Hilton Santa Fe Historic Plaza Hotel Floorplan

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This meeting took place in 2009



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Frontiers of NMR in Biology (B8)


Organizer(s) Mitsuhiko Ikura, Ann E. McDermott and Ad Bax
February 15—20, 2009
Hilton Santa Fe Historic Plaza Hotel • Santa Fe, New Mexico USA
Abstract Deadline: Oct 15, 2008
Late Abstract Deadline: Nov 14, 2008
Scholarship Deadline: Oct 15, 2008
Early Registration Deadline: Dec 15, 2008

Supported by the Directors' Fund

Summary of Meeting:
Over the past several decades Nuclear Magnetic Resonance (NMR) spectroscopy has become an indispensable tool in structural and molecular biology, with most recent contributions to genomics, proteomics and metabolomics. Advances in NMR technology would not be possible without our continued efforts to develop new methodologies and applications. This symposium will focus on the latest technological advances in NMR spectroscopy as well as recent biological discoveries made through NMR studies. Emphasis will be placed on the investigation of large biological systems, membrane proteins, folding and dynamics, and transient states of enzymatic reactions or protein interactions. As such, those using NMR have been extending its application to more complex and challenging systems in combination with other biophysical tools such as X-ray crystallography and electron microscopy. The purpose of this symposium is to provide a forum for discussion on these and other new trends in biological NMR.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 15

15:00—19:30
Registration

Promenade
18:30—19:30
Refreshments

Promenade
19:30—21:30
Keynote Session: Roles of NMR and X-ray in the Future of Biology
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* Michael F. Summers, HHMI/University of Maryland, Baltimore County, USA

Peter E. Wright, The Scripps Research Institute, USA
Beyond 3D Structure: Insights from NMR into Protein Disorder, Dynamics, and Interactions

Wayne A. Hendrickson, Columbia University, USA
Prospects and Challenges for X-ray Diffraction in Biology


MONDAY, FEBRUARY 16

07:00—08:00
Breakfast

Chamisa/Ortiz
08:00—11:00
New Methods
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* Mitsuhiko Ikura, University of Toronto, Canada

Ad Bax, NIDDK, National Institutes of Health, USA
Proteins, Membranes, and their Interaction Viewed by NMR

Stephan Grzesiek, University of Basel, Switzerland
Probing Protein Structure and Dynamics of Unfolded and Folded Proteins by NMR

Christian Griesinger, Max Planck Institute for Biophysical Chemistry, Germany
Recognition Dynamics from NMR Residual Dipolar Couplings

Robert G. Griffin, Massachusetts Institute of Technology, USA
Protein Structure Determination with Solid State NMR

Erik R. P. Zuiderweg, University of Michigan, USA
Short Talk: Structural Basis of the Allosteric Trigger of the Hsp70 Chaperone Proteins

09:20—09:40
Coffee Break

Promenade
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Chamisa/Mesa C
13:00—22:00
Poster Viewing

Chamisa/Mesa C
14:30—16:30
Workshop 1: Tackling Membrane Proteins

Mesa Ballroom
* Angela M. Gronenborn, University of Pittsburgh, USA

Mark Girvin, Albert Einstein College Of Medicine, USA
Talk Title to be Determined

Francesca M. Marassi, Sanford-Burnham Medical Research Institute, USA
NMR of Membrane Proteins in Lipid Bilayers, Bicelles, and Micelles

Ichio Shimada, University of Tokyo, Japan
Interaction Analyses between Membrane Proteins and Ligands

Chad M. Rienstra, University of Illinois at Urbana-Champaign, USA
Magic-Angle Spinning NMR for Membrane Protein Structure Determination

Volker Dötsch, University of Frankfurt, Germany
Combination of Cell-Free Expression and Liquid State NMR Spectroscopy for the Structural Investigation of Membrane Proteins

16:30—17:00
Coffee Available

Promenade
17:00—19:00
Protein Folding and Dynamics
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* Ann E. McDermott, Columbia University, USA

Charles R. Sanders, Vanderbilt University School of Medicine, USA
NMR Studies of the Transmembrane C-Terminal Domain of the Amyloid Precursor Protein: Does APP Function as a Cholesterol Sensor?

