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This meeting took place in 2010



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Stem Cell Differentiation and Dedifferentiation (B4)


Organizer(s) Shinya Yamanaka and Fiona M. Watt
February 15—20, 2010
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 15, 2009
Late Abstract Deadline: Nov 16, 2009
Scholarship Deadline: Oct 15, 2009
Early Registration Deadline: Dec 15, 2009

Sponsored by Genzyme Corporation, Pfizer Global Research & Development and Sangamo BioSciences, Inc.

Summary of Meeting:
Recent progress in induced pluripotent stem (iPS) cells has shown that stem cells can be generated from differentiated progenies by introducing just a few defined factors. In addition, various stem cells have been isolated from human tissues. Stem cells from patients will provide various tools in understanding disease mechanisms, searching for effective drugs, and evaluating toxicity of drug candidates. Furthermore, human iPS cells and other stem cells may provide various types of cells for regenerative medicine. In this meeting, we will discuss how stem cells, including iPS cells, are isolated, generated and maintained. We will also provide an update on induction of differentiated cells from stem cells. We then will discuss progress in application of pluripotent stem cells and other stem cells in basic research, drug discovery, toxicology, and regenerative medicine.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, FEBRUARY 15

15:00—19:30
Registration

Longs Peak Foyer
18:30—19:30
Refreshments

Longs Peak Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Shinya Yamanaka, Center for iPS Cell Research and Application, Kyoto University, Gladstone Institutes, Japan

* Fiona M. Watt, King's College London School of Medicine, UK

James A. Thomson, Morgridge Institute for Research, University of Wisconsin, USA
Human ES Cells and iPS Cells


TUESDAY, FEBRUARY 16

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:15
iPS Cells
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Fiona M. Watt, King's College London School of Medicine, UK

Shinya Yamanaka, Center for iPS Cell Research and Application, Kyoto University, Gladstone Institutes, Japan
Induction of Pluripotency by Defined Factors

Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA
Molecular Mechanisms of Pluripotency and Reprogramming

Juan Carlos Izpisua-Belmonte, The Salk Institute for Biological Studies, USA
Linking the p53 Tumor Suppressor Pathway to Somatic Cell Reprogramming

Helen M. Blau, Stanford University, USA
Reprogramming Towards Pluripotency Requires AID-Dependent DNA Demethylation

Jing Liao, Harvard University, USA
Short Talk: Generation of Induced Pluripotent Stem Cell Lines from Rat Adult Cells

Christoph Bock, Austrian Academy of Sciences, Austria
Short Talk: The Epigenome of Pluripotent Cells: Variations of a Common Theme

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Pluripotency
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Shinya Yamanaka, Center for iPS Cell Research and Application, Kyoto University, Gladstone Institutes, Japan

Austin Smith, University of Cambridge, UK
Intrinsic and Extrinsic Regulation of the Pluripotent Ground State

Ihor R. Lemischka, Icahn School of Medicine at Mount Sinai, USA
Genome-Wide Analyses of Molecular Mechanisms Underlying Pluripotency

Amanda G. Fisher, MRC Clinical Sciences Centre, Imperial College London, UK
Stem Cells and Epigenetic Reprogramming

Lay Teng Ang, Genome Institute of Singapore, Singapore
Short Talk: MicroRNA Function in Regulating Pluripotency and Differentiation of Human Embryonic Stem Cells

Li-Fang Chu, University of Wisconsin-Madison, USA
Short Talk: Primordial Germ Cells as the Immediate Precursors of Embryonic Stem Cells

19:15—20:15
Social Hour with Lite Bites

Shavano/Torreys
19:30—22:00
Poster Session 1

Shavano/Torreys

WEDNESDAY, FEBRUARY 17

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:30
Reprogramming
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Austin Smith, University of Cambridge, UK

Azim Surani, University of Cambridge, UK
Resetting the Epigenome during Germ Cell Specification and by LIF-STAT3 Signaling

Hans R. Schöler, Max Planck Institute for Molecular Biomedicine, Germany
Induction of Pluripotency in Adult Somatic and Germline Stem Cells

Kevin C. Eggan, Harvard University, USA
Identification and Characterization of Small Reprogramming Molecules

Chad A. Cowan, Harvard University, USA
Programming and Reprogramming: New Approaches for Understanding Disease

Azadeh Golipour, Samuel Lunenfeld Research Institute, Canada
Short Talk: A Systematic Approach to Identify Novel Regulators of Somatic Cell Reprogramming

Collin A. Melton, University of California, San Francisco, USA
Short Talk: Opposing microRNA Families Regulate Self-Renewal in Mouse Embryonic Stem Cells

