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This meeting took place in 2009



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The Biology of RNA Silencing (D6)


Organizer(s) Witold Filipowicz and Erik Sontheimer
April 25—30, 2009
Fairmont Empress Victoria • Victoria, British Columbia Canada
Abstract Deadline: Dec 29, 2008
Late Abstract Deadline: Jan 28, 2009
Scholarship Deadline: Dec 29, 2008
Early Registration Deadline: Feb 25, 2009

Supported by the Directors' Fund

Summary of Meeting:
During the past decade, a set of pathways collectively known as “RNA silencing” has been shown to use small RNA molecules to regulate gene expression and protect cells from pathogens. RNA silencing pathways control an ever-expanding range of biological phenomena, and defects in these pathways lead directly to disease. In addition, small RNAs hold great promise as therapeutic agents. The physiological mechanisms of RNA silencing are only partially understood. Furthermore, small RNAs are known to affect gene expression at many different levels, but the ways in which these different levels of silencing are integrated remain obscure. Our ability to harness RNA silencing for therapeutic purposes depends critically on our knowledge of the underlying biology. The goals of this meeting are to bring together leading researchers working on different branches of RNA silencing to share their findings and facilitate a deeper understanding of the breadth and complexity of small RNA-related phenomena.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, APRIL 25

15:00—19:30
Registration

Palm Court
18:30—19:30
Refreshments

Palm Court
19:30—21:30
Keynote Session
Meeting has ended...abstracts no longer viewable online.

Crystal Ballroom
* Witold Filipowicz, Friedrich Miescher Institute for Biomedical Research, Switzerland

* Erik Sontheimer, University of Massachusetts Medical School, USA
Welcoming Remarks

Andrew Fire, Stanford University, USA
Adventures in the Small RNA-ome

David P. Bartel, HHMI, MIT and Whitehead Institute, USA
MicroRNAs and Other Small Regulatory RNAs


SUNDAY, APRIL 26

07:00—08:00
Breakfast

Crystal Ballroom
08:00—11:30
Mechanism of Small RNAs I
Meeting has ended...abstracts no longer viewable online.

Salon B-C
* David C. Baulcombe, University of Cambridge, UK

V. Narry Kim, Seoul National University, South Korea
Biogenesis of miRNAs

Gunter Meister, University of Regensburg, Germany
Regulation of Argonaute Function

Qinghua Liu, University of Texas Southwestern Medical Center, USA
Short Talk: C3PO Promotes Drosophila RNAi by Enhancing RISC Activity

Bruce M. Paterson, National Cancer Institute, National Institutes of Health, USA
Short Talk: Identification of an RNA-Dependent RNA Polymerase in Drosophila Involved in RNAi and Transposon Suppression

Erik Sontheimer, University of Massachusetts Medical School, USA
CRISPR Interference in Bacteria

Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA
Structural Biology of Argonaute-Mediated RNA Silencing

Jin-Biao Ma, University of Alabama at Birmingham, USA
Short Talk: Structural Insights into the Molecular Mechanism of the Small RNA Methyltransferase HEN1

09:20—09:40
Coffee Break

Prefunction, Level 2
11:30
On Own for Lunch

11:30—13:00
Poster Setup

Salon A
13:00—22:00
Poster Viewing

Salon A
16:30—17:00
Coffee Available

Prefunction, Level 2
17:00—19:15
Chromatin Silencing and Modification
Meeting has ended...abstracts no longer viewable online.

Salon B-C
* Irene Bozzoni, University La Sapienza, Rome, Italy

Shiv I. S. Grewal, NCI, National Institutes of Health, USA
Epigenetic Genome Control by RNAi and Transposon-Derived Proteins

Nicholas J. Proudfoot, University of Oxford, UK
Autoregulation of Convergent RNAi Genes by Transient Heterochromatin Formation in S. pombe

Thomas A. Volpe, Northwestern University, Feinberg School of Medicine, USA
Short Talk: RNA-Dependent RNA Polymerase Links Assembly of Heterochromatin Domains to Secondary siRNA Synthesis

Steven E. Jacobsen, University of California, Los Angeles, USA
DNA Methylation on Arabidopsis

Andrzej T. Wierzbicki, University of Michigan, USA
Short Talk: RNA Polymerase V Transcription Recruits AGO4 to Chromatin

19:15—20:15
Social Hour with Lite Bites

Salon A
19:30—22:00
Poster Session 1

Salon A

MONDAY, APRIL 27

07:00—08:00
Breakfast

Crystal Ballroom
07:00—08:00
Poster Setup

Salon A
08:00—11:30
Mechanism of Small RNAs II
Meeting has ended...abstracts no longer viewable online.

