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This meeting took place in 2010



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Metabolism and Cancer Progression (X4)


Organizer(s) Eileen P. White, Craig B. Thompson and Chi Van Dang
March 12—17, 2010
Fairmont Hotel Vancouver • Vancouver, British Columbia Canada
Abstract Deadline: Nov 12, 2009
Late Abstract Deadline: Dec 10, 2009
Scholarship Deadline: Nov 12, 2009
Early Registration Deadline: Jan 12, 2010

Sponsored by Celgene Corporation


Summary of Meeting:
Otto Warburg initially drew attention to the distinct metabolic state of tumors compared to normal tissues over 75 years ago, where tumor cells commonly favor glycolysis over oxidative phosphorylation even in the presence of oxygen (Warburg effect or aerobic glycolysis). Insight into the role and mechanism of this metabolic switch in tumorigenesis, and the utility of and means to therapeutically exploit altered metabolism in cancer was not clear, other than for utilization for FDG-PET imaging. Recently the metabolic requirements of tumor cells and the links to common pathway alterations in human cancers have been gradually emerging. It is now apparent that metabolic demand in tumor cells is high due to deregulation of cell growth, and that this constitutive activation of growth signaling pathways can disconnect cellular metabolism from nutrient and growth factor availability. Subversion of cellular metabolism for biosynthetic purposes is required to sustain deregulated tumor cell growth but can also restrict energy production that can limit tumor cell adaptation to metabolic stress. Hypoxic and acidic conditions in the tumor microenvironment are byproducts of these events and are common features of the tumor microenvironment that can activate stress responses, influence tumor growth, and impair treatment. Many of the oncogenic pathways altered in tumor cells modulate cell metabolism while enabling growth in these adverse conditions. Adaptation of tumor cells to stress through activation of the catabolic pathway of autophagy and its role in damage mitigation and promoting tumor cell survival to metabolic stress is also now emerging. The vision for this meeting is to bring together leaders in the fields of cancer, signaling and metabolism to discuss emerging discoveries and their application to improving cancer therapy.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, MARCH 12

15:00—19:30
Registration

BC Foyer
18:30—19:30
Refreshments

BC Foyer
19:30—21:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* Eileen P. White, Rutgers University, USA

Joan S. Brugge, Harvard Medical School, USA
Diversity of Cell Death Pathways in Organogenesis and Oncogenesis

Lewis C. Cantley, Weill Cornell Medicine, USA
PI 3-Kinase and Cancer Cell Metabolism


SATURDAY, MARCH 13

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:15
Metabolism Regulation in Model Organisms
Meeting has ended...abstracts no longer viewable online.

Columbia Ballroom
* Joan S. Brugge, Harvard Medical School, USA

Steven L. McKnight, University of Texas Southwestern Medical Center, USA
Lessons from Metabolic Regulation in Yeast

Nika N. Danial, Dana-Farber Cancer Institute, USA
Energy Metabolism in Genetically Defined Subtypes of Diffuse Large B Cell Lymphoma

Yue Xiong, University of North Carolina at Chapel Hill, USA
Acetylation Regulation of Metabolism

Chi Van Dang, University of Pennsylvania, USA
Regulation of Cancer Metabolism by Myc

Jing Chen, Winship Cancer Institute, Emory University, USA
Short Talk: Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

William C. Comb, University of North Carolina, Chapel Hill, USA
Short Talk: IKK-Dependent Phosphorylation and Feedback Inhibition of PI3K Promotes Nutrient Deprivation-Induced Autophagy

08:00—11:15
Apoptosis Pathways
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Anthony G. Letai, Dana-Farber Cancer Institute, USA

Suzanne Cory-Adams, Walter & Eliza Hall Institute of Medical Research, Australia
The Bcl-2 Family in Cancer Development and Cancer Treatment

Loren D. Walensky, Dana-Farber Cancer Institute, USA
Dissecting the Activation Pathway of Pro-Apoptotic BAX: Mechanistic Insights and Pharmacologic Opportunities

Xin Niu, McMaster University, Canada
Short Talk: Identification and Mechanistic Characterization of Novel Bax Inihibitors

Vishva M. Dixit, Genentech, Inc., USA
Identification of a Stabilizing Deubiquitinase for Mcl-1 that is Over-Expressed in Tumors

