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This meeting took place in 2009



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

MicroRNA and Cancer (E1)


Organizer(s) Frank J. Slack and Amy E. Pasquinelli
June 10—15, 2009
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Feb 10, 2009
Late Abstract Deadline: Mar 13, 2009
Scholarship Deadline: Feb 10, 2009
Early Registration Deadline: Apr 10, 2009

Supported by the Directors' Fund

Summary of Meeting:
MicroRNAs have recently emerged as key regulators of gene expression during development and are frequently mis-expressed in human disease states, in particular cancer. MicroRNAs act to promote or repress cell proliferation, migration and apoptosis during development, all processes that can go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. Their small size and molecular properties make miRNAs amenable as targets and therapeutics in cancer treatment. While hundreds of human microRNAs are known, relatively little is known about their roles and targets. This meeting will focus on the exciting biology of microRNAs in controlling developmental and cancer processes like cell proliferation, differentiation, cell cycle, apoptosis and metastasis. It will also focus on the latest efforts to harness the power of these small RNAs as agents in the fight against cancer.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, JUNE 10

15:00—19:30
Registration

Shavano Peak Foyer
18:30—19:30
Refreshments

Shavano Peak Foyer
19:30—19:45
Welcome Remarks

Red Cloud/Crestone
Frank J. Slack, BIDMC Cancer Center/Harvard Medical School, USA

19:45—20:45
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Crestone
Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
Deconstructing Metastasis


THURSDAY, JUNE 11

07:30—08:30
Breakfast

Shavano/Torreys
08:30—11:00
Regulation of Development by miRNAs
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Crestone
* Helge Großhans, Friedrich Miescher Institute - FMI, Switzerland

Alexander F. Schier, Harvard University, USA
MicroRNAs in Embryogenesis

Amy E. Pasquinelli, University of California, San Diego, USA
Regulation of Gene Expression by MicroRNAs in C. elegans

Eric C. Lai, Sloan-Kettering Institute, USA
Biogenesis and Function of Short Regulatory RNAs in Drosophila

Seogang Hyun, Seoul National University, South Korea
Short Talk: Conserved microRNA miR-8 and its Target USH Control Body Size by Regulating Insulin Signaling in Fat Calls

Silvia Monticelli, Institute for Research in Biomedicine, Switzerland
Short Talk: MicroRNAs in Mast Cells

Debora Marks, Harvard Medical School, USA
Short Talk: Transfection of Small RNAs Globally Perturbs Gene Regulation by Endogeneous microRNAs

09:50—10:10
Coffee Break

Shavano Peak Foyer
11:45
On Own for Lunch

11:45—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
14:30—16:30
Workshop 1: Bench to Bedside: Translating miRNA Discoveries into Clinical Applications

Red Cloud/Crestone
* Joanne B. Weidhaas, Yale University School of Medicine, USA

Doyel Mitra, University of Colorado Denver, USA
The Role of the Histone Demethylase JARID1b in the Regulation of miRNA Expression in Breast Cancer Cells

Helen M. Heneghan, National University of Ireland, Galway, Ireland
Circulating miRNAs as Novel Minimally Invasive Biomarkers for Breast Cancer

Galina Gabriely, Harvard University Brigham & Women's Hospital, USA
The Role of Onco-MicroRNA miR-21 in Gliomagenesis

Stoil D. Dimitrov, Moderna Therapeutics, USA
Regulation of BRCA1 Expression by MicroRNA-545

Dalia Cohen, Beryllium, USA
Identification of Tumor Tissue Origin by a MicroRNA-based Molecular Assay

Kim A. Lennox, Integrated DNA Technologies, USA
A Direct Comparison of miRNA Antagonist Potency

Yan Li, National Eye Institute, USA
Characterization of a Corneal/Lens-Specific miRNA Gene, miR-184

Karen Angelica Cavassani, Cedars Sinai Medical Center, USA
microRNA as Regulators of Tumor Growth in Post-Septic Hosts

16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:00
Gene Regulation by Non-Coding RNAs
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Crestone
* Alla Grishok, Columbia University Medical Center, USA

