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This meeting took place in 2004



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Molecular Biology of Cardiac Disease (X3)


Organizer(s) Jonathan G. Seidman and Christine E. Seidman
March 7—12, 2004
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Nov 24, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 7, 2004

Sponsored by The Director's Sponsor Fund


Summary of Meeting:
Modern technologies are identifying the molecular mechanisms leading to heart disease, a leading cause of death in the United States. Over the past several years, mutations leading to some forms of hypertrophic cardiomyopathy, dilated cardiomyopathy, cardiac arrhythmias, atrial fibrillation, and congenital heart disease have been identified. The process of disease gene identification continues and we anticipate that new discoveries will be discussed at this meeting. Most of these disease gene identifications define steps in cardiac development or cardiac physiology. The identification of disease causing mutations leads to new challenges: How do these mutations cause disease? Does understanding the mechanisms that lead to disease lead to therapies? Bringing together cardiac physiologists, developmental biologists, human geneticists and cardiologists will allow interactions that should help address these questions.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


SUNDAY, MARCH 7

3:00—7:00 PM
Registration

Longs Peak Foyer
6:15—7:15 PM
Refreshments

Longs Peak Foyer
7:15—7:30 PM
Orientation

Grays/Longs Peak
7:30—8:30 PM
Keynote Address: Molecular Motors
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Christine E. Seidman, Harvard Medical School, USA

James A. Spudich, Stanford University, USA
The Myosin Family of Molecular Motors: Diversity of Function and Mechanism


MONDAY, MARCH 8

7:00—8:00 AM
Breakfast

Shavano/Torreys
8:00—11:00 AM
Sarcomere Proteins and Hypertrophy
Meeting has ended...abstracts no longer viewable online.

Grays
Jonathan G. Seidman, Harvard Medical School, USA
Hypertrophic Cardiomyopathy in Mice and Man

Neal D. Epstein, National Institutes of Health, USA
The Role of Myosin Light Chain Phosphorylation in Regulating the Cardiac Stretch-Activation Response

* Leslie A. Leinwand, University of Colorado Boulder, USA
Molecular Mechanisms of Cardiac Adaptations

Deborah L. Yelon, University of California, San Diego, USA
Primary and Secondary Effects of Chamber-Specific Myosin Heavy Chain Defects in Zebrafish

Sharlene M. Day, University of Michigan, USA
Short Talk: Transgenic and Gene Transfer-Based Expression of Cardiac Troponin I Mutant A164H Increases Myofilament Calcium Sensitivity Under Acidic Conditions

8:00—11:00 AM
Cardiac Specification
Meeting has ended...abstracts no longer viewable online.

Longs Peak
Manfred Frasch, Mount Sinai School of Medicine, USA
Induction and Function of T-Box Genes during Cardiac and Visceral Muscle Specification in Drosophila

Andrew B. Lassar, Harvard Medical School, USA
Signaling Pathways that Regulate Heart Formation

* Mark Mercola, Stanford University, USA
Molecular Relays for Heart Induction: Identification of Proteins that Act Downstream of Wnt Antagonists and Notch to Regulate Cardiac Cell Fate

Richard P. Harvey, University of New South Wales, Victor Chang Cardiac Research Institute, Australia
Transcriptional Control of Cardiac Chamber Formation

Ching-Pin Chang, Indiana University, USA
Short Talk: Repression of VEGF Expression by NFAT Underlies Initiation of Heart Valve Morphogenesis

9:20—9:40 AM
Coffee Break

Longs Peak Foyer
11:00 AM—1:00 PM
Poster Setup

Shavano/Torreys
1:00—10:00 PM
Poster Viewing

Shavano/Torreys
4:30—5:00 PM
Coffee & Snacks Available

Longs Peak Foyer
5:00—7:00 PM
Cross Species Approach to Cardiac Development and Disease (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs
* Jonathan G. Seidman, Harvard Medical School, USA

Eric N. Olson, University of Texas Southwestern Medical Center, USA
Transcriptional Regulation in Cardiac Development and Disease

* Deepak Srivastava, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA
Cardiac Developmental Genes: Implications for Childhood and Adult Disease

Christine E. Seidman, Harvard Medical School, USA
Deciphering Genetic Remodeling of the Human Heart in Zebrafish

Karl Ludwig Laugwitz, Technical University Munich, Germany
Short Talk: Identification, Renewal and Differentiation of Postnatal is l1+ Cardioblasts

7:00—8:00 PM
Social Hour

Shavano/Torreys
7:30—10:00 PM
Poster Session 1

Shavano/Torreys

TUESDAY, MARCH 9

7:00—8:00 AM
Breakfast

Shavano/Torreys
8:00—11:15 AM
Electrophophysiologic Disorders
Meeting has ended...abstracts no longer viewable online.

