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This meeting took place in 2009



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Axonal Connections: Molecular Cues for Development and Regeneration (J6)


Organizer(s) John G. Flanagan, Marie T. Filbin and Liqun Luo
February 17—22, 2009
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 17, 2008
Late Abstract Deadline: Nov 18, 2008
Scholarship Deadline: Oct 17, 2008
Early Registration Deadline: Dec 17, 2008

Sponsored by Eli Lilly and Company


Summary of Meeting:
The functioning of the nervous system depends on formation of a complex pattern of connections during development. If these connections are subsequently lost through injury or degeneration, axons in the adult CNS fail to regenerate, creating a major clinical challenge. The last several years have seen tremendous progress in identifying molecular mechanisms for axon development and regeneration, although much remains to be learned about these complex processes. Rapid progress is being made in identifying new classes of extracellular regulators, understanding the mechanisms by which this extracellular information is transduced by the neuron into appropriate responses, and learning the underlying molecular logic for the formation of neural connectivity. This meeting will bring together researchers in the fields of axon development, degeneration and regeneration. The meeting will promote exchange of ideas, information and collaboration among these fields, and will train young scientists in the questions, approaches, and opportunities in these exciting and topical research areas. It will also promote scientific and translational goals of understanding the basic mechanisms for the formation of neural circuits, and developing new strategies for therapeutic repair.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 17

15:00—19:30
Registration

Longs Peak Foyer
18:30—19:30
Refreshments

Longs Peak Foyer
19:30—21:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays Peak / Longs Peak
Michael E. Greenberg, Harvard Medical School, USA
Signaling Networks that Control Synapse Development and Cognitive Function

Huda Y. Zoghbi, HHMI/Baylor College of Medicine, USA
Pathogenic Mechanisms in Neurodegenerative Disorders


WEDNESDAY, FEBRUARY 18

07:00—08:00
Breakfast

Quandary 1-3
08:00—11:00
Molecular Cues for Axon Guidance
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Rüdiger Klein, Max Planck Institute of Neurobiology, Germany

Yimin Zou, University of California, San Diego, USA
Wnt Signaling and Axon Guidance Along the CNS Anteroposterior Axis

Dietmar Schmucker, Dana-Farber Cancer Institute, Harvard Medical School, USA
Functional and Molecular Studies of the Hypervariable Receptor Dscam

Hitoshi Sakano, University of Tokyo, Japan
Axon Wiring in the Mouse Olfactory System

Fred Charron, Montreal Clinical Research Institute (IRCM), Canada
Short Talk: Sonic Hedgehog Guides Axons through a Novel, Non-Canonical Signaling Pathway

Eric O. Williams, Cornell University, USA
Short Talk: Identifying Axon Guidance Molecules during the Development and Regeneration of the Mouse Olfactory System

Jason W. Triplett, University of California, Santa Cruz, USA
Short Talk: Activity-Driven Alignment of Visual Topographic Maps in the Superior colliculus

08:00—11:15
Autophagy - Common Themes in Neurodegenerative Disease?
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Richard I. Morimoto, Northwestern University, USA

David C. Rubinsztein, Cambridge Institute for Medical Research, UK
Autophagy Induction: A Possible Therapeutic Strategy for Neurodegenerative Diseases Caused by Aggregate-Prone Intracytoplasmic Proteins

Masaaki Komatsu, School of Medicine Niigata University, Japan
Inclusion Body Formed by Autophagy-Deficient Mice

Ron R. Kopito, Stanford University, USA
Prion-Like Properties of Polyglutamines

Matthew J. Elrick, University of Michigan, USA
Short Talk: Tau Deletion Exacerbates the Phenotype of Niemann-Pick Type C Mice and Implicates Autophagy in Pathogenesis

Ishrat Ahmed, Johns Hopkins School of Medicine, USA
Short Talk: Dopamine Neurons are Sensitive to Impaired Autophagy in Vivo

Mona Bains, University of Colorado Denver, USA
Short Talk: Regulation of Neuronal Autophagy

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Quandary 1-3
13:00—22:00
Poster Viewing

Quandary 1-3
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Axon Degeneration (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays Peak / Longs Peak
* Marie T. Filbin, Hunter College, USA

Freda D. Miller, Hospital for Sick Children, Canada
p75 and Axon Degeneration: From Pruning to Injury

Marc R. Freeman, Vollum Institute, Oregon Health & Science University, USA
Wallerian Degeneration and Wlds Function in Drosophila

Marc Tessier-Lavigne, Stanford University, USA
Axonal Self-Destruction and Neurodegenerative Disease

Wenbiao Gan, Skirball Institute Program of Molecular Neurobiology, USA
Imaging Neuronal Injury and Repair

