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This meeting took place in 2016
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Cell Biology and Immunology of Persistent Infection (A8)
Organizer(s) Herbert (Skip) W. Virgin, E. John Wherry, Anne O'Garra and Andrea Lynn Cox
January 31—February 4, 2016
Fairmont Banff Springs • Banff, Alberta Canada
Discounted Abstract Deadline: Oct 1, 2015
Abstract Deadline: Nov 3, 2015
Scholarship Deadline: Oct 1, 2015
Discounted Registration Deadline: Dec 1, 2015
Supported by the Directors' Fund
Summary of Meeting:
Persistent infections are a major source of morbidity and mortality around the world. However, it is increasingly clear that the bacterial microbiome, the virome and the mycobiome can have beneficial roles for the host. Chronic infections with pathogens represent a failure of sterilizing immunity, but the mechanisms responsible for persistence and the balance between host health and disease resulting from infection are not completely understood. Recent discoveries reveal that multiple components of both the infecting organism and the host response to infection determine infection outcome, illustrating that a range of disciplines must be brought together to understand the fundamental mechanisms of chronic infection. This meeting is designed to bring together diverse communities of researchers at the cutting edge of their fields to understand whether and how to manipulate persistent infections to prevent disease and enhance health.
View Scholarships/Awards
Persistent infections are a major source of morbidity and mortality around the world. However, it is increasingly clear that the bacterial microbiome, the virome and the mycobiome can have beneficial roles for the host. Chronic infections with pathogens represent a failure of sterilizing immunity, but the mechanisms responsible for persistence and the balance between host health and disease resulting from infection are not completely understood. Recent discoveries reveal that multiple components of both the infecting organism and the host response to infection determine infection outcome, illustrating that a range of disciplines must be brought together to understand the fundamental mechanisms of chronic infection. This meeting is designed to bring together diverse communities of researchers at the cutting edge of their fields to understand whether and how to manipulate persistent infections to prevent disease and enhance health.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, January 31 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 4 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, February 5 in order to fully experience the meeting.
SUNDAY, JANUARY 31
MONDAY, FEBRUARY 1
TUESDAY, FEBRUARY 2
WEDNESDAY, FEBRUARY 3
THURSDAY, FEBRUARY 4
FRIDAY, FEBRUARY 5
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, January 31 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 4 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, February 5 in order to fully experience the meeting.
SUNDAY, JANUARY 31
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.
*
Herbert (Skip) W. Virgin,
Vir Biotechnology, USA
Anne O'Garra,
Francis Crick Institute, UK
Systems Approaches to Studying the Immune Response in Tuberculosis
Systems Approaches to Studying the Immune Response in Tuberculosis
09:00—11:00
Genetics and Systems Biology of Persistent Infection
Meeting has ended...abstracts no longer viewable online.
*
Herbert (Skip) W. Virgin,
Vir Biotechnology, USA
Ramnik Xavier,
Massachusetts General Hospital, USA
Genetics, Autophagy and Checkpoints for Intracellular Pathogen Defense
Genetics, Autophagy and Checkpoints for Intracellular Pathogen Defense
Elina I. Zuniga,
University of California, San Diego, USA
Immune Adaptation During Chronic Viral Infection
Immune Adaptation During Chronic Viral Infection
Brad Rosenberg,
Rockefeller University, USA
Short Talk: Transcriptomic Characterization of the Immune Response to Acute Hepatitis C Virus Infection
Short Talk: Transcriptomic Characterization of the Immune Response to Acute Hepatitis C Virus Infection
14:30—16:30
Workshop 1
*
Elina I. Zuniga,
University of California, San Diego, USA
Anneliese S. Ashhurst,
Centenary Institute, Australia
