Purinergic Signaling (J5)

joint with the meeting on Cancer Immunotherapy: Immunity and Immunosuppression Meet Targeted Therapies (J6)

Scientific Organizers: Joel Linden, Mark J. Smyth, Simon C. Robson and Kenneth A. Jacobson


January 24—28, 2016

Fairmont Hotel Vancouver, Vancouver, British Columbia, Canada


Sponsored by Bayer HealthCare Pharmaceuticals and Roche


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** Meeting has ended **

Discounted Abstract Deadline: September 29, 2015

*All deadlines end at 11:59 PM US Mountain Standard Time

Abstract Submission Fee: 100.00 USD*
Submission by this date receives 50.00 USD discount.
*50.00 USD will be applied to Registration Fee when you register

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(The Abstract Deadline: is October 29, 2015)

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Scholarship Deadline: September 29, 2015

*All deadlines end at 11:59 PM US Mountain Standard Time


Scholarship Details: You MUST submit your abstract by the Scholarship Deadline and complete the other required steps (submit a scholarship application and submit a mentor letter) to be considered for a scholarship.

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Abstract Deadline: October 29, 2015

*All deadlines end at 11:59 PM US Mountain Standard Time


Abstract Submission Fee: 100.00 USD*
*50.00 USD will be applied to Registration Fee when you register

Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadline. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract by the Abstract Deadline allows us to:

  • submit your abstract to organizers to be considered for a short talk
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
Abstracts submitted after the Abstract Deadline will NOT be considered for a short talk.

(Discounted Abstract Deadline: is September 29, 2015)

Discounted Registration Deadline: November 24, 2015

*All deadlines end at 11:59 PM US Mountain Standard Time


Registration Fee: 845.00 USD* (includes 150.00 USD discount)
Student Registration Fee: 620.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

After the Discounted Registration Deadline:


Registration Fee: 995.00 USD*
Student Registration Fee: 770.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

Registration spaces are limited and may fill prior to discounted registration deadline.

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Meeting Summary



Purines including ATP and adenosine play dual roles as intracellular mediators of metabolism and as critical extracellular signaling molecules, the latter via 19 purinergic receptors that control responses to stress and injury. This meeting will integrate rapidly emerging information about the regulation of purine release from cells (in vesicles and via channels and transporters); signaling via membrane-associated receptors (adenosine, P2X and P2Y) and extracellular metabolism (via CD73, CD39 and other ecto-enzymes); and new structural information that is facilitating drug discovery. These processes mediate tissue responses to a continual flux of signaling purines in the extracellular space that profoundly influence inflammatory diseases, tissue repair and immune function. A focus on the effects of hypoxia, metabolic stress and cytokines will fill gaps in our current knowledge of how these factors influence signaling during the evolution of acute and chronic inflammation. An understanding of how purinergic signals are dynamically regulated is needed to identify improved therapies, e.g., for cancer immunotherapy, since tumors exploit these pathways to avoid immune surveillance. Of particular interest is the growing realization that purinergic regulation controls remodeling of inflamed tissues and the functions of innate and adaptive immune cells, endothelial cells and platelets. The significance of extracellular purines in multiple tissues will be covered. The meeting should generate new mechanistic and therapeutic concepts. Prior meetings have defined the triad of purinergic "players" (channels, receptors and enzymes) generally in unstressed animals. The meeting will focus on the paradigm-shifting realization of dynamic purinergic regulation in the setting of disease progression.