Hilton Santa Fe Historic Plaza Hotel Floorplan

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This meeting took place in 2009



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Multiple Sclerosis (A8)


Organizer(s) James L. Salzer, Anne H. Cross and John Fleming
January 21—26, 2009
Hilton Santa Fe Historic Plaza Hotel • Santa Fe, New Mexico USA
Abstract Deadline: Sep 24, 2008
Late Abstract Deadline: Oct 24, 2008
Scholarship Deadline: Sep 24, 2008
Early Registration Deadline: Nov 21, 2008

Sponsored by the National Multiple Sclerosis Society

Summary of Meeting:
Despite important recent progress, the etiology of Multiple Sclerosis (MS) remains unknown and important therapeutic needs are unmet. This conference will discuss advances in basic pathogenetic mechanisms and emergent therapies for MS. Emphasis will be on the immunopathogenesis of MS, including mechanisms of lymphocyte activation and trafficking across the blood brain barrier, on sources of axonal pathology, and genetic risk factors. New imaging methods and therapeutic strategies that target the immune system and promote remyelination will be discussed. An important challenge in MS research is to integrate emerging insights in the basic mechanisms of myelination, autoimmune demyelination, and neurodegeneration with translational science. The goal of this meeting is to provide a broad spectrum of MS researchers with a forum to discuss recent advances, and to foster cross-disciplinary interactions and collaborations.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, JANUARY 21

15:00—19:30
Registration

Promenade
18:30—19:30
Refreshments

Promenade
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
Howard L. Weiner, Brigham and Women’s Hospital, Harvard Medical School, USA
Role of the Innate Immune System in Multiple Sclerosis

20:30—21:00
Orientation for New Attendees and New Investigators
Keystone Symposia's Chief Scientific Officer, Dr. Andy Robertson, to lead discussion in a "What to Expect during your Attendance" for interested delegates.

Mesa Ballroom

THURSDAY, JANUARY 22

07:00—08:00
Breakfast

Chamisa
08:00—11:15
Pathogenetic Mechanisms of Demyelination and MS
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* John Fleming, University of Wisconsin, Madison, USA
Overview of MS and Major Challenges; and The Hygiene Hypothesis and Multiple Sclerosis

Alberto Ascherio, Harvard School of Public Health, USA
Epidemiology of MS: Could MS be Prevented?

Claudia Lucchinetti, Mayo Clinic, USA
Evolution of Pathogenic Concepts in Multiple Sclerosis

Nicole Schaeren-Wiemers, University Hospital Basel, Switzerland
Short Talk: Characterization of Molecular Alterations in Normal Appearing Grey Matter of Multiple Sclerosis Brain Tissues

Stephen D. Miller, Northwestern University Medical School, USA
Pathogenic Mechanisms and Regulation of Susceptibility/Resistance to Theiler’s Virus-Induced Demyelination by CD4+CD25+ Regulatory T Cells

Alison L. Christy, Northwestern University, USA
Short Talk: Mast Cells Regulate BBB Permeability in EAE

09:20—09:40
Coffee Break

Promenade
11:15
On Own for Lunch

11:15—13:00
Poster Setup

Chamisa/Ortiz
13:00—22:00
Poster Viewing

Chamisa/Ortiz
16:30—17:00
Coffee Available

Promenade
17:00—19:00
Biology and Pathobiology of the Myelinated Axon
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* James L. Salzer, New York University School of Medicine, USA
Assembly and Molecular Architecture of Myelinated Axons

Klaus-Armin Nave, Max Planck Institute of Experimental Medicine, Germany
An Emerging Role of Oligodendrocytes in Maintaining Axonal Integrity

Bruce D. Trapp, Cleveland Clinic Foundation, Lerner Research Institute, USA
Mechanisms of Axonal Degeneration in Chronic MS Lesions

Volker Siffrin, Charité University Medicine Berlin, Germany
Short Talk: Intravital Imaging of Immune-Neuronal Interaction in Experimental Autoimmune Encephalomyelitis

