This meeting took place in 2019

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Autophagy: From Model Systems to Therapeutic Opportunities (B2)

Organizer(s) Vojo Deretic, Li Yu and Leon O. Murphy
February 17—21, 2019
Eldorado Hotel & Spa • Santa Fe, New Mexico USA
Discounted Abstract Deadline: Oct 23, 2018
Abstract Deadline: Nov 15, 2018
Scholarship Deadline: Oct 23, 2018
Discounted Registration Deadline: Dec 13, 2018

This activity is supported by an educational grant from Celgene Corporation

Summary of Meeting:
Autophagy is a homeostatic process strategically positioned at the intersection of metabolism and intracellular quality control, with broad physiological and medical manifestations ranging from metabolic imbalance to neurodegeneration, infections, immune disorders, cancer and aging. In yeast, the formation and organization of the autophagosomal apparatus follows a highly prescribed sequence, starting with the pre-autophagosomal structure and ending in autophagosomal fusion with the yeast vacuole. However, in other model organisms, as well as in mammals, the autophagy machinery and its regulators show both similarities and notable differences relative to yeast. The goals/aims of the conference are: 1) Compare and contrast autophagy in yeast and higher organisms with a focus on both the shared regulators and on those factors that have no counterparts in yeast. 2) Cover the intersection of autophagy with energy metabolism, innate immune signaling and endomembrane damage. 3) Cover how signaling cascades regulate the process of selective autophagy whereby substrates are recruited to forming autophagosomes by receptors and molecular tags such as ubiquitin, galectins, or through other modalities. The conference will cover fundamental principles as outlined above and how they apply to basic and translational aspects of human disease. Intersections with several other stress response processes will be addressed.

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Burroughs Wellcome Fund ECITA Scholarship Recipients

Eliseo F. Castillo
University of New Mexico Health Sciences, USA

Keystone Symposia Future of Science Fund Scholarship Recipients

Chiara De Leonibus
Telethon Institute of Genetics and Medicine, Italy

Jose Norberto (Jobert) Sagullo Vargas
University College London / NINDS, USA

Shenliang Yu
Yale University, USA

National Cancer Institute (NCI) Scholarship Recipients

Damian Gatica
University of Michigan, USA

Ana Mesquita
Albert Einstein College of Medicine, USA

Adam Lee Yokom
University of California, Berkeley, USA