John S. Mattick, Garvan Institute of Medical Research, Australia
The Hidden Layer of Regulatory RNA in Evolution, Development and Cognition

George A. Calin, University of Texas MD Anderson Cancer Center, USA
A Noncoding RNA Revolution in the Cancer Society

Mark A. Kay, Stanford University, USA
The Role of Small RNAs in Gene Regulation

YS Lee, National Cancer Center, South Korea
Short Talk: A Novel Class of Small RNAs, tRNA-Derived RNA Fragments (tRFs), is Highly Expressed in Proliferating Cells and Required for Cell Proliferation

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys
19:30—22:00
Poster Session 1

Shavano/Torreys

FRIDAY, JUNE 12

07:30—08:30
Breakfast

Shavano/Torreys
08:30—11:45
MicroRNAs in Cancer
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Crestone
* Scott M. Hammond, University of North Carolina at Chapel Hill, USA

Curtis C. Harris, NCI, National Institutes of Health, USA
Inflamation and Cancer: Microenvironment, Inflamatory Cytokines microRNA and p53

Frank J. Slack, BIDMC Cancer Center/Harvard Medical School, USA
In vivo Role for miR-34 in Radiation Response

Joshua T. Mendell, HHMI/University of Texas Southwestern Medical Center, USA
MicroRNA Reprogramming in Cancer: Mechanisms and Therapeutic Opportunities

Carlo M. Croce, Ohio State University, USA
Role of microRNAs in Human Cancer

Mathijs Voorhoeve, Duke-NUS Graduate Medical School, Singapore
Short Talk: Genetic Dissection of the Role of microRNAs and Other ncRNAs in Cancer

Florian Kuchenbauer, Institute of Experimental Cancer Research, Germany
Short Talk: Emerging Evidence of Differential Expression of miRNA*s and its Contribution to the Development of Acute Myeloid Leukemia

09:50—10:10
Coffee Break

Shavano Peak Foyer
11:45
On Own for Lunch

11:45—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:00
Hot Topics in miRNA Research
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Crestone
* Lin He, University of California, Berkeley, USA

Hannele Ruohola-Baker, University of Washington, USA
microRNAs Function in Stem Cells

Eric Marcusson, Providence Therapeutics, USA
Therapeutic Targeting of miRNA

Isidore Rigoutsos, International Business Machines Corporation, USA
Evidence of an Expanded Role of microRNAs Going Beyond the 3'UTR

Zain Paroo, University of Illinois, USA
Short Talk: Phosphorylation of the Human Micro-RNA Generating Complex Mediates MAPK/Erk Signaling

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys
19:30—22:00
Poster Session 2

Shavano/Torreys

SATURDAY, JUNE 13

07:30—08:30
Breakfast

Shavano/Torreys
08:30—11:45
Mechanisms of miRNA Form and Function
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Crestone
* George A. Calin, University of Texas MD Anderson Cancer Center, USA

Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
Biogenesis of small regulatory RNAs

Marianthi Kiriakidou, University of Pennsylvania School of Medicine, USA
Mamalian Ago2 in vitro and in vivo in Cancer

Alla Grishok, Columbia University Medical Center, USA
Gene Expression Regulation by Endogenous RNAi and Rb in C. elegans

Elaine V. Fuchs, HHMI/Rockefeller University, USA
MicroRNA Regulation in Skin Stem Cells: Fine Tuning the Balance between Growth and Differentiation

Liang Zhang, Rockefeller University, USA
Short Talk: Systematic Analysis of Dynamic miRNA-Target Interactions during C. elegans Development

Ulrich Tschulena, DKFZ, Germany
Short Talk: A Novel Large-Scale Screen to Identify Modulators of miR-21

09:50—10:10
Coffee Break

Shavano Peak Foyer
11:45
On Own for Lunch

11:45—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
14:30—16:30
Workshop 2: Emerging Ideas and Technologies in Small RNAs

Red Cloud/Crestone
* Allison L. Abbott, Marquette University, USA

Carl D. Novina, Dana-Farber Cancer Institute, USA
Identification of microRNA-Mediated Tumor Suppressive Activity in Melanoma

