RACV Royal Pines Resort Floorplan

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This meeting took place in 2009



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Telomere Biology and DNA Repair (T1)


Organizer(s) Roger R. Reddel, Michael B. Kastan and Titia de Lange
October 9—14, 2009
RACV Royal Pines Resort • Ashmore, Queensland Australia
Abstract Deadline: Jun 10, 2009
Late Abstract Deadline: Jul 13, 2009
Scholarship Deadline: Jun 10, 2009
Early Registration Deadline: Aug 10, 2009

Supported by The Directors' Fund

Summary of Meeting:
There is emerging evidence that telomere dysfunction has ramifications in a wide range of pathologies including cancer, bone marrow failure, pulmonary fibrosis and diseases of aging. Telomeric DNA poses special problems for the DNA repair machinery. The ends of telomeres need to avoid being recognized as DNA breaks and thereby avoid being subjected to DNA repair events that may lead to chromosome end-to-end fusions and result in chromosomal instability. The proteins that bind to telomeres and the higher order telomeric structures that protect the ends from repair events are of particular interest. Another special biological problem is posed by the gradual shortening of telomeres that occurs in somatic cells. Excessively short telomeres may trigger DNA damage checkpoints and be substrates for DNA repair reactions, and the similarities and differences between these processes at telomeres and elsewhere in the genome require examination. The role of DNA repair proteins that are present at normally functioning telomeres, and the possible role of telomere binding proteins elsewhere in the genome is of particular interest. This meeting will explore these and other exciting areas of convergence in the fields of telomere biology and DNA repair.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, OCTOBER 9

15:00—19:00
Registration

Marquis Foyer

SATURDAY, OCTOBER 10

07:30—08:30
Breakfast

Kalinda Restaurant
08:30—09:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Marquis Room
* Michael B. Kastan, St. Jude Children's Research Hospital, USA

Stephen C. West, Francis Crick Institute, UK
Defects in DNA Strand Break Repair and Links to Inheritable Disease

09:30—12:30
DNA Damage Sensing and Signaling 1
Meeting has ended...abstracts no longer viewable online.

Marquis Room
* Alan D. D'Andrea, Dana-Farber Cancer Institute, USA

Martin F. Lavin, Queensland Institute for Medical Research, Australia
DNA Damage Signaling through the MRN Complex

Roger A. Greenberg, University of Pennsylvania Perelman School of Medicine, USA
Ubiquitin Recognition and Remodeling at DNA Double Strand Breaks

David Faucher, Universite de Sherbrooke, Canada
Short Talk: Methylated H3K4, a Transcription Associated Histone Modification, is Involved in the DNA Damage Response Pathway

Jiri Lukas, Novo Nordisk Foundation Center for Protein Research, Denmark
Dynamic Organization of the DNA Damage Response in Space and Time

09:50—10:10
Coffee Break

Marquis Foyer
12:30—13:30
Poster Setup

Monarch Room
13:30—22:00
Poster Viewing

Monarch Room
16:30—17:00
Coffee Available

Marquis Foyer
17:00—19:00
Telomeres and DNA Damage Response
Meeting has ended...abstracts no longer viewable online.

Marquis Room
* Roger R. Reddel, Children’s Medical Research Institute, Sydney, Australia

Michael B. Kastan, St. Jude Children's Research Hospital, USA
ATM-Dependent DNA Damage Signaling

Titia de Lange, Rockefeller University, USA
Persistent Telomere Damage Induces By-Pass of Mitosis and Tetraploidy

Fuyuki Ishikawa, Kyoto University, Japan
RPA-like Mammalian Ctc1-Stn1-Ten1 Complex Binds to Single-Stranded DNA and Protects Telomeres Independently of the Pot1 Pathway

Eric Gilson, Université de Lyon, France
TRF2 and Apollo Protect the Inner Part of Human Telomeres from Replicative Damages

Amy D. Gelinas, University of Colorado at Boulder, USA
Short Talk: Telomere Capping Proteins are Structurally Related to RPA

19:00—20:00
Social Hour with Lite Bites

Monarch Room
19:30—22:00
Poster Session 1

Monarch Room

SUNDAY, OCTOBER 11

07:30—08:30
Breakfast

Kalinda Restaurant
07:30—08:30
Poster Setup

Monarch Room
08:00—17:30
Poster Viewing

Monarch Room
08:30—11:30
DNA Repair 1
Meeting has ended...abstracts no longer viewable online.

Marquis Room
* Jan Karlseder, The Salk Institute for Biological Studies, USA

Alan D. D'Andrea, Dana-Farber Cancer Institute, USA
The Fanconi Anemia Pathway and the DNA Damage Response

Camilla Sjögren, Karolinska Institutet, Sweden
The SMC5/6 Complex – More than Repair?

Judith L. Campbell, California Institute of Technology, USA
Short Talk: The Roles of Yeast and Human Dna2 in Nuclear DNA DSB Repair and Telomere

Maria Jasin, Memorial Sloan Kettering Cancer Center, USA
Double Strand Break Repair Pathways

Jörg Heierhorst, St. Vincent's Institute of Medical Research, Australia
Short Talk: Role of the Rad53 SQ/TQ Cluster Domain as a Phospho-Counting Switch in the DNA Damage Response

09:50—10:10
Coffee Break

Marquis Foyer
11:30—12:30
Lunch

Monarch Room
12:30—15:00
Poster Session 2

Monarch Room
15:00—15:30
Coffee Available

Marquis Foyer
15:30—17:30
BIR and ALT
Meeting has ended...abstracts no longer viewable online.