Grays
Kenneth R. Chien, Karolinska Institutet, Sweden
Cardiomyopathy, Conduction, and Cardioblasts: New Genetic Insights and Model Systems

J. Kevin Donahue, Johns Hopkins University, USA
Gene Therapy for Cardiac Arrhythmias

* Glenn I. Fishman, New York University School of Medicine, USA
Modeling the Conduction System

D. Woodrow Benson, Cincinnati Children's Hospital, USA
Genetic Origins of Cardiac Arrhythmias in the Young

Sameer S. Chopra, Vanderbilt University School of Medicine, USA
Short Talk: The Zebrafish as a Model for the Functional Analysis of Cardiac Sodium Channel alpha and beta Subunits

Antoinette Groenewegen, , Netherlands
Short Talk: Association of Human Connexin40 Gene Polymorphisms with Atrial Vulnerability for Initiation of Idiopathic Atrial Fibrillation

8:00—11:00 AM
Cardiac Patterning and Chamber Formation
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Antoon F.M. Moorman, University of Amsterdam, Netherlands
Development of the Building Plan of the Heart

Didier Stainier, Max Planck Institute for Heart and Lung Research, Germany
Cardiovascular Development in Zebrafish

Margaret E. Buckingham, Institut Pasteur, France
The Origin of Myocardial Cells and their Oriented Cell Growth during Heart Morphogenesis

Jonathan A. Epstein, University of Pennsylvania, USA
The Homeodomain Only Protein, Hop, in Development, Hypertrophy and Heart Failure

Jose Luis de la Pompa, Centro Nacional de Investigaciones Cardiovasculares, Spain
Short Talk: Notch Promotes Epithelial-Mesenchymal Transition during Cardiac Development and Oncogenic Transformation

9:20—9:40 AM
Coffee Break

Longs Peak Foyer
11:00 AM—1:00 PM
Poster Setup

Shavano/Torreys
1:00—10:00 PM
Poster Viewing

Shavano/Torreys
4:30—5:00 PM
Coffee & Snacks Available

Longs Peak Foyer
5:00—7:00 PM
Congenital Heart Disease/Genetics of Pediatric Heart Disease (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs
* Christine E. Seidman, Harvard Medical School, USA

Jeffrey A. Towbin, Cincinnati Children's Hospital Medical Center, USA
Genetics of Pediatric Cardiomyopathies and CHD

Vidu Garg, Ohio State University/Nationwide Children's Hospital, USA
The Role of GATA4 in Congenital Heart Disease

Cecilia W. Lo, University of Pittsburgh, USA
ENU Mutagenesis and Mouse Mutations Causing Congenital Heart Defects

Jean-Jacques Schott, INSERM, France
Short Talk: Genetics of Valvular Diseases

7:00—8:00 PM
Social Hour

Shavano/Torreys
7:30—10:00 PM
Poster Session 2

Shavano/Torreys

WEDNESDAY, MARCH 10

7:00—8:00 AM
Breakfast

Shavano/Torreys
8:00—11:00 AM
Cardiac Regeneration (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs
Michael D. Schneider, Imperial College London, UK
Cardiac Progenitor Cells from Adult Myocardium

Bernardo Nadal-Ginard, New York Medical College, USA
Cardiac Stem Cells and Myocardial Regeneration

* Nadia A. Rosenthal, The Jackson Laboratory, USA
Growth Factor Enhancement of Cardiac Regeneration

Stefanie Dimmeler, University of Frankfurt, Germany
Circulating Progenitor Cells for Vasculogenesis and Cardiac Regeneration

Ellen Heber-Katz, Lankenau Institute for Medical Research, USA
Short Talk: MRL Mouse Heart Healing Using Bone Marrow Chimeras Shows Host Dominance

9:20—9:40 AM
Coffee Break

Longs Peak Foyer
11:00 AM—1:00 PM
Poster Setup

Shavano/Torreys
1:00—10:00 PM
Poster Viewing

Shavano/Torreys
4:30—5:00 PM
Coffee & Snacks Available

Longs Peak Foyer
5:00—7:15 PM
Signaling in Cardiac Remodeling
Meeting has ended...abstracts no longer viewable online.

Grays
Richard T. Lee, Harvard University, USA
Mechanotransduction and Two Interesting Puzzles in Cardiomyopathy

Rhonda Bassel-Duby, University of Texas Southwestern Medical Center, USA
Control of Muscle Growth and Remodeling by Calcium-Dependent Signaling

* R. Sanders Williams, Duke University Medical Center, USA
Calcium Regulated Gene Transcription in Myocyte Remodeling

Miei Shimura, Yokosuka City Hospital, Japan
Short Talk: Sarcalumenin, a Sarcoplasmic Reticulum Luminal Ca2+ Binding Protein Plays an Important Role in Maintaining Cardiac Function

Jonathan A. Stiber, Duke University, USA
Short Talk: Homer Proteins Influence Muscle Remodeling Through the Calcineurin Signaling Pathway

5:00—7:00 PM
Pharyngeal Arch and Neural Crest Development
Meeting has ended...abstracts no longer viewable online.

