Snowbird Resort Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

DNA Replication and Genome Instability: From Mechanism to Disease (A1)

Scientific Organizers: Karlene A. Cimprich, Mark J. O'Connor and Johannes C. Walter


January 13—17, 2019

Snowbird Resort, Snowbird, Utah, USA


Organized in collaboration with Cancer Research UK

Sponsored by Editas Medicine, EMD Serono Research and Development Institute, Inc. and TESARO, Inc.


Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.
BEWARE of booking lodging through companies unaffiliated with Keystone Symposia. Click here for more details.

Keystone Symposia is committed to maintaining a positive and respectful environment at its meetings. To this end, please review and comply with our policies.

DEADLINES:
*All deadlines end at 11:59 PM US Mountain Standard Time
Scholarship Deadline: Oct 4, 2018 [details]
Discounted Abstract Deadline: Oct 4, 2018 [details]
Abstract Deadline: Oct 16, 2018 [details]
Discounted Registration Deadline: Nov 13, 2018 [details]

Click here to view Cancellation Policy

Register Yourself Deadlines and Fees

Rates and Deadlines listed below are for the 2019-A1 "DNA Replication and Genome Instability: From Mechanism to Disease" conference only.

*All deadlines end at 11:59 PM US Mountain Standard Time

Deadline Date Cost
Discounted Abstract Deadline
More details
Before and On October 4, 2018 100.00 USD*
- 50.00 USD discount
Abstract Deadline
More details
After October 4, 2018 until December 2, 2018 100.00 USD*
* 50.00 USD of Abstract fee deducted from your registration fee when you register for this meeting
Scholarship
More details
October 4, 2018 n/a
Discounted NON-STUDENT Registration
More details
Before and On November 13, 2018 845.00 USD
(includes 200.00 discount)
Regular NON-STUDENT Registration
More details
After November 13, 2018 1045.00 USD
Discounted STUDENT Registration
More details
Before and On November 13, 2018 620.00 USD
(includes 200.00 discount)
Regular STUDENT Registration
More details
After November 13, 2018 820.00 USD

* Changes in payment type that result in a refund are subject to a processing fee.
* Currency exchange gains/losses are the responsibility of the registrant and the Keystone Symposia will accept no liability for money loss through bank charges, transfers or currency fluctuations.




Discounted Abstract Deadline: October 4, 2018

*All deadlines end at 11:59 PM US Mountain Standard Time

Abstract Submission Fee: 100.00 USD*
Submission by this date receives 50.00 USD discount.
*50.00 USD will be applied to Registration Fee when you register

Abstract Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadlines. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract early allows us to:
  • submit your abstract to organizers to be considered for a short talk
  • accept your abstract online
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
(The Abstract Deadline: is October 16, 2018)

Global Health Travel Award Deadline:

*All deadlines end at 11:59 PM US Mountain Standard Time


Global Health Travel Award Details: You MUST complete your Global Health Travel Award appplication by the Global Health Travel Award Deadline and complete the other required steps (verify your contact information and submit a recommendation letter) to be considered for a travel award.


Click here to learn more about Global Health Travel Awards.

Scholarship Deadline: October 4, 2018

*All deadlines end at 11:59 PM US Mountain Standard Time


Scholarship Details: You MUST submit your abstract by the Scholarship Deadline and complete the other required steps (submit a scholarship application and submit a mentor letter) to be considered for a scholarship.

Click here to learn more about Scholarships.

Abstract Deadline: October 16, 2018

*All deadlines end at 11:59 PM US Mountain Standard Time


Abstract Submission Fee: 100.00 USD*
*50.00 USD will be applied to Registration Fee when you register

Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadline. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract by the Abstract Deadline allows us to:

  • submit your abstract to organizers to be considered for a short talk
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
Abstracts submitted after the Abstract Deadline will NOT be considered for a short talk.

