Eldorado Hotel & Spa Floorplan

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This meeting took place in 2010



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NF-kappaB in Inflammation and Disease (A1)


Organizer(s) Michelle A. Kelliher, Manolis Pasparakis and Jürg Tschopp
January 5—10, 2010
Eldorado Hotel & Spa • Santa Fe, New Mexico USA
Abstract Deadline: Sep 14, 2009
Late Abstract Deadline: Oct 5, 2009
Scholarship Deadline: Sep 14, 2009
Early Registration Deadline: Nov 2, 2009

Sponsored by Amgen Inc.

Summary of Meeting:
In the past 10 years, impressive progress has been made on how the NF- kappaB transcription factor is regulated and how diverse signals frequently use ubiquitin-dependent mechanisms to activate NF- kappaB. Many of the signal transducers and regulatory enzymes have been identified and their essential roles in NF- kappaB regulation revealed through genetic analyses in mice. More recent work highlights the importance of NF- kappaB in innate immune signaling by cell surface Toll-like receptors and cytosolic Nod-like receptors. Although current research clearly implicates NF- kappaB in diabetes, inflammatory diseases and cancer, a challenge for the future will be to reveal the precise molecular and cellular mechanisms of NF- kappaB dysfunction in disease. The realization that NF- kappaB activity is regulated by kinases and ubiquitin modifying enzymes presents multiple opportunities for therapeutic intervention. In addition to highlights from basic research, results from clinical trials using IKK and other NF- kappaB inhibitors are expected to be presented at this meeting.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, JANUARY 5

15:00—19:30
Registration

Zia Concourse
18:30—19:30
Refreshments

Zia Concourse
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Michelle A. Kelliher, University of Massachusetts Medical School, USA

Vishva M. Dixit, Genentech, Inc., USA
The Importance of Restraint – Ubiquitin Hydrolases – Brakes in Signaling


WEDNESDAY, JANUARY 6

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
Regulation of the NF-kappaB Pathway
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Michael Karin, University of California, San Diego, USA

Zhijian James Chen, University of Texas Southwestern Medical Center, USA
Mechanism of Protein Kinase Activation by Ubiquitin in the NFkappaB Pathways

Ivan Dikic, Goethe University Medical School, Germany
Ubiquitin Chains in NFkappaB Signaling

Kazuhiro Iwai, Osaka University, Japan
Short Talk: Linear Polyubiquitination: A Newly Identified Regulator of NF-kappaB Signaling

David Komander, MRC Laboratory of Molecular Biology, UK
Short Talk: Specificity of TAB2 Ubiquitin Interaction

Hao Wu, Harvard Medical School, Boston Children's Hospital, USA
Crystal Structures of TRAF2, cIAP2 and TRAF1:TRAF2:cIAP Complexes

09:20—09:40
Coffee Break

Zia Concourse
11:00—13:00
Poster Setup

Sunset Room/Eldorado Court
11:00
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Sunset Room/Eldorado Court
14:30—16:30
Workshop 1: NF-kappaB Regulation

Anasazi Ballroom
* Zhijian James Chen, University of Texas Southwestern Medical Center, USA

Trevor William Siggers, Boston University, USA
Examining the DNA Binding Specificity Landscape of NF-kB Dimers using Protein-Binding Microarrays

Noula D. Shembade, University of Miami Sylvester Comprehensive Cancer Centre, USA
A20 Downregulates NF-kappaB Signaling by Disrupting E2:E3 Ubiquitin Enzyme Complexes

Alain Chariot, University of Liege, CHU, Belgium
Insights into the BCL-3 Oncogene Through Interactomic Studies

Mireille Y. Delhase, Nagoya City University Medical School, Japan
Insights into the Anti-Apoptotic Function of the Protein Kinase TBK1

Dirk Brenner, Luxembourg Institute of Health, Luxembourg
Phosphorylation of CARMA1 by HPK1 is Critical for NF-kappaB Activation in T Cells

Markus Brechmann, German Cancer Research Center, Germany
Genetic Screening for Phosphatases that Regulate NF-kappB Activity in T Lymphocytes

16:30—17:00
Coffee Available

Zia Concourse
17:00—19:00
Transcriptional Regulation by NF-kappaB
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* David Baltimore, California Institute of Technology, USA

Gioacchino Natoli, IEO, European Institute of Oncology, Italy
The Epigenome and the Control of the NF-kB Transcriptional Responses in Innate Immunity and Inflammation

Sankar Ghosh, Columbia University, USA
Regulation of Gene Expression by NFkappaB and Regulation of Inflammation by NFkappaB

Alexander Hoffmann, University of California, Los Angeles, USA
Short Talk: Two Roles of IkBs: Inhibitors and Generators of NFkappaB

Michael R.H. White, University of Manchester, UK
Short Talk: Control of Gene Expression by NF-kappaB Oscillations: A Source and Function for Cellular Heterogeneity?