Angela Anderegg, Northwestern University, USA
The Role of MicroRNAs in Midbrain Dopaminergic Neurogenesis

Jennifer Young, Centenary Institute, Australia
Regulation of Angiogenesis by MicroRNAs

Lu Ping Tan, University Medical Center Groningen, Netherlands
A High Throughput Experimental Approach to Identify miRNA Target , in Human Cells

Ivan Martinez, West Virginia University, USA
Rb-Dependent Cellular Senescence Induce the Expression of miR-29 and miR-30 that Target the Cell Cycle Regulatory Gene MYBL2

Aleishia Geraldine Harris, Stanford School of Medicine, USA
Epstein-Barr Virus Latent Membrane Protein 1 Modulates Host MicroRNAs in B Cell Lymphomas

Andrei Thomas-Tikhonenko, Children's Hospital of Philadelphia and University of Pennsylvania, USA
Clusterin, an Inhibitor of Tumor Growth and Angiogenesis, is Negatively Regulated by c-Myc though miR-17-92 and the type II TGFbeta Receptor

16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:00
Roles of Small RNAs in Cancer
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Crestone
* Joshua T. Mendell, HHMI/University of Texas Southwestern Medical Center, USA

Aurora Esquela-Kerscher, Eastern Virginia Medical School, USA
The Role of miRNAs during Development and Cancer Progression

Bryan R. Cullen, Duke University Medical Center, USA
Herpesvirus microRNAs and Cancer

Judy Lieberman, Harvard University, USA
miRNAs and Breast Cancer also Small RNAs as Therapeutics

Joel R. Neilson, Baylor College of Medicine, USA
Short Talk: 3' UTR Dynamics in Cellular Activation and Transformation

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys
19:30—22:00
Poster Session 3

Shavano/Torreys

SUNDAY, JUNE 14

07:30—08:30
Breakfast

Shavano Peak
08:30—11:45
MiRNAs as Diagnostics and Therapeutics
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Crestone
* Aurora Esquela-Kerscher, Eastern Virginia Medical School, USA

Michele A. Cleary, Merck & Co., Inc, USA
miRNAs as Diagnostics and Therapeutics

Lin He, University of California, Berkeley, USA
Functional Dissection of miR-17-92 Oncogene

Joanne B. Weidhaas, Yale University School of Medicine, USA
A MicroRNA Binding Site Polymorphism as a Biomarker of Cancer Risk

Scott M. Hammond, University of North Carolina at Chapel Hill, USA
MicroRNAs in Development and Disease

Sónia A. Melo, i3S - Instituto de Investigação e Inovação em Saúde, Portugal
Short Talk: microRNA Machinery in Human Cancer

Alexander Pertsemlidis, UT Health Science Center at San Atonio, USA
Short Talk: miR-337 Modulates Sensitivity to Paclitaxel in Non-Small Cell Lung Cancer

09:50—10:10
Coffee Break

Shavano Peak Foyer
11:45
On Own for Lunch

16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:00
Lessons from Developmental Biology
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Crestone
* Eric C. Lai, Sloan-Kettering Institute, USA

Allison L. Abbott, Marquette University, USA
Genetic Analysis of microRNA Functions in C. elegans Development

Helge Großhans, Friedrich Miescher Institute - FMI, Switzerland
Life and Death of MicroRNAs

David Brown, Mirna Therapeutics, USA
Therapeutic Applications of a miR-34 Mimic

Eric A. Miska, University of Cambridge, UK
Short Talk: Genetic Analysis in C. elegans Reveals New Insights into miRNA Mechanism

19:00—19:15
Closing Remarks
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Crestone
Amy E. Pasquinelli, University of California, San Diego, USA

19:15—20:15
Social Hour with Lite Bites

Shavano Peak
20:00—23:00
Entertainment

Shavano Peak

MONDAY, JUNE 15

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA139690-01




We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. Illumina, Inc.
Integrated DNA Technologies
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Asuragen, Inc.


Merck & Co., Inc.


Regulus Therapeutics Inc.


Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Biomed Central Cell Press
Royal Society of Chemistry
 

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676