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This meeting took place in 2010



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The Macrophage: Intersection of Pathogenic and Protective Inflammation (J8)


Organizer(s) Peter J. Murray, Sabine Ehrt and Ajay Chawla
February 12—17, 2010
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: Oct 12, 2009
Late Abstract Deadline: Nov 13, 2009
Scholarship Deadline: Oct 12, 2009
Early Registration Deadline: Dec 14, 2009

Sponsored by Novo Nordisk A/S


Summary of Meeting:
Recent insights into macrophage biology have focused on their prodigiously varied roles: as sensors, effectors and regulators of immunity; as cells central to tissue repair and homeostasis; as the host cell of diverse pathogens; and as cells pivotal to the pathogenesis of numerous inflammatory diseases. The conservation of underlying common mechanisms of macrophage activation and subsequent control forms the overall thematic organization of this meeting. A special focus will be on areas of macrophage biology that are often neglected, including the role of macrophages in inflammatory diseases not obviously linked to pathogens including atherosclerosis, cancer, metabolic diseases and other forms of ‘sterile’ inflammation. The meeting is intended to provide a state-of-the-art overview of macrophage biology, to highlight the translational implications of this work, to provide researchers with access to diverse model systems, topics and levels of investigation, and to help define the most important questions to be addressed.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, FEBRUARY 12

15:00—19:30
Registration

Van Horne Foyer
18:30—19:30
Refreshments

Van Horne Foyer
19:30—20:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A-B
Carl F. Nathan, Weill Cornell Medical College, USA
Non-Resolving Inflammation: Disease, Defense and Therapy


SATURDAY, FEBRUARY 13

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:00
Macrophages and Pathogens I
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A-B
* De' Broski R. Herbert, University of Pennsylvania, USA

Lalita Ramakrishnan, University of Cambridge, UK
An Eicosanoid Pathway Rheostat Controls Susceptibility to Mycobacteria in Zebrafish and Humans

Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA
Nod-like receptors: Role in immunity and inflammatory diseases

Sabine Ehrt, Weill Cornell Medical College, USA
Mycobacterial Survival Strategies in the Macrophage Phagosome

Alan Sher, NIAID, National Institutes of Health, USA
Poly-IC Treatment Exacerbates Tuberculosis by the Pulmonary Recruitment of a Pathogen-permissive Monocyte/macrophage Population

08:00—11:15
Genetics and Functional Genomics of Atherosclerosis
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
Sekar Kathiresan, Massachusetts General Hospital, USA
Mapping Genes for Plasma Lipids and Myocardial Infarction in Humans

Eric Schadt, Mount Sinai School of Medicine, USA
Moving Toward a Systems Biology Understanding of Complex Human Diseases

Karen Reue, University of California, Los Angeles, USA
Identification of Novel Lipid Metabolism Genes from Spontaneous Mouse Mutants

* Daniel J. Rader, University of Pennsylvania, USA
Functional Characterization of Novel Loci Associated with Plasma Lipids

Yajaira Suárez, New York University School of Medicine, USA
Short Talk: TNF-Induced microRNAs Regulate TNF-Induce Expression of E-Selectin and ICAM-1 in Human Endothelial Cells

Johan Lars Markus Björkegren, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Multi-Organ Expression Profiling to Uncover Gene Networks and Modules of Importance to Coronary Artery Disease

09:20—09:40
Coffee Break

Van Horne Foyer
11:00
On Own for Lunch and Recreation

11:00—13:00
Poster Setup

Mezzanine 2
13:00—22:00
Poster Viewing

Mezzanine 2
14:30—16:30
Workshop 1

Van Horne Ballroom A-B
* Lalita Ramakrishnan, University of Cambridge, UK

Jennifer Philips, Washington University School of Medicine, USA
Functional Genomics of the Host: Defining Macrophage Susceptibility to Mycobacterial Infection

Dennis Montoya, University of California, Los Angeles, USA
Plasticity of Macrophage Phagocytic and Antimicrobial Programs in Leprosy