Marquis Room
* Maria Jasin, Memorial Sloan Kettering Cancer Center, USA

Peter M. Burgers, Washington University School of Medicine, USA
A Tale of Two Tails: Activation of the Mec1/ATR Checkpoint Kinase by 9-1-1 and by Dpb11/TopBp1

Michael J. McEachern, University of Georgia, USA
Studies of Telomere Maintenance in the ALT-like stn1-M1 Mutant of Kluyveromyces lactis

Roger R. Reddel, Children’s Medical Research Institute, Sydney, Australia
ALT-like Activity in Normal Mammalian Somatic Cells In Vivo

Hyunsook Lee, Seoul National University, South Korea
Short Talk: BRCA2 is Involved in Telomere End Protection through Suppression of ALT-like Telomeric Recombination

17:30
On Own for Dinner


MONDAY, OCTOBER 12

07:30—08:30
Breakfast

Kalinda Restaurant
08:30—11:30
Telomerase/Control of Telomerase
Meeting has ended...abstracts no longer viewable online.

Marquis Room
* Titia de Lange, Rockefeller University, USA

Steven E. Artandi, Stanford University, USA
Telomerase Assembly, Telomere Synthesis and Wnt Signaling

Raymund J. Wellinger, University of Sherbrooke, Canada
Adaptation to Telomere Uncapping in Yeast

Prabhat Khadka, Yonsei University, South Korea
Short Talk: KIP Modulates Telomerase Activity through Interaction with TRF2

Virginia A. Zakian, Princeton University, USA
The Role of the Pif1 DNA Helicase in Maintaining Telomere Length

Martina M. Stagno d'Alcontres, Centro Nacional de Investigaciones Oncologicas, Spain
Short Talk: TPP1 Recruits TERT to Chromatin and Positively Regulates Telomere Length, Maintains Telomere Integrity and Prevents Premature Development of Degenerative Pathologies in Mice

Ken Masutomi, National Cancer Center, Japan
Short Talk: A Mammalian RNA Dependent RNA Polymerase Formed by hTERT and the RNA Component of RNase MRP

09:50—10:10
Coffee Break

Marquis Foyer
11:30—13:00
Poster Setup

Monarch Room
13:00—22:00
Poster Viewing

Monarch Room
16:30—17:00
Coffee Available

Marquis Foyer
17:00—19:15
DNA Damage Sensing and Signaling 2
Meeting has ended...abstracts no longer viewable online.

Marquis Room
* Virginia A. Zakian, Princeton University, USA

Junjie Chen, University of Texas MD Anderson Cancer Center, USA
DNA Damage Signaling and DNA Repair

Amanda Wraith Kijas, Queensland Institute of Medical Research, Australia
Short Talk: Autophosphorylation and ATM Activation: Additional Sites Add to the Complexity

Jan Karlseder, The Salk Institute for Biological Studies, USA
Telomere Driven Epigenetic Reprogramming during Cellular Aging

Zeenia Kaul, Children's Medical Research Institute, Australia
Short Talk: Five Dysfunctional Telomeres Precede Cellular Senescence in Normal Human Diploid Fibroblasts

Woodring E. Wright, University of Texas Southwestern Medical Center, USA
The Comparative Biology Of Replicative Senescence

19:15—20:15
Social Hour with Lite Bites

Monarch Room
19:30—22:00
Poster Session 3

Monarch Room

TUESDAY, OCTOBER 13

07:30—08:30
Breakfast

Kalinda Restaurant
08:30—11:30
DNA Repair 2
Meeting has ended...abstracts no longer viewable online.

Marquis Room
* Camilla Sjögren, Karolinska Institutet, Sweden

Frederick W. Alt, Boston Children's Hospital, USA
DNA Double Strand Breaks, Translocations and B Cell Lymphoma

David O. Ferguson, University of Michigan Medical School, USA
Multiple Roles of MRN in Double Strand Break Repair Pathways

Marco F. Foiani, Instituto FIRC di Oncologia Molecolare, Italy
The DNA Damage Response during DNA Replication

Huiling Xu, Peter MacCallum Cancer Centre, Australia
Short Talk: Cohesin-Mediated Modulation of Radiation-Induced DNA Damage Response

Claudia Lukas, Novo Nordisk Foundation Center for Protein Research, Denmark
Short Talk: 53BP1 Nuclear Bodies: A Dynamic, Cell-Cycle-Regulated Surrogate of Replication, Proteotoxic, and Transcription-Coupled Genomic Stress

09:50—10:10
Coffee Break

Marquis Foyer
16:30—17:00
Coffee Available

Marquis Foyer
17:00—19:00
Telomeres, DNA Repair and Human Disease
Meeting has ended...abstracts no longer viewable online.

Marquis Room
* Steven E. Artandi, Stanford University, USA

Monica Bessler, Children's Hospital of Philadelphia, USA
Dyskeratosis Congenita

Katharina Schlacher, MD Anderson Cancer Center, USA
Short Talk: BRCA2 (FANCD1) Protects Stalled Replication Forks from Degradation, a Novel Pathway Shared with BRCA1 and Fanconi Anemia

Peter J. McKinnon, St. Jude Children's Research Hospital, USA
Differential ATM Signaling from DNA Strand Breaks and Dysfunctional Telomeres

Jerry W. Shay, University of Texas Southwestern Medical Center, USA
Will Telomerase Inhibitors Target Cancer Stem Cells?

19:00—20:00
Social Hour with Lite Bites

Monarch Room
20:00—23:00
Entertainment

Monarch Room

WEDNESDAY, OCTOBER 14

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13ES017583-01




We gratefully acknowledge additional support for this conference from:

CSIRO The Queensland Government, through the Department of Employment, Economic Development and Innovation's Office of Biotechnology and Therapeutic Medicines and Devices

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


AusBiotech


Australian and New Zealand Society for Cell and Developmental Biology


Australian Society for Biochemistry & Molecular Biology


Gold Coast Convention Bureau


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676