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This meeting took place in 2014


Here are the related meetings in 2015:
Host Response in Tuberculosis (J3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Novel Therapeutic Approaches to Tuberculosis (C7)


Organizer(s) Christopher M. Sassetti and Thomas G. Evans
March 30—April 4, 2014
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Dec 3, 2013
Abstract Deadline: Jan 7, 2014
Scholarship Deadline: Dec 3, 2013
Discounted Registration Deadline: Jan 29, 2014

Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation

Summary of Meeting:
Despite more than a century of research, tuberculosis kills millions every year. The reasons we are unable to control this disease are well documented; the lack of an effective vaccine, inefficient chemotherapy, and an inability to predict who is at risk of disease. Traditional approaches to antibacterial and vaccine development have produced only incremental improvements in TB therapy, and have had little effect on transmission in the developing world. This symposium will explore novel strategies to treat this disease, either through direct antimicrobial interventions or the manipulation of host immunity. The sessions will explore three topical areas: • The mechanisms underlying the inflammatory response to M. tuberculosis, and novel strategies to ameliorate disease through the manipulation of this response. • New approaches to accelerate TB chemotherapy, concentrating on genetic/chemical synergies, specific targeting of persistent bacterial populations, and host-directed antimicrobial therapies. • Immunotherapy for both latent and active disease, with an emphasis on cytokine modulation and therapeutic vaccines. This symposium will assemble a diverse group of scientists specializing in immunology, bacteriology, cell biology, and therapeutic development. To ensure that insights from basic science are discussed in the context of practical therapeutic solutions, attendees will be drawn from both academic and industrial institutions. A particular emphasis will be placed on lessons gleaned from other systems, such as cancer, acute inflammation, and viral infections, which could be applied to tuberculosis. This diversity of background and approach will encourage the development of truly novel approaches to treat this devastating disease.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 30

16:00—20:00
Arrival and Registration

MONDAY, MARCH 31

07:00—08:00
Breakfast
08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Charles N. Serhan, Brigham and Women's Hospital, USA
Regulation of Acute Inflammation and Resolution: Lessons from Novel Lipid Mediators

09:00—11:45
Inflammation: Balance between Bacterial Control and Immunopathology
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Babak Javid, Tsinghua University School of Medicine, China

David M. Tobin, Duke University Medical Center, USA
Modulation of Eicosanoids and Angiogenesis as Host-Directed Therapies for Mycobacterial Infections

Bibhuti B. Mishra, University of Massachusetts Medical School, USA
Short Talk: 12-Lipoxygenase Controls Neutrophil Influx to the Lungs and Regulates Tolerance to Tuberculosis Disease

Andrea M. Cooper, Trudeau Institute, USA
The Impact of Bacterial Dose on the Development of Early Cellular Responses to Mycobacterium tuberculosis Infection and the Consequences for Survival

Helen A. Fletcher, London School of Hygiene and Tropical Medicine, UK
Role of Myeloid Signatures in the Prediction of Active Tuberculosis

Ajay Grover, Colorado State University, USA
Short Talk: Early Immune Responses Associated with the Severity of Tuberculosis Disease Outcome

Janice J. Endsley, University of Texas Medical Branch, USA
Short Talk: Inflammation and Accelerated Mycobacterial Growth in M.tb/HIV-1 Co-Infected Humanized Mice

09:40—10:00
Coffee Break
11:45—13:00
Poster Setup
13:00—22:00
Poster Viewing
11:45—14:00
On Own for Lunch and Recreation
14:00—16:30
Workshop 1: Understanding and Overcoming Resistance
James E. Posey, Centers for Disease Control, USA
The Known Unknowns of Drug Resistance in Mycobacterium tuberculosis

Sarah M. Fortune, Harvard School of Public Health, USA
On the Clock: Identifying Drivers of Drug Resistance

* David Alland, Rutgers University - NJMS, USA
Exploring the Mycobacterium tuberculosis Resistome: Lessons on the Multiple Pathways to Drug Resistance

William R. Jacobs, Jr., HHMI/Albert Einstein College of Medicine, USA
Visualizing Mycobacterium tuberculosis Persisters to see their Roles Latency and Drug Resistance

Eric Nuermberger, Johns Hopkins University, USA
Short Talk: Studying Resistance Selection in Preclinical Animal Models

Anne Lenaerts, Colorado State University, USA
Short Talk: Spectinamides, A Novel Class of Antituberculosis Agents that also Overcome Native Drug Efflux

16:30—17:00
Coffee Available
18:00—20:00
Mixer
17:00—19:00
Strategies to Ameliorate Lung Damage
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Sanjay K. Jain, Johns Hopkins University, USA

