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This meeting took place in 2009



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Common Mechanisms in Arrhythmias and Heart Failure (D3)


Organizer(s) Alfred L. George, Jeffrey A. Towbin and Elizabeth M. McNally
April 2—7, 2009
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Dec 3, 2008
Late Abstract Deadline: Jan 5, 2009
Scholarship Deadline: Dec 3, 2008
Early Registration Deadline: Feb 2, 2009

Supported by the Directors' Fund

Summary of Meeting:
Electrical and mechanical disturbances in heart function underlie most cardiovascular morbidity and mortality. Investigations into the causes of cardiac arrhythmias and heart failure have led to considerable improvements in diagnosis and treatment of these conditions. Recent advances uncovering the molecular genetic basis for familial cardiomyopathy and inherited arrhythmia susceptibility have fueled greater interest in defining common pathophysiological mechanisms. This Keystone Symposia meeting will bring together experts in both fields to exchange ideas and explore common areas of interest. Major areas of emphasis for the symposium will include genetic mechanisms, electrical and transcriptional remodeling, regulation and disorders of cardiac ion homeostasis, and the complex interplay between molecules governing electrical and contractile events in the heart. The goal of this meeting is to stimulate new areas of investigation at the interface between the biology of heart rhythm and contraction, ideally leading to new therapeutic strategies and targets.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, APRIL 2

15:00—19:30
Registration

Shavano Peak Foyer
18:30—19:30
Refreshments

Shavano Peak Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Alfred L. George, Jr., Vanderbilt University, USA

Christine E. Seidman, Harvard Medical School, USA
Molecular Genetics of Familial Cardiomyopathies


FRIDAY, APRIL 3

07:00—08:00
Breakfast

Torreys Peak 1-4
08:00—11:00
Genetic Modifiers
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Jeffrey A. Towbin, Cincinnati Children's Hospital Medical Center, USA

Connie R. Bezzina, Academic Medical Center, Netherlands
Modifier Genes in Cardiac Sodium Channelopathy

Dan Arking, Johns Hopkins School of Medicine, USA
QT Interval Genes as Modifiers of Sudden Cardiac Death

Michael R. Bristow, University of Colorado Anschutz Medical Campus, USA
Modifier Genes in the Cardiomyopathies

Howard A. Rockman, Duke University Medical Center, USA
Mapping Modifiers in Drosophila

Sharlene M. Day, University of Michigan, USA
Short Talk: Genetic and Phenotypic Complexity in a Unique Family with Arrhythmogenic Right Ventricular Cardiomyopathy

09:20—09:40
Coffee Break

Torreys Peak 1-4
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Torreys Peak 1-4
13:00—22:00
Poster Viewing

Torreys Peak 1-4
16:30—17:00
Coffee Available

Torreys Peak 1-4
17:00—19:00
Transcriptional Remodeling
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Howard A. Rockman, Duke University Medical Center, USA

Katherine T. Murray, Vanderbilt University Medical Center, USA
Transcriptional Profiles in Healthy and Arrhythmic Heart

Nikhil V. Munshi, University of Texas Southwestern Medical Center, USA
A GATA4-Dependent Transcriptional Pathway Regulates Normal Atrioventricular Delay

Fikru B. Bedada, University of Minnesota, USA
Short Talk: MiR208 Prevents Phenylephrine Induced Hypertrophy in Adult Rat Cardiac Myocytes

Farah Sheikh, University of California, San Diego, USA
Short Talk: Early Defects in Connexin Signaling Underlie Arrhythmogenic Right Ventricular Cardiomyopathy in a Novel Mouse Model

19:00—20:00
Social Hour with Lite Bites

Torreys Peak 1-4
19:30—22:00
Poster Session 1

Torreys Peak 1-4

SATURDAY, APRIL 4

07:00—08:00
Breakfast

Torreys Peak 1-4
08:00—11:15
Physiological Remodeling
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Alfred L. George, Jr., Vanderbilt University, USA

Penelope A. Boyden, Columbia University, USA
Ionic Mechanisms Influencing Regional Action Potentials and Conduction

Marc A. Vos, UMC Utrecht, Netherlands
Proarrhythmic Myocardial Remodeling

Jeffrey E. Saffitz, Beth Israel Deaconess Medical Center, USA
Modulation of Gap Junctions in Heart Disease

George E. Billman, Ohio State University, USA
Autonomic Neural Remodeling after Myocardial Infarction

Michael P. O'Quinn, Medical University of South Carolina, USA
Short Talk: A Peptide Containing the Carboxy-Terminal Domain of Connexin43 Inhibits Cardiac Dilation and Reduces Arrhythmias after Myocardial Injury

Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA
Short Talk: Studying the Genetics of Cardiac Dysfunction in Drosophila

09:20—09:40
Coffee Break

Torreys Peak 1-4
11:15
On Own for Lunch

11:15—13:00
Poster Setup

Torreys Peak 1-4
13:00—22:00
Poster Viewing

Torreys Peak 1-4
16:30—17:00
Coffee Available

Torreys Peak 1-4
17:00—19:00
Novel Genetic Pathways
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Connie R. Bezzina, Academic Medical Center, Netherlands

