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This meeting took place in 2009



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Chromatin Dynamics and Higher Order Organization (C4)


Organizer(s) Terumi Kohwi-Shigematsu and Patrick D. Varga-Weisz
February 25—March 2, 2009
Coeur d'Alene Resort • Coeur d'Alene, Idaho USA
Abstract Deadline: Oct 27, 2008
Late Abstract Deadline: Nov 25, 2008
Scholarship Deadline: Oct 27, 2008
Early Registration Deadline: Dec 30, 2008

Supported by the Directors' Fund

Summary of Meeting:
Research in the past decade has revealed the intimate link of chromatin structure at the levels of histone modifications and nucleosome remodeling to nuclear functions, especially gene regulation. Yet the molecular mechanisms of higher orders of chromatin organization beyond the nucleosomal array remain largely obscure. Evidence is emerging that chromatin folding and large-scale chromatin interactions, including trans-interactions between chromosomes, play an important role in gene regulation, recombination, and other nuclear processes. Chromatin looping may be a key component of regulatory mechanisms. New roles of non-coding RNAs in regulating chromatin function are also uprising. Furthermore, functional compartments, such as transcription factories, replication factories, and polycomb bodies have been suggested to organize the nucleus. This meeting will focus on recent breakthroughs in our understanding of the mechanisms that govern dynamics of higher-order chromatin architecture in order to gain important insights into gene regulation and disregulation, DNA repair, normal development, stem cell function, epigenetic inheritance and diseases such as cancer.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, FEBRUARY 25

15:00—19:30
Registration

Conference Center Lobby
18:30—19:30
Refreshments

Bay 4
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Bay 2-3
* Terumi Kohwi-Shigematsu, Lawrence Berkeley National Laboratory, USA

Michael G. Rosenfeld, HHMI/University of California, San Diego, USA
Life, Death, and Translocation: Movements, Repeats, and ncRNAs


THURSDAY, FEBRUARY 26

07:00—08:00
Breakfast

Bay 5
08:00—11:15
The Regulation of Chromatin Dynamics
Meeting has ended...abstracts no longer viewable online.

Bay 2-3
* Peter Fraser, Florida State University, USA
Inter-Chromosomal Gene Regulatory Networks

David M. Gilbert, Florida State University, USA
Global Re-Organization of Replication Domains during Embryonic Stem Cell Differentiation

Sarah Javaid, Merck, USA
Short Talk: Nucleosome Remodeling Catalyzed by the Human hMSH2-hMSH6 Mismatch Recognition Complex

Craig L. Peterson, University of Massachusetts Medical School, USA
Chromatin Dynamics during DNA Repair

Irina Solovei, Ludwig Maximilians University, Germany
Inverted Nuclear Architecture and Its Development during Differentiation of Mouse Rod Photoreceptor Cells

Samantha Gail Zeitlin, University of California, San Diego, USA
Short Talk: The Centromeric H3 Variant CENP-A is Targeted by and Functions in DNA Repair

09:20—09:40
Coffee Break

West Conference Center Lobb
11:15
On Own for Lunch

11:15—13:00
Poster Setup

Bay 4
13:00—22:00
Poster Viewing

Bay 4
16:30—17:00
Coffee Available

West Conference Center Lobb
17:00—19:15
Chromatin Transitions Underlying Development
Meeting has ended...abstracts no longer viewable online.

Bay 2-3
* Peter B. Becker, University of Munich, Germany
CHRAC/ACF Initiates the Stratification of the Epigenome

Patrick D. Varga-Weisz, Babraham Institute, UK
ATP-Dependent Chromatin Remodeling Factors: Guardians of the Epigenome

Sophie Rousseaux, Institut Albert Bonniot, France
Molecular Basis of Post-Meiotic Male Genome Reprogramming: Essential Role for Histone Hyperacetylation

Antoine H.F.M. Peters, Friedrich Miescher Institute for Biomedical Research, Switzerland
The Role of Polycomb-Group Proteins in Higher Order Chromatin Organization and Genomic Imprinting

19:15—20:15
Social Hour with Lite Bites

Bay 4
19:30—22:00
Poster Session 1

Bay 4

FRIDAY, FEBRUARY 27

07:00—08:00
Breakfast

Bay 5
07:00—08:00
Poster Setup

Bay 4
08:00—11:15
Chromatin Folding and Gene Regulation
Meeting has ended...abstracts no longer viewable online.

Bay 2-3
* Gary Felsenfeld, NIDDK, National Institutes of Health, USA
Chromatin Boundaries

Job Dekker, University of Massachusetts Medical School, USA
Three-Dimensional Folding of Chromosomal Domains in Relation to Gene Expression

Olivier Cuvier, LBME- CNRS, France
Short Talk: Chromatin Dual-Cores Define Nucleosome-Associated Cis-Regulatory Insulator Elements that Control the Deposition of H3K9 Methylation Marks in Hundreds of Promoters of Genes Regulating Chromosome Organization/Segregation

Rolf Ohlsson, Karolinska Institute, Sweden
Imprinted Domains Form Extensive Interaction-Networks to Regulate Epigenetic States

Gordon L. Hager, NCI, National Institutes of Health, USA
Genome-Wide Interaction of Nuclear Receptors with Chromatin

Joke G. van Bemmel, Netherlands Cancer Institute, Netherlands
Short Talk: The Insulator Protein Su(Hw) Marks Borders of Lamina Associated Domains

09:20—09:40
Coffee Break

West Conference Center Lobb
11:15—12:00
Lunch

Bay 4
12:00—14:30
Poster Session 2

Bay 4
16:30—17:00
Coffee Available

West Conference Center Lobb
17:00—19:00
Non-Coding RNAs and Chromatin Function
Meeting has ended...abstracts no longer viewable online.

