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This meeting took place in 2009



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Protein Dynamics, Allostery and Function (E3)


Organizer(s) Ivet Bahar and Lila M. Gierasch
June 5—10, 2009
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Feb 5, 2009
Late Abstract Deadline: Mar 5, 2009
Scholarship Deadline: Feb 5, 2009
Early Registration Deadline: Apr 6, 2009

Supported by the Directors' Fund

Summary of Meeting:
With recent progress in exploring biomolecular systems dynamics, an emerging view is that of the ‘intrinsic ability’ of biomolecular systems to populate an ensemble of fluctuating conformations, or alternative states, which include, in particular, the functional forms stabilized upon ligand/substrate binding or protein-protein interactions. Allosteric changes in conformations, or signal transduction mechanisms, thus emerge as properties encoded by the structure and energy landscape, which are evolutionarily selected due to their functional predisposition. Of particular interest is to elucidate the mechanisms of information flow, not only at the level of residue interactions, but also between the components of biomolecular machines or cell signaling networks. This Keystone Symposia meeting will provide a forum for researchers from diverse fields to explore the basic principles underlying allosteric responses at the molecular level, and their higher (cellular) level consequences, and to exchange expertise on methods to illuminate key dynamic properties of biomolecular systems.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, JUNE 5

15:00—19:30
Registration

Shavano Peak Foyer
18:30—19:30
Refreshments

Shavano Peak Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Red Cloud Peak
Kenneth A. Dill, Stony Brook University, USA
Protein Folding: Physical Approaches to Predicting Structures and Stabilities


SATURDAY, JUNE 6

07:00—08:00
Breakfast

Crestone Peak
08:00—11:00
Dynamics, Energy Landscapes and Evolutionary Selection
Meeting has ended...abstracts no longer viewable online.

Red Cloud Peak
Hans Frauenfelder, Los Alamos National Laboratory, USA
A Unified Model of Protein Dynamics

Cecilia Clementi, Rice University, USA
Prediction of Protein Functional States by Multi-Resolution Protein Modeling

Michele Vendruscolo, University of Cambridge, UK
Advances in the use of NMR Spectroscopy to Characterize Free Energy Landscapes of Proteins

Walter Englander, University of Pennsylvania, USA
Short Talk: How Proteins Fold

Matthias Buck, Case Western Reserve University, Medical School, USA
Short Talk: Conformational Coupling in an Effector-GTPase Interaction: Differences in the Complex Formation of the Plexin GTPase Binding Domain with Rac1 and Rnd1

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Crestone Peak
13:00—22:00
Poster Viewing

Crestone Peak
14:30—16:30
Workshop

Red Cloud Peak
* Ada Yonath, Weizmann Institute of Science, Israel

Chad M. Petit, University of North Carolina, USA
Entropically Modulated Function in a PDZ domain

Miles A. Pufall, University of Iowa, USA
Modulating Protein Function: DNA as an Allosteric Effector of Glucocorticoid Receptor Activity

Paula Therese Lang, University of California, Berkeley, USA
Ghosts in the Machines: Using Novel X-Ray Crystallographic Methods to Identify Side Chain Polymorphism in Protein-Ligand Interactions

Jianpeng Ma, Baylor College of Medicine, USA
Minimalist Network Model (MNM): A Novel Coarse-grained Normal Mode Analysis

Eileen K. Jaffe, Fox Chase Cancer Center - TUHS, USA
Dynamic Dissociating Homo-Oligomers and Allosteric Regulation

Gail E. Fanucci, University of Florida, USA
Monitoring Motions and Flexibility of HIV-1 Protease with Pulsed EPR Spectroscopy

Ahmet Bakan, University of Pittsburgh, USA
Effect of Inhibitor Binding on Protein Structure and Dynamics: Intrinsic Dynamics or Induced Dynamics?

Michelle A. Markus, Wyeth Pharmaceuticals, USA
Identifying Novel, Non-Chelating Inhibitors of MMP-9 using Virtual Screening, NMR Spectroscopy, and X-Ray Crystallography

16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:00
Catalysis and Allostery
Meeting has ended...abstracts no longer viewable online.

