This meeting took place in 2019



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Cellular Plasticity: Reprogramming, Regeneration and Metaplasia (J3)


Organizer(s) Jason C. Mills, Maike Sander and Ben Z. Stanger
January 27—31, 2019
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Oct 17, 2018
Abstract Deadline: Oct 25, 2018
Scholarship Deadline: Oct 17, 2018
Discounted Registration Deadline: Nov 28, 2018

Sponsored by Novartis Institutes for BioMedical Research


Summary of Meeting:
Traditionally, differentiated cells were thought to be post-mitotic. However, now we know mature cells in diverse tissues can reprogram, re-enter the cell cycle, and spawn other lineages (e.g., they revert back to stem cells or adopt other identities). The scientific and health implications are substantial. For one, cellular plasticity might be harnessed to regenerate damaged tissue (e.g., insulin-secreting cells, liver, gut), but repeated reprogramming events – as cells respond to inflammation/injury – can also cause tissue derangement (metaplasia) that predisposes to cancer. Furthermore, cancer cells can harness such plasticity mechanisms to subvert therapy. Thus, defining the mechanisms that allow mature cells to switch identities holds great promise for understanding disease pathogenesis and developing new therapies. This conference gathers the diverse, dynamic field of plasticity/reprogramming together for the first time with the aim of understanding if similar mechanisms underlie plasticity in diverse organs and organisms. The hypothesis is that cellular reprogramming occurs via evolutionarily conserved cellular processes as fundamental to a multicellular organism as apoptosis. Specifically, the conference aims to: 1) Elucidate mechanisms of plasticity in diverse adult tissues; 2) Explore plasticity’s evolutionary context; 3) Elucidate its role in metaplasia/cancer; and 4) Investigate how it can be harnessed therapeutically.

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Scholarships/Awards

Keystone Symposia Future of Science Fund Scholarship Recipients

Bisiayo E. Fashemi
Washington University in St Louis, USA

Daysha Ferrer-Torres
University of Michigan, USA

Anne Meyer
Vanderbilt University, USA

Jason Pitarresi
University of Pennsylvania, USA

Megan Radyk
Washington University in St. Louis, USA

Salina Yuan
University of Pennsylvania, USA

Integra Foundation Scholarship Recipients

Robert Jarrett Bliton
University of North Carolina at Chapel Hill, USA