CXCR6 Deficiency Alters Control of Chronic Mycobacterium tuberculosis Infection and the Inflammatory Kinetics of Acute Respiratory infection
CXCR6 Deficiency Alters Control of Chronic Mycobacterium tuberculosis Infection and the Inflammatory Kinetics of Acute Respiratory infection
Katelyn D. Miller,
University of Pennsylvania, USA
Persistent Measles Virus in the Brain After Resolution of Acute Infection
Persistent Measles Virus in the Brain After Resolution of Acute Infection
Eugene Drokhlyansky,
Broad Institute, USA
Type I Interferon Response Can Limit Virus Spread in the Brain
Type I Interferon Response Can Limit Virus Spread in the Brain
Michael Eschbaumer,
Oak Ridge Institute for Science and Education, USA
Host Factors Associated with Acute and Persistent Foot-and-Mouth Disease Virus Infection
Host Factors Associated with Acute and Persistent Foot-and-Mouth Disease Virus Infection
Charles Grose,
University of Iowa, USA
Varicella Virus Envelopment Pathway Intersects and Redirects the Autophagy Pathway
Varicella Virus Envelopment Pathway Intersects and Redirects the Autophagy Pathway
Hanne Marcella Dubois,
VIB - Ghent University, Belgium
A Novel Innate Immune Response Induced by Murine Norovirus Infection
A Novel Innate Immune Response Induced by Murine Norovirus Infection
Eui-Cheol Shin,
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, South Korea
IFN-lambda4 Potently Induces ISG15/USP18-Mediated IFN-alpha Unresponsiveness
IFN-lambda4 Potently Induces ISG15/USP18-Mediated IFN-alpha Unresponsiveness
Victor H. Carpio,
Arbutus Biopharma, USA
IFN-gamma and IL-21 Double Producing T Cells are Bcl6-Independent and Survive into the Memory Phase in Plasmodium chabaudi Infection
IFN-gamma and IL-21 Double Producing T Cells are Bcl6-Independent and Survive into the Memory Phase in Plasmodium chabaudi Infection
17:00—19:00
Co-Infection and Microbiome in Persistent Infection
Meeting has ended...abstracts no longer viewable online.
*
Andrea Lynn Cox,
Johns Hopkins University, USA
Herbert (Skip) W. Virgin,
Vir Biotechnology, USA
Transkingdom Interactions within the Metagenome Regulate Virus Infection and Immunity
Transkingdom Interactions within the Metagenome Regulate Virus Infection and Immunity
Lora V. Hooper,
University of Texas Southwestern Medical Center, USA
Microbiota-Immune System Interactions in the Intestine
Microbiota-Immune System Interactions in the Intestine
George Kassiotis,
Francis Crick Institute, UK
Immunity to Exogenous and Endogenous Retroviruses
Immunity to Exogenous and Endogenous Retroviruses
Taylor S. Cohen,
MedImmune LLC, USA
Short Talk: S. aureus Alpha Toxin Renders Macrophages Incapable of Defending Against Gram-Negative Lung Infections
Short Talk: S. aureus Alpha Toxin Renders Macrophages Incapable of Defending Against Gram-Negative Lung Infections
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Cell Biology of Persistent Infection
Meeting has ended...abstracts no longer viewable online.
*
Yasmine Belkaid,
NIAID, National Institutes of Health, USA
Christina L. Stallings,
Washington University School of Medicine, USA
Role of Autophagy Proteins in Controlling Mycobacterium Tuberculosis Infection
Role of Autophagy Proteins in Controlling Mycobacterium Tuberculosis Infection
Andrea Lynn Cox,
Johns Hopkins University, USA
Inflammasome Regulation in Chronic HIV and HCV Infection
Inflammasome Regulation in Chronic HIV and HCV Infection
John W. Schoggins,
University of Texas Southwestern Medical Center, USA
Type I and III IFN Interactions and Effector Functions in Chronic Viral Infection
Type I and III IFN Interactions and Effector Functions in Chronic Viral Infection
Cheryl L. Day,
Emory University, USA
Short Talk: Differential NK Cell Reactivity to Mycobacterial Antigens in Mycobacterium tuberculosis-Infected and Uninfected Individuals in a TB-Endemic Setting
Short Talk: Differential NK Cell Reactivity to Mycobacterial Antigens in Mycobacterium tuberculosis-Infected and Uninfected Individuals in a TB-Endemic Setting
Ulf Dittmer,
University of Duisburg-Essen, Germany
Short Talk: PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing
Short Talk: PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing
17:00—19:00
Nutrition and Metabolism and Persistent Infection
Meeting has ended...abstracts no longer viewable online.
