Fairmont Hotel Vancouver Floorplan

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This meeting took place in 2009



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TH17 Cells in Health and Disease (F1)


Organizer(s) Chen Dong, Vijay Kuchroo and Brigitta Stockinger
February 5—10, 2009
Fairmont Hotel Vancouver • Vancouver, British Columbia Canada
Abstract Deadline: Oct 6, 2008
Late Abstract Deadline: Nov 6, 2008
Scholarship Deadline: Oct 6, 2008
Early Registration Deadline: Dec 5, 2008

Supported by the Directors' Fund

Summary of Meeting:
T lymphocytes are important mediators of autoimmune diseases and their tolerance to self-antigens is tightly regulated. Regulatory T (Treg) cells maintain immune tolerance. Recently, a novel subset of CD4+ T cells that produce IL-17 (named Th17) has been identified and shown to be highly pathogenic in many autoimmune diseases. Surprisingly, there appears to be a reciprocal relationship between Th17 and Treg cells in their generation, and function. Therefore, T cell biology needs to be further re-examined in the context of molecular pathways that are required for their generation, mechanisms that are involved in their antagonism and function. The goal of this symposium is to bring the leaders in the field together to assess the increased complexity in the generation of pathogenic and regulatory T cells at the cellular, molecular and organismal levels and discuss the potential impact of these new findings on the development of treatments of human autoimmune diseases.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, FEBRUARY 5

15:00—19:30
Registration

BC Foyer
18:30—19:30
Refreshments

BC Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Chen Dong, Tsinghua University, China

Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Helper T Cell Differentiation and Autoimmunity


FRIDAY, FEBRUARY 6

07:00—08:00
Breakfast

Columbia Ballroom
08:00—11:00
Cytokines and TH17 Differentiation
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Brigitta Stockinger, Francis Crick Institute, UK

Daniel J. Cua, Merck Research Laboratories, USA
IL-23 and TH17 Regulation

Marc Veldhoen, Faculdade de Medicina da Universidade de Lisboa Avenida, Portugal
Modulation of Th17 Differentiation and Function

Christopher A. Hunter, University of Pennsylvania, USA
IL-27 and Th17 Regulation

Ed C. Lavelle, Trinity College Dublin, Ireland
Promotion of IL-1 and TH17 Cells using Vaccine Adjuvants

09:20—09:40
Coffee Break

BC Foyer
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Columbia Ballroom
13:00—22:00
Poster Viewing

Columbia Ballroom
16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
IL-17 Signaling
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Jay K. Kolls, Tulane School of Medicin, USA

Sarah L. Gaffen, University of Pittsburgh, USA
Mechanisms of IL-17 Receptor Signaling

Steven D. Levin, Alpine Immune Sciences, USA
Identification of the IL-17 Receptor Related Molecule, IL-17RC as the Receptor for IL-17F

Reen Wu, University of California, Davis, USA
IL-17 and Airway Mucosal Immunity

19:00—20:00
Social Hour with Lite Bites

Columbia Ballroom
19:30—22:00
Poster Session 1

Columbia Ballroom

SATURDAY, FEBRUARY 7

07:00—08:00
Breakfast

Columbia Ballroom
07:00—08:00
Poster Setup

Columbia Ballroom
08:00—11:00
Treg, TH17 and Autoimmunity
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Casey T. Weaver, University of Alabama at Birmingham, USA

Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
Reciprocal Relationship between CD4+, Fox-P3+ T-reg and Proinflammatory Th17 Cells

Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, USA
Controlling Tolerance and Protective Immunity from the Outside In

Joan Goverman, University of Washington, USA
Th17/Th1 Ratios Shape Neuroinflammatory Responses

Marie Wahren-Herlenius, Karolinska Institute, Sweden
Short Talk: Ro52 and TH17-Mediated Skin Inflammation

Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA
Short Talk: Innate Immune Recognition of Infected Apoptotic Cells Directs TH17 Cell Differentiation

09:20—09:40
Coffee Break

BC Foyer
11:00—12:00
Lunch

Columbia Ballroom
12:00—14:30
Poster Session 2

Columbia Ballroom
14:30—16:30
Workshop 1: Regulation of TH17 Cells

British Ballroom
* Rachel R. Caspi, NEI, National Institutes of Health, USA

Koji Atarashi, Research Center for Allergy & Immunology, RIKEN, Japan
Lamina Propria TH17 Cell Differentiation is Controlled by ATP Derived from Commensal Bacteria

Song Guo Zheng, University of Southern California, USA
Neither Smad2 or Smad3 is Essential for TGF-â to Induce Foxp3+ Tregs and Th17

Alessandra Pernis, Hospital for Special Surgery, USA
IBP (IRF-4 Binding Protein) Inhibits IL-17 and IL-21 Production by Controlling IRF-4 Function

Elisabetta Volpe, European Centre for Brain Research, Santa Lucia Foundation, Italy
A Multiparametric Analysis of Cytokine-Driven Human Th17 Differentiation

Kojiro Sato, Saitama Medical University, Japan
Proto-Oncogene MAF Plays an Important Role in Th17-Cell Differentiation

Andrew M. Jackson, University of Nottingham, UK
Interleukin-17 Expression in Human Tumours: Association with Survival and Cancer Invasiveness