19:00—20:00
Social Hour with Lite Bites

Chamisa/Ortiz
19:30—22:00
Poster Session 1

Chamisa/Ortiz

FRIDAY, JANUARY 23

07:00—08:00
Breakfast

Chamisa
07:00—08:00
Poster Setup

Chamisa/Ortiz
08:00—11:15
Immunopathogenetic Mechanisms in MS
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
T-regs and Th17 Cells: Role in Induction and Regulation of Tissue Inflammation

Zsuzsanna Fabry, University of Wisconsin, USA
Short Talk: Intracerebral Dendritic Cells Modulate Encephalitogenic Versus Regulatory Immune Responses in the CNS

Dan R. Littman, HHMI/New York University School of Medicine, USA
Transcriptional Regulation of Th17 Cell Differentiation

Izumi Kawachi, Brain Research Institute, Niigata University, Japan
Short Talk: The Distinct Lineage: Double Negative T Cells Expressing IL-17 in MS

Colleen E. Hayes, University of Wisconsin-Madison, USA
Regulatory Role of Vitamin D in Autoimmune Demyelination

* Joan Goverman, University of Washington, USA
Triggering CD8+ T Cells to Mediate CNS Autoimmunity

09:20—09:40
Coffee Break

Promenade
11:15—12:00
Lunch

Ortiz/Chamisa
12:00—14:30
Poster Session 2

Chamisa/Ortiz
14:30—16:30
Workshop 1: Mechanisms of Myelination and Remyelination Cells

Mesa Ballroom
* Klaus-Armin Nave, Max Planck Institute of Experimental Medicine, Germany

Maria Traka, University Of Chicago, USA
Development of a Mouse Model for Adult Onset Ablation of Oligodendrocytes

Jayshree Samanta, New York University, USA
Role of Sonic Hedgehog in Remyelination

Kevin S. Carbajal, University of California, Irvine, USA
CXCL12 Enhances Migration of Implanted Glial-Committed Progenitor Cells in a Viral Model of Multiple Sclerosis

Angeliki Mela, Columbia University, USA
KAI1/CD82 is Required for CNS Myelination by Oligodendrocyte Progenitors

Patrick Kuery, University of Duesseldorf, Germany
CXCL12-Dependent Oligodendroglial Differentiation

Manzoor Bhat, University of North Carolina, Chapel Hill, USA
Formation and Maintenance of the Paranodal Axo-glial Junctions in Myelinated Axons

16:30—17:00
Coffee Available

Promenade
17:00—19:00
Mechanisms of T Cell Trafficking into the CNS
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* Richard M. Ransohoff, Biogen, USA
MS Pathogenesis from the Outside-In: A New Perspective

Britta Engelhardt, Theodor Kocher Institute/Universitat Bern, Switzerland
Imaging Leukocyte Recruitment across the Blood Brain Barrier

Robyn S. Klein, Washington University School of Medicine, USA
Blood-Brain Barrier Dysfunction During MS: Signals that Promote T Cell Entry

Harald F. Langer, National Cancer Institute, National Institutes of Health, USA
Short Talk: A Novel Function of Platelets in the Pathogenesis of Experimental Autoimmune Encephalomyelitis (EAE)

19:00
On Own for Dinner


SATURDAY, JANUARY 24

07:00—08:00
Breakfast

Chamisa
08:00—11:00
Identification of Genetic Risk Factors for MS and Autoimmune Diseases
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* David A. Hafler, Yale University School of Medicine, USA
Common Risk Alleles Associated with Multiple Sclerosis

Jacob McCauley, University of Miami, USA
Interleukin-7 Receptor (IL7R) Pathway Genes as Risk Factors for MS

Sergio E. Baranzini, University of California, San Francisco, USA
Genomic Approaches in MS

Allan James Bieber, Mayo Clinic, USA
Short Talk: Genetic Determinants of CNS Repair

Mario Clerici, Dipartimento di Fisiologia Medico-Chirurgica e dei Trapianti, Italy
Short Talk: RAC2 Gene Single Nucleotide Polymorphisms Modulate MBP-Specific Immune Responses and Correlate with Disease Progression in MS

09:20—09:40
Coffee Break

Promenade
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Chamisa/Ortiz
13:00—22:00
Poster Viewing

