Development

4:30—6:30 PM
POSTER SESSION 3: Chemoprevention/Genomic Profiling/Gene Testing

Chamisa Ballroom 1
5:30—6:30 PM
Social Hour

Chamisa Ballroom 1
7:50—8:10 PM
Coffee Break

Chamisa Lobby
6:30—9:30 PM
Genomic Profiling
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
Camille Locht, Institut Pasteur de Lille, France
Biochemical, Functional and Immunological Characterization of the Heparin-Binding Hemagglutinin Adhesin of Mycobacterium tuberculosis

John D. McKinney, Swiss Federal Institute of Technology (EPFL), Switzerland
Chewing hte Fat: In vivo Metabolism of Mycobacterium tuberculosis

John T. Belisle, Colorado State University, USA
Quorum Sensing and Growth Regulation in Mycobacterum tuberculosis


MONDAY, JANUARY 29

7:00—8:00 AM
Breakfast

Los Vaqueros
8:00—11:00 AM
Gene Testing
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany
Cellular Immune Response Against Mycobacterium tuberculosis

David N. McMurray, Texas A & M University, USA
Animal Modelsof Pulmonary Tuberculosis: What are they Telling Us about Resistance to Disease

Bryce M. Buddle, Wallaceville Animal Research Center, New Zealand
Cattle: The Ultimate Animal Model

JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA
Immune Responses Important in Laten tuberculosis: Studies in Animal Models

9:20—9:40 AM
Coffee Break

Chamisa Lobby
5:00—6:00 PM
Workshop: New Genomic Technologies and Modern Medicine

Chamisa Ballroom 2
5:00—6:00 PM
Coffee Available

Chamisa Lobby
7:00—8:00 PM
Social Hour

Chamisa Lobby
8:00—10:00 PM
Banquet

Chamisa Ballroom 1
9:00 PM—12:00 AM
Entertainment

Chamisa Ballroom 1

TUESDAY, JANUARY 30

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI48914-01




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