Larry Stanton, Genome Institute of Singapore, Singapore
Short Talk: Converting Sox17 into a Pluripotency Reprogramming Factor

09:20—09:40
Coffee Break

Longs Peak Foyer
11:30
On Own for Lunch and Recreation

11:30—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Other Pluripotent Stem Cells
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Hans R. Schöler, Max Planck Institute for Molecular Biomedicine, Germany

Takashi Shinohara, Kyoto University, Japan
Positive and Negative Regulators of Mouse Germline Stem (GS) Cell Proliferation

Anthony Atala, Wake Forest University, USA
Amniotic Fluid and Placental-Derived Stem Cells

Thomas P. Zwaka, Icahn School of Medicine at Mount Sinai, USA
Short Talk

Shin-Ichi Nishikawa, RIKEN Center for Developmental Biology, Japan
The Pathway of Hematopoietic Stem Cell Development Explained

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys
19:30—22:00
Poster Session 2

Shavano/Torreys

THURSDAY, FEBRUARY 18

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:15
Somatic Stem Cells
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Hideyuki Okano, Keio University School of Medicine, Japan

Fiona M. Watt, King's College London School of Medicine, UK
Defining the Epidermal Stem Cell Niche

Toshio Suda, Keio University, Japan
Hematopoietic Stem Cells and their Niches

Amy J. Wagers, Harvard University, USA
Regenerative Potential of Skeletal Muscle Stem Cells

Fred (Rusty) H. Gage, The Salk Institute for Biological Studies, USA
Neural Stem Cells and their Fates

Valerie Horsley, Yale University, USA
Short Talk: Extrinsic Regulation of Skin Stem Cells

Tae-Hee Kim, Hospital for Sick Children / University of Toronto, Canada
Short Talk: A Role for Notch Signaling in Stomach Epithelial Stem Cell Homeostasis

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:30
Differentiation of Stem Cells I
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Toshio Suda, Keio University, Japan

Deepak Srivastava, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA
microRNA Regulation of Cardiac Stem Cell Fate

Hideyuki Okano, Keio University School of Medicine, Japan
Regeneration of the Damaged CNS with iPS Cells

Hans Keirstead, University of California, Irvine, USA
Clinically-Compliant Differentiation of hESCs for the Treatment of Spinal Cord Injury and Disease

Catherin Niemann, University of Cologne, Germany
Short Talk: Important Role of Hair Follicle Stem Cells for Generation and Differentiation of Sebaceous Gland Cells during Skin Homeostasis

19:30—20:30
Social Hour with Lite Bites

Shavano/Torreys
19:30—22:00
Poster Session 3

Shavano/Torreys

FRIDAY, FEBRUARY 19

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Differentiation of Stem Cells II
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Deepak Srivastava, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA

Emmanuel E. Baetge, Nestlé Institute of Health Sciences, Switzerland
Functional Pancreatic Islet Cells from Embryonic Stem Cells

Ronald D. McKay, Lieber Institute for Brain Development, USA
Neural Differentiation of Stem Cells

Rita R. Perlingeiro, University of Minnesota, USA
From ES Cells to Skeletal Muscle Precursors

Nobuko Uchida, StemCells, Inc., USA
Therapeutic Potential of Human Central Nervous System-Stem Cell: Neuroprotection Strategies

Micha Drukker, Helmholtz Center Munich, Germany
Short Talk: Prospective Isolation of Four of the Earliest Precursors to Emerge from Human Embryonic Stem Cells

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Application of Stem Cells
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Ronald D. McKay, Lieber Institute for Brain Development, USA

Amy Sinor, Harvard Stem Cell Institute, USA
ES Cell-Derived Cells for Disease Mechanism and Drug Discovery

Zhong Zhong, GlaxoSmithKline R&D China, China
Drug Discovery Targeting Neural Stem Cells

Gabriela Gebrin Cezar, Pfizer, Brazil
Metabolomics of Human Embryonic Stem Cells: Unraveling Biochemical Pathways of Neurodevelopmental Disorders

Karl-Dimiter Bissig, Baylor College of Medicine, USA
Short Talk: Cell Based Therapy for Liver Disease

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys
20:00—23:00
Entertainment

Shavano/Torreys

SATURDAY, FEBRUARY 20

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HD063192-01




We gratefully acknowledge additional support for this conference from:

Abcam plc Biospherix, Ltd.
Cell Signaling Technology, Inc. Genzyme Corporation
Pfizer Global Research & Development Sangamo BioSciences, Inc.
STEMCELL Technologies, Inc. StemCells, Inc.
Vitro Biopharma
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



GlaxoSmithKline R&D China


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676