Paul T. Elkington, University of Southampton, UK
Targeting Matrix Metalloproteinase Activity to Reduce Immunopathology

Eric Nuermberger, Johns Hopkins University, USA
Short Talk: Cavitary TB in C3HeB/FeJ Mice

Samuel M. Behar, Brigham and Women's Hospital, USA
Tissue-Protective Activities of Anti-Microbial Immune Responses

Anca Dorhoi, Max Planck Institute for Infection Biology, Germany
Regulators of Neutrophil-Mediated Tissue Injury

Bintou Ahmadou Ahidjo, Johns Hopkins University, USA
Short Talk: Pirfenidone, an Approved Anti-Fibrotic Agent, Alters TB Lung Pathology and Is Detrimental to Multidrug Treatment of TB in Mice

19:00—20:00
Social Hour with Lite Bites
19:30—22:00
Poster Session 1

TUESDAY, APRIL 1

07:00—08:00
Breakfast
08:00—11:15
Novel Antimicrobial Strategies
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Philana Ling Lin, University of Pittsburgh, USA
The Fuzzy Logic of Tuberculosis: Reconciling Biology with Disease

* Christina Leigh Stallings, Washington University School of Medicine, USA
Genetic and Chemical Approaches to Discovering New Anti-Virulence Strategies

Lalita Ramakrishnan, University of Washington, USA
Targeting Host and in vivo Induced Bacterial Determinants for TB Treatment

Terry Roemer, Merck, USA
Chemical Genetics, Combination Agents and Antibacterial Lead Finding: A Staphylococcus aureus Case Study

Donald R. Ronning, University of Toledo, USA
Short Talk: Understanding Trehalose Biosynthesis, Utilization and Salvage as a Basis for Developing New TB Drugs

Robert B. Abramovitch, Michigan State University, USA
Short Talk: High-Throughput Screens for Inhibitors of Mycobacterium tuberculosis Two-Component Regulatory Systems

Pradeep Kumar, Rutgers-New Jersey Medical School, USA
Short Talk: Pathway-Driven Approach to Antitubercular Drug Discovery

09:20—09:40
Coffee Break
11:15—13:00
Poster Setup
13:00—22:00
Poster Viewing
11:15—17:00
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
17:00—19:00
Host-Directed Antimicrobial Therapies
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Mamodikoe Makhene, NIAID, National Institutes of Health, USA

Robert J. Wilkinson, University of Cape Town, South Africa
The Interaction between Antimicrobial and Adjunctive Therapies and the Immune Response to Tuberculosis

William R. Bishai, Johns Hopkins School of Medicine, USA and K-RITH, South Africa
Immunomodulation during Therapy

Mariëlle C. Haks, Leiden University Medical Center, Netherlands
Short Talk: A Novel High-Content siRNA and Chemical Compound Screening Assay for Host Regulation of Intracellular Bacterial survival

Daniel Kalman, Emory University, USA
Host-Directed Tyrosine Kinase Inhibitors as Therapeutics for Antibiotic-Resistant TB

Lauren T. Robertson, Harvard University, USA
Short Talk: Macrophage Lipid Chaperones Mediate Protection from Tuberculosis Pathogenesis

19:00—20:00
Social Hour with Lite Bites
19:30—22:00
Poster Session 2

WEDNESDAY, APRIL 2

07:00—08:00
Breakfast
08:00—11:15
Targeting Persistent Bacterial Populations
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Bree B. Aldridge, Tufts University, USA

Rodney Dawson, University of Cape Town, South Africa
Toward Treatment Shortening Regimens in Tuberculosis

Tawanda Gumbo, University of Texas Southwestern Medical Center, USA
Accelerating Kill of Tuberculosis Persisters: Interaction of Drug Concentrations and Novel Bacterial Complex Adaptive Systems

Christopher M. Sassetti, University of Massachusetts Medical School, USA
Bacterial Adaptations to the Host Environment

Adrie J. C. Steyn, K-RITH, South Africa
Short Talk: Untargeted Metabolomic Discovery of a Redox Hierarchy in Mycobacteria and Human Tuberculosis

Stewart T. Cole, École Polytechnique Fédérale de Lausanne, Switzerland
SS18b - a Drug Discovery Tool for Latent Tuberculosis

Thulasi Warrier, Weill Cornell Medical College, USA
Short Talk: Identification of Novel Anti-Mycobacterial Compounds by Screening a Pharmaceutical Company Library Against Non-Replicating M. tuberculosis

Martin Cohen-Gonsaud, Centre de Biochimie Structurale, France
Short Talk: Metabolite-Regulated Shutdown of Efflux Pumps is Critical for Mycobacterial Survival in Non-Permissive Growth Conditions