Longs Peak
Erik N. Meyers, Duke University Medical Center, USA
Fgf8 Signaling in Cardiovascular Development

Antonio Baldini, Institute of Genetics and Biophysics, Italy
Dissection of the Cardiovascular Phenotype in Mouse Models of DiGeorge Syndrome

* Margaret L. Kirby, Duke University Medical Center, USA
Collaboration of Cardiac Neural Crest and Caudal Pharynx is Needed for Patterning the Preseptation Arterial Pole

Aaron D. Gitler, Stanford University School of Medicine, USA
Short Talk: PlexinD1 is a Novel Endothelial-Specific Semaphorin Receptor Essential for Outflow Tract Septation and Aortic Arch Artery Patterning

7:00—8:00 PM
Social Hour

Shavano/Torreys
7:30—10:00 PM
Poster Session 3

Shavano/Torreys

THURSDAY, MARCH 11

7:00—8:00 AM
Breakfast

Shavano/Torreys
8:00—11:15 AM
Pathways to Dilated Cardiomyopathy
Meeting has ended...abstracts no longer viewable online.

Grays
* Andrew R. Marks, Columbia University College of Physicians and Surgeons, USA
A Unifying Principle Underlying Cardiac Arrhythmias and Heart Failure

Luisa Mestroni, University of Colorado Denver-AMC, USA
Genotype/Phenotype Correlations in Dilated Cardiomyopathy

Kevin P. Campbell, University of Iowa, USA
Dystroglycan, Dysferlin and Cardiomyopathy

Elizabeth M. McNally, Northwestern University, USA
Genetic Diversity in Cardiomyopathy

David H. MacLennan, University of Toronto, Canada
Short Talk: Identification of Biochemical Adaptations in Hyper- or Hypocontractile Hearts from Phospholamban Mutant Mice by Expression Proteomics

Charles Redwood, University of Oxford, UK
Short Talk: Dilated Cardiomyopathy-Causing Mutations in Troponin T, Troponin C and alpha-Tropomyosin Reduce Ca2+-Sensitivity and Maximum Activation

8:00—11:00 AM
Signaling Pathways in Cardiac Development
Meeting has ended...abstracts no longer viewable online.

Longs Peak
Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA
Genetic Control of Cardiac Development and Aging

* H. Joseph Joseph Yost, University of Utah, USA
Cell Signaling in Cardiac Left-Right Development

Martina Brueckner, Yale University School of Medicine, USA
Cilia are at the Heart of the Development of Left-Right Asymmetry

Tom Gridley, The Jackson Laboratory, USA
Notch Signaling in Cardiovascular Development and Disease

Deborah L. Yelon, University of California, San Diego, USA
Short Talk: Retinoic Acid Signaling Restricts the Cardiac Progenitor Pool

9:20—9:40 AM
Coffee Break

Longs Peak Foyer
4:30—5:00 PM
Coffee & Snacks Available

Longs Peak Foyer
5:00—7:15 PM
Models of Human Heart Disease
Meeting has ended...abstracts no longer viewable online.

Grays
Harry (Hal) C. Dietz, Johns Hopkins University School of Medicine, USA
Novel Insights into Pathogenesis and Therapy of Marfan Syndrome

Craig T. Basson, Weill Medical College of Cornell University, USA
Molecular Genetic Mechanisms Underlying PKA-Dependent Cardiac Tumorigenesis

* Jeffrey Robbins, Cincinnati Children's Hospital Medical Center, USA
The Desmin-Related Cardiomyopathies: Form and Function

Mark T. Keating, Novartis Institutes for BioMedical Research, USA
Cardiac Regeneration

5:00—7:00 PM
Transcriptional Circuits in Cardiomyocyte Development
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Robert J. Schwartz, Texas A&M University, USA
Serum Response Factor a Master Cardiogenic Regulatory Platform and a Novel Phosphorylatable Gene Switch Target

William T. Pu, Children's Hospital, Harvard Medical School, USA
Regulation of Heart Development by GATA4: Distinct Functional Requirements in the Endocardium and Myocardium

Robert A. Schulz, University of Texas MD Anderson Cancer Center, USA
Transcriptional Control of Heart Morphogenesis in Drosophila

7:00—8:00 PM
Social Hour

Quandary Peak
8:00—11:00 PM
Entertainment

Quandary Peak

FRIDAY, MARCH 12

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HL076493-01




We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676