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This meeting took place in 2017
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Engineered Cells and Tissues as Platforms for Discovery and Therapy (K1)
Organizer(s) Laura E. Niklason, Milica Radisic and Nenad Bursac
March 9—12, 2017
Fairmont Copley Plaza • Boston, Massachusetts USA
Discounted Abstract Deadline: Nov 9, 2016
Abstract Deadline: Dec 13, 2016
Scholarship Deadline: Nov 9, 2016
Discounted Registration Deadline: Jan 13, 2017
Sponsored by Editas Medicine, Inc., Juno Therapeutics, Merck & Co., Inc. and Thermo Fisher Scientific Inc.
Summary of Meeting:
Tissue engineering, cell therapies and regenerative medicine have witnessed accelerated progress over the past decade. Fueled by fundamental discoveries in iPS, progenitor, and developmental cell biology, cells are now used as building blocks to create model systems, as testing platforms for drug interventions and as active therapeutics. High-throughput production of various types of “microtissues” or “organoids” is making increasing contributions to our understanding of human development, disease and repair. This Keystone Symposia meeting will highlight these rapidly emerging cell-based tools for fundamental and applied discovery. Culture systems ranging from simple cell cluster organoids, to highly advanced cell-electronic composites, will be discussed. In addition, the encouraging progress that is being made in cell-based therapies across a range of organs and diseases will be featured. The goal of this meeting is to provide a state-of-the-art review of both pluripotent and differentiated cells as tools for discovery and therapy. A broad range of cell types and therapeutic areas will be included.
View Scholarships/Awards
Tissue engineering, cell therapies and regenerative medicine have witnessed accelerated progress over the past decade. Fueled by fundamental discoveries in iPS, progenitor, and developmental cell biology, cells are now used as building blocks to create model systems, as testing platforms for drug interventions and as active therapeutics. High-throughput production of various types of “microtissues” or “organoids” is making increasing contributions to our understanding of human development, disease and repair. This Keystone Symposia meeting will highlight these rapidly emerging cell-based tools for fundamental and applied discovery. Culture systems ranging from simple cell cluster organoids, to highly advanced cell-electronic composites, will be discussed. In addition, the encouraging progress that is being made in cell-based therapies across a range of organs and diseases will be featured. The goal of this meeting is to provide a state-of-the-art review of both pluripotent and differentiated cells as tools for discovery and therapy. A broad range of cell types and therapeutic areas will be included.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Thursday, March 9 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Sunday, March 12 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Monday, March 13 in order to fully experience the meeting.
THURSDAY, MARCH 9
FRIDAY, MARCH 10
SATURDAY, MARCH 11
SUNDAY, MARCH 12
MONDAY, MARCH 13
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Thursday, March 9 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Sunday, March 12 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Monday, March 13 in order to fully experience the meeting.
THURSDAY, MARCH 9
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.
*
Laura E. Niklason,
Yale University, USA
Danilo A. Tagle,
NCATS, National Institutes of Health, USA
Catalyzing Translational Innovation
Catalyzing Translational Innovation
09:30—12:15
Biologically-Based Microsystems
Meeting has ended...abstracts no longer viewable online.
*
Jordan S. Miller,
, USA
Jeffrey Beekman,
University Medical Center Utrecht, Netherlands
Epithelial Organoids as Tools for Discovery in Cystic Fibrosis
Epithelial Organoids as Tools for Discovery in Cystic Fibrosis
Coffee Break
Takanori Takebe,
Yokohama City University / Cincinnati Children's Hospital Medical Center, Japan
De novo Generation of Diverse Organ Buds from Stem Cells
De novo Generation of Diverse Organ Buds from Stem Cells
Eduardo Marban,
Cedars-Sinai Medical Center, USA
Self-Assembling Cardiac Microtissues and their Progeny in Clinical Therapeutics
Self-Assembling Cardiac Microtissues and their Progeny in Clinical Therapeutics
14:30—16:30
Workshop 1: Human iPS Cells in Disease Modeling
*
Todd C. McDevitt,
Gladstone Institutes, USA
Olga Kashpur,
Tufts University, USA
Reprogramming of Diabetic Foot Ulcer Fibroblasts to iPSCs Reveals an Altered Wound Healing Potential
Reprogramming of Diabetic Foot Ulcer Fibroblasts to iPSCs Reveals an Altered Wound Healing Potential
Adriana Blazeski,
Johns Hopkins University, USA
Engineered Heart Slices Represent Syncytial Model of Arrhythmogenic Cardiomyopathy
Engineered Heart Slices Represent Syncytial Model of Arrhythmogenic Cardiomyopathy
Miguel Angel Hermida,
Heriot Watt University, Scotland
3D Printing of Multilineage Human Glioblastoma Models
3D Printing of Multilineage Human Glioblastoma Models
Alex Ng,
Harvard Medical School, USA
Transcription Factor-Wide Engineering of Human Cell Types from Pluripotent Stem Cells
Transcription Factor-Wide Engineering of Human Cell Types from Pluripotent Stem Cells
Jeffrey D. Serrill,
City of Hope, USA
Using NGN3 Fusion Protein Constructs to Elucidate Optimal Cytoarchitecture in hPSC-Derived Pseudoislets
Using NGN3 Fusion Protein Constructs to Elucidate Optimal Cytoarchitecture in hPSC-Derived Pseudoislets
Kacey Ronaldson,
Columbia University, USA
Adult-Like Cardiac Tissue Bio-Engineered From Human Ips Derived Cells Enables Predictive Modeling of Toxicity and Disease
Adult-Like Cardiac Tissue Bio-Engineered From Human Ips Derived Cells Enables Predictive Modeling of Toxicity and Disease
17:00—19:00
Engineered Organoids for Biological Discovery
Meeting has ended...abstracts no longer viewable online.
