Nucleic Acid Sensing Pathways: Innate Immunity, Immunobiology and Therapeutics (E2)

Scientific Organizers: Thomas Tuschl, Veit Hornung and Karl-Peter Hopfner


May 8—12, 2016

Maritim Hotel & International Congress Center Dresden, Dresden, Germany


Sponsored by DFG Deutsche Forschungsgemeinschaft


BEWARE of booking lodging through companies unaffiliated with Keystone Symposia. Click here for more details.

Keystone Symposia is committed to maintaining a positive and respectful environment at its meetings. To this end, please review and comply with our policies.

** Meeting has ended **

Discounted Abstract Deadline: January 7, 2016


Abstract Submission Fee: 100.00 USD*
Submission by this date receives 50.00 USD discount.
*50.00 USD will be applied to Registration Fee when you register

Abstract Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadlines. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract early allows us to:
  • submit your abstract to organizers to be considered for a short talk
  • accept your abstract online
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
(The Abstract Deadline: is February 9, 2016)

Global Health Travel Award Deadline:


Global Health Travel Award Details: You MUST complete your Global Health Travel Award appplication by the Global Health Travel Award Deadline and complete the other required steps (verify your contact information and submit a recommendation letter) to be considered for a travel award.


Click here to learn more about Global Health Travel Awards.

Scholarship Deadline: January 7, 2016


Scholarship Details: You MUST submit your abstract by the Scholarship Deadline and complete the other required steps (submit a scholarship application and submit a mentor letter) to be considered for a scholarship.

Click here to learn more about Scholarships.

Abstract Deadline: February 9, 2016


Abstract Submission Fee: 100.00 USD*
*50.00 USD will be applied to Registration Fee when you register

Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadline. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract by the Abstract Deadline allows us to:
  • submit your abstract to organizers to be considered for a short talk
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
Abstracts submitted after the Abstract Deadline will NOT be considered for a short talk.

(Discounted Abstract Deadline: is January 7, 2016)

Discounted Registration Deadline: March 8, 2016


Registration Fee: 845.00 USD* (includes 150.00 USD discount)
Student Registration Fee: 620.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

After the Discounted Registration Deadline:


Registration Fee: 995.00 USD*
Student Registration Fee: 770.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

Registration spaces are limited and may fill prior to discounted registration deadline.

Please be advised that a few meeting participants have received calls and emails from a number of different housing services - "Exhibitors Housing Services", "Global Housing", etc. THESE COMPANIES ARE NOT AFFILIATED WITH KEYSTONE SYMPOSIA and are not authorized by Keystone Symposia to contact you. These companies may tell you that the meeting is filling and seek to take your lodging reservation and obtain your credit card number. We highly recommend that you not make a reservation with these companies or any other housing service! These companies' representations to participants have been misleading. Please report to Keystone Symposia any calls or correspondence you might have received and book only through the lodging link on our website, an established travel agency, or directly with the hotel.

Meeting Summary



Human cells possess intricate nucleic acid recognition processes for monitoring cellular stress and pathogen infection, which trigger the production and release of interferons and cytokines to alert neighboring cells including cells of the immune system. Various classes of nucleic acid sensors, each specific to detecting modified or unmodified, structured or unstructured DNA or RNA, have been identified and are characterized by distinct subcellular localization and also cell-type-specific expression patterns. These sensors include various nucleotidyl transferases producing second messenger small ribonucleic nucleic acid molecules as well as membrane-bound receptors ultimately leading to phosphorylation of transcription factors driving cytokine and interferon expression. This meeting focuses on cytoplasmic DNA and RNA sensors and the function of their linear and circular oligonucleotide second messenger cGAMP and 2’,5’-oligoadenylate produced upon activation. Substantial progress has been made in identification of the structures of these sensors, their nucleic acid ligands and second messenger molecules, as well as the underlying molecular pathways leading to transcriptional activation. Animal models inactivating various pathways of innate immunity have been developed. This progress has enabled targeted development of antagonists and agonists of cytokine and interferon production for therapeutic targeting of inflammatory diseases and vaccine adjuvant development, respectively. An international group of academic and industry scientists and clinicians with expertise in biochemistry and structural biology, nucleic acid chemistry, immunology, human genetics, virology, rheumatology and vaccine development will converge at this meeting to discuss the latest developments in this field.