Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic Dysfunction (D3)

This meeting brings fundamental cellular and physiological principles involving nuclear receptors and other transcription factors to the boundaries between physiology and disease oriented research. As evidenced by the session titles, the organizers have developed a program that covers the involvement of nuclear receptors (NR) and other transcription factors (TFs) regulating energy balance (food intake, energy expenditure and fat deposition), and their pathophysiological dysregulation leading to obesity associated cardiometabolic complications. The program has been configured to bring together diverse, sometimes conflicting ideas, and novel approaches to investigate the involvement of NR and TFs that may help to elucidate them. A primary goal is to gather junior and senior investigators who study transcriptional mechanisms controlling different aspects of energy homeostasis and metabolic adaptation, and thereby stimulate new ideas on how transcriptional networks could be targeted therapeutically in the context of metabolic disease. Taken together, the program design will provide an interdisciplinary integration of multiple organs and systems regulating energy homeostasis. Thus, this meeting is highly likely to attract a wide variety of investigators, many of whom might not otherwise interact.