19:00—20:00
Social Hour with Lite Bites

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 1

Sunset Room/Eldorado Court

THURSDAY, JANUARY 7

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
Innate Immune Receptor Signaling to NF-kappaB
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Vishva M. Dixit, Genentech, Inc., USA

Jürg Tschopp, University of Lausanne, Switzerland
The NALP3 Inflammasome: A Sensor for Metabolic Danger

Michelle A. Kelliher, University of Massachusetts Medical School, USA
RIP Proteins Mediate Diverse Stress Responses

Laurence Arbibe, Institut Pasteur, France
Innate Immune Subversion by Chromatin Manipulation: A New Face of Host-Bacterial Pathogen Interaction

Jun-Ichiro Inoue, Institute of Medical Science, University of Tokyo, Japan
Short Talk: Two Mechanistically and Temporally Distinct NF-kappaB Activation Pathways in IL-1 Signaling

Mikyoung Chang, MD Anderson Cancer Center, USA
Short Talk: Peli1 Facilitates TRIF-Dependent Toll-like Receptor Signaling and Proinflammatory Cytokine Production

09:20—09:40
Coffee Break

Zia Concourse
11:00—13:00
Poster Setup

Sunset Room/Eldorado Court
11:00
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Sunset Room/Eldorado Court
14:30—16:30
Workshop 2: NF-kappaB and Innate Immunity

Anasazi Ballroom
* Gioacchino Natoli, IEO, European Institute of Oncology, Italy

Ido Amit, Weizmann Institute, Israel
Reconstructing the Regulatory Circuit of Pathogen Sensing in Mammals

Mathieu JM Bertrand, VIB / Ghent University, Belgium
Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2

Ee Tsin Wong, Institute of Molecular and Cell Biology, Singapore
Identification of a Factor Essential for Toll-like Receptor Signaling

Christine S. Cheng, University of California, San Diego, USA
The NF-kappaB p50 Homodimer is a Regulator of Interferon Regulatory Elements (IRE) and Anti-Viral Innate Immune Responses

Marc Riemann, Leibniz Institute on Aging - Fritz Lipmann Institute, Germany
Role of RelA and RelB in Medullary Thymic Epithelial Cells for the Establishment of Immunological Self-Tolerance

Lawrence P. Kane, University of Pittsburgh, USA
Recruitment of the IKK Complex to TCR Microclusters during T Cell Activation

16:30—17:00
Coffee Available

Zia Concourse
17:00—19:00
NF-kappaB in the Immune Response
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Sankar Ghosh, Columbia University, USA

David Baltimore, California Institute of Technology, USA
MicroRNAs and Regulation of NF-kB

Margot Thome, University of Lausanne, Switzerland
MALT1: Role of its Protease Activity in T cell Activation and Lymphoma Development

Bruce H. Horwitz, Brigham and Women's Hospital, USA
Short talk: Regulation of Inflammation by p50/p105

Ashish K. Jain, National Institutes of Health, USA
Short Talk: CYLD Regulates TGFâ Signaling in T cells

19:00—20:00
Social Hour with Lite Bites

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 2

Sunset Room/Eldorado Court

FRIDAY, JANUARY 8

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
NF-kappaB in Disease
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Jürg Tschopp, University of Lausanne, Switzerland

Manolis Pasparakis, University of Cologne, Germany
IKK/NFkappaB Signaling in Mouse Models of Inflammatory Disease and Cancer

Jorge Moscat, Sanford Burnham Prebys Institute, USA
The p62/atypical PKC Complex in Cancer and Metabolism

Etienne Meylan, Koch Institute for Integrative Cancer Research at MIT, USA
Requirement for NFkappaB Signaling in a Mouse Model of Lung Adenocarcinoma

Daniela S. Basseres, University of North Carolina at Chapel Hill, USA
Role of NFkappaB in Ras Induced Lung Tumorigenesis

