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This meeting took place in 2004



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NF-kappaB: Biology and Pathology (A4)


Organizer(s) Ulrich K. Siebenlist, Anjana Rao and Sankar Ghosh
January 11—16, 2004
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Sep 17, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 11, 2003

Sponsored by Lilly Research Laboratories and the Director's Sponsor Fund

Summary of Meeting:
Upon completion of this conference, participants should be able to: - Understand the activation mechanisms and functions of NF-kappaB transcription factors in various biologic contexts, including innate immunity. - Gain insight into the multiple modes of regulation that govern NF-kappaB activity, with a new emphasis on actions at the promoter/chromatin level. - Identify novel molecular targets for therapeutic intervention, particularly those potentially related to specific NF-kappaB-activation signals and/or specific NF-kappaB-controlled genes. - Examine the mechanisms by which NF-kappaB can be inappropriately activated in disease and the specific functions of NF-kappaB that can contribute to disease, such as its anti-apoptotic functions in promoting cancer. - Develop new collaborations among attendees, promoted by the mix of scientists with diverse backgrounds ranging from immunobiology and inflammatory diseases to signal transduction, chromatin regulation and cancer.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


SUNDAY, JANUARY 11

3:00—7:00 PM
Registration

Ballroom Mezzanine
6:15—7:15 PM
Refreshments

Ballroom Mezzanine
7:15—7:30 PM
Orientation

Ballroom 2-3
7:30—8:30 PM
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Michael Karin, University of California, San Diego, USA
The IkB Kinase (IKK) – A Signaling Machine and its Role in Innate and Adaptive Immunity


MONDAY, JANUARY 12

7:00—8:00 AM
Breakfast

Golden Cliff/Eagles Nest
8:00—11:00 AM
Structure and Regulation Session Sponsored in part by Celgene Signal Research Division
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* David Baltimore, California Institute of Technology, USA

Gourisankar Ghosh, University of California, San Diego, USA
PSO Homodimer: Generations and Ligand Binding

Yinon M. Ben-Neriah, Hebrew University, Hadassah Medical School, Israel
Control of IkappaB Degradation

Warner Craig Greene, Gladstone Institute of Virology and Immunology, USA
A Role for NF-kappaB/Rel Transcription Factors in Spatial Learning and Memory

Lin Chen, University of Southern California, USA
Structural and Biochemical Analyses of NFAT Complexes

Shigeki Miyamoto, University of Wisconsin, Madison, USA
Short Talk: NF-kappaB Activation by Genotoxic Stress Inducers

9:20—9:40 AM
Coffee Break

Ballroom Mezzanine
11:00 AM—1:00 PM
Poster Setup

Wasatch, Maybird, Superior
1:00—10:00 PM
Poster Viewing

Wasatch, Maybird, Superior
2:00—4:00 PM
Workshop 1: Regulatory Pathways

Ballroom 2-3
* Jorge Moscat, Sanford Burnham Prebys Institute, USA
Control of NF-kappaB and the Immune Response by zetaPKC and its Modulators Par-4 and p62

M. Frances Shannon, Australian National University, Australia
C-Rel, T Cell Activation and Chromatin

Mark R. Boothby, Vanderbilt University Medical Center, USA
The NF-kappaB Signaling Network in T Cell Survival and Effector Function

Guido Franzoso, Imperial College London, UK
The Control of JNK Signaling and Apoptosis by NF-kappaB

Xiaoxia Li, Cleveland Clinic Foundation, USA
Act1, A Negative Regulator in CD40- and BAFF-Mediated B Cell Survival

Jun-Ichiro Inoue, University of Tokyo, Japan
Identification of TIFA as an Adapter Protein that Links TRAF6 to IRAK-1

4:30—5:00 PM
Coffee & Snacks Available

Ballroom Mezzanine
5:00—7:00 PM
New Functions for NF-kappaB and NFAT
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Sankar Ghosh, Columbia University, USA