Hanne Gunda Schoenen, Institute for Clinical Microbiology and Hygiene, Germany
Mincle is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analogue Trehalose-Dibehenate1

Antoine Tinel, Harvard Medical School, USA
A Crucial Role for SIRT1 in Host-Defense Mechanisms

Sandra E. Nicholson, Walter and Eliza Hall Institute of Medical Research, Australia
The SPRY Domain-containing SOCS Box Protein SPSB2 Targets iNOS for Ubiquitination and Proteasomal Degradation

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:15
Signaling and Gene Expression (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A-B
* Linda K. Curtiss, The Scripps Research Institute, USA
Atherosclerosis: An Unfortunate Mix of Lipids and Inflammation Whipped Up by Toll-Like Receptors

Joachim Herz, University of Texas Southwestern Medical Center, USA
Importance of Cholesterol Homeostasis in Vascular Smooth Muscle Cells

Petra Keul, University of Duisburg, Essen, Germany
Short Talk: Deletion of the S1P Receptor S1P3 Attenuates Macrophage-Driven Inflammation in Atherosclerotic Lesions of S1P3-/-/ApoE -/- Double Knockout Mice

Jay W. Heinecke, University of Washington School of Medicine, USA
Short Talk: Defining the Proteome of the Macrophage Foam Cell

Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Regulation of Inflammatory Gene Expression in Macrophages

19:15—20:15
Social Hour with Lite Bites

Mezzanine 2
19:30—22:00
Poster Session 1

Mezzanine 2

SUNDAY, FEBRUARY 14

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:00
Understanding Human Macrophages
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A-B
* Peter J. Murray, St. Jude Children's Research Hospital, USA

Lionel B. Ivashkiv, Hospital for Special Surgery, New York, USA
Signal Integration during Macrophage Activation and Cytokine Production

David A. Hume, University of Edinburgh, UK
Transcriptional Networks in Macrophage Differentiation and Activation

Menno Van Lookeren Campagne, Genentech, Inc., USA
A Central Role for Complement and Liver Kupffer Cells in Host Defense

Christopher L. Karp, Bill & Melinda Gates Foundation, USA
Pathogen Contact with Human Macrophages

Molly Ingersoll, Institut Pasteur, France
Short Talk: Comparison of Gene Expression Profiles between Human and Mouse Monocyte Subsets

08:00—11:15
Immune Mechanisms and Atherosclerosis
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
Göran K. Hansson, Karolinska University Hospital, Sweden
Interplay of Innate and Adaptive Immune Mechanisms in Atherosclerosis

* Joseph L. Witztum, University of California, San Diego, USA
Oxidation-Specific Epitopes are a Major Target of Innate Immunity

Ziad Mallat, University of Cambridge, UK
Regulatory T Cell Immunity in Atherosclerosis

Gwendalyn J. Randolph, Washington University, USA
Fate of Monocyte-Derived Cells in Atherosclerotic Plaques versus Sites of Resolving Inflammation

David Weismann, Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
Short Talk: Discovery of a novel malondialdehyde (MDA) binding protein

Yue Zhao, Vanderbilt University, USA
Short Talk: The NR4A Orphan Nuclear Receptor NOR1 Mediates Monocyte Adhesion and Atherosclerosis Formation in Mice

09:20—09:40
Coffee Break

Van Horne Foyer
11:00
On Own for Lunch and Recreation

11:00—13:00
Poster Setup

Mezzanine 2
13:00—22:00
Poster Viewing

Mezzanine 2
16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Macrophage Movement (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A-B
* Gerald Krystal, British Columbia Cancer Research Centre, Canada

Israel F. Charo, ChemoCentryx, Inc., USA
CCR2 in atherosclerosis, insulin resistance, and hematopoietic stem cell trafficking

Frederic Geissmann, Memorial Sloan Kettering Cancer Center, USA
Function of the mononuclear phagocyte system: In vivo in human and model organisms