Chamisa/Ortiz
16:30—17:00
Coffee Available

Promenade
17:00—19:00
Evaluation of MS Lesions and Axonal Pathology
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
Gavin Giovannoni, Barts and The London School of Medicine and Dentistry, UK
Biomarkers in Multiple Sclerosis

Yanming Wang, Case Western Reserve University, USA
Short Talk: Direct Quantification of Myelin Changes in the Vertebrate Nervous System

Sheng-Kwei Song, Washington University School of Medicine, USA
Distinguishing Axonal from Myelin Pathology by DTI

* Paul M. Matthews, Imperial College London, UK
Using fMRI to Study MS: Understanding Plasticity

19:00—20:00
Social Hour with Lite Bites

Chamisa/Ortiz
19:30—22:00
Poster Session 3

Chamisa/Ortiz

SUNDAY, JANUARY 25

07:00—08:00
Breakfast

Chamisa
08:00—11:15
Emergent Immunotherapeutics: What Do They Teach Us About MS?
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
Lawrence Steinman, Stanford University, USA
Antigen Specific Tolerance in MS

Gordon Francis, Novartis, USA
Natalizumab Therapy in MS

Lisa M. Mendoza, Bayer Healthcare Pharmaceuticals, USA
Short Talk: A Role for Leukotriene A4 Hydrolase in Disease Progression in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

* Anne H. Cross, Washington University, USA
B Cell Depletion in MS Patients using Rituximab (antiCD20)

Mehrdad Matloubian, University of California, San Francisco, USA
Regulation of Lymphocyte Egress by Innate and Adaptive Immune Responses

Patrizia De Sarno, University of Alabama at Birmingham, USA
Short Talk: Targeting GSK3 is Therapeutic in EAE: Effects on Dendritic Cells and Encephalitogenic Activity of T Cells

09:20—09:40
Coffee Break

Promenade
11:15
On Own for Lunch

14:30—16:30
Workshop 2: New Therapeutic Approaches to MS

Mesa Ballroom
* Lawrence Steinman, Stanford University, USA

* Henry McFarland, NINDS, National Institutes of Health, USA

Jacqueline Kirchner, Bill & Melinda Gates Foundation, USA
Prophylactic or Therapeutic Administration of Anti-GM-CSF-M250 Inhibits Disease in Multiple Experimental Autoimmune Models of MS

Jennifer S. Lam, SRI International, USA
SR16951, a New Small Molecule for the Treatment of Multiple Sclerosis

V. Wee Yong, University of Calgary, Canada
EMMPRIN: A New Regulator of Neuroinflammation in Multiple Sclerosis

Jochen Schmitz, Lilly Research Laboratories, USA
The Orally Bioavailable Portein Kinase C Inhibitor RGE-80 can Abrogate EAE Disease Induction and Ameliorates Disease in a Therapeutic Setting

Chandra Deb, Mayo Clinic College of Medicine, USA
Neuronal Stress Sensitizes Axons to Immune-Mediated Injury

Takashi Yamamura, National Institute of Neuroscience, NCNP, Japan
NKT Cell-Dependent Amelioration of EAE by Altering Gut Flora

16:30—17:00
Coffee Available

Promenade
17:00—19:00
Neural Protection and Remyelination
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* Robin Franklin, University of Cambridge, UK
The Biology of CNS Remyelination – the Key to Therapeutic Advances

Sha Mi, Biogen Idec, Inc., USA
Remyelination and Repair of the CNS by anti-LINGO1 Antibody

Rhonda R. Voskuhl, University of California, Los Angeles, USA
Hormone Treatment in MS

Marnie Preston, Oregon National Primate Research Center, USA
Short Talk: Hyaluronidase Activity Prevents Remyelination and Inhibits Neural Stem Cell and Oligodendrocyte Progenitor Differentiation

20:00—21:00
Social Hour with Lite Bites

Mesa C
20:00—23:00
Entertainment

Mesa C

MONDAY, JANUARY 26

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13NS063455-01




We gratefully acknowledge additional support for this conference from:

National Multiple Sclerosis Society

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Elan Pharmaceuticals, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Cell Press

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676