Brian F. Volkman, Medical College of Wisconsin, USA
Native State Interconversion between Unrelated Protein Folds

Robert Tycko, NIDDK, National Institutes of Health, USA
Solid State NMR of Amyloid Fibrils and Freeze-Trapped Protein Folding Intermediates

Anthony Mittermaier, McGill University, Canada
Short Talk: Mapping the Energy Landscape of Protein Folding and Binding Using NMR and Calorimetry

19:00—20:00
Social Hour with Lite Bites

Chamisa/Ortiz
19:30—22:00
Poster Session 1

Chamisa/Mesa C

TUESDAY, FEBRUARY 17

07:00—08:00
Breakfast

Chamisa/Ortiz
07:00—08:00
Poster Setup

Chamisa/Mesa C
08:00—11:00
Membrane Proteins
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* Hideo Akutsu, Osaka University, Japan

Ann E. McDermott, Columbia University, USA
Conformational Changes in Enzymes and Membrane Proteins

Lukas K. Tamm, University of Virginia, USA
Structure and Dynamics of OmpG in Detergent Micelles

Mei Hong, Massachusetts Institute of Technology, USA
Dynamic Conformation and Orientation of Membrane Proteins

Stanley J. Opella, University of California, San Diego, USA
Membrane Proteins Studied by Solid State NMR

Daniel Nietlispach, University of Cambridge, UK
Short Talk: Solution-NMR Structural Studies of the 7-Helix Transmembrane Receptor Sensory Rhodopsin pSRII

09:20—09:40
Coffee Break

Promenade
11:00—12:00
Lunch

Chamisa
12:00—14:30
Poster Session 2

Chamisa/Mesa C
14:30—16:30
Workshop 2: Paramagnetic Relaxation Enhancement and Residual Dipolar Coupling

Mesa Ballroom
* Kevin H. Gardner, CUNY Advanced Science Research Center, USA

Angela M. Gronenborn, University of Pittsburgh, USA
Title to be Determined

Alexander Grishaev, NIDDK, National Institutes of Health, USA
Combining RDC and Scattering Data for Structure Determination

Lucia Banci, University of Florence, Italy
Approaches for Characterizing Metal- or Redox-Mediated Protein Complexes

Rieko Ishima, University of Pittsburgh School of Medicine, USA
Application of F-19 NMR to Study Protein Structure and Dynamics

Rafael Brüschweiler, Ohio State University, USA
Structural Protein Dynamics Elucidated by Spin Relaxation, Dipolar Couplings, and Computation

16:30—17:00
Coffee Available

Promenade
17:00—19:00
Protein Dynamics and Transient States
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* A. Joshua Wand, University of Pennsylvania, USA

G. Marius Clore, NIDDK, National Institutes of Health, USA
Visualizing Lowly-Populated Regions of the Free Energy Landscape of Macromolecular Complexes by Paramagnetic Relaxation Enhancement

Dorothee Kern, Brandeis University, HHMI, USA
The Climb Over the Mountain – Molecular Pathways of Conformational Transitions

Gary P. Drobny, University of Washington, USA
Dynamics of Nucleic Acids

Giuseppe Melacini, McMaster University, Canada
Short Talk: Understanding cAMP-Dependent Allostery by NMR Spectroscopy

19:00
On Own for Dinner


WEDNESDAY, FEBRUARY 18

07:00—08:00
Breakfast

Chamisa/Ortiz
08:00—11:00
Human Disease Targets
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* John L. Markley, University of Wisconsin-Madison, USA

Torleif Härd, University of Gothenburg, Sweden
An Engineered Monomer Binding Protein Eliminates Alzheimer Amyloid-Beta Peptide Neurotoxicity

Michael F. Summers, HHMI/University of Maryland, Baltimore County, USA
Structural Basis for Trafficking of HIV-1 and HIV-2 Proteins to Virus Assembly Sites

Michael K. Rosen, University of Texas Southwestern Medical Center, USA
Dynamic Origins of Interdomain Cooperativity in the Vav1 Proto-Oncoprotein

Juli Feigon, University of California, Los Angeles, USA
Structure and Function of Human Telomerase and H/ACA RNA

Christopher B. Marshall, University Health Network, Canada
Short Talk: Characterization of Intrinsic and TSC2 GAP-Accelerated GTPase Activity of Rheb by Real-Time NMR