Luis Alejandro Zúñiga, Merck, USA
IL17A Moderates Adipocyte Lipid Accumulation in vitro and Obesity in vivo, and is Expressed by gammadelta T-Cells in Fat

16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Human TH17 Cells
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Dan R. Littman, HHMI/New York University School of Medicine, USA

Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
Human TH17 Differentiation

Rene de Waal Malefyt, Merck Research Labs, USA
The Role of IL-23 and Th17 Cells in Chronic Immune Mediated Inflammatory Diseases

David A. Hafler, Yale University School of Medicine, USA
Natural Human CD4+CD25high Tregs and Th17 Effector Cells

19:00
On Own for Dinner


SUNDAY, FEBRUARY 8

07:00—08:00
Breakfast

Columbia Ballroom
08:00—11:00
Molecular Control of TH17 Cells
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA

Dan R. Littman, HHMI/New York University School of Medicine, USA
RORgammat and TH17 Differentiation

Michael Lohoff, University of Marburg, Germany
The Role of the Transcription Factor IRF4 for T Helper Cell Differentiation

John J. O'Shea, NIAMS, National Institutes of Health, USA
STATs and T Cell Differentiation

Gang Pei, TongJi University, China
A microRNA mediated Regulation of Th17 Cell Differentiation Contributes to Multiple Sclerosis

09:20—09:40
Coffee Break

BC Foyer
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Columbia Ballroom
13:00—22:00
Poster Viewing

Columbia Ballroom
16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
TH17 in Mucosal Immunity
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Wenjun Ouyang, Amgen, Inc., USA

Casey T. Weaver, University of Alabama at Birmingham, USA
TH17 Cell and Intestinal Inflammation

Andrea M. Cooper, University of Leicester, UK
Protection versus Pathogenesis in Tuberculosis, the Role of IL-17, IL-23 and IL-27

Jay K. Kolls, Tulane School of Medicin, USA
Th17 Cells and Cytokines: Roles in Mucosal Immunity and Chronic Inflammation

19:00—20:00
Social Hour with Lite Bites

Columbia Ballroom
19:30—22:00
Poster Session 3

Columbia Ballroom

MONDAY, FEBRUARY 9

07:00—08:00
Breakfast

Columbia Ballroom
08:00—11:00
TH17 Cytokines
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Daniel J. Cua, Merck Research Laboratories, USA

Yoichiro Iwakura, Institute of Medical Science, University of Tokyo, Japan
The Roles of IL-17A and IL-17F in the Immune System

Wenjun Ouyang, Amgen, Inc., USA
The Roles of Th17 Cytokine IL-22 and IL-17 in Autoimmune and Infectious Diseases

Chen Dong, Tsinghua University, China
Regulation and Function of TH17 Cells

Deborah Ann Young, Wyeth Research, USA
IL-22: A Th17 Cytokine Contributes to Chronic Skin Inflammation

09:20—09:40
Coffee Break

BC Foyer
11:00
On Own for Lunch

14:30—16:30
Workshop 2: Novel Function of TH17 Cells/IL-17

British Ballroom
* Sarah L. Gaffen, University of Pittsburgh, USA

Christopher Crowe, University of Pittsburgh, USA
Critical Role for IL-17RA Signaling in Immunopathology of Influenza Infection

Gaia Codolo, University of Padua, Italy
NapA of Borrelia Burgdorferi Drives Th17 Inflammation in Lyme Arthritis

Meena S. Kumar, Emory University, USA
Interleukin 17 Modulates Expression of Inflammatory Markers in Vascular Cells and Promotes the Late Phase of Angiotensin II Induced Hypertension In Vivo

Christine Delprat, CNRS5239, France
IL-17A Induces Cell Fusion and a New Anti Mycobacterium Program in GM-CSF-Stimulated Monocyte-Derived Dendritic Cells

Marika C. Kullberg, Centre for Immunology and Infection, University of York, UK
Th17 Cells in Helicobacter Hepaticus-Induced Intestinal Inflammation

Cintia S. De Paiva, Cullen Eye Institute, Baylor College of Medicine, USA
Neutralization of IL-17 Ameliorates Desiccating Stress-Induced Corneal Barrier Dysfunction

Manuela Raffatellu, University of California, Irvine, USA
Lipocalin-2, an IL-17 and IL-22-Induced Antimicrobial Peptide, is a Host Defense Exploited by Salmonella Typhimurium to Colonize the Inflamed Gut

16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Targeting TH17 in Clinics
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Chen Dong, Tsinghua University, China

Michael Elliott, Centocor Inc., USA
Targeting IL-12/23 p40 in Autoimmune Disease

Tadamitsu Kishimoto, Osaka University, Japan
Anti-IL6 Receptor, TH17 and Arylhydrocarbon Receptor

Dhavalkumar D. Patel, Inflazome, Switzerland
Inhibition of IL-17A in Psoriasis

19:00—20:00
Social Hour with Lite Bites

Columbia Ballroom
20:00—23:00
Entertainment

Columbia Ballroom

TUESDAY, FEBRUARY 10

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI081325-01




We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Novartis Institutes for BioMedical Research


ZymoGenetics, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Cell Press

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-2676