(Discounted Abstract Deadline: is October 4, 2018)

Discounted Registration Deadline: November 13, 2018

*All deadlines end at 11:59 PM US Mountain Standard Time


Registration Fee: 845.00 USD* (includes 200.00 USD discount)
Student Registration Fee: 620.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

After the Discounted Registration Deadline:


Registration Fee: 1045.00 USD*
Student Registration Fee: 820.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

Registration spaces are limited and may fill prior to discounted registration deadline.

Please be advised that some meeting participants have received calls and emails from a number of different housing services, including "Exhibitors Housing Services," “Expo Housing Services,” "Global Housing," etc. THESE COMPANIES ARE NOT AFFILIATED WITH KEYSTONE SYMPOSIA and are not authorized by Keystone Symposia to contact you. These companies may tell you that the meeting is filling, without any actual knowledge to that effect, and pressure you into giving them your credit card number to make a lodging reservation with them.

We highly recommend that you not make a reservation with these companies or any other housing service! These companies' representations to participants have been misleading. Please report any calls or correspondence you might have received to Keystone Symposia and book only through lodging links in your Keystone Symposia account, an established travel agency or directly with the hotel(s) listed on our website.
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 13 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 17 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, January 18 in order to fully experience the meeting.

SUNDAY, JANUARY 13

16:00—20:00
Arrival and Registration

Ballroom Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Ballroom Lobby

MONDAY, JANUARY 14

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—09:30
Welcome and Keynote Session
Registered attendees can view abstracts starting on 12/13/2018

Ballroom 2-3
* Karlene A. Cimprich, Stanford University, USA

* Johannes C. Walter, Harvard Medical School, USA

David Cortez, Vanderbilt University School of Medicine, USA
Replication Fork Proteomes: How Many Proteins are Needed?

Eric C. Greene, Columbia University, USA
Single Molecule Analysis of Recombination

Coffee Break

09:50—11:30
The Influence of Chromatin on Replication and Repair
Registered attendees can view abstracts starting on 12/13/2018

Ballroom 2-3
Iestyn Whitehouse, Memorial Sloan Kettering Cancer Center, USA
Interplay of Chromatin and Replication

Gaelle Legube, Center for Integrative Biology, France
Chromatin and Chromosome dynamics during DNA Double Strand break repair

Andrew N. Blackford, University of Oxford, UK
Short Talk: How Cells Respond to DNA Double-Strand Breaks in Mitosis

Philipp Oberdoerffer, NCI, National Institutes of Health, USA
Short Talk: Epigenetic Control of Genome Stability at the Inactive X Chromosome

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Superior/Superior Lobby/Wasatch
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Wasatch
14:30—16:30
Workshop 1: Basic Mechanisms of Replication

Ballroom 2
* Joseph Yeeles, MRC Laboratory of Molecular Biology, UK

Bik Kwoon Tye, Hong Kong University of Science and Technology, Hong Kong
Selectivity for Replication Origins by the Origin Recognition Complex

Neha Puri, Johns Hopkins Medicine, USA
Structural and Functional Coupling of ATP Turnover to Replicative Helicase Loading and Activation

Conrad A. Nieduszynski, University of Oxford, UK
Capturing the Dynamics of DNA Replication on Individual Ultra-Long Nanopore Sequencing Reads

Marko Lõoke, MIT, USA
Life without Mcm10: Identification and Characterization of Mcm2-7 Mutations that Fully Bypass Mcm10 Function

Nicholas E. Dixon, University of Wollongong, Australia
A Primase-Induced Conformational Switch Controls Polymerase Exchange in the Bacterial Replisome

Tatiana Moiseeva, University of Pittsburgh, USA
ATR/Chk1-Dependent Replication Initiation Control in Undamaged Cells

Sriram Sridharan, Center for Cancer Research, USA
Landscape of Replication Stress Induced DNA Damage Sites

14:30—16:30
Workshop 2: Basic Mechanisms of Recombination

Ballroom 3
* Sharon B. Cantor, University of Massachusetts Medical School, USA

Wolf-Dietrich Heyer, University of California, Davis, USA
Mechanisms of Recombination: D-loop Reversal and Pathway Control

