Stem Cells and Regeneration in the Digestive Organs (X6)

joint with the meeting on Islet Biology: From Cell Birth to Death (X5)

Scientific Organizers: Linheng Li, Martín G. Martín, James M. Wells and Markus Grompe


March 13—17, 2016

Keystone Resort, Keystone, Colorado, USA


Sponsored by Merck & Co., Inc.


BEWARE of booking lodging through companies unaffiliated with Keystone Symposia. Click here for more details.

Keystone Symposia is committed to maintaining a positive and respectful environment at its meetings. To this end, please review and comply with our policies.

Registered attendees of one meeting in a joint pair may participate in sessions of the other, pending space availability.

** Meeting has ended **

Discounted Abstract Deadline: November 12, 2015

*All deadlines end at 11:59 PM US Mountain Standard Time

Abstract Submission Fee: 100.00 USD*
Submission by this date receives 50.00 USD discount.
*50.00 USD will be applied to Registration Fee when you register

Abstract Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadlines. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract early allows us to:
  • submit your abstract to organizers to be considered for a short talk
  • accept your abstract online
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
(The Abstract Deadline: is December 15, 2015)

Global Health Travel Award Deadline:

*All deadlines end at 11:59 PM US Mountain Standard Time


Global Health Travel Award Details: You MUST complete your Global Health Travel Award appplication by the Global Health Travel Award Deadline and complete the other required steps (verify your contact information and submit a recommendation letter) to be considered for a travel award.


Click here to learn more about Global Health Travel Awards.

Scholarship Deadline: November 12, 2015

*All deadlines end at 11:59 PM US Mountain Standard Time


Scholarship Details: You MUST submit your abstract by the Scholarship Deadline and complete the other required steps (submit a scholarship application and submit a mentor letter) to be considered for a scholarship.

Click here to learn more about Scholarships.

Abstract Deadline: December 15, 2015

*All deadlines end at 11:59 PM US Mountain Standard Time


Abstract Submission Fee: 100.00 USD*
*50.00 USD will be applied to Registration Fee when you register

Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadline. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract by the Abstract Deadline allows us to:

  • submit your abstract to organizers to be considered for a short talk
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
Abstracts submitted after the Abstract Deadline will NOT be considered for a short talk.

(Discounted Abstract Deadline: is November 12, 2015)

Discounted Registration Deadline: January 14, 2016

*All deadlines end at 11:59 PM US Mountain Standard Time


Registration Fee: 795.00 USD* (includes 150.00 USD discount)
Student Registration Fee: 570.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

After the Discounted Registration Deadline:


Registration Fee: 945.00 USD*
Student Registration Fee: 720.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

Registration spaces are limited and may fill prior to discounted registration deadline.

Please be advised that some meeting participants have received calls and emails from a number of different housing services, including "Exhibitors Housing Services," “Expo Housing Services,” "Global Housing," etc. THESE COMPANIES ARE NOT AFFILIATED WITH KEYSTONE SYMPOSIA and are not authorized by Keystone Symposia to contact you. These companies may tell you that the meeting is filling, without any actual knowledge to that effect, and pressure you into giving them your credit card number to make a lodging reservation with them.

We highly recommend that you not make a reservation with these companies or any other housing service! These companies' representations to participants have been misleading. Please report any calls or correspondence you might have received to Keystone Symposia and book only through lodging links in your Keystone Symposia account, an established travel agency or directly with the hotel(s) listed on our website.

Meeting Summary



The gastrointestinal, pancreatic and hepatobiliary systems serve many essential functions, and stem cell (SC)-based tissue regeneration holds promise for treating diseases of the digestive system (DS). Recent advances in the field include differentiation of pluripotent SCs (ESCs, iPSCs) into intestinal, pancreatic and hepatic cells that may someday be used to replace defective cell types. However, a gap remains between these achievements in basic research and translation into clinical treatment. Among the barriers to overcome include: 1) An incomplete understanding of stemness under homeostasis and stressed conditions; 2) Failure of SC in vitro to extend to in vivo conditions; 3) Questions of SC subpopulation; 4) Reversion of progenitor cells (PC) to SC; and 5) Effects of the microenvironment on SC and PC. This meeting is the first to bring together a broad representation of scientists researching SC from the interrelated fields of the DS. With open and vigorous discussion, the meeting will “cross boundaries” and capitalize on the common principles and unique features of the three systems. Specific aims of the meeting are to: 1) Facilitate characterization of the properties of DS SC in vivo; 2) Address how the heterogeneity of the microenvironment influences the state and fate of SCs/PCs; 3) Narrow the gap between findings of in vitro and in vivo identification; and 4) Explore applications for converting stem into functional DS cell systems to overcome disease. The meeting should result in new scientific methods, insights, collaborations and technical capabilities for the entire DS, and facilitate further clinical advances.