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This meeting took place in 2009



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The Molecular Basis of Schizophrenia and Bipolar Disorder (X1)


Organizer(s) Pamela Sklar, David J. Porteous and Christopher A. Ross
March 6—10, 2009
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Nov 6, 2008
Late Abstract Deadline: Dec 4, 2008
Scholarship Deadline: Nov 6, 2008
Early Registration Deadline: Jan 6, 2009

Sponsored by Johnson & Johnson Pharmaceutical Research and Development, L.L.C.


Summary of Meeting:
This meeting brings together experts in a range of disciplines, including genetics, neurobiology, cell and developmental biology, psychiatry, and chemical biology to discuss the molecular bases of bipolar disorder and schizophrenia. The time is opportune, since new methods in genetics are identifying plausible candidate genes, which can be studied by sophisticated techniques of cell biology and neuroscience, in both laboratory and clinical settings. Bipolar disorder and schizophrenia are severe psychiatric syndromes characterized by mood and cognitive disorders and psychosis. Both genetic and environmental factors are believed to contribute. New findings in genetics and neuroscience will likely help redefine the phenotypes and make possible the development of new therapeutic targets. Among the topics to be explored include emerging data from genetics implicating new genes and genetic variation in disease; the current status of the epidemiology, including environmental factors, and boundaries of the disorders; the genetics and neurobiology of several current candidate genes and pathways; and the relevance of advances in neurogenesis, fast-evolving brain genes, and cerebral circuitry development. Finally, prospects for new approaches to therapeutics will be covered. The overall goal of this meeting is to integrate molecular studies across basic and clinical disciplines and facilitate the development of new approaches.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, MARCH 6

15:00—19:30
Registration

Longs Peak Foyer
18:30—19:30
Refreshments

Longs Peak Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays 1 & 2
* Pamela Sklar, Harvard Medical School, Massachusetts General Hospital, USA

Thomas R. Insel, Mindstrong Health, USA
The Molecular Basis of Schizophrenia and Bipolar Disorder: What Do We Know? What Do We Need?

20:30—21:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays 1 & 2
* Xinyu Zhao, University of Wisconsin-Madison, USA
and

* Peng Jin, Emory University School of Medicine, USA
Opening Remarks

Fred (Rusty) H. Gage, The Salk Institute for Biological Studies, USA
L1 Retrotransposition and Neuronal Diversity


SATURDAY, MARCH 7

07:00—08:00
Breakfast

Longs Peak
08:00—11:00
Genome-Wide Studies of Disease-Related Variation
Meeting has ended...abstracts no longer viewable online.

Grays 1 & 2
Shaun Purcell, Massachusetts General Hospital, USA
Varieties of Genetic Variation of Neuropsychiatric Disease

* Pamela Sklar, Harvard Medical School, Massachusetts General Hospital, USA
Genetics and Genomics of Schizophrenia and Bipolar Disorder

Patrick F. Sullivan, University of North Carolina, USA
SCZ GWAS - Update 3/09

Jonathan Sebat, University of California, San Diego, USA
Microduplication of 16p11.2 is Associated with Schizophrenia

08:00—11:15
Epigenetic Mechanisms in Human Biology
Meeting has ended...abstracts no longer viewable online.

Quandary 1 & 2
Peter A. Jones, Van Andel Research Institute, USA
Epigenetic Regulation in Cancer

* Joseph F. Costello, University of California, San Francisco, USA
Role of Intragenic DNA Methylation in Gene Expression

Guoping Fan, University of California, Los Angeles, USA
Epigenetic Regulation in Neuronal Survival and Brain Development

John A. Stamatoyannopoulos, Altius Institute for Biomedical Sciences and University of Washington, USA
Profiling Chromatin Structure Across Cell Lineages

Dengke Ma, Johns Hopkins University, USA
Short Talk: Neuronal Induction of Gadd45b Links Epigenetic DNA Demethylation to Activity-Dependent Adult Neurogenesis

Jing Wang, Hospital for Sick Children, Canada
Short Talk: The Histone Acetyltransferase Activity of the CBP Transcriptional Coactivator, which is Haploinsufficient in Rubinstein-Taybi Syndrome, is Essential for Differentiation of Developing Neural Stem Cells

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Longs Peak
13:00—22:00
Poster Viewing

Longs Peak
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Clinical Epidemiology and Etiology
Meeting has ended...abstracts no longer viewable online.