Akira Shinohara, Osaka University, Japan
Human RAD51 Paralog, SWSAP1, Promotes RAD51 Assembly by Regulating the Anti-Recombinase, FIGNL1 AAA+ATPase

Yizhou Joseph He, Dana Farber Cancer Institute, USA
DYNLL1 Binds MRE11 to Limit DNA End Resection in BRCA1-Deficient Cells

Jordan Becker, University of Oxford, UK
The ASCIZ-DYNLL1 Axis Promotes 53BP1-Dependent Non-Homologous End Joining and PARP Inhibitor Sensitivity

Yang Yu, Baylor College of Medicine, USA
Dna2 Nuclease Deficiency Results in Large and Complex DNA Insertions at Chromosomal Breaks

Dongyi Xu, Peking University, China
NAIF1-Constituted Nucleoskeleton Suppresses Chromosome Translocation and Tumorigenesis

Abigail Shea†, CRUK Cambridge Institute, UK
A Co-Clinical Trial Investigating Targeted Agents in Breast Cancer Using Patient-Derived Tumour Xenograft Models

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Mechanisms of DNA Replication
Registered attendees can view abstracts starting on 12/13/2018

Ballroom 2-3
* Bik Kwoon Tye, Hong Kong University of Science and Technology, Hong Kong

John F.X. Diffley, Francis Crick Institute, UK
Mechanisms of DNA Replication Initiation and Progression

Joseph Yeeles, MRC Laboratory of Molecular Biology, UK
Short Talk: Cryo-EM Structures of a 1.4 MDa Eukaryotic Replisome Progression Complex

James M. Dewar, Vanderbilt University, USA
Short Talk: Multiple Roles for Topoisomerase IIα During Termination of Vertebrate DNA Replication

Karim Labib, University of Dundee, UK
Mechanism of DNA Replication Termination and Replisome Disassembly

Kathleen Collins, University of California, Berkeley, USA
Telomerase Assembly and Action at Telomeres

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
19:30—22:00
Poster Session 1

Superior/Superior Lobby/Wasatch

TUESDAY, JANUARY 15

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Mechanisms of Recombination and Repair
Registered attendees can view abstracts starting on 12/13/2018

Ballroom 2-3
* Wolf-Dietrich Heyer, University of California, Davis, USA

Stephen C. West, Francis Crick Institute, UK
Multiple Roles for MUS81 and GEN1 in the Resolution of DNA Replication and Recombination Intermediates

Anna Malkova, University of Iowa, USA
In Search for the Link between Alternative Lengthening of Telomeres and the Mode of Telomere Erosion

Aparna Gorthi, University of Texas Health at San Antonio, USA
Short Talk: Role of STAG2 in R-Loop Processing, Replication and Recombinational Repair

Coffee Break

Joseph J. Loparo, Harvard Medical School, USA
How Non-Homologous End Joining Avoids Mistakes

Agnel Sfeir, New York University School of Medicine, USA
Mechanism of Alternative End-Joining

Chao Dong, University of Hong Kong, China
Short Talk: Fine-tuning of Transcriptional Activities at DSBs by the DYRK1 Kinases

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Superior/Superior Lobby/Wasatch
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Wasatch
16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Understanding and Exploiting Replication Stress
Registered attendees can view abstracts starting on 12/13/2018

Ballroom 2-3
* David Cortez, Vanderbilt University School of Medicine, USA

Massimo Lopes, University of Zürich, Switzerland
Replication Fork Remodeling upon Cancer-Relevant Replication Stress

Sharon B. Cantor, University of Massachusetts Medical School, USA
Short Talk: Defining Mechanisms that Subvert the Replication Stress Response in Cancer

Mark J. O'Connor, AstraZeneca, UK
Reversing PARP Inhibitor Resistance by Targeting the Replication Stress Response

