St. John's College - Cambridge Floorplan

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This meeting took place in 2008



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Structural Biology and Activation Mechanisms of Membrane Receptors (S1)


Organizer(s) Pierre De Meyts, Briony E. Forbes and Tom L. Blundell
September 16—21, 2008
St. John's College - Cambridge • University of Cambridge, Cambridge UK
Abstract Deadline: Jun 17, 2008
Late Abstract Deadline: Jul 17, 2008
Scholarship Deadline: May 15, 2008
Early Registration Deadline: Jul 17, 2008

Supported by the Directors' Fund

Summary of Meeting:
Considerable progress has been made in understanding the structure and function of membrane receptors and receptor signaling complexes since the first radioligand binding studies nearly four decades ago. The structures of the extracellular domains of many receptors in diverse classes are now available. However, the structural data have not always provided unambiguous information as to what the relevant physiological structure is or the precise nature of the binding and activation mechanism. To get the full picture, it is necessary to integrate structural information, biochemical and molecular biology approaches such as site-directed mutagenesis, photoaffinity crosslinking and bioluminescence resonance energy transfer, kinetics, and mathematical modeling. This symposium brings together experts in these various disciplines, both seasoned and fresh, for an open-minded debate on how to realize this integrative approach. A strong theme of the meeting is that there are more similarities than previously estimated between the mechanisms of activation of various classes of receptors. The study of the biological evolution of the ligand and receptor families and signal transduction mechanisms also provides key information on highly conserved modules. Finally, the promises and challenges in translating our knowledge of the structural biology of membrane receptor signaling to drug discovery will be discussed.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, SEPTEMBER 16

15:00—19:30
Registration

Palmerston Foyer
18:30—19:30
Refreshments

Palmerston Foyer
19:30—21:30
Keynote Session
Meeting has ended...abstracts no longer viewable online.

Palmerston
* Pierre De Meyts, Hagedorn Research Institute, Novo Nordisk A/S, Denmark

Michael C. Lawrence, Walter and Eliza Hall Institute of Medical Research, Australia
Structural Insights into Ligand Binding in the Insulin Receptor Family

Brian K. Kobilka, Stanford University School of Medicine, USA
Structure and Dynamics of the Human beta 2 Adrenergic Receptor


WEDNESDAY, SEPTEMBER 17

07:30—08:30
Breakfast

The Buttery
07:30—11:30
Poster Setup

Castlereigh/Foyer
08:30—11:30
Structural Biology of Ligands and Receptors of the Insulin/IGF Peptide Families
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Tom L. Blundell, University of Cambridge, UK

Michael A. Weiss, Case Western Reserve University, USA
How Insulin Binds: Studies with Photoaffinity Crosslinking

Jonathan Whittaker, Case Western Reserve University, USA
Insights into Insulin and IGF-I Ligand-Receptor Interactions from Mutational Analysis

Briony E. Forbes, University of Adelaide, Australia
IGF Structural Determinants Involved in Receptor and Binding Protein Binding

Yvonne Jones, University of Oxford, UK
Crystal Structure of the IGF-II/Mannose-6-Phosphate Receptor Complex

09:40—10:00
Coffee Break

Palmerston Foyer
11:30—12:30
Lunch

The Hall
12:30—14:30
Poster Session 1

Castlereigh/Foyer
14:30—16:30
Workshop 1: New Structures or Structural Aspects

Ballroom 3
Brian M. Baker, University of Notre Dame, USA
T Cell Receptor Cross-Reactivity via Cooperative Conformational Plasticity

* Tim R. Hercus, University of South Australia and SA Pathology, Australia
The Structure of the GM-CSF Receptor Complex Reveals a New Mode of Cytokine Receptor Activation

Jonathan K. Tyzack†, Trends in Biochemical Sciences, UK
Dragging (and Zooming and Rotating) Publication of 3D Molecular Structures into the 21st Century

Marie Parat, University of Montreal, Canada
Molecular Analysis of Natriuretic Peptide Receptor: A Transmembrane Signal Transduction

Lennart Zabeau, Ghent University, Belgium
A Model for a Hexameric 2:4 Leptin:Leptin Receptor Complex

16:30—17:00
Coffee Available

Palmerston Foyer
17:00—19:00
Evolution of the Insulin/IGF Receptor Systems
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Donald F. Steiner, University Of Chicago, USA

Pierre De Meyts, Hagedorn Research Institute, Novo Nordisk A/S, Denmark
Structure, Function and Evolution of Ligands and Receptors of the Insulin Peptide Family

Shu-Jin Chan, University Of Chicago, USA
Where Insulin Binds: Mapping Contact Points in the Insulin:Insulin Receptor Complex

Robert S. Garofalo, , USA
Insulin Receptors and Signaling in Drosophila

19:00
On Own for Dinner


THURSDAY, SEPTEMBER 18

07:30—08:30
Breakfast

The Buttery
08:30—11:30
From Receptor Structure to Activation Mechanism
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Joseph Schlessinger, Yale University School of Medicine, USA
Cell Signaling by Receptor Tyrosine Kinases: From Basic Principles to Cancer Therapy

Michael J. Waters, University of Queensland, Australia
The Mechanism of Growth Hormone Receptor Activation Revisited

Krzysztof Palczewski, Case Western Reserve University, USA
Oligomerization and Activation of GPCRs: Insights from Rhodopsin Structures

Wayne A. Hendrickson, Columbia University, USA
Dimeric Associations in G-Protein Coupled Receptors

09:40—10:00
Coffee Break

Palmerston Foyer
11:30
On Own for Lunch

16:30—17:00
Coffee & Snacks Available

Palmerston Foyer
17:00—19:00
The Proximal Steps of Receptor Activation and Signaling
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Kenneth Siddle, University of Cambridge, UK