Red Cloud Peak
* Amnon Horovitz, Weizmann Institute of Science, Israel

Patrick Loria, Yale University, USA
Short and Long-Range Interactions and Motions and their Impact on Enzyme Function

Sebastian Doniach, Stanford University, USA
Allostery and riboswitch function

Susan S. Taylor, University of California, San Diego, USA
Dynamics of Signaling by PKA

Andrea Mozzarelli, University of Parma, Italy
Short Talk: Hemoglobin: Still the Paradigm for Allostery

19:00—20:00
Social Hour with Lite Bites

Crestone Peak
19:30—22:00
Poster Session 1

Crestone Peak

SUNDAY, JUNE 7

07:00—08:00
Breakfast

Crestone Peak
08:00—08:50
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Red Cloud Peak
Jean-Pierre Changeux, Institut Pasteur, France
The Nicotinic Acetylcholine Receptor: A Membrane Allosteric Protein Engaged in Neuronal Communication

08:50—11:15
Allosteric Events in Membrane Proteins
Meeting has ended...abstracts no longer viewable online.

Red Cloud Peak
D. Peter Tieleman, University of Calgary, Canada
Coupling between Nucleotide Binding and Transmembrane Domains in ABC Transporters

Ivet Bahar, University of Pittsburgh, USA
Allosteric Dynamics of Glutamate Transporters: Insights from Multiscale Computations

Heidi E. Hamm, , USA
Allosteric Connections from a G Protein-Coupled Receptor to the Nucleotide-Binding Pocket of a Heterotrimeric G Protein

* Ofer Yifrach, Ben-Gurion University of the Negev, Israel
Short Talk: Principles Underlying Energetic Coupling Along an Allosteric Communication Trajectory of a Voltage-Activated K+ Channel

Nikolaos G. Sgourakis, University of California, Santa Cruz, USA
Short Talk: Simulation of a Protein Tertiary Complex: Study of the Interaction Interface and Conformational Dynamics of Dark State Rhodopsin in Complex with Transducin

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:30
On Own for Lunch

11:30—13:00
Poster Setup

Crestone Peak
13:00—22:00
Poster Viewing

Crestone Peak
16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:15
Dynamics and Biomolecular Machines
Meeting has ended...abstracts no longer viewable online.

Red Cloud Peak
* David A. Agard, University of California, San Francisco, USA

Ada Yonath, Weizmann Institute of Science, Israel
Ribosomal Machinery: Peptide Bond Formation, Chaperone Assistance, and Antibiotics Inactivation

Devarajan Thirumalai, University of Maryland, USA
Structural Basis of Allosteric Transitions in Biological Machines: Common Themes

Amnon Horovitz, Weizmann Institute of Science, Israel
Linking Allostery in Chaperonins to Protein Folding

Lars Skjaerven, Universitetet i Bergen, Norway
Short Talk: Discovering the Intrinsic Dynamical Abilities of the GroEL Subunit by Molecular Dynamics Simulation

David P. Giedroc, Indiana University, USA
Short Talk: Structure and Energetics of Metal-induced Allosteric Regulation of DNA binding by ArsR Family Metal Sensor Proteins

19:15—20:15
Social Hour with Lite Bites

Crestone Peak
19:30—22:00
Poster Session 2

Crestone Peak

MONDAY, JUNE 8

07:00—08:00
Breakfast

Crestone Peak
08:00—11:15
Signal Propagation in Molecular and Cellular Systems I
Meeting has ended...abstracts no longer viewable online.