Jeffrey A. Towbin, Cincinnati Children's Hospital Medical Center, USA
Final Common Pathways in Cardiomyopathy and Arrhythmias

William J. McKenna, Heart Hospital, UK
Genetics of Arrhythmogenic Right Ventricular Cardiomyopathy

Michael J. Ackerman, Mayo Clinic, USA
Novel Pathogenic Mechanisms for Heritable Arrhythmia Syndromes

Marie-Louise Bang, Institute of Biomedical Technologies (ITB), Italian Research Council (CNR), Italy
Short Talk: Ablation of Myopalladin Results in Pressure Overload-Induced Dilated Cardiomyopathy

19:00—20:00
Social Hour with Lite Bites

Torreys Peak 1-4
19:30—22:00
Poster Session 2

Torreys Peak 1-4

SUNDAY, APRIL 5

07:00—08:00
Breakfast

Torreys Peak 1-4
08:00—11:15
Regulation and Disorders of Ion Homeostasis I
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Penelope A. Boyden, Columbia University, USA

Donald M. Bers, University of California, Davis, USA
Regulation of Intracellular Sodium and Calcium in Cardiac Myocytes

Xander H.T. Wehrens, Baylor College of Medicine, USA
Role of Ryanodine Receptor Leak in Heart Failure and Sudden Cardiac Death

Björn C. Knollmann, Vanderbilt University School of Medicine, USA
Calsequestrin in Cardiac Calcium Homeostasis and Arrhythmogenesis

James N. Weiss, University of California, Los Angeles, USA
Early Afterdepolarizations: How They Synchronize in Tissue to Cause Arrhythmias

Changwon Kho, Mount Sinai School of Medicine, USA
Short Talk: SUMO Modification Modulates SERCA2a Function

Saumya Das, Massachusetts General Hospital, USA
Short Talk: The Serum and Glucocorticoid Responsive Kinase-1 (SGK1) Mediates Hypertrophy-Induced Changes in SCN5a by Phosphorylation and Altered Binding to Ubiquitin Ligase Nedd4-2

09:20—09:40
Coffee Break

Torreys Peak 1-4
11:15
On Own for Lunch

16:30—17:00
Coffee Available

Torreys Peak 1-4
17:00—19:00
Regulation and Disorders of Ion Homeostasis II
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Donald M. Bers, University of California, Davis, USA

Mark E. Anderson, Johns Hopkins University School of Medicine, USA
Calmodulin Kinase II in Heart Failure and Arrhythmias

Kenneth D. Philipson, University of California, Los Angeles, USA
Cardiac-Specific Knockout of Na-Ca Exchange

Alfred L. George, Jr., Vanderbilt University, USA
Sodium Channel Dysfunction in Arrhythmias and Heart Failure

Hiroshi Watanabe, Niigata University School of Medicine, Japan
Short Talk: D1275N SCN5A Mutation causes Dilated Cardiomyopathy and Arrhythmias: Mechanisms Revealed in Mice but Absent by Heterologous Expression

19:00—20:00
Social Hour with Lite Bites

Torreys Peak 1-4

MONDAY, APRIL 6

07:00—08:00
Breakfast

Torreys Peak 1-4
08:00—11:00
Sarcomeric and Cystoskeletal Proteins I
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Michael J. Ackerman, Mayo Clinic, USA

R. John Solaro, University of Illinois at Chicago, USA
Arrhythmias, Heart Failure, and Signaling in Cardiac Sarcomeres

Gisèle Bonne, INSERM UR 582, France
Laminopathies

Peter J. Mohler, University of Iowa, USA
Dysfunction in Ankyrin-Based Pathways and Human Arrhythmia

Elizabeth M. McNally, Northwestern University, USA
Disorders of the Dystrophin-Sarcoglycan Complex

Carolina Vasquez, New York University School of Medicine, USA
Short Talk: Arrhythmogenic Potential of Activated Fibroblasts

09:20—09:40
Coffee Break

Torreys Peak 1-4
11:00
On Own for Lunch

16:30—17:00
Coffee Available

Torreys Peak 1-4
17:00—19:00
Sarcomeric and Cystoskeletal Proteins II
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Elizabeth M. McNally, Northwestern University, USA

Matteo Vatta, Baylor College of Medicine, USA
Z-Disk Disruption in Cardiac Failure and Arrhythmias

Jil C. Tardiff, University of Arizona, USA
Thin Filament Protein Dynamics and Cardiomyopathies

Jeffrey Robbins, Cincinnati Children's Hospital Medical Center, USA
Myosin Binding Protein C and Regulation of Cardiac Hemodynamics

19:00—20:00
Social Hour with Lite Bites

Torreys Peak 1-4
20:00—23:00
Entertainment

Torreys Peak 1-4

TUESDAY, APRIL 7

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HL096236-01




We gratefully acknowledge additional support for this conference from:


American Heart Association's Council on Basic Cardiovascular Sciences

Medtronic

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676