David Baltimore, California Institute of Technology, USA
NF-KappaB in Neurons

Inder M. Verma, The Salk Institute, USA
Regulation of NF-kappaB Activity

Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
NFAT, a Family of Transcription Factors Related to Rel/ NFkappaB

7:00—8:00 PM
Social Hour

Wasatch, Maybird, Superior
7:30—10:00 PM
Poster Session 1

Wasatch, Maybird, Superior

TUESDAY, JANUARY 13

7:00—8:00 AM
Breakfast

Golden Cliff/Eagles Nest
8:00—11:00 AM
Immunology
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Alain Israël, Institut Pasteur, France

Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
and

Ulrich K. Siebenlist, NIAID, National Institutes of Health, USA
Regulatory Pathways of NF-kappaB in Biologic Context

Marc Schmidt-Supprian, Max Planck Institute of Biochemistry, Germany
IKK Signaling in Lymphocyte Differentiation and Homeostasis

Steve D. Gerondakis, Monash University, Australia
Rel/NF-kappaB and Call Activation in the Immune System

Hsiou-Chi Liou, Weill Medical College of Cornell University, USA
C-Rel in Antigen Receptor-Mediated Lymphocyte Activation and Selection

Céline Gélinas, Center for Advanced Biotechnology and Medicine, USA
Insights into Rel/NF-kappaB Function in the Oncogenic Transformation of Lymphocytes

9:20—9:40 AM
Coffee Break

Ballroom Mezzanine
11:00 AM—1:00 PM
Poster Setup

Wasatch, Maybird, Superior
1:00—10:00 PM
Poster Viewing

Wasatch, Maybird, Superior
4:30—5:00 PM
Coffee & Snacks Available

Ballroom Mezzanine
5:00—7:00 PM
Innate Immunity
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany

Shizuo Akira, Osaka University, Japan
Toll-Like Receptor Signaling

Gabriel Nuñez, University of Michigan, USA
NODs: Cytosolic Proteins Involved in Innate Immunity and Inflammatory Disease

Zhijian James Chen, University of Texas Southwestern Medical Center, USA
Ubiquitin Signaling in the NF-kappaB Pathway

7:00—8:00 PM
Social Hour

Wasatch, Maybird, Superior
7:30—10:00 PM
Poster Session 2

Wasatch, Maybird, Superior

WEDNESDAY, JANUARY 14

7:00—8:00 AM
Breakfast

Golden Cliff/Eagles Nest
8:00—11:30 AM
Chromatin, Targets and Pathology
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Inder M. Verma, The Salk Institute, USA

* Michael Karin, University of California, San Diego, USA

Sankar Ghosh, Columbia University, USA
Regulation of NF-kappaB Transcriptional Activity

Albert S. Baldwin Jr., University of North Carolina School of Medicine, USA
Regulation of NF-kappaB Function by the IKKs and Other Signal Transduction Pathways

Shao-Cong Sun, University of Texas MD Anderson Cancer Center, USA
Novel Signaling Functions of NF-kappaB and IKK

Gioacchino Natoli, Humanitas University, Italy
An Essential Contribution of p65 Degradation to NF-kappaB Response Termination

Gail E. Sonenshein, Boston University Medical School, USA
Roles and Regulation of NF-kappaB/Rel in Breast Cancer

Gary J. Nabel, Sanofi, USA
Murr1 Inhibits NF-kappaB Activation and Restricts HIV Replication in Resting and Activated T Cells through its Effects on the Proteasome

9:20—9:40 AM
Coffee Break

Ballroom Mezzanine
11:30 AM—1:00 PM
Poster Setup

Wasatch, Maybird, Superior
1:00—10:00 PM
Poster Viewing

Wasatch, Maybird, Superior
2:00—4:00 PM
Workshop 2: Pathology to Clinic

Ballroom 2-3
* Thomas D. Gilmore, Boston University, USA
The REL Transcription Factor as a Molecular Target in Human Lymphoma