*
Christina L. Stallings,
Washington University School of Medicine, USA
Yasmine Belkaid,
NIAID, National Institutes of Health, USA
Long-Term Consequences of Infection for Tissue Immunity and Metabolism
Long-Term Consequences of Infection for Tissue Immunity and Metabolism
Edward S. Mocarski,
Emory University, USA
Necroptosis in Host Defense and Species Restriction of Herpesviruses
Necroptosis in Host Defense and Species Restriction of Herpesviruses
Debattama Sen,
Harvard Medical School, USA
Short Talk: CD8+ T Cell Exhaustion is Associated with a Distinct Epigenetic Landscape
Short Talk: CD8+ T Cell Exhaustion is Associated with a Distinct Epigenetic Landscape
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Pharmacologic and Biologic Manipulation of Persistent Infection
Meeting has ended...abstracts no longer viewable online.
*
Katja Simon,
University of Oxford, UK
Man-Wah Tan,
Genentech, Inc., USA
Using Antibody-Antibiotic Conjugates as Therapeutics against Persistent Intracellular Pathogens
Using Antibody-Antibiotic Conjugates as Therapeutics against Persistent Intracellular Pathogens
Jennifer Philips,
Washington University School of Medicine, USA
Mycobacterium Tuberculosis Inhibits Macrophage Autophagy and Lipid Catabolism
Mycobacterium Tuberculosis Inhibits Macrophage Autophagy and Lipid Catabolism
Ashwin Balagopal,
Johns Hopkins University, USA
HIV-1 Control Decreases Intrahepatic Hepatitis C: A Study of Twin Viruses that Chronically Reside in the Liver
HIV-1 Control Decreases Intrahepatic Hepatitis C: A Study of Twin Viruses that Chronically Reside in the Liver
Rick L. Tarleton,
University of Georgia, USA
Silent Invasion and Misdirected Immune Responses Allow for Parasite Persistence in Chagas Disease
Silent Invasion and Misdirected Immune Responses Allow for Parasite Persistence in Chagas Disease
Megan T. Baldridge,
Washington University School of Medicine, USA
Short Talk: Transkingdom Metagenomic Interactions and IFN-lambda Determine Persistence of Enteric Norovirus Infection
Short Talk: Transkingdom Metagenomic Interactions and IFN-lambda Determine Persistence of Enteric Norovirus Infection
Mary F. Fontana,
University of Washington, USA
Short Talk: Insights into Human Malaria from a Novel Model of Asymptomatic Plasmodium Infection
Short Talk: Insights into Human Malaria from a Novel Model of Asymptomatic Plasmodium Infection
17:00—19:00
Humoral Immunity and Persistent Infection
Meeting has ended...abstracts no longer viewable online.
*
E. John Wherry,
University of Pennsylvania, USA
Dennis R. Burton,
The Scripps Research Institute, USA
Broadly Neutralizing Antibodies to HIV and Vaccine Design and Evaluation
Broadly Neutralizing Antibodies to HIV and Vaccine Design and Evaluation
Galit Alter,
Ragon Institute of MGH, MIT, and Harvard, USA
Non-Neutralizing Antibodies for Protection from Chronic Infection
Non-Neutralizing Antibodies for Protection from Chronic Infection
Peter D. Crompton,
National Institutes of Health, USA
Insights into the B Cell and Tfh Cell Biology Underlying the Inefficient Acquisition of Humoral Immunity to Malaria
Insights into the B Cell and Tfh Cell Biology Underlying the Inefficient Acquisition of Humoral Immunity to Malaria
Katherine Y. King,
Baylor College of Medicine, USA
Short Talk: Chronic Infection Depletes Hematopoietic Stem Cells Through Apoptosis and Differentiation
Short Talk: Chronic Infection Depletes Hematopoietic Stem Cells Through Apoptosis and Differentiation
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
T Cell-Mediated Immunity and Persistent Infection
Meeting has ended...abstracts no longer viewable online.