Giorgia Federico, University of Naples Federico II, Italy
Short Talk: NCOA4 Protein Couples Iron Availability to DNA Replication

Sarah AE Lambert, Institute Curie, France
Nuclear Spatial Organization of Replication Fork Processing in Fission Yeast

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
19:30—22:00
Poster Session 2

Superior/Superior Lobby/Wasatch

WEDNESDAY, JANUARY 16

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:45
Overcoming Replication Fork Obstacles
Registered attendees can view abstracts starting on 12/13/2018

Ballroom 2-3
Johannes C. Walter, Harvard Medical School, USA
The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate their Repair

Ralph Scully, Beth Israel Deaconess Medical Center, USA
Recombination and Repair at Stalled Mammalian Replication Forks

Gerry P. Crossan, MRC Laboratory of Molecular Biology, UK
Short Talk: Embryonic Development Damages the Genome of Germ Cells

Coffee Break

David Gallo, University of Toronto, Canada
Short Talk: Rad5 Recruits Error-Prone DNA Polymerases for Mutagenic Repair of ssDNA Gaps on Undamaged Templates

Alessandro Vindigni, St. Louis University, USA
Short Talk: PrimPol-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA1-Deficient Tumors

Dana Branzei, FIRC Institute of Molecular Oncology, Italy
AND-1 Fork Protection Function Prevents Fork Resection and is Essential for Proliferation

Wojciech Niedzwiedz, Institute of Cancer Research, UK
Short Talk: EXD2 Protects Stressed Replication Forks and is Required for Cell Viability in the Absence of BRCA1/2

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Superior/Superior Lobby/Wasatch
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Wasatch
14:30—16:30
Workshop/Panel Discussion 3: Translating Basic Science to the Clinic

Ballroom 2-3
* Mark J. O'Connor, AstraZeneca, UK

* Daniel Durocher, Lunenfeld-Tanenbaum Research Institute, Canada

Yves G. Pommier, NCI, National Institutes of Health, USA
Schlafen 11 (SLFN11), Replication Stress Executioner and its Potential Translation to the Clinic

Alan D. D'Andrea, Dana-Farber Cancer Institute, USA
Talk Title to be Announced

Lauren A. Byers, MD Anderson Cancer Center, USA
Targeting DNA Damage Response (DDR) in Lung Cancer

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
RNA-Induced Genome Instability
Registered attendees can view abstracts starting on 12/13/2018

Ballroom 2-3
* Gaelle Legube, Center for Integrative Biology, France

Karlene A. Cimprich, Stanford University, USA
The Causes and Consequences of Replication Stress

Andrew Jackson, University of Edinburgh, UK
The Fifth Element: Genomic Consequences of Embedded Ribonucleotides

Peter C. Stirling, University of British Columbia, Canada
Short Talk: Nuclease-Independent Functions of Mre11-Rad50-Nbs1 Coordinate Cellular R-Loop Tolerance

Jan-Gert Brüning, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Investigation of Replication-Transcription Collisions in vitro

Houra Merrikh, University of Washington, USA
The Impact of DNA Topology on Replication-Transcription Conflicts

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
19:30—22:00
Poster Session 3

Superior/Superior Lobby/Wasatch

THURSDAY, JANUARY 17

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Genomic Drivers of Tumorigenesis and Drug Resistance
Registered attendees can view abstracts starting on 12/13/2018

Ballroom 2-3
* Agnel Sfeir, New York University School of Medicine, USA

Daniel Durocher, Lunenfeld-Tanenbaum Research Institute, Canada
Mapping DNA Damage Networks with CRISPR-Based Genetic Screens

Christopher Lord, Institute of Cancer Research, UK
Using Genetics to Understand Synthetic Lethal Sensitivity and Resistance to DDR Inhibitors