Guy Haegeman, Ghent University, Belgium
Repression of Inflammatory Gene Expression by Phyto-Estrogen

Towia A. Libermann, Beth Israel Deaconess Medical Center, USA
New Insights into the Anti-Apoptotic Function of NF-kappaB in Cancer Cells

Vincent M. Bours, University of Liege, Belgium
Regulation of Bcl-3 Oncogenic Potential by Phosphorylation

Bruce H. Horwitz, Brigham and Women's Hospital, USA
Inhibition of Pathological Inflammatory Responses by NF-kappaB Subunits p50 and p65

Neil D. Perkins, University of Newcastle, UK
Repression of Anti-Apoptotic Gene Expression by RelA(p65) NF-kappaB

4:30—5:00 PM
Coffee & Snacks Available

Ballroom Mezzanine
5:00—7:00 PM
Model Organisms
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Ulrich K. Siebenlist, NIAID, National Institutes of Health, USA

Ruth Steward, Rutgers University, USA
NF-kappaB/Rel Pathways in Drosophila.

Dominique Ferrandon, Institute of Cellular and Molecular Biology, France
Activation of NF-kappaB Members in Drosophila Immunity

Steven A. Wasserman, University of California, San Diego, USA
Toll Signaling in Drosophila

7:00—8:00 PM
Social Hour

Wasatch, Maybird, Superior
7:30—10:00 PM
Poster Session 3

Wasatch, Maybird, Superior

THURSDAY, JANUARY 15

7:00—8:00 AM
Breakfast

Golden Cliff/Eagles Nest
8:00—11:30 AM
Pathology
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Anjana Rao, La Jolla Institute for Allergy and Immunology, USA

Alain Israël, Institut Pasteur, France
Biochemical and Genetic Analysis of the NF-kappaB Signaling Pathway

Claus Scheidereit, Max Delbrück Center for Molecular Medicine, Germany
Activation and Homeostatic Control of IKK and NF-kappaB in Oncogenesis and Innate Immunity

Alexander Hoffmann, University of California, Los Angeles, USA
Mechanisms that Generate Stimulus Specificity in the NF-kappaB Pathway

Elliott D. Kieff, Harvard University, USA
Role of TRAF6 and IRAK1 in LMP1 Induced NF-kappaB Activation

George Mosialos, B.S.R.C. Alexander Fleming, Greece
Short Talk: Regulation of NF-kappaB by the Cylindromatosis Tumor Suppressor Gene Product

Manolis Pasparakis, University of Cologne, Germany
Short Talk: Analysis of the Function of IKK2 and NEMO in Adult Mice by Conditional Targeting

9:20—9:40 AM
Coffee Break

Ballroom Mezzanine
4:30—5:00 PM
Coffee & Snacks Available

Ballroom Mezzanine
5:00—7:00 PM
Pathology to Clinic. Session Sponsored in part by GlaxoSmithKline Research & Development Ltd.
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Albert S. Baldwin Jr., University of North Carolina School of Medicine, USA

Louis M. Staudt, NCI, National Institutes of Health, USA
NF-kappaB as a Therapeutic Target in Lymphoma

Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Tissue-Specific Roles for IKKb/NF-kappaB in Insulin Resistance and Muscle Wasting

Frank Mercurio, BioTheryX, Inc., USA
IKK-Related Kinase as a Target for Drug Therapy

Carter Van Waes, NIDCD, National Institutes of Health, USA
NF-kappaB and Proteasome Inhibition in Therapy of Head and Neck Cancer

7:00—8:00 PM
Social Hour

Ballroom I/Lobby/Mezzanine I & II
8:00—11:00 PM
Entertainment

Ballroom I/Lobby/Mezzanine I & II

FRIDAY, JANUARY 16

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA106223-01




We gratefully acknowledge additional support for this conference from:

Educational grant from Lilly USA, LLC GlaxoSmithKline Research & Development, Ltd.

Celgene Corporation
 

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Phone:+1 970-262-2690

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