19:15—20:15
Social Hour with Lite Bites

Quandary 1-3
19:30—22:00
Poster Session 1

Quandary 1-3

THURSDAY, FEBRUARY 19

07:00—08:00
Breakfast

Quandary 1-3
08:00—11:15
Signaling Pathways in Neural Connectivity
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Stephen M. Strittmatter, Yale University, USA

David D. Ginty, HHMI/Harvard Medical School, USA
Growth Factor Signals Controlling Development of the Peripheral Nervous System

Alex L. Kolodkin, Johns Hopkins University School of Medicine, USA
Molecular Mechanisms Underlying the Establishment of Neuronal Connectivity

Liqun Luo, Stanford University, USA
Cell Autonomous Function of NMDA Receptor in Dendrite Patterning

Yi Rao, Peking University, China
Slit and Netrin

Thomas Fothergill, University of Wisconsin, Madison, USA
Short Talk: DCC Modulates Slit-Robo Signaling during Corpus callosum Development

Uwe Drescher, King's College London, UK
Short Talk: Neurotrophin Receptors in EphrinA Reverse Signaling

08:00—11:15
Proteostasis in Neurodegenerative Disease: Chaperones and Protein Misfolding
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Ron R. Kopito, Stanford University, USA

Richard I. Morimoto, Northwestern University, USA
Proteostasis Networks and the Regulation of Proteotoxicity in Neurodegenerative Disease

Heather L. True, Washington University, USA
Yeast Prions as Intragenic and Extragenic modifiers of protein aggregation

Marc I. Diamond, University of Texas Southwestern Medical Center, USA
Prion-Like Properties of the Microtubule Associated Protein Tau: Diversity and Propagation of Protein Misfolding

Andrew G. Dillin, University of California, Berkeley, USA
Connecting Mechanisms of Aging and Neurodegeneration

Jeppe Pedersen Falsig, IRBM Promidis, Italy
Short Talk: Neurodegeneration in Organotypic Brain Slice Cultures

Kenneth Matthew Scaglione, University of Michigan, USA
Short Talk: Deciphering the Ubiquitination Cycle: The de Ubiquitinating Enzyme Ataxin-3 Regulates the Chaperone-Dependent Ligase CHIP

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Quandary 1-3
13:00—22:00
Poster Viewing

Quandary 1-3
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
RNA and Regulated Protein Expression in Axon Guidance
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Michael E. Greenberg, Harvard Medical School, USA

John G. Flanagan, Harvard Medical School, USA
RNA-Based Regulation Mechanisms in Axon Development

Gary J. Bassell, Emory University, USA
Mechanisms of mRNA Transport and Local Protein Synthesis in Axon Guidance and Regeneration

Oliver Hobert, Columbia University, USA
Molecular Mechanisms of Maintaining Nervous System Architecture

Catia Andreassi, University College London, UK
Short Talk: Identification of a Novel Localization Element that Targets mRNA Transcripts in Sympathetic Neuron Axons

17:00—19:00
Models of Neurodegenerative Diseases
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Bart De Strooper, University College London, UK

Susan L. Ackerman, University of California, San Diego, USA
Novel Pathways Underlying Neurodegeneration Revealed by Forward Genetics

Ted M. Dawson, Johns Hopkins University School of Medicine, USA
Molecular Mechanisms Underlying Mitochondrial Dysfunction and Neurodegeneration in Parkinson’s Disease

Karen Duff, Columbia University, USA
Insight into Pathogenic Mechanisms and Potential Therapeutic Approaches from Transgenic Models of AD

Sara K. Custer, St. Jude Children's Research Hospital, USA
Short Talk: Mutant VCP Leads to Cytotoxicity and Redistribution of TDP-43 in vivo

19:00—20:00
Social Hour with Lite Bites

Quandary 1-3
19:30—22:00
Poster Session 2

Quandary 1-3

FRIDAY, FEBRUARY 20

07:00—08:00
Breakfast

Quandary 1-3
08:00—11:15
Axon Regeneration (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays Peak / Longs Peak
* Liqun Luo, Stanford University, USA

Marie T. Filbin, Hunter College, USA
Signaling Axonal Regeneration in the CNS

Jerry Silver, Case Western Reserve University, USA
Functional Regeneration Into and Beyond the Glial Scar

Zhigang He, Children's Hospital, Boston, USA
Intrinsic Control of Axon Regeneration

Stephen M. Strittmatter, Yale University, USA
Failure of Adult CNS Axonal Growth after Injury

Andrew D. Chisholm, Wellcome Trust, UK
Short Talk: Mechanisms of Axonal Regeneration in C. elegans