Linda J. Pike, Washington University School of Medicine, USA
Negative Cooperativity in EGF Receptor Signaling

Stevan R. Hubbard, New York University School of Medicine, USA
Mechanisms of Protein Recruitment to the Insulin Receptor

Tarik Issad, Institut Cochin-Institute de Recherches Biomédicales, France
Dynamics of Insulin and IGF-I Receptor Partnerships using BRET (Bioluminescence Resonance Energy Transfer)

19:00
On Own for Dinner


FRIDAY, SEPTEMBER 19

07:30—08:30
Breakfast

The Buttery
07:30—11:30
Poster Setup

Castlereigh/Foyer
08:30—11:30
Structure, Function and Crosstalk of G-Protein-Coupled Receptors (GPCRs)
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Gilbert Vassart, Université Libre de Bruxelles, Belgium

Robert J. Lefkowitz, HHMI/Duke University Medical Center, USA
beta-Arrestin Biased Agonism at Seven Transmembrane Receptors

Ross A.D. Bathgate, University of Melbourne, Australia
Structural Relationships of the INSL/Relaxin Ligands and their G-Protein Coupled Receptors

Sabine Costagliola, IRIBHM-Université libre de Bruxelles, Belgium
Functional Significance of Oligomerization and Negative Cooperativity in Glycoprotein Hormone Receptors

Ilpo Huhtaniemi, Imperial College London, UK
In vivo Validation of LH Receptor Dimerization by Complementation in Knockout Mice

09:40—10:00
Coffee Break

Palmerston Foyer
11:30—12:30
Lunch

The Hall
12:30—14:30
Poster Session 2

Castlereigh/Foyer
14:30—16:30
Workshop 2: New Methodological Approaches

Ballroom 3
* Fariba M. Assadi-Porter, University of Wisconsin-Madison, USA
Direct NMR Detection of the Binding of Functional Ligands to the Human Sweet Receptor, a Heterodimeric Family 3 GPCR

Helen L. Attrill, University of Oxford, UK
Characterising The Multimerization Of The Neurotensin Receptor Type I In Model Lipid Membrane Bilayers

Nancy E. Caceres, Ludgwig Institute for Cancer Research, Belgium
Investigating the Stoichiometry of the Active G-CSF Receptor (G-CSFR) Complex by Testing the Activity of coiled coil-G-CSFR Fusion Proteins

Anja Krippner-Heidenreich, University of Newcastle, UK
Efficient Activation of the Tumour Necrosis Factor (TNF) Receptor is Highly Determined by the Stalk Region

Philippe Rondard, Institut de Génomique Fonctionnelle, France
Molecular Functioning of the GABAB Receptor Revealed by Glycan Wedge Scanning

Johannes van Agthoven, Biological NMR and Crystallography, France
The Stoichiometry and Stability of the Prolactin/Prolactin Receptor Complex is Influenced by its N-Terminus

16:30—17:00
Coffee Available

Palmerston Foyer
17:00—19:00
From Receptor Activation to Signal Transduction: Quantitative Approaches
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Ralph A. Bradshaw, University of California, Irvine, USA

Blagoy Blagoev, University of Southern Denmark, Denmark
Quantitative Proteomics: Analysis of Signal Transduction Networks

James Faeder, University of Pittsburgh School of Medicine, USA
Structure-Based Modeling of EGF Receptor Signal Transduction

Yuko Saeki, RIKEN, Genomic Sciences Center, Japan
Crosstalk between Signaling and Transcription Produces Switch-like Response in ErbB Receptor Network

19:00
On Own for Dinner


SATURDAY, SEPTEMBER 20

07:30—08:30
Breakfast

The Buttery
08:30—11:30
Challenges in Structural Biology of Membrane Receptors
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Wayne A. Hendrickson, Columbia University, USA

Gebhard F. X. Schertler, Paul Scherrer Institut, Switzerland
Structure of a Conformationally Stabilized beta1 Adrenergic G Protein-Coupled Receptor

Ulf Skoglund, Karolinska Institutet, Sweden
Studies on Proteins, Membrane Proteins and Receptors using Molecular Electron Tomography

Milka Vrecl, Univerza v Ljubljani, Slovenia
The Use of Bioluminescence Resonance Energy Transfer 2 (BRET2) to Study G-Protein-Coupled Receptor (GPCR) Partner Interactions

Marisa Martin-Fernandez, Daresbury Laboratory, UK
ErbB1 Inside-Out Signalling Regulates Global Ectodomain Orientation and Oligomer Topology

09:40—10:00
Coffee Break

Palmerston Foyer
11:30
On Own for Lunch

16:30—17:00
Coffee & Snacks Available

Palmerston Foyer
17:00—19:00
Receptor Structural Biology and Drug Discovery
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
Maja Jensen, Plougmann and Vingtoft, Denmark
Allosteric and Biological Properties of Insulin Mimetic and Antagonist Peptides Targeting the Insulin Receptor Binding Sites

* Alexander Levitzki, Hebrew University of Jerusalem, Israel
Developments in Signal Transduction Therapy of Cancer

Tom L. Blundell, University of Cambridge, UK
Targeting Membrane Receptors and Signalling Systems for Drug Discovery

19:00—19:30
Social Hour

The Hall
19:30—20:30
Dinner

The Hall
20:00—23:00
Entertainment

The Hall

SUNDAY, SEPTEMBER 21

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge additional support for this conference from:

BBSRC - Biotechnology & Biological Sciences Research Council, UK

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Novo Nordisk A/S


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