*
Gary A. Gintant,
AbbVie, USA
Anjelica Leticia Gonzalez,
Yale University, USA
Interstitial and Microvascular Interfaces in Inflammatory and Fibrotic Disease
Interstitial and Microvascular Interfaces in Inflammatory and Fibrotic Disease
Nenad Bursac,
Duke University, USA
Microtissues for Studies of Skeletal Muscle Physiology and Disease
Microtissues for Studies of Skeletal Muscle Physiology and Disease
Eva-Maria Dehne,
TissUse GmbH and Technische Universitat Berlin, Germany
Microphysiological Systems – State of the Art and Future Perspectives
Microphysiological Systems – State of the Art and Future Perspectives
Abhishek Ananthanarayanan,
Invitrocue Pte Ltd., Singapore
Short Talk: Hepatocyte Spheroid Cultures in Galactosylated Cellulosic Sponge for Drug DMPK and Efficacy Testing
Short Talk: Hepatocyte Spheroid Cultures in Galactosylated Cellulosic Sponge for Drug DMPK and Efficacy Testing
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:30
Cell-Based Platforms for Drug Screening
Meeting has ended...abstracts no longer viewable online.
*
Nenad Bursac,
Duke University, USA
Gary A. Gintant,
AbbVie, USA
Development of an in vitro Pro-Arrhythmia Assay
Development of an in vitro Pro-Arrhythmia Assay
Sharon Presnell,
Organovo, Inc., USA
Bioprinting of Liver Organoids
Bioprinting of Liver Organoids
Coffee Break
Milica Radisic,
University of Toronto, Canada
Evaluation of Cardiotoxicity Using Biowires
Evaluation of Cardiotoxicity Using Biowires
Karl-Heinz Krause,
University of Geneva Faculty of Medicine, Switzerland
Engineered Neural Tissues as Human Disease Models
Engineered Neural Tissues as Human Disease Models
Patrick Guye,
InSphero AG, Switzerland
Short Talk: A Microfluidic Multi-Tissue Culturing Platform Based on 3D Microtissue Spheroids
Short Talk: A Microfluidic Multi-Tissue Culturing Platform Based on 3D Microtissue Spheroids
14:30—16:30
Workshop 2: Career Development
The organizers will facilitate an interactive session on early career development in an effort to enhance the interactions between young and established investigators.
*
Laura E. Niklason,
Yale University, USA
*
Milica Radisic,
University of Toronto, Canada
*
Nenad Bursac,
Duke University, USA
17:00—19:00
Engineered Tissues in Cancer
Meeting has ended...abstracts no longer viewable online.
*
Milica Radisic,
University of Toronto, Canada
Biju Parekkadan,
Rutgers University, USA
Engineered Cancer-Stroma Microenvironments
Engineered Cancer-Stroma Microenvironments
Alison P. McGuigan,
University of Toronto, Canada
TRACER: An Engineered Tumor for Exploring Cellular Phenotype and Microenvironment in Hypoxic Gradients
TRACER: An Engineered Tumor for Exploring Cellular Phenotype and Microenvironment in Hypoxic Gradients
Deena Mohamad Ameen Gendoo,
Nottingham Trent University, UK
Short Talk: Comprehensive Assessment of the Genetic Landscape of Matched Primary, Xenograft, and Organoid Models for Pancreatic Cancer
Short Talk: Comprehensive Assessment of the Genetic Landscape of Matched Primary, Xenograft, and Organoid Models for Pancreatic Cancer
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:30
The Current Wave – Cells as Therapeutics
Meeting has ended...abstracts no longer viewable online.