Steven L. Kunkel, University of Michigan Medical School, USA
Writers, Readers, and Erasers: Dynamic Epigenetic Regulation of the Macrophage Phenotype

Andrea L. Hevener, University of California, Los Angeles, USA
Short Talk: Myeloid-specific Deletion of Estrogen Receptor-alpha (ERalpha) Promotes Obesity and Insulin Resistance in Mice

19:00—20:00
Social Hour with Lite Bites

Mezzanine 2
19:30—22:00
Poster Session 2

Mezzanine 2

MONDAY, FEBRUARY 15

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:00
Sterile Inflammation and Cancer Inflammation
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A-B
* Christopher L. Karp, Bill & Melinda Gates Foundation, USA

Kenneth L. Rock, University of Massachusetts Medical School, USA
The Sterile Inflammatory Response

Vincenzo Bronte, University of Verona, Italy
Myeloid-Derived Suppressor Cells

Thorsten Hagemann, Barts and The London Queen Mary's Medical School, UK
Cancer-Related Inflammation

Shigekazu Nagata, IFReC, Osaka University, Japan
Engulfment and degradation of apoptotic cells

Antonio Castrillo, Instituto Investigaciones Biomedicas CSIC, Spain
Short Talk: LXR Nuclear Receptors Regulate Apoptotic Cell Clearance and Immune Tolerance

08:00—11:15
The Vulnerable Plaque
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
Philippe Boucher, UMR CNRS 7213, University of Strasbourg, France
PPAR-gamma Inhibits Vascular Calcification by Controlling an LRP1/beta-Catenin Signaling Pathway

Peter Libby, Brigham and Women's Hospital, USA
Extracellular Matrix Metabolism and Determinants of Plaque Stability

Garret A. FitzGerald, University of Pennsylvania, USA
Cardiovascular Complexity in the Prostanoid System

* Ira Tabas, Columbia University, USA
Mechanisms and Consequences of Macrophage Apoptosis in Atherosclerosis

Kristiina Satu Susanna Rajamäki, Wihuri Research Institute, Finland
Short Talk: Cholesterol Crystals Activate Inflammasome Signaling in Human Macrophages

Walter S. Speidl, Medical University of Vienna, Austria
Short Talk: The Complement Component C5a Induces the Expression of MMP-1 and MMP-9 in Human Macrophages

09:20—09:40
Coffee Break

Van Horne Foyer
11:00
On Own for Lunch and Recreation

11:00—13:00
Poster Setup

Mezzanine 2
13:00—22:00
Poster Viewing

Mezzanine 2
14:30—16:30
Workshop 2

Van Horne Ballroom A-B
* Steven L. Kunkel, University of Michigan Medical School, USA

Jan Van den Bossche, Academic Medical Center, Netherlands
Alternatively Activated Macrophages Engage in Homotypic and Heterotypic Interactions through IL-4 and Polyamine-Induced E Cadherin/Catenin Complexes

Mark Gilchrist, Seattle BioMed, USA
Sumo 1 Modification and Regulation of the Transcription Factor ATF3 in Macrophages

Karin Reif, Genentech, Inc., USA
A Novel Highly Specific Small Molecule Inhibitor for BTK Suppresses Fc Receptor Function in Macrophages and Prevents Inflammatory Arthritis

Jacob Rachmilewitz, Goldyn Savad Institute for Gene Therapy, Israel
Cells Exposed to Sub-Lethal Oxidative-Stress Attract Monocytes via a MYD88-Linked Receptor but do not Provoke the Release of Pro-Inflammatory Cytokines

Jessica A. Hamerman, Benaroya Research Institute, USA
ITAM Signaling Adapters Regulate Macrophage and Dendritic Cell Function and Homeostasis

Amrom Obstfeld, Columbia University, USA
Obesity Induced Hepatic Myeloid Cells Modulate Liver Steatosis