Yousef Abu-Amer, Washington University School of Medicine, USA
The Role of IKKâ in Skeletal Pathophysiology

09:20—09:40
Coffee Break

Zia Concourse
11:00—13:00
Poster Setup

Sunset Room/Eldorado Court
11:00
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Sunset Room/Eldorado Court
16:30—17:00
Coffee Available

Zia Concourse
17:00—19:00
NF-kappaB and Inhibitors in Preclinical Models
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Inder M. Verma, The Salk Institute, USA
NF-kB: Regulation and Function

Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Roles of NFkappaB in Pathogenesis and Treatment of Type 2 Diabetes

Friedrich Thaiss, University Hospital, Germany
Short Talk: Resolution of Renal Inflammation: A New Role for IKK2/ NF-kappaB Pathway in Nephrotoxic Nephritis

Lih-Ling Lin, Pfizer Pharmaceuticals, USA
Targeting TPL2 and IKK2 for Treating Rheumatoid Arthritis

19:00—20:00
Social Hour with Lite Bites

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 3

Sunset Room/Eldorado Court

SATURDAY, JANUARY 9

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
NF-kappaB and Cancer
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
Michael Karin, University of California, San Diego, USA
IKK Signaling in Cancer

Yinon M. Ben-Neriah, Hebrew University, Hadassah Medical School, Israel
Intricate Control of the p53 Tumor Suppressor Function in the Gut

William C. Hahn, Harvard Medical School, USA
Non Canonical IKKs and Cancer

Laura Pasqualucci, Columbia University, USA
Mutations of Multiple Signaling Proteins Deregulate NF-kappaB in Diffuse Large B-Cell Lymphoma

09:20—09:40
Coffee Break

Zia Concourse
11:00
On Own for Lunch and Recreation

14:30—16:30
Workshop 3: NF-kappaB in Disease Pathogenesis

Anasazi Ballroom
* Yinon M. Ben-Neriah, Hebrew University, Hadassah Medical School, Israel

Michael Lattke, Francis Crick Institute, UK
Astrocyte-Specific IKK2 Activation is Sufficient to Induce Neuroinflammation and Results in Impaired Brain Development

Daniel Starczynowski, Cincinnati Children's Hospital Medical Center, USA
miR-145 and miR-146a Mediate the Pathogenesis of 5q- Syndrome by Targeting TRAF6 Signaling

Paul D. Robbins, University of Pittsburgh, USA
Role of IKK/NF-kappaB in Aging

Geert van Loo, VIB-Ghent University, Belgium
Study of A20/tnfaip3 in Mouse Models of Inflammatory Disease

Dietrich B. Conze, National Cancer Institute, National Institutes of Health, USA
Non-Canonical NF-kappB Activation and Abnormal B Cell Accumulation in Mice Expressing Ubiquitin Protein Ligase-Inactive c-IAP2

Zhaohui Wu, University of Tennessee Health Science Center, USA
ATM-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation upon Genotoxic Stress

16:30—17:00
Coffee Available

Zia Concourse
17:00—19:15
NF-kappaB Response to Genotoxic and Oxidative Stress
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Michelle A. Kelliher, University of Massachusetts Medical School, USA

Martin Krönke, Institute of Medical Microbiology, Immunology and Hygiene, Germany
TNF Signaling and Regulation of ROS Production

Richard M. Siegel, NIAMS, National Institutes of Health, USA
ROS and Abnormal TNFR1 Signaling in TRAPS

Renée Johnson, University of Bristol, UK
Short Talk: An Interaction between RelA and Mortalin Regulates Mitochondrial Function and Cellular Respiration

Claus Scheidereit, Max Delbrück Center for Molecular Medicine, Germany
Short Talk: Mechanism of IKK Activation by Genotoxic Stress

Shigeki Miyamoto, University of Wisconsin, Madison, USA
Short Talk Autoinhibitory Feedback and SUMO Protease Regulation of NFkappaB Signaling by DNA Damage

Manolis Pasparakis, University of Cologne, Germany
Concluding Remarks

19:15—20:15
Social Hour with Lite Bites

Eldorado Court/Sunset Room
20:00—23:00
Entertainment

Eldorado Court/Sunset Room

SUNDAY, JANUARY 10

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI084376-01




We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. Educational donation provided by Amgen

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


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