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Twitter hashtag for this meeting: #KSautophagy

Autophagy, Inflammation and Immunity (B4)

Scientific Organizers: Herbert (Skip) W. Virgin, Beth Levine and Gökhan S. Hotamisligil

February 17—22, 2013

Fairmont The Queen Elizabeth, Montreal, QC, Canada

Sponsored by AbbVie Inc., Cell Research, EMD Millipore, Shire Human Genetic Therapies and Vertex Pharmaceuticals Incorporated

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Meeting Summary

Autophagy is a lysosomal degradation pathway by which eukaryotic cells break down their own components to adapt to nutrient deprivation. In multicellular organisms, autophagy and autophagy proteins also play a key role in the orchestration of diverse aspects of cellular and organismal responses to multiple dangerous stimuli, including infection. Thus, autophagy and autophagy proteins represent a key nexus within the cell through which multiple cellular and organismal stresses are integrated. This emerging understanding has led to exciting recent advances that, together, begin to paint a picture of how autophagy and autophagy proteins are involved in multiple diseases. Of particular interest, recent studies reveal a crucial role for autophagy pathways and proteins in immunity and inflammation. They balance the beneficial and detrimental effects of immunity and inflammation, and thereby may protect against infectious, autoimmune, and inflammatory diseases. The time is therefore ripe for a Keystone Symposia meeting that brings together researchers from a variety of fields to focus on emerging themes and concepts in 'Autophagy, Inflammation, and Immunity'. Key advances in this area include the identification of signaling pathways that regulate autophagy, inflammation, and immunity and the finding that inflammation, immunity and autophagy are tightly, and reciprocally, intertwined. The goal of this meeting is to relate the cell biology and signaling pathways that regulate autophagy and autophagy proteins to fundamental aspects of immunity and inflammation, as well as to diseases associated with alterations in these processes such as autoimmunity, infection, cancer, diabetes, the metabolic syndrome, and cardiovascular disease.