David W. Andrews, Sunnybrook Research Institute, Canada
Mechanisms of Mitochondrial Membrane Permeabilization by Pro-Apoptotic Bcl-2 Family Proteins

Ingrid E. Wertz, Genentech, Inc., USA
Short Talk: Resistance to Anti-tubulin Chemotherapeutics is Regulated by Mcl–1 and FBW7

09:20—09:40
Coffee Break

BC Foyer
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
14:30—16:30
Workshop 1: PI3 Kinase Regulation and Cancer

Columbia Ballroom
* Lewis C. Cantley, Weill Cornell Medicine, USA

Brian Grabiner, Biogen, USA
Identification and Clinical Assessment of Genes that Regulate the Response of Cancers to Rapamycin through Pooled RNAi Screens

Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA
Alternative Metabolic Strategies for Growth in Glioblastoma: Glucose vs. Glutamine for Support of Cell Proliferation and Tumorigenesis

Barry Bochner, Biolog, Inc., USA
Metabolic Analysis of Isogenic Cells with Altered Cancer-Related Genes

Jonathan L. Coloff, Harvard Medical School, USA
A Metabolic Checkpoint Controls Puma Transcription and Protein Stability For Survival of Activated and Leukemic T Cells

Kurt Fisher, Transplant Center at the Nebraska Medical Center, USA
The Molecular Scaffold, Kinase Suppressor of Ras 1 (KSR1), Potentiates H-RasV12 Induced Transformation and Expands Cellular Capacity for Glycolysis and Oxidative Phosphorylation

Ching-yi Chang, Duke University Medical Center, USA
The Metabolic Regulator ERRalpha, a Downstream Target of HER2/IGF1, as a Therapeutic Target in Breast Cancer

Christina H. Eng, Pfizer, USA
Ammonia Derived from Glutaminolysis is a Diffusible Regulator of Autophagy

James M. Phang, NCI at Frederick, National Institutes of Health, USA
MiR-23b* Regulates Proline Oxidase, a Mitochondrial Metabolic Tumor Suppressor, in Renal Cancer

14:30—16:30
Workshop 1: Methods for the Detection of Non-Apoptotic Cell Death

British Ballroom
* Douglas R. Green, St. Jude Children's Research Hospital, USA

Vassiliki Karantza, Cancer Institute of New Jersey, USA
Autophagy Regulates keratin 8 Homeostasis in Mammary Epithelial Cells and in Breast Tumors

Brandon White, San Jose State University, USA
Flavonoids Kill Breast Cancer Cells While Inhibiting Caspase Activity: Is this Apoptosis?

Katja Simon, University of Oxford, UK
Detection of Autophagic Flux in Clinical Samples

Suzanne Hibbs, Sigma-Aldrich Research Biotech, USA
An Application of Zinc Finger Nuclease Technology to Create Knockout Cancer Lines

Jayanta Debnath, University of California, San Francisco, USA
ATG12 Conjugation to ATG3 Restricts The Expansion of Mitochondrial Mass and Promotes Cell Death

Haymanti Bhanot, University of Toledo, College of Medicine, USA
Mechanisms Underlying Methuosis in Human Glioblastoma Cells

16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Metabolic Differences between Normal and Cancer Cells
Meeting has ended...abstracts no longer viewable online.

Columbia Ballroom
* David M. Sabatini, Whitehead Institute for Biomedical Research, USA

Eyal Gottlieb, Technion Integrated Cancer Center, Israel
The Roles of Prolyl Hydroxylases in Metabolism and Cancer

Valeria Fantin, ORIC Pharmaceuticals, USA
Metabolic Signaling in Cancer

Sybille Mazurek, Universität Gießen, ScheBo Biotech AG, Germany
Pyruvate Kinase M2 and Cancer

Claudio Santos, London Research Institute, UK
Short Talk: Identification of Metabolic Enzymes Essential for Survival of Prostate Cancer Cells by Functional Studies

17:00—19:00
Non-Apoptotic Pathways in Model Organisms
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Daniel J. Klionsky, University of Michigan, USA

Frank Madeo, University of Graz, Austria
Programmed Cell Death in Yeast: Subroutines, Mechanisms and Purposes

Vladimir I. Titorenko, Concordia University, Canada
Short Talk: Novel Anti-Aging Compounds Greatly Extend Yeast Life Span by Targeting a Programmed Necrotic Cell Death Pathway Triggered by the Age-Related Buildup of Free Fatty Acids

Thomas P. Neufeld, University of Minnesota, USA
Autophagic Pathways in Drosophila: Good or Evil?