Suneil K. Koliwad, University of California, San Francisco, USA
Macrophage Triacylglycerol Storage as a Modulator of the Inflammatory and Metabolic Response to Dietary Fats

Pavel Kovarik, University of Vienna, Austria
Qualitative and Temporal Control of mRNA Decay during Inflammatory Response of Macrophages

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Deactivating Macrophage Activity (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A-B
Peter J. Murray, St. Jude Children's Research Hospital, USA
Cytokine-Mediated Deactivation of the Activated Macrophage

Gerald Krystal, British Columbia Cancer Research Centre, Canada
The Role of SHIP in Macrophage Skewing and Activation

* Christopher K. Glass, University of California, San Diego, USA
Nuclear Receptor Repression Pathways that Regulate Inflammation

Tim Ian Smallie, Kennedy Institute of Rheumatology Division, UK
Short Talk: IL-10 Negatively Regulates Macrophage Activation by Inhibiting Transcription Elongation

19:00—20:00
Social Hour with Lite Bites

Mezzanine 2
19:30—22:00
Poster Session 3

Mezzanine 2

TUESDAY, FEBRUARY 16

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:00
Macrophage and Pathogens II
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A-B
* Sabine Ehrt, Weill Cornell Medical College, USA

De' Broski R. Herbert, University of Pennsylvania, USA
Alternatively Activated Macrophages Control Helminth-Driven Immunopathology

Thomas A. Wynn, Pfizer, USA
The Role of IL-4/IL-13 Activated Macrophages in Fibrosis

Judith E. Allen, University of Manchester, UK
The Macrophage and the Worm

Sara R. Cherry, University of Pennsylvania School of Medicine, USA
Using high-throughput screening to identify cell-intrinsic innate immune pathways

08:00—11:15
Cholesterol Homeostasis/Foam Cell Formation
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Russell A. DeBose-Boyd, University of Texas Southwestern Medical Center, USA
Cholesterol Homeostasis and Sterol-Accelerated Degradation of HMG CoA Reductase

Alan R. Tall, Columbia University, USA
HDL, ABC Transporters and Atherosclerosis

Kathryn J. Moore, New York University Medical Center, USA
Micro-Managing Macrophage Cholesterol Metabolism

Edward A. Fisher, New York University School of Medicine, USA
HDL and Atherosclerosis Regression: Effects on the Quantity and Quality of Monocyte-Derived Cells in Plaques

Prakash Gopaldas Chandak, Institute of Molecular Biology and Biochemistry, Austria
Short Talk: Adipose Triglyceride Lipase Deficiency Affects Macrophage Morphology and Function and Significantly Reduces Atherosclerosis in LDLR -/- Mice

Shunxing Rong, Wake Forest University School of Medicine, USA
Short Talk: High Polyunsaturated fatty acid (PUFA) diet unmasks role of 12/15 lipoxygenase in lipid metabolism

09:20—09:40
Coffee Break

Van Horne Foyer
11:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Metabolism and Macrophages at the Intersection of Metabolic Control (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A-B
* Russell A. DeBose-Boyd, University of Texas Southwestern Medical Center, USA

* Ajay Chawla, University of California, San Francisco, USA
Immune regulation of nutrient metabolism and aging

William A. Muller, Northwestern University Feinberg School of Medicine, USA
All Roads Lead to the LBRC: A common mechanism for leukocyte transendothelial migration

Ebru Erbay, Bilkent University, Turkey
The Role of Endoplasmic Reticulum Stress in Atherosclerosis and its Regulation by Lipids

Hwee Ying Lim, National University of Singapore, Singapore
Short Talk: Ezetimibe Restores lymphatic vessel function and dendritic cell migration, in hypercholesterolemic apoE deficient mice

19:00—20:00
Social Hour with Lite Bites

Mezzanine 2
20:00—23:00
Entertainment

Mezzanine 2

WEDNESDAY, FEBRUARY 17

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI085791-01




We gratefully acknowledge additional support for this conference from:

Novo Nordisk A/S

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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