Violeta Serra, Vall d'Hebron Institute of Oncology, Spain
Short Talk: Lack of RAD51 Nuclear Foci Formation Identifies Homologous Recombination Repair (HRR) Deficient, PARPi-Sensitive Tumors Beyond Germline BRCA1/BRCA2 Mutation

Coffee Break

Lee Zou, Harvard Medical School, USA
Roles of ATR in Countering APOBECs in Cancer Cells

Domenic Pilger, Sidney Sussex College, UK
Short Talk: ATM Orchestrates the DNA-Damage Response to Counter Toxic Non-Homologous End-Joining at Broken Replication Forks

Titia de Lange, Rockefeller University, USA
53BP1/Rif1/Shieldin Counteract DSB Resection through CST/Pol alpha-Dependent Fill-In

11:15—17:00
On Own for Lunch

14:30—16:30
Workshop 4: Chromatin, Replication and Repair

Ballroom 2
* Evi Soutoglou, Institute of Genetics and Molecular and Cellular Biology, France
Double Strand Break Relocation Correlates with Heterochromatic Repeat Clustering

Dominika T. Gruszka, Francis Crick Institute, UK
Replication-Coupled Parental Histone Dynamics Probed at Single Molecule Level

John K. Barrows, Medical University of South Carolina, USA
Establishing an in Vitro System for Regulated Transcription and mRNA Processing

Caitlin Purman, Washington University in St. Louis, USA
Determining the Local Transcriptional Response to DNA Double-Strand Breaks in G1 Phase

Nataliia Serbyn, University of Geneva, Switzerland
The Aspartic Protease Ddi1 Contributes to DPC Repair in Yeast

Diana E. Libuda, University of Oregon, USA
Temperature Increases Cause Transposon-Associated DNA Damage Specific to Spermatocytes and Not Oocytes

Mihaela Todorova Peycheva, IMP - Research Institute of Molecular Pathology, Austria
DNA Replication is Critical for the Genesis of AID-Dependent Chromosomal Translocations in B Cells

14:30—16:30
Workshop 5: Replication Stress and DNA Damage Signaling

Ballroom 3
* Niels Mailand, University of Copenhagen, Denmark
Profiling Cellular Signaling Responses to DNA-Protein Crosslinks

Kristijan Ramadan, University of Oxford, UK
SPRTN Protease and Checkpoint Kinase 1 Cross-Activation Loop Safeguards DNA Replication

Ya-Chu Chang, University of Minnesota, USA
Uncovering the Molecular Dynamics Upon Replication Fork Stalling using Proteomics

Claus Sørensen, University of Copenhagen, Denmark
CtIP Variants Associated with Early Onset Breast Cancer Compromise Replication Fork Stability

Sarem Hailemariam, Washington University, St. Louis, USA
Rif2 Inhibits the MRX-Dependent Activation of Tel1 Kinase

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—18:45
Linking DNA Damage Response to the Immune Response
Registered attendees can view abstracts starting on 12/13/2018

Ballroom 2-3
* Andrew Jackson, University of Edinburgh, UK

Roger A. Greenberg, University of Pennsylvania Perelman School of Medicine, USA
DNA Damage Signaling to the Immune System

Alberto Bardelli, University of Torino, Italy
Inactivation of DNA Repair to Improve Immune Surveillance

Sophie Postel-Vinay, Gustave Roussy Cancer Campus, France
Combining DNA Damage Response (DDR) Inhibitors with Immunotherapy: The Next Step Change in Cancer Therapy?

Timo Reislander, University of Oxford, UK
Short Talk: PARP Inhibitors Potentiate Cell-Intrinsic Immune Responses Triggered by BRCA2 Inactivation

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Registered attendees can view abstracts starting on 12/13/2018

Ballroom 2-3
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ballroom 1-2
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Ballroom 1-2

FRIDAY, JANUARY 18

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Organized in collaboration with Cancer Research UK Editas Medicine
EMD Serono Research and Development Institute, Inc. TESARO, Inc.

We gratefully acknowledge additional support for this conference from:

AstraZeneca

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676