09:20—09:40
Coffee Break
11:15—13:00
Poster Setup
13:00—22:00
Poster Viewing
11:15—14:00
On Own for Lunch and Recreation
14:00—16:30
Workshop 2: Basic Science: Foundations of the Next Generation of Therapeutics
* Tom H. M. Ottenhoff, Leiden University Medical Center, Netherlands
Short Talk: In situ Genome-Wide Expression Profiling Helps Deciphering New M. tuberculosis Antigens for Vaccine Development

Kees Korbee, Leiden University Medical Center, Netherlands
Identification of Host Signalling Intermediates Regulating Survival of Intracellular Bacteria

Christoph Grundner, Seattle Biomedical Research Institute, USA
Protein Tyrosine Phosphorylation in Mycobacterium tuberculosis

Daniel L. Barber, NIAID, National Institutes of Health, USA
Control of Mycobacterium tuberculosis Infection by a Subset of Lung Parenchyma Homing CD4 T Cells

Thomas R. Hawn, University of Washington, USA
Variation in Macrophage Responses: Can Genetics Lead to Novel Therapeutics?

Israël Casabon, University of British Columbia, Canada
Cholesterol Catabolism by Mycobacterium tuberculosis: Still Many Unknowns

Marcela Henao-Tamayo, Colorado State University, USA
Short Talk: BCG Vaccination Augments Regulatory T Cell Immunosuppression during Mycobacterium tuberculosis Infection

16:30—17:00
Coffee Available
17:00—19:00
Therapy for Latent TB Infection
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Christine F. Sizemore, NIAID, National Institutes of Health, USA

David M. Margolis, University of North Carolina at Chapel Hill, USA
Eradication of Latent Pathogens: Lessons from HIV

Peter Andersen, Statens Serum Institut, Denmark
Progress toward a Vaccine Targeting LTBI

Gavin J. Churchyard, Aurum Institute NPC, South Africa
Community/Population-Based Interventions for LTBI

Parul Mehrotra, International Centre for Genetic Engineering and Biotechnology, India
Short Talk: Pathogenicity of Mycobacterium tuberculosis is Governed by its Ability to Thread through Metabolic Thresholds of the Host Macrophage

Sara Suliman, University of Cape Town, South Africa
Short Talk: Impact of M. tuberculosis Pre-Clearance with Isoniazid (INH) on Innate and Adaptive T-Cell Responses to BCG Revaccination in Latently Infected Adults

19:00—20:00
Social Hour with Lite Bites
19:30—22:00
Poster Session 3

THURSDAY, APRIL 3

07:00—08:00
Breakfast
08:00—11:00
Immunotherapy for Active Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* W. Henry Boom, Case Western Reserve University, USA

Robert L. Modlin, University of California, Los Angeles, USA
Immune Networks in Human Tuberculosis

Selvakumar Subbian, , USA
Changing the Course of TB Pathogenesis and Treatment

Steven Holland, NIAID, National Institutes of Health, USA
Genetic Determinants of Reactivation

Dipendra Kumar Mitra, All India Institute of Medical Sciences - AIIMS, India
Short Talk: Inhibiting PD-1 Pathway Restores M. tuberculosis Specific Effector T Cell Response in Human Tuberculosis

Alan Sher, NIAID, National Institutes of Health, USA
Innate Immune Mediators as Targets for Host-Directed Therapy of Tuberculosis

Katrin D. Mayer-Barber, NIAID, National Institutes of Health, USA
Short Talk: Interleukin-1 - Type I Interferon Counter-Regulation Reveals Eicosanoids as Targets for Host-Directed Therapy of Tuberculosis

09:20—09:40
Coffee Break
11:00—17:00
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
17:00—19:00
Therapeutic Vaccines
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Warwick J. Britton, Centenary Institute, Australia

Geneviève Inchauspe, Transgène, France
Immune Modulation in Latent and Active Diseases through Vaccination

Rhea N. Coler, Infectious Disease Research Institute, USA
Preclinical and Clinical Testing of a Prophylactic and Therapeutic TB Vaccine

Cláudio Nunes-Alves, University of Massachusetts Medical School, USA
Short Talk: Clonal T Cell Expansions Against Immunodominant Epitopes Are Protective during Tuberculosis

Dominique N. Price, University of New Mexico, USA
Short Talk: Inhaled BCG Immunization: A Vaccination Strategy to Bypass Interference by Environmental Mycobacteria and Increase Protective Efficacy

Thomas G. Evans, Aeras, USA
The Promise of Therapeutic Vaccination

19:00—20:00
Social Hour with Lite Bites
20:00—23:00
Entertainment

FRIDAY, APRIL 4

 
Departure

*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Bill & Melinda Gates Foundation

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI109839-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Transgene SA


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