*
Laura E. Niklason,
Yale University, USA
Joanne Kurtzberg,
Duke University, USA
Game Changers: Using Cord Blood to Help the Brain
Game Changers: Using Cord Blood to Help the Brain
Thomas Schulz,
ViaCyte, Inc., USA
Development of Stem-Cell Derived, Islet Replacement for Type 1 Diabetes
Development of Stem-Cell Derived, Islet Replacement for Type 1 Diabetes
Coffee Break
Gordana V. Vunjak-Novakovic,
Columbia University, USA
Human Cardiac and Tumor Platforms for Study of Disease
Human Cardiac and Tumor Platforms for Study of Disease
Jorge Mansilla-Soto,
Memorial Sloan Kettering Cancer Center, USA
Short Talk: CRISPR/Cas9-Targeted Chimeric Antigen Receptor Enhances CAR T Cell-Mediated Tumor Eradication
Short Talk: CRISPR/Cas9-Targeted Chimeric Antigen Receptor Enhances CAR T Cell-Mediated Tumor Eradication
14:30—16:30
Workshop 3: 3-Dimensional Cellular Models
*
Laura E. Niklason,
Yale University, USA
Amir Ali Khan,
University of Sharjah, United Arab Emirates
Unravelling the Gene Expression Profiles of the Early Differentiation of Mesenchymal Stem Cells into Neural Lineage
Unravelling the Gene Expression Profiles of the Early Differentiation of Mesenchymal Stem Cells into Neural Lineage
Sijie Sun,
University of Washington, USA
Bioengineering 3D Human Skin Equivalent with Perfused Microvascular Network to Study Host-Viral Interactions During Infection
Bioengineering 3D Human Skin Equivalent with Perfused Microvascular Network to Study Host-Viral Interactions During Infection
Christopher Hubert,
Cleveland Clinic, Lerner Research Institute, USA
Modeling Glioblastoma through Cancer Stem Cell Organoids
Modeling Glioblastoma through Cancer Stem Cell Organoids
Anastasia Korolj,
University of Toronto, Canada
Biomimetic Curvature in Cell Culture Platform Improves Podocyte Differentiation in vitro
Biomimetic Curvature in Cell Culture Platform Improves Podocyte Differentiation in vitro
Sara Nunes Vasconcelos,
University of Toronto, Canada
Diabetes Impairs Arterio-Venous Specification in Engineered Vascular Tissues in a Perivascular Cell Recruitment-Dependent Manner
Diabetes Impairs Arterio-Venous Specification in Engineered Vascular Tissues in a Perivascular Cell Recruitment-Dependent Manner
Ryan LaRanger,
University of Texas Southwestern Medical Center, USA
Engineering Reconstituted Decellularized Mouse Lungs with Conditionally Reprogrammed Human Bronchial Epithelial Cells
Engineering Reconstituted Decellularized Mouse Lungs with Conditionally Reprogrammed Human Bronchial Epithelial Cells
17:00—18:45
The Next Wave – Cells as Building Blocks
Meeting has ended...abstracts no longer viewable online.
*
Sara Nunes Vasconcelos,
University of Toronto, Canada
Miguel Gonzalez-Andrades,
Harvard University, USA
Tissue Engineered Corneas: A Clinical Reality?
Tissue Engineered Corneas: A Clinical Reality?
Daniela Franco Bueno,
Institute of Teaching and Research of Sirio Libanes Hospital, Brazil
Alveolar Bone Tissue Engineering for Cleft Lip and Palate
Alveolar Bone Tissue Engineering for Cleft Lip and Palate
Laura E. Niklason,
Yale University, USA
Engineered Arteries in Renal Failure and Arteriosclerosis
Engineered Arteries in Renal Failure and Arteriosclerosis
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
We gratefully acknowledge support for this conference from:
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We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:
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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:
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Symposia, please contact: Sarah Lavicka,
Director of Development, Email: sarahl@keystonesymposia.org, Phone:+1 970-262-2690 Click here for more information on Industry Support and Recognition Opportunities. If you are interested in becoming an advertising/marketing in-kind partner, please contact: Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org, Phone:+1 970-262-1179 |
