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This meeting took place in 2009



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Deregulation of Transcription in Cancer: Controlling Cell Fate Decisions (E2)


Organizer(s) Beverly M. Emerson and Edison T. Liu
June 21—26, 2009
INEC-Ireland's National Events Centre • Killarney, Co. Kerry Ireland
Abstract Deadline: Feb 23, 2009
Late Abstract Deadline: Mar 24, 2009
Scholarship Deadline: Feb 23, 2009
Early Registration Deadline: May 8, 2009

Organized in Collaboration with Science Foundation Ireland. Sponsored by Amgen Inc.

Summary of Meeting:
Transcription is an intricate process that is regulated with exquisite specificity at both the genetic and epigenetic levels through such aspects as chromatin and core RNA polymerase machinery. Sophisticated mechanisms have been recently deciphered concerning how specific genes and pathways are deregulated in human cancers. Master cancer regulators are commonly transcription factors. Yet a great disparity exists between the nonspecificity of most cancer therapies and this advanced understanding of aberrant gene expression. This conference will focus on exploiting novel mechanistic information to generate more efficacious targeted therapies . Current insights into the mechanisms by which specific genes are deregulated in cancer, the resulting transcriptome signature for particular cancers, and state-of-the-art therapeutic approaches using small molecules or RNA interference will be presented. The goals of this meeting are to explore how transcription as a regulator for cell fate outcomes can be parlayed into specific cancer therapies.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JUNE 21

15:00—19:30
Registration

INEC Conference Centre Foyer
18:30—19:30
Refreshments

INEC Conference Centre Foyer
19:30—21:45
Keynote Session
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
Frank Gannon, QIMR Berghofer Medical Research Institute, Australia
Welcoming Remarks

Robert G. Roeder, Rockefeller University, USA
Function of Transcriptional Coactivators in Animal Cells

René Bernards, Netherlands Cancer Institute, Netherlands
Finding Mechanisms and Biomarkers of Drug Resistance in Cancer


MONDAY, JUNE 22

08:00—09:00
Breakfast

INEC Conference Centre Foyer
09:00—12:00
Transcriptional Regulation through Epigenetic Control in Cancer
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Kristian Helin, University of Copenhagen, Denmark
Histone Methyltransferases and Demethylases in Cell Proliferation and Cancer

Maarten Van Lohuizen, Netherlands Cancer Institute, Netherlands
Regulation of Stem Cell Commitment and Tumor Development by Polycomb Repressors

Manel Esteller, Belvitge Biomedical Research Institute (IDIBELL), Spain
Epigenetic Dysregulation in Human Cancer

Sung Hee Baek, Seoul National University, South Korea
Short Talk: Negative Regulation of Hypoxic Responses via Induced Reptin Methylation

Reuven Agami, Netherlands Cancer Institute, Netherlands
BRD 7 is Required for P53 Tumor Suppressor Activity

10:20—10:40
Coffee Break

INEC Conference Centre Foyer
12:00
On Own for Lunch

12:00—13:00
Poster Setup

INEC Conference Centre Foyer
13:00—22:00
Poster Viewing

INEC Conference Centre Foyer
15:00—16:30
Workshop 1: Presentations Selected from Submitted Abstracts

INEC Main Auditorium
* Deborah L. Johnson, University of Southern California, USA
The c-Jun-N-Terminal Kinases Differentially Regulate RNA Polymerase III Transcription by Coordinately Modulating the Expression of all TFIIIB Subunits

Rajnish A. Gupta, Stanford University School of Medicine, USA
Reprogramming of the Breast Cancer Epigenome and Promotion of Metastasis by a HOX Long Noncoding RNA

Ralf Kittler, University of Texas Southwestern Medical Center, USA
A Nuclear Receptor Cis-regulatory Map for Breast Cancer

Erich S. Huang, Duke University Medical Center, USA
An Experimentally-Annotated Strategy for Developing Factor Models of Oncogenic Activities & Sensitivity to Pathway-Specific Therapeutics