Grays 1 & 2
Peter B. Jones, Cambridge University, UK
Epidemiology and Risk Factors, Shared or Not?

Nick J. Craddock, Cardiff University School of Medicine, UK
Boundaries of the phenotypes: Reconstructing and Rethinking Psychosis

* Christopher A. Ross, Johns Hopkins University School of Medicine, USA
Neurogenetics: Insights from Neurodegeneration, Approaches to Psychiatric Disease

17:00—19:00
Psychiatric Epigenetics
Meeting has ended...abstracts no longer viewable online.

Quandary 1 & 2
* Art Petronis, University of Toronto, Canada
Epigenomics of Major Psychosis

Schahram Akbarian, Icahn School of Medicine at Mount Sinai, USA
Epigenetic Regulation in Human and Mouse Brain - Focus on Histone Lysine Methylation

Yue Feng, Emory University, USA
Talk Title to be Determined

Anne O'Donnell-Luria, Massachusetts General Hospital, USA
Short Talk: Whole Genome DNA Methylation Profiling of Major Depression

Fatemeh G. Haghighi, Columbia University, USA
Short Talk: DNA Methylation Profiling of Schizophrenia

19:00—20:00
Social Hour with Lite Bites

Longs Peak
19:30—22:00
Poster Session 1

Longs Peak

SUNDAY, MARCH 8

07:00—08:00
Breakfast

Longs Peak
08:00—11:00
Genes and Pathways
Meeting has ended...abstracts no longer viewable online.

Grays 1 & 2
* David J. Porteous, University of Edinburgh, UK
DISC1: Approaching Causality

Hongjun Song, University of Pennsylvania, USA
Regulation of Development of Dentate Granule Neurons by Disrupted-In-Schizophrenia 1 (DISC1)

Li-Huei Tsai, Massachusetts Institute of Technology, USA
Disrupted In Schizophrenia 1 (DISC1) Regulates Neural Progenitor Proliferation via beta-Catenin/GSKbeta Signaling

Jonathan D. Wood, University of Sheffield Medical School, UK
Short Talk: Schizophrenia Susceptibility Genes in Zebrafish

Gianluca De Rienzo, Whitehead Institute, USA
Short Talk: DISC-1 is an Essential Modulator of the Wnt Signaling Pathway

08:00—11:00
Autism
Meeting has ended...abstracts no longer viewable online.

Quandary 1 & 2
Daniel H. Geschwind, University of California, Los Angeles, USA
Autism: From Genes to Brain

David H. Ledbetter, Geisinger Health System, USA
Early Identification of Genetic Sub-Types of Autism Spectrum Disorders (ASDs) by Clinical aCGH Testing and Establishment of an International Public Database

* Janine M. LaSalle, University of California, Davis, USA
Epigenetic Etiologies of Autism Spectrum Disorders

Addie May Ingrid Nesbitt, University of Connecticut, USA
Short Talk: Genomic Imprinting of the X-Linked Gene Transketolase-like 1 in Mouse and Human

Rodney C. Samaco, Baylor College of Medicine, USA
Short Talk: Haploinsufficiency of Crh Ameliorates the Autistic-Like Features in a Mouse Model of MECP2 Duplication Syndrome

Steven W. Long, University of Illinois, USA
Short Talk: Purification of a Novel MeCP2 Complex from Rat Brain

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00
On Own for Lunch

13:00—22:00
Poster Viewing

Longs Peak
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Genes and Pathways II
Meeting has ended...abstracts no longer viewable online.

Grays 1 & 2
Marc G. Caron, Duke University Medical Center, USA
D2 Dopamine Receptor-Mediated Akt/GSK3 Signaling: Behavioral and Therapeutic Implications

Ricardo E. Dolmetsch, Novartis Institutes for BioMedical Research, USA
From Calcium Channels to Autism

* Daniel R. Weinberger, NIMH/National Institutes of Health, USA
Genetic and Molecular Studies of NRG1/ErbB4

17:00—19:00
Imprinting Disorders
Meeting has ended...abstracts no longer viewable online.