Red Cloud Peak
* Rama Ranganathan, University of Texas Southwestern Medical Center, USA

Vincent J. Hilser, University of Texas Medical Branch, USA
Allostery in an Ensemble

Kevin Donald Ridge, University of Texas, Houston, USA
Signaling via Structure Change: NMR Analysis of GPCR and G Protein Activation

Michael Grabe, University of Pittsburgh, USA
Insight into the Nature of Voltage Sensing in Voltage-gated Potassium Channels

Lila M. Gierasch, University of Massachusetts Amherst, USA
The Mechanism of Allostery in an Hsp70 Molecular Chaperone

Jeffrey W. Peng, University of Notre Dame, USA
Short Talk: Towards Establishing Flexibility-Activity-Relationships for Dynamic Protein-Ligand Interactions

Akash Bhattacharya, University of Michigan, USA
Short Talk: A Comprehensive View of Allostery in the Hsp70 Chaperone Proteins

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:15
On Own for Lunch

11:15—13:00
Poster Setup

Crestone Peak
13:00—22:00
Poster Viewing

Crestone Peak
16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:15
Signal Propagation in Molecular and Cellular Systems II
Meeting has ended...abstracts no longer viewable online.

Red Cloud Peak
* Susan S. Taylor, University of California, San Diego, USA

Rama Ranganathan, University of Texas Southwestern Medical Center, USA
The Evolutionary Design of Proteins

David A. Agard, University of California, San Francisco, USA
Conformational Dynamics, Structure and Mechanism of Hsp90 Chaperones

Andrew Hopkins, University of Dundee, UK
Pharmacological Approaches to Biological Network Perturbation and Allosteric Modulation

Giorgio Colombo, Istituto di Chimica del Riconoscimento Molecolare, Italy
Short Talk: Modeling Signal Propagation Mechanisms and Ligand-Based Conformational Dynamics of the Hsp90 Molecular Chaperone Full Length Dimer

Saskia Neher, University of California at San Francisco, USA
Short Talk: Signal Sequences Activate the Catalytic Switch of SRP RNA

19:15—20:15
Social Hour with Lite Bites

Crestone Peak
19:30—22:00
Poster Session 3

Crestone Peak

TUESDAY, JUNE 9

07:00—08:00
Breakfast

Crestone Peak
08:00—11:00
Novel Methods for Dynamics and Allostery
Meeting has ended...abstracts no longer viewable online.

Red Cloud Peak
* Patrick Loria, Yale University, USA

G. Marius Clore, NIDDK, National Institutes of Health, USA
Visualizing Transient Lowly-Populated Regions of the Free Energy Landscape of Macromolecules and their Complexes by Paramagnetic Relaxation Enhancement

Ruben Abagyan, University of California, San Diego, USA
Induced Fit in Ligand Docking and Drug Discovery

Ad Bax, NIDDK, National Institutes of Health, USA
Proteins, Lipids, and their Dynamic Interaction Viewed by NMR

Justin L. P. Benesch, University of Oxford, UK
Short Talk: Thermo-Dynamically Controlled Chaperone Function of the Small Heat Shock Proteins

Aron W. Fenton, University of Kansas Medical Center, USA
Short Talk: Mapping Individual Residues within the N-Terminus that are Energetically Coupled to Allosteric and Active Site Functions of Human Liver Pyruvate Kinase

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:00
On Own for Lunch

16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—18:45
Novel Methods for Equilibrium Fluctuations
Meeting has ended...abstracts no longer viewable online.

Red Cloud Peak
* Ad Bax, NIDDK, National Institutes of Health, USA

Elliot L. Elson, Washington University School of Medicine, USA
Chemical Reaction Fluxes in Non-Equilibrium Steady State Systems

Patrice Vachette, IBBMC, France
Synchrotron SAXS Study of Quaternary Structure Equilibrium for Wild-Type and Mutant Forms of Allosteric Aspartate Transcarbamoylase

Brian M. Baker, University of Notre Dame, USA
Short Talk: T Cell Receptor Cross-Reactivity Triggered by Peptide-Specific Conformational Dynamics in an Unligated Peptide/MHC Complex

18:45—19:15
Closing Remarks
Meeting has ended...abstracts no longer viewable online.

Ivet Bahar, University of Pittsburgh, USA

Lila M. Gierasch, University of Massachusetts Amherst, USA

19:15—20:15
Social Hour with Lite Bites

Crestone Peak
20:00—23:00
Entertainment

Crestone Peak

WEDNESDAY, JUNE 10

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13GM087771-01




We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Cell Press

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676