*
Derek T. O'Hagan,
GlaxoSmithKline Vaccines, USA
E. John Wherry,
University of Pennsylvania, USA
Molecular Basis of T cell Exhaustion: Insights for Immunotherapy
Molecular Basis of T cell Exhaustion: Insights for Immunotherapy
Barbara Rehermann,
NIDDK, National Institutes of Health, USA
Innate and Adaptive Immune Responses in Viral Hepatitis
Innate and Adaptive Immune Responses in Viral Hepatitis
Lawrence Corey,
Fred Hutchinson Cancer Research Center, USA
Local Immunity to Chronic Herpesvirus Infection
Local Immunity to Chronic Herpesvirus Infection
Mala Maini,
University College London, UK
Innate/Adaptive Immune Interactions in the Hepatitis B-Infected Liver
Innate/Adaptive Immune Interactions in the Hepatitis B-Infected Liver
Kristen Elaine Pauken,
Harvard Medical School, USA
Short Talk: Epigenetic and Transcriptional Reprogramming of Exhausted CD8 T Cells Following PD-1 Pathway Blockade
Short Talk: Epigenetic and Transcriptional Reprogramming of Exhausted CD8 T Cells Following PD-1 Pathway Blockade
Angela Pack,
University of Georgia, USA
Short Talk: Trypanosoma cruzi Specific CD8+ T Cells Continue to Mediate Parasite Control Despite Chronic Antigen Exposure
Short Talk: Trypanosoma cruzi Specific CD8+ T Cells Continue to Mediate Parasite Control Despite Chronic Antigen Exposure
14:30—16:30
Workshop 2
*
Christina L. Stallings,
Washington University School of Medicine, USA
Luka Cicin-Sain,
Helmholtz Centre for Infection Research, Germany
Peptide Expression Context within Viral Genes Determines Direct T-Cell Responsiveness, Memory Inflation and Immune Protection by CMV Vectors
Peptide Expression Context within Viral Genes Determines Direct T-Cell Responsiveness, Memory Inflation and Immune Protection by CMV Vectors
Isabel Barnstorf,
ETH Zurich, Switzerland
Impact of Persistent Viral Infections on Immune Homeostasis in Mice
Impact of Persistent Viral Infections on Immune Homeostasis in Mice
Nadia Martinez-Martin,
Genentech, Inc., USA
Discovery of Host Receptors for Human Cytomegalovirus Immunomodulatory Proteins Using a Comprehensive Extracellular Protein library
Discovery of Host Receptors for Human Cytomegalovirus Immunomodulatory Proteins Using a Comprehensive Extracellular Protein library
Robert Orchard,
Washington University School of Medicine, USA
Genome-Wide CRISPR Screen Identifies CD300lf as a Receptor for Murine Norovirus
Genome-Wide CRISPR Screen Identifies CD300lf as a Receptor for Murine Norovirus
Jernej Godec,
Apple Tree Life Sciences, USA
CD39 Expression Identifies Terminally Exhausted CD8+ T Cells and Limits Immunopathology in Chronic Infection
CD39 Expression Identifies Terminally Exhausted CD8+ T Cells and Limits Immunopathology in Chronic Infection
Birendra Kumar Prusty,
Institute of Life Sciences, India
Immunomodulation during Murine Chronic Malaria
Immunomodulation during Murine Chronic Malaria
Simon Peter Preston,
Walter and Eliza Hall Institute of Medical Research, Australia
Bim Deficiency Prevents PD-1 Mediated T Cell Attrition and Rescues CD8 T Cell Exhaustion
Bim Deficiency Prevents PD-1 Mediated T Cell Attrition and Rescues CD8 T Cell Exhaustion
Pamela Marie Odorizzi,
Vir Biotechnology, USA
Investigating the Effects of in utero Malaria Exposure on CD4+ T Cell Immunity in Infants
Investigating the Effects of in utero Malaria Exposure on CD4+ T Cell Immunity in Infants
17:00—19:00
Vaccination Against Persistent Viral Infection
Meeting has ended...abstracts no longer viewable online.
*
Anne O'Garra,
Francis Crick Institute, UK
Derek T. O'Hagan,
GlaxoSmithKline Vaccines, USA
Opportunities and Challenges for Vaccines
Opportunities and Challenges for Vaccines
Tiffany A. Reese,
University of Texas Southwestern Medical Center, USA
Short Talk: Infection History of Mice Dictates Vaccine-Induced Gene Expression and Antibody Response
Short Talk: Infection History of Mice Dictates Vaccine-Induced Gene Expression and Antibody Response
Louis J. Picker,
Oregon Health & Science University, USA
Vaccination against Lentivirus Infection
Vaccination against Lentivirus Infection
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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