Anchit Khanna, IMT, University of Tampere, Finland
C-Myc-Dependent Regulation and Prognostic Role of c-Myc Stabilizing Protein CIP2A, in Human Gastric Cancer

Anchit Khanna, IMT, University of Tampere, Finland
C-Myc-Dependent Regulation and Prognostic Role of c-Myc Stabilizing Protein CIP2A, in Human Gastric Cancer

16:30—17:00
Coffee Available

INEC Conference Centre Foyer
17:00—19:15
Mechanisms of Transcriptional Misregulation
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Joan W. Conaway, Stowers Institute for Medical Research, USA
Alc1, a Putative Oncogene and Chromatin Remodeling Enzyme Regulated by Poly(ADP-ribosyl)ation

Beverly M. Emerson, The Salk Institute, USA
Aberrant Transcriptional Silencing in Human Cancers

Peter N. Cockerill, Leeds Institute of Molecular Medicine, UK
Epigeneitc and Transcriptional Mechanisms Regulating Haematopoeitic Cells in Normal and Malignant Cancer Cells

Howard Y. Chang, Stanford University, USA
A Histone Demethylase in Cell Cycle Control

19:15—20:15
Social Hour with Lite Bites

INEC Conference Centre Foyer
19:30—22:00
Poster Session 1

INEC Conference Centre Foyer

TUESDAY, JUNE 23

08:00—09:00
Breakfast

INEC Conference Centre Foyer
08:00—09:00
Poster Setup

INEC Conference Centre Foyer
09:00—12:00
Tumor Promotion through Aberrant Transcription
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Karen H. Vousden, Crick Institute, UK
Functions of Mutant p53 in Promoting Invasion

Joaquín M. Espinosa, University of Colorado Boulder, USA
Novel Mechanisms of Transcriptional Control in the p53 and Serum Response Gene Networks

Constanze Bonifer, University of Birmingham, UK
Short Talk: Aberrant Transcriptional Activation of CSF-1R in Hodgkins Lymphoma

Hugues de Thé, Hopital St. Louis, France
Recent Insights into PML/RARA Function in APL Pathogenesis

Michael Karin, University of California, San Diego, USA
Inflammation induced Transcriptional Reprogramming in Metastatic Progression

09:00—17:30
Poster Viewing

INEC Conference Centre Foyer
10:20—10:40
Coffee Break

INEC Conference Centre Foyer
12:00—13:00
Lunch

INEC Conference Centre Foyer
12:30—15:00
Poster Session 2

INEC Conference Centre Foyer
15:00—15:30
Coffee Available

INEC Conference Centre Foyer
15:30—17:30
Activation of Developmental Transcription Pathways in Cancer
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Katherine A. Jones, The Salk Institute, USA
SKIP/SNW1 Regulates Transcription Elongation and Methylation

Stephen C. Blacklow, Harvard Medical School, USA
Transcriptional Dysregulation by Aberrant Notch Signaling in Leukemia

Jason S. Carroll, Cancer Research UK, University of Cambridge, UK
Short Talk: Defining the Role for Pioneer Factors in Estrogen Receptor Transcriptional Activity

Thea D. Tlsty, University of California, San Francisco, USA
Clues on the Activation and Regulation of Epigenetic Remodeling in Cancer

17:30
On Own for Dinner


WEDNESDAY, JUNE 24

08:00—09:00
Breakfast

INEC Conference Centre Foyer
09:00—12:00
Mapping the Transcriptome in Cancer States
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Bing Ren, Ludwig Institute for Cancer Research, USA
Global Analysis of Gene Regulation in Human Cells

Alexander Meissner, Max Planck Institute for Molecular Genetics, Germany
Epigenomics and Cellular States

Dearbhaile Collins, Royal College of Surgeons, Ireland, Ireland
Short Talk: Steroid and Growth Factor Pathway Crosstalk in Breast Cancer: The Impact of c-Myc and SMRT Interaction

Yijun Ruan, University of Connecticut, USA
Mapping Cancer Transcriptome and Long-Range Chromatin Interactions of Transcription Regulatory Elements through Genomic Sequencing Approaches