John M. Abrams, University of Texas Southwestern Medical Center, USA
Cell Death Regulatory Networks in Drosophila

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
19:30—22:00
Poster Session 1

Pacific Ballroom

SUNDAY, MARCH 14

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:00
Metabolic Adaptation in Cancer (Joint)
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* Marja Jäättelä, Danish Cancer Society Research Center, Denmark

Eileen P. White, Rutgers University, USA
Role of Autophagy in Cancer and Therapy

Guido Kroemer, Cordeliers Research Center, France
Autophagy in Stress Adaptation, Avoidance of Cell Death and Longevity

Karen H. Vousden, Crick Institute, UK
Control of Metabolism by p53

Rob Cairns, University Health Network, Canada
Short Talk: Cancer-Associated Metabolite 2-Hydroxyglutarate Accumulates in AML with IDH1/2 Mutations

Josh Lyon Andersen, Brigham Young University, USA
Short Talk: Metabolic Regulation of Caspase-2

09:20—09:40
Coffee Break

BC Foyer
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Therapeutic Modulation of Metabolism
Meeting has ended...abstracts no longer viewable online.

Columbia Ballroom
* Robert T. Abraham, Pfizer Worldwide Research and Development, USA

Peter F. Carmeliet, University of Leuven, VIB, Belgium
Oxygen, Metabolism and Angiogenesis

John L. Cleveland, The Scripps Research Institute, USA
Therapeutic Modulation of Autophagy in Cancer

Uwe Haberkorn, University Hospital Heidelberg, Germany
Imaging Metabolism in Cancer

Paul C. McDonald, British Columbia Cancer Research Center, Canada
Short Talk: Therapeutic Targeting of Carbonic Anhydrase IX Results in Inhibition of Growth and Metastasis of Breast Tumors

17:00—19:00
Autophagic Pathways
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Noboru Mizushima, University of Tokyo, Japan

Daniel J. Klionsky, University of Michigan, USA
The Regulation of Macroautophagy

Francesco Cecconi, Danish Cancer Society Research Center, Denmark
Short Talk: Ambra1 Regulates Autophagosome Formation and Plays a Role in Controlling Cell Proliferation

Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Chaperone-Mediated Autophagy in Organismal Aging

Vojo Deretic, University of New Mexico Health Sciences Center, USA
Autophagy in Immunity: Microbes, Mitochondria and Cell Survival vs Cell Death

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
19:30—22:00
Poster Session 2

Pacific Ballroom

MONDAY, MARCH 15

07:00—11:00
Poster Setup

Pacific Ballroom
07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:15
Survival and Death in Development and Disease (Joint)
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* Karen H. Vousden, Crick Institute, UK

Noboru Mizushima, University of Tokyo, Japan
Lessons from Autophagy Deficient Mouse Models

Marja Jäättelä, Danish Cancer Society Research Center, Denmark
Lysosomal Sphingolipid Metabolism as a Target for Cancer Therapy

Douglas R. Green, St. Jude Children's Research Hospital, USA
The Mitochondrion: The Weapon Employed in Apoptopic Suicide

Gerard I. Evan, University of Cambridge, UK
Inhibiting Oncogenes for Cancer Therapy

Joan Boren, Cambridge Research Institute, CRUK, UK
Short Talk: Changes in Cell Lipid Content during Induction of Apoptosis

Rebecca Lock, University of California, San Francisco, USA
Short Talk: Autophagy Inhibition Alters Glucose Metabolism and Promotes Epithelial Differentiation During Ras-Mediated Oncogenic Transformation

09:20—09:40
Coffee Break

BC Foyer
11:30—12:30
Lunch

Pacific Ballroom
12:30—14:30
Poster Session 3

Pacific Ballroom
14:30—16:30
Workshop 2: Metabolic Assessment and Regulation

Columbia Ballroom
* Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA

Michelle F. Clasquin, Agios Pharmaceuticals, USA
High-Resolution Full-Scan Mass Spectrometry for Discovery and Characterization of Unknown Metabolites

Andrew N. Lane, University of Louisville, USA
Translational Metabolomics in Human Lung Cancer