Bay 2-3
* Shiv I. S. Grewal, NCI, National Institutes of Health, USA
Epigenetic Genome Control by RNAi and Transposon-Derived Proteins

Howard Y. Chang, Stanford University, USA
Programming Chromatin States by Long Noncoding RNAs

Jeannie T. Lee, Massachusetts General Hospital, USA
New Lessons from the X-Inactivation Paradigm

Keith E. Giles, University of Alabama at Birmingham, USA
Short Talk: Histone Deacetylation and Dicer-Dependent Small RNAs Control Chromatin Condensation within Vertebrate Constitutive Heterochromatin

19:00
On Own for Dinner


SATURDAY, FEBRUARY 28

07:00—08:00
Breakfast

Bay 5
08:00—11:15
Genome Organization and Structure
Meeting has ended...abstracts no longer viewable online.

Bay 2-3
* Giacomo Cavalli, Institute of Human Genetics, France
Polycomb Proteins and Nuclear Organization in Drosophila

Victor G. Corces, Emory University, USA
Genome Organization and Chromatin Insulators

Matthias Merkenschlager, Imperial College London, UK
Cohesins in Gene Regulation and Genome Organization

Keji Zhao, NHLBI, National Institutes of Health, USA
Dynamic Change of Histone Modifications during Differentiation

Jung S. Byun, National Cancer Institute, National Institutes of Health, USA
Short Talk: p300 Facilitates the Formation of Pre-Positioned RNA Polymerase

Dale Dorsett, St. Louis University School of Medicine, USA
Short Talk: Gene Regulation in Cohesin-Binding Chromosomal Domains

09:20—09:40
Coffee Break

West Conference Center Lobb
11:15
On Own for Lunch

11:15—13:00
Poster Setup

Bay 4
13:00—22:00
Poster Viewing

Bay 4
16:30—17:00
Coffee Available

West Conference Center Lobb
17:00—19:00
The Chromatin Landscape for Stem Cells and Development
Meeting has ended...abstracts no longer viewable online.

Bay 2-3
* Wolf Reik, Babraham Institute, UK
Imprinting and Epigenetic Reprogramming in Mammalian Development

Stuart H. Orkin, Dana-Farber Cancer Institute, USA
The Transcriptional Network and Chromatin Structure in ES Cells

Manjari Mazumdar, Indiana University, USA
Short Talk: The Molecular Motor Chromokinesin KIF4 is a Modulator of Interphase Chromatin Structure

Yukiko Gotoh, University of Tokyo, Japan
Short Talk: Temporal Regulation of Neural Precursor Cell Fate by Polycomb-Group Proteins

19:00—20:00
Social Hour with Lite Bites

Bay 4
19:30—22:00
Poster Session 3

Bay 4

SUNDAY, MARCH 1

07:00—08:00
Breakfast

Bay 5
08:00—11:15
Chromatin Dynamics in Aging and Disease
Meeting has ended...abstracts no longer viewable online.

Bay 2-3
* Stephen B. Baylin, Johns Hopkins University School of Medicine, USA
Epigenetic Control of Cancer

Paolo Sassone-Corsi, University of California, Irvine, USA
Epigenetic Control of the Circadian Clock: SIRT1 and Metabolism

Andrew S. Koh, Stanford University, USA
Short Talk: Essential Role for Chromatin in Aire-Mediated Tolerance to Autoimmunity

Kyoko Yokomori, University of California, Irvine, USA
Differential Recruitment and Function of the Essential Sister Chromatid Cohesion Complex Cohesin in Gene Activation and Heterochromatin Organization

Le Zhang, University of Hong Kong, USA
Short Talk: Prelamin A Induces Premature Senescence and Accelerated Aging by Activating Heterochromatin Formation

Alexander Tarakhovsky, Rockefeller University, USA
Chromatin Control of Antiviral Response

09:20—09:40
Coffee Break

West Conference Center Lobb
11:00
On Own for Lunch

16:30—17:00
Coffee Available

West Conference Center Lobb
17:00—19:00
Altered Chromatin Structure in Disease
Meeting has ended...abstracts no longer viewable online.

Bay 2-3
* Cynthia T. McMurray, Lawrence Berkeley National Laboratory, USA
Age-Dependent CAG Trinucleotide Expansion in Post-Mitotic Neurons

Siavash K. Kurdistani, University of California, Los Angeles, USA
Histone Modification Dynamics in Oncogenic Transformation

Colyn Crane-Robinson, University of Portsmouth, UK
Short Talk: The Chromatin of Active Genes is not in a Permanently Open Conformation

Terumi Kohwi-Shigematsu, Lawrence Berkeley National Laboratory, USA
The Genome Organizer SATB1 in Mouse Brain

19:00—20:00
Social Hour with Lite Bites

Bay 4
20:00—23:00
Entertainment

Bay 4

MONDAY, MARCH 2

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

BioMed Central Cell Press

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676