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The Innate Immune Response in the Pathogenesis of Infectious Disease (E1)

Scientific Organizers: Ricardo T. Gazzineli, Gustavo P. Amarante-Mendes, Anne O'Garra and Alan Sher

May 10—15, 2013

Centro de Artes e Convenções (UFOP), Ouro Preto, MG, Brazil

Organized as an international collaboration and with generous support from CNPq — the National Council for Scientific and Technological Development, Brazil, and FAPEMIG — Minas Gerais State Agency for Research Development. Part of the Keystone Symposia Global Health Series, travel awards supported by the Bill & Melinda Gates Foundation.

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Meeting Summary

The rational development of immunological interventions that are effective for treating or preventing infectious diseases is still on its infancy. For decades, the majority of the studies on immunopathogenesis have dealt with physical damage and inflammation, primarily mediated by lymphocytes. The main focus of this Keystone Symposia meeting will be on the interface of the innate immune system and microbial pathogens and the role that it plays in protective versus deleterious immune responses and, thereby, of disease outcome. The program will promote discussions on fundamental concepts as well as new advances in the role of innate immunity in host resistance and pathogenesis of infectious diseases, with special emphasis on infections of the tropics. Investigators from different areas, such as biochemistry, cell biology, immunology, microbiology, parasitology, infectious diseases, tropical medicine and biotechnology will be included to encourage the discussion of interdisciplinary concepts and new directions for the field. This is the first of a series of Keystone Symposia meetings to be held in Brazil, and should also foster the participation of Latin American students and scientists. The close interaction of these participants with leading international experts in the field should lead to a stimulating atmosphere that we hope will promote the development of new South-North collaborations and research networks.