Edison T. Liu, The Jackson Laboratory, USA
Cellular Decisions in Transcription: The Topology of Transcription Factor Binding and Decision Nodes for Binding Site Selection

10:20—10:40
Coffee Break

INEC Conference Centre Foyer
12:00
On Own for Lunch

12:00—13:00
Poster Setup

INEC Conference Centre Foyer
13:00—22:00
Poster Viewing

INEC Conference Centre Foyer
15:00—16:30
Workshop 2: Panel Discussion, Perspectives on Transcription as a Therapeutic Target

INEC Main Auditorium
René Bernards, Netherlands Cancer Institute, Netherlands

Robert G. Roeder, Rockefeller University, USA

Gregory L. Verdine, Harvard University, USA

Paul Workman, Institute of Cancer Research, UK

John J. Rossi, Beckman Research Institute of the City of Hope, USA

16:30—17:00
Coffee Available

INEC Conference Centre Foyer
17:00—19:00
Gene Expression Cassettes and Transcriptional Networks in Cancer
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Joseph R. Nevins, Duke University Medical Center, USA
Genomic Analysis of Oncogenic Cell Signaling Networks

Erik S. Knudsen, UT Southwestern, USA
Short Talk: Disruption of the RB/E2F Regulatory Network in Cancer: Variant Impact on Tumorigenesis & Therapeutic Response

Fabrizio Bianchi, Istituto Europeo di Oncologia, Italy
Short Talk: Global Mapping of Oncogenic Expression Signatures in Lung Adenocarcinoma

Arul M. Chinnaiyan, University of Michigan, USA
The Next Generation of Gene Fusion Discovery in Cancer

19:00—20:00
Social Hour with Lite Bites

INEC Conference Centre Foyer
19:30—22:00
Poster Session 3

INEC Conference Centre Foyer

THURSDAY, JUNE 25

08:00—09:00
Breakfast

INEC Conference Centre Foyer
09:00—12:00
Modifying Transcription and Transcription Targeted Therapeutics I
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Gregory L. Verdine, Harvard University, USA
Drugging “Undruggable” Targets Using Stapled Peptides

John J. Rossi, Beckman Research Institute of the City of Hope, USA
RNAi Post-transcriptional and Transcriptional Gene Silencing Mechanism

Sandra E. Dunn, University of British Columbia, Canada
YB-1 induces CD44 and CD49f thereby promoting the capacity for tumor initiation

Qiang Yu, Genome Institute of Singapore, Singapore
Combinatorial Treatment Targeting EZH2-Mediated Epigenetic Event for Cancer Therapy

Lyubomir T. Vassilev, Roche Pharmaceuticals, USA
Small Molecule Inhibitors of p53-MDM2 Complexes for Cancer Therapy

10:20—10:40
Coffee Break

INEC Conference Centre Foyer
12:00
On Own for Lunch

16:30—17:00
Coffee Available

INEC Conference Centre Foyer
17:00—19:00
Modifying Transcription and Transcription Targeted Therapeutics II
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Paul Workman, Institute of Cancer Research, UK
Drugging the Cancer Genome

Sheng Ding, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA
Stem Cell Biology

Elisabeth D. Martinez, University of Texas Southwestern Medical Center, USA
Short Talk: An Epigenetic Cell Based Screen Identifies a Novel Small Molecule with Specific Anti-Cancer Activity

Yosef Yarden, Weizmann Institute of Science, Israel
Oncogenic Signal Transduction Networks and their Feedback Regulation

19:00—20:00
Social Hour with Lite Bites

INEC Conference Centre Foyer
19:30—22:00
Entertainment

INEC Conference Centre Foyer

FRIDAY, JUNE 26

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA139720-01




We gratefully acknowledge additional support for this conference from:

Educational donation provided by Amgen Fáilte Ireland
Lilly Singapore Centre for Drug Discovery Science Foundation Ireland

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Merck & Co., Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Cell Press Royal Society of Chemistry

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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