09:20—09:40
Coffee Break

Promenade
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Chamisa/Mesa C
13:00—22:00
Poster Viewing

Chamisa/Mesa C
14:30—16:30
Workshop 3: Automation and Refinement Methods

Mesa Ballroom
* Frank D. Sönnichsen, Christian Albrechts Universität, Germany

John L. Markley, University of Wisconsin-Madison, USA
Approaches to the Investigation of More Challenging Proteins and Protein Complexes

Masatsune Kainosho, Nagoya University, Japan
Applications of the Residue-Selective SAIL Approach for Structures and Dynamics of Proteins

David A. Case, Rutgers University, USA
Building Better Models for Rotational Diffusion in Biomolecular NMR

Alexandre M.J.J. Bonvin, Universiteit Utrecht, Netherlands
Information-Driven Modeling of Biomolecular Complexes

Vladislav Orekhov, Gothenburg University, Sweden
Hyper-Dimensional NMR Spectroscopy with Multi Dimensional Decomposition

16:30—17:00
Coffee Available

Promenade
17:00—19:00
Macromolecular Interactions
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* Robert Kaptein, University of Utrecht, Netherlands

Robert B. Russell, University of Heidelberg, Germany
Discovery of New Peptides Mediating Interaction Networks

James Jeiwen Chou, Harvard Medical School, USA
NMR Studies of Viral Proton Channels

Gerhard Wagner, Harvard Medical School, USA
Topology and Regulation of the eIF4A/4G/4H Helicase Complex in Translation Initiation

Masayori Inouye†, University of Medicine and Dentistry of New Jersey, USA
Short Talk: Production and Isotopic Enrichment of a Single Membrane Protein in E. coli for NMR Studies without Purification

19:00—20:00
Social Hour with Lite Bites

Chamisa/Ortiz
19:30—22:00
Poster Session 3

Chamisa/Mesa C

THURSDAY, FEBRUARY 19

07:00—08:00
Breakfast

Chamisa/Ortiz
08:00—11:00
Drug Discovery and Chemical Biology
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* Melissa A. Starovasnik, Genentech, Inc., USA

Maurizio Pellecchia, University of California, Riverside, USA
NMR Based Drug Discovery: Screening and Design of Novel Chemical Probes

Patricia J. LiWang, University of California, Merced, USA
Structural and Functional Studies of Chemokines: Blocking HIV-1 and Stopping Inflammation

Wolfgang Jahnke, Novartis Institutes for BioMedical Research, Switzerland
NMR in Drug Discovery: The Blessing and Curse of Versatility

Benjamin F. Cravatt III, The Scripps Research Institute, USA
Activity-Based Proteomics

Timothy A. Cross, Florida State University, USA
Short Talk: Solid State NMR: A Novel Approach for Membrane Protein Drug Screening

09:20—09:40
Coffee Break

Promenade
11:00
On Own for Lunch

16:30—17:00
Coffee Available

Promenade
17:00—19:00
Large Systems and New Methods
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* Ad Bax, NIDDK, National Institutes of Health, USA

Patrik Lundstrom, University of Toronto, Canada
Short Talk: Accurate Measurement of Protein Excited State Chemical Shifts by Relaxation Dispersion NMR Spectroscopy

Charalampos Kalodimos, Rutgers University, USA
NMR of the Transcription Machinery

James H. Prestegard, University of Georgia, USA
Sparse Labeling and Resonance Assignments for Structural Studies of Large and Glycosylated Proteins

Kurt Wüthrich, ETH Zürich, The Scripps Research Institute, Switzerland
Automation in NMR Structure Determination of Proteins in Solution

19:00—20:00
Social Hour with Lite Bites

Mesa C
20:00—23:00
Entertainment

Mesa C

FRIDAY, FEBRUARY 20

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13GM086958-01




We gratefully acknowledge additional support for this conference from:

Bruker BioSpin Corp. Cambridge Isotope Laboratories
Varian, Inc.
Affymetrix, Inc.

ISOTEC, a member of the Sigma-Aldrich Group

New Era Enterprises, Inc.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Novartis Institutes for BioMedical Research


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Cell Press Royal Society of Chemistry

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676