Alvaro Sagasti, University of California, Los Angeles, USA
Short Talk: Plasticity of Sensory Axon Arbors in the Zebrafish Skin is Controlled by a Nogo Receptor/RhoA Pathway

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15
On Own for Lunch

11:15—13:00
Poster Setup

Quandary 1-3
13:00—22:00
Poster Viewing

Quandary 1-3
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Synapse Formation
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Marc Tessier-Lavigne, Stanford University, USA

Kang Shen, Stanford University, USA
Regulators of Synapse Formation in C. elegans

Rüdiger Klein, Max Planck Institute of Neurobiology, Germany
Cell Autonomous Function of NMDA Receptor in Dendritic Patterning

Ben A. Barres, Stanford University, USA
How do Astrocytes Induce CNS Synapse Formation?

Wei Shen, University of Wisconsin, Madison, USA
Short Talk: Autophagy and Ubiquitin Proteasome System Converge in Regulating Drosophila Synaptic Growth

17:00—19:00
RNA Actions in Neurodegeneration
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Ted M. Dawson, Johns Hopkins University School of Medicine, USA

Bart De Strooper, University College London, UK
The Role of miRNA in Alzheimer¡¦s Disease and recent insights in ƒ×-secretase biology

Shai Shaham, Rockefeller University, USA
A New C. elegans Cell Death Program

Valina L. Dawson, Johns Hopkins University School of Medicine, USA
Survival and Death Choices Regulated by MiR's

Wim Mandemakers, Erasmus MC, Netherlands
Short Talk: Regulation of Alpha-Synuclein Expression by miRNAs

19:00—20:00
Social Hour with Lite Bites

Quandary 1-3
19:30—22:00
Poster Session 3

Quandary 1-3

SATURDAY, FEBRUARY 21

07:00—08:00
Breakfast

Quandary 1-3
08:00—11:15
Stem Cells (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays Peak / Longs Peak
* David M. Holtzman, Washington University, USA

Fred (Rusty) H. Gage, The Salk Institute for Biological Studies, USA
Stem Cells in the Adult Brain

Fiona Doetsch, Columbia University, USA
Stem Cells and their Niche in the Adult Mammalian Brain

Hongjun Song, University of Pennsylvania, USA
Activity-Dependent Regulation of Adult Mammalian Neural Stem Cells and Neurogenesis

Lorenz Studer, Memorial Sloan Kettering Cancer Center, USA
Pluripotent Stem Cell Based Strategies for Disease Modeling and Cell Repair in Neurodegenerative Disease

Orly Lazarov, University of Illinois at Chicago, USA
Short Talk: Presenilin-1 Regulates Neurogenesis in the Adult Brain

Maria Lehtinen, Boston Children's Hospital, Harvard Medical School, USA
Short Talk: The Cerebrospinal Fluid (CSF) Proteome Provides a Niche for Neural Progenitor Cells

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15
On Own for Lunch

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Dendrite Patterning and Complex Circuits
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Ben A. Barres, Stanford University, USA

Andrew D. Huberman, , USA
Short Talk: Genetic Dissection of Mammalian Neural Circuitry

Wesley B. Grueber, Columbia University Medical Center, USA
Control of Dendritic Deversification

Ofer Reizes, Cleveland Clinic Foundation, USA
Short Talk: Axonal Connections in the Circuits Controlling Feeding Behavior in Syndecan-3 Null Mice are Wired for Leanness

Catherine C. Dulac, Harvard University, USA
Molecular and Genetic Approaches to Brain Circuits and Behavior

17:00—19:00
New Therapeutic Approaches
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Valina L. Dawson, Johns Hopkins University School of Medicine, USA

David M. Holtzman, Washington University, USA
Fluid Biomarkers of Antecedent Alzheimer's Disease and New Therapies and Methods to Assess Treatments in Neurodegenerative Disease

Beverly L. Davidson, Children’s Hospital of Philadelphia and The University of Pennsylvania, USA
Noncoding RNAs and Huntington’s Disease

Timothy M. Miller, Washington University School of Medicine, USA
Gene Downregulation as a Therapy for ALS

Leila M. Luheshi, University of Cambridge, UK
Short Talk: Inhibiting the Aggregation and Toxicity of Amyloid Beta in Vivo using an Engineered Amyloid Beta Binding Protein

19:00—20:00
Social Hour with Lite Bites

Quandary 1-3
20:00—23:00
Entertainment

Quandary 1-3

SUNDAY, FEBRUARY 22

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13NS064822-01




We gratefully acknowledge additional support for this conference from:

Educational grant from Lilly USA, LLC
Alzheimer's Drug Discovery Foundation

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Cell Press

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676