Salon B-C
* Javier A. Martinez, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Austria

Scott G. Kennedy, University of Wisconsin, USA
siRNAs Initiate a NRDE-2-Dependent Co-Transcriptional Gene Silencing Program that Regulates RNAP II Elongation

Craig C. Mello, University of Massachusetts Medical School, USA
Complexity of RNA Silencing in C. elegans

Thomas F. Duchaine, McGill University, Canada
Short Talk: Architecture of the ERI endoRNAi Initiation Machinery in C. elegans

David C. Baulcombe, University of Cambridge, UK
Imprinted Expression of siRNA loci in Arabidopsis

Peter Sarnow, Stanford University School of Medicine, USA
Modulation of Hepatitis C Virus RNA Abundance by Liver-Specific microRNA miR-122

Yukihide Tomari, University of Tokyo, Japan
Short Talk: Dissection of Ago1-RISC Assembly Pathway in Drosophila

Eric C. Lai, Sloan-Kettering Institute, USA
Short Talk: Sorting of miRNA* Strands in Drosophila

09:20—09:40
Coffee Break

Prefunction, Level 2
11:30—12:30
Lunch

Salon A
12:00—14:30
Poster Session 2

Salon A
12:00—19:15
Poster Viewing

14:30—16:30
Workshop 1: Identification of New miRNA Targets

Salon B-C
* Mihaela Zavolan, Biozentrum, University of Basel, Switzerland
Sequence and Structure Determinants of miRNA Targeting Specificity

Daehyun Baek, Whitehead Institute for Biomedical Research, USA
The Impact of microRNAs on Protein Output

Artemis G. Hatzigeorgiou, BSRC "Al. Fleming", Greece
DIANA-MicroT 4: Machine Learning based microRNA Target Prediction

Markus Hafner, Rockefeller University, USA
PURE-CLIP - Transcriptome-Wide Identification of miRNA Targets and RNA Targets and Binding Sites of RNA-Binding Proteins

Dimitrios G. Zisoulis, Regulus Therapeutics, USA
Massive Identification of miRNA Target Sites in Endogenous mRNAs

Vincenzo Alessandro Gennarino, Telethon Institute of Genetics and Medicine, Italy
MicroRNA Target Prediction by Expression Analysis of Host Genes

Francesca Moretti, European Molecular Biology Laboratory, Germany
Positional Effects of microRNA-Mediated Translational Regulation and their Mechanistic Basis

Yevgeniy Grigoryev, The Scripps Research Institute, USA
The Role of miRNAs in Regulating Human T and B Lymphocyte Activation

16:30—17:00
Coffee Available

Prefunction, Level 2
17:00—19:15
Intersection of RNAi/miRNA Silencing with Other Cellular Pathways
Meeting has ended...abstracts no longer viewable online.

Salon B-C
* Brenda L. Bass†, University of Utah, USA

Olivier Voinnet, Swiss Federal Institute of Technology, Zürich, Switzerland
RNAi and Pathogen Defense in Plants

Bryan R. Cullen, Duke University Medical Center, USA
Viruses, microRNAs and RNA Interference

Craig P. Hunter, Harvard University, USA
Intercellular RNA Transporters in Worms and Vertebrates

Raul Andino, University of California, San Francisco, USA
Short Talk: Antiviral Immunity in Drosophila Requires Systemic RNAi Spread

Yi Liu, University of Texas Southwestern Medical Center, USA
Short Talk: A Novel Type of Small Interference RNA Induced by DNA Damage

19:15
On Own for Dinner


TUESDAY, APRIL 28

07:00—08:00
Breakfast

Crystal Ballroom
08:00—11:30
Regulation of Translation and Stability by miRNAs
Meeting has ended...abstracts no longer viewable online.

Salon B-C
* Haruhiko Siomi, Keio University School of Medicine, Japan

Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany
GW182 Proteins are Essential for miRNA-mediated Gene Silencing in Animal Cells

Witold Filipowicz, Friedrich Miescher Institute for Biomedical Research, Switzerland
Mechanism and Regulation of miRNA Repression in Mammalian Cells

Xiaozhong Alec Wang, Northwestern University, USA
Short Talk: Genetic Analysis of Argonaute Function in ES Cells

Nahum Sonenberg, McGill University, Canada
Dissecting microRNA Mechanisms of Action in vitro

Joan A. Steitz, HHMI, Yale University, USA
MicroRNPs: Versatile Regulators of Translation in Vertebrate Cells

Sara R. Cherry, University of Pennsylvania School of Medicine, USA
Short Talk: Ars2 Regulates both miRNA- and siRNA-Dependent Silencing and Suppresses RNA Virus Infection in Drosophila

Helge Großhans, Friedrich Miescher Institute - FMI, Switzerland
Short Talk: Active Turnover Modulates Mature microRNA Activity in C. elegans

09:20—09:40
Coffee Break

Prefunction, Level 2
11:30
On Own for Lunch

11:30—13:00
Poster Setup

Salon A
13:00—22:00
Poster Viewing

Salon A
14:30—16:30
Workshop 2: Lessons from Deep Sequencing

Salon B-C
* Nikolaus Rajewsky, Max Delbruck Center for Molecular Medicine, Germany
Dynamic Small RNA Expression in Precisely Staged Early C. elegans Embryos and the Planarian Small RNAome

Thomas Hohn, University of Basel, Switzerland
RNA-Based Silencing Suppression

Nicholas D. Socci, Memorial Sloan Kettering Cancer Center, USA
Analysis of SmallRNA Expression Profiles in Liposarcoma via Deep Sequencing

