Small RNA Silencing: Little Guides, Big Biology (A6)

Scientific Organizers: Phillip D. Zamore, Yukihide Tomari and Mihaela Zavolan


January 24—28, 2016

Keystone Resort, Keystone, Colorado, USA


Supported by the Directors' Fund


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** Meeting has ended **

Discounted Abstract Deadline: September 28, 2015

*All deadlines end at 11:59 PM US Mountain Standard Time

Abstract Submission Fee: 100.00 USD*
Submission by this date receives 50.00 USD discount.
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(The Abstract Deadline: is October 28, 2015)

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Scholarship Deadline: September 28, 2015

*All deadlines end at 11:59 PM US Mountain Standard Time


Scholarship Details: You MUST submit your abstract by the Scholarship Deadline and complete the other required steps (submit a scholarship application and submit a mentor letter) to be considered for a scholarship.

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Abstract Deadline: October 28, 2015

*All deadlines end at 11:59 PM US Mountain Standard Time


Abstract Submission Fee: 100.00 USD*
*50.00 USD will be applied to Registration Fee when you register

Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadline. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract by the Abstract Deadline allows us to:

  • submit your abstract to organizers to be considered for a short talk
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
Abstracts submitted after the Abstract Deadline will NOT be considered for a short talk.

(Discounted Abstract Deadline: is September 28, 2015)

Discounted Registration Deadline: November 23, 2015

*All deadlines end at 11:59 PM US Mountain Standard Time


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*Includes 50.00 USD of your abstract submission fee

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Registration Fee: 945.00 USD*
Student Registration Fee: 720.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

Registration spaces are limited and may fill prior to discounted registration deadline.

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Meeting Summary



Small RNAs have emerged as remarkably pervasive and versatile regulators of gene expression in species ranging from viruses to animals. Although diverse in biogenesis and mode of action, these small, ~21 nucleotide riboregulators, including microRNAs, small interfering RNAs (siRNAs) and PIWI-interacting RNAs, act as guides for Argonaute proteins. As part of these ribonucleoprotein complexes, small RNAs regulate virtually every step of gene expression, playing key roles in nearly every biological process. Nucleic acid-guided Argonautes can be found in eubacteria, archaea, and eukaryotes, suggesting ancient origins of the RNA interference (RNAi) mechanisms. Furthermore, prokaryotes have an RNA-guided immune system — the CRISPR system — that shares functional similarities with RNAi. Although our understanding of these small RNA pathways has progressed rapidly in the past decade, new questions continue to emerge, reflecting our ever more precise and comprehensive methods to quantify the abundance of molecular species and, consequently, the regulatory impact of small RNAs. This meeting seeks to catalyze the open exchange of ideas about the molecular mechanisms by which small RNAs are made and function, the quantitative interplay among small RNAs, between small RNAs and targets, and, ultimately, the consequences of these interactions for cellular function, in normal and pathological states. Special emphasis is placed on showcasing the work of young investigators, and on complementary approaches for studying gene regulation by small RNAs. Finally, the meeting seeks to continue the intellectually rigorous but congenial atmosphere that is the tradition of this exciting field.