Quandary 1 & 2
* Arthur L. Beaudet, Baylor College of Medicine, USA
Molecular Basis of Angelman Syndrome

Laura Herzing, Children's Memorial Research Center, USA
Epigenetic Consequences of Fetal Alcohol Exposure

Edwin J. Weeber, University of South Florida, USA
Synaptic Plasticity Defects in Angelman Syndrome

Jon F. Wilkins, Ronin Institute, USA
Short Talk: Imprinted Genes, Risk Preferences, and Delay Discounting

19:00—20:00
Social Hour with Lite Bites

Longs Peak

MONDAY, MARCH 9

07:00—08:00
Breakfast

Longs Peak
08:00—11:00
Evolution and Development of the Brain
Meeting has ended...abstracts no longer viewable online.

Grays 1 & 2
* David J. Porteous, University of Edinburgh, UK

Fred (Rusty) H. Gage, The Salk Institute for Biological Studies, USA
L1 Retrotransposons During Neurogenesis

Bruce T. Lahn, University of Chicago, USA
Fast-Evolving Genes of the Human Brain

Vann Bennett, Duke University Medical Center, USA
Facile Evolution of Ankyrin-Binding Activity as a Mechanism for Co-Localization of Functionally Related Proteins at Axon Initial Segments

Judith L. Rapoport, NIMH, National Institutes of Health, USA
Genetics and Brain Development of Childhood Onset Schizophrenia: Update 2009

08:00—09:20
Monogenic Neurodevelopmental Disorders: Rett Syndrome
Meeting has ended...abstracts no longer viewable online.

Quandary 1 & 2
David Katz, Case Western Reserve University School of Medicine, USA
Dysregulation of Neuronal Excitability in Mecp2 Null Mice

Xinyu Zhao, University of Wisconsin-Madison, USA
Methyl-CpG Binding Proteins in Neurogenesis and Autism Spectrum Disorders

09:40—11:15
Monogenic Neurodevelopmental Disorders: Fragile X Syndrome
Meeting has ended...abstracts no longer viewable online.

Quandary 1 & 2
Stephen T. Warren, Emory University School of Medicine, USA
Newborn and Conventional Mutation Screening in Fragile X

* David L. Nelson, Baylor College of Medicine, USA
Development of Animal Models for Fragile X Syndrome

Peng Jin, Emory University School of Medicine, USA
Fragile X Mental Retardation Protein and Stem Cells

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00
On Own for Lunch

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Chemical Biology and Therapeutic Strategies
Meeting has ended...abstracts no longer viewable online.

Grays 1 & 2
* Christopher A. Ross, Johns Hopkins University School of Medicine, USA

John R. Kelsoe, University of California, San Diego, USA
Perspectives on Pharmacogenomics: Medication Response in Bipolar Disorder as an Endophenotype

Edward M. Scolnick, MIT Broad Institute, USA
Clinical Applications of Emerging Psychiatric Genetics

17:00—19:00
Lessons, Conclusions, and Perspectives
Meeting has ended...abstracts no longer viewable online.

Quandary 1 & 2
* Xinyu Zhao, University of Wisconsin-Madison, USA

* Peng Jin, Emory University School of Medicine, USA

Jeffrey M. Besterman, MethylGene Inc., Canada
Epigenetic Therapy of Neurodegenerative Diseases

Bing Ren, Ludwig Institute for Cancer Research, USA
Global Chromatin Modifications at Transcriptional Enhancers Correlate with Cell Type-Specific Gene Expression in the Human Genome

19:00—20:00
Social Hour with Lite Bites

Longs Peak
20:00—23:00
Entertainment

Longs Peak

TUESDAY, MARCH 10

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health
National Institute of Mental Health (NIMH)

Grant No. 1R13MH085429-01




We gratefully acknowledge additional support for this conference from:

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Cell Press

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676