Priyamvada Rajasethupathy, Stanford University, USA
Characterization of Small RNAs in Aplysia Reveals Neuronal piRNAs and a Neuron-Specific miRNA that Constrains Long-Term Synaptic Plasticity

Xiaoming Zhang, University of California, Riverside, USA
Diverse Classes of Endogenous siRNAs with Distinct Biogenesis Pathways Identified from Bacterial-Challenged Arabidopsis

Michael T. McManus, University of California, San Francisco, USA
EXPANDed RNAi Libraries for High-Throughput Deep Screening

Constance Ciaudo, ETH, Switzerland
Highly Dynamic and Sex-Specific Expression of Micro RNAs during Early ES Cell Differentiation

Hervé Seitz, CNRS, France
The Spectacular Diversity of Small Silencing RNAs in Animals is Ancient and not a Vertebrate Innovation

16:30—17:00
Coffee Available

Prefunction, Level 2
17:00—19:15
RNA Silencing in the Germline
Meeting has ended...abstracts no longer viewable online.

Salon B-C
* Richard W. Carthew, Northwestern University, USA

Gregory J. Hannon, University of Cambridge, UK
Conserved Roles of Small RNAs in Genome Defense

Mikiko C. Siomi, University of Tokyo, Japan
PiRNA Biogenesis Systems in Drosophila Germline Cells

René F. Ketting, Institute for Molecular Biology, Germany
RNAi and Chromosome Segregation

Yohei Kirino, Thomas Jefferson University, USA
Short Talk: Methylation of Piwi Proteins is Conserved across Phyla and in D. melanogaster it is Catalyzed by PRMT5 and Required for Ago3 and Aub Stability

Michael Reuter, EMBL, France
Short Talk: Loss of the Mili-Associated Tudor Domain Containing Protein 1 Specifically Derepresses LINE1 Transposons

19:00—20:00
Social Hour with Lite Bites

Salon A
19:30—22:00
Poster Session 3

Salon A

WEDNESDAY, APRIL 29

07:00—08:00
Breakfast

Crystal Ballroom
08:00—11:30
MicroRNAs in Development
Meeting has ended...abstracts no longer viewable online.

Salon B-C
* Olivier Voinnet, Swiss Federal Institute of Technology, Zürich, Switzerland

Richard W. Carthew, Northwestern University, USA
Silencing by Small RNAs is Linked to Endosome Trafficking

Victor R. Ambros, University of Massachusetts, USA
MicroRNA Pathways in Animal Development

Antonio J. Giraldez, Yale University School of Medicine, USA
The Role of microRNAs during Zebrafish Development

Gerhard Schratt, Philipps-University-Marburg, Germany
Short Talk: microRNA Regulation of Dendritic and Synaptic Plasticity

Eran Hornstein, Weizmann Institute of Science, Israel
Short Talk: Loss of miRNA Activity in Pathogenesis of ALS-like Motor Neuron Disease

Hun-Way Hwang, Johns Hopkins University, USA
Short Talk: Cell-Cell Contact Globally Activates microRNA Biogenesis

Yang Yu, Institute of Biophysics, CAS, China
Short Talk: Enhanced Magnitude of miRNA-Mediated Regulation Upon Muscle Differentiation

Joel R. Neilson, Baylor College of Medicine, USA
Short Talk: 3' UTR Dynamics in Cellular Activation and Transformation

09:20—09:40
Coffee Break

Prefunction, Level 2
11:30
On Own for Lunch

16:30—17:00
Coffee Available

Prefunction, Level 2
17:00—19:30
Small RNAs in Medicine
Meeting has ended...abstracts no longer viewable online.

Salon B-C
* Anastasia Khvorova, University of Massachusetts Medical School, USA

John Van der Oost, Wageningen University, Netherlands
Interference by Small CRISPR RNA in Prokaryotes

Gunther Hartmann, Universitätsklinikum Bonn, Germany
RIG-I Immunorecognition of siRNA and Application for Tumor Therapy

Beverly L. Davidson, Children’s Hospital of Philadelphia and The University of Pennsylvania, USA
Noncoding RNAs and Huntington’s disease.

Tariq M. Rana, University of California, San Diego, USA
Short Talk: Role of P-Bodies and microRNAs in Modulating Host-HIV-1 Interactions

Kumi Sakurai, Sanford-Burnham Medical Research Institute, USA
Short Talk: Characterization and in vivo Application of a Dual Inhibitory Aptamer-siRNA Delivery System for HIV-1 Therapy

Sakari Kauppinen, Aalborg University, Denmark
Short Talk: Therapeutic Silencing of microRNA-122 in Primates with Chronic HCV Infection

19:30—20:30
Social Hour with Lite Bites

Crystal Ballroom
20:00—23:00
Entertainment

Crystal Ballroom

THURSDAY, APRIL 30

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

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We gratefully acknowledge additional support for this conference from:

Applied Biosystems Integrated DNA Technologies

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