Kenjiro Kami, Human Metabolome Technologies, Inc., Japan
CE-MS-based Metabolomics Identified a Novel Anaerobic Energy Metabolism of Cancer Cells

Fionnuala M. Morrish, Fred Hutchinson Cancer Research Center, USA
The Metabolism of Tumor Progression and Regression in the pInsMycERTam/Bcl-xL Mouse Model of Pancreatic Beta Cell Neoplasia

Min Wu, Massachusetts General Hospital and Broad Institute, USA
Metabolic Dependency on Fatty Acid Oxidation of Glioblastoma SF188

Ameeta Kelekar, University of Minnesota, USA
Post-Translational Regulation of Human Noxa; its Role in Glucose Deprivation Induced Death

Kathryn E. Wellen, University of Pennsylvania, USA
The Hexosamine Biosynthetic Pathway Links Glutamine Metabolism and Signaling to Regulate Cell Growth

Linda Z. Penn, Princess Margaret Cancer Centre, Canada
Connecting the Dots between Tumor Cell Metabolism and the Mevalonate Pathway

14:30—16:30
Workshop 2: Pathological Implications of Non-Apoptotic Cell Death

British Ballroom
* Junying Yuan, Harvard Medical School, USA

Nelson Cesar Di Paolo, Emory University, USA
Necrosis and Autophagy, but not Apoptosis, are Induced in Macrophages in vivo upon Interaction with Adenovirus

Sam McNeal, Rhode Island Hospital, USA
Divergent Roles of RIP1 in Septic Liver Injury

Cristina Muñoz-Pinedo, Institut d'Investigacio Biomedica de Bellvitge, Spain
Glucose Deprivation Induces an Atypical Form of Apoptosis Mediated by Caspase-8 in Bax, Bak Deficient Cells

Andrey A. Parkhitko, Brigham and Women's Hospital Harvard Medical School, USA
Role of Autophagy in the Pathogenesis of Tuberous Sclerosis Complex

Poonam Sansanwal, Stanford University, USA
Mitochondrial Autophagy: A Novel Mechanism for Cellular Injury in Nephropathic Cystinosis

Andrew M. Leidal, University of California, San Francisco, USA
Autophagy Contributes to KSHV v-cyclin-induced Senescence

16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Cancer and Predisposition Genes
Meeting has ended...abstracts no longer viewable online.

Columbia Ballroom
* William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA

Cheryl L. Walker, Baylor College of Medicine, USA
Participation of TSC2 in a Cytoplasmic ATM Signaling Pathway that Regulates mTORC1 in Response to ROS

Kwok-Kin Wong, Dana-Farber Cancer Institute, USA
Integrative Genomic and Proteomic Analyses Identify Novel Targets for Lkb1 Deficient Metastatic Lung Tumors

Jason A. Chesney, University of Louisville, USA
Coupling Glycolysis With Cell Cycle Progression

Sang-Min Jeon, Ajou University, South Korea
Short Talk: The LKB1-AMPK Pathway is Essential for Cell Survival during Glucose Starvation through Redox Regulation

17:00—19:00
Cell Death Induction for Cancer Therapy
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* John A. Hickman, Agon, France

Anthony G. Letai, Dana-Farber Cancer Institute, USA
Why Chemotherapy Works – Chemosensitive Cancer Cells are more Primed for Apoptosis

Jerry M. Adams, Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: Puma-Mediated Leukocyte Apoptosis is Critical for gamma-Irradiation-Induced Thymic Lymphoma Development

Saul H. Rosenberg, Abbott Laboratories, USA
Bcl-2 Family Inhibitors for the Treatment of Cancer

Leigh Zawel, Merck Research Labs, USA
Therapeutic Targeting of Inhibitor of Apoptosis Proteins

19:00
On Own for Dinner


TUESDAY, MARCH 16

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:15
mTOR and Nutrient Sensing
Meeting has ended...abstracts no longer viewable online.

Columbia Ballroom
* Gerard I. Evan, University of Cambridge, UK

David M. Sabatini, Whitehead Institute for Biomedical Research, USA
mTOR and the Control of Growth

Reuben J. Shaw, The Salk Institute for Biological Studies, USA
The LKB1/ AMPK Pathway Controls Metabolism and Cell Growth

Michael N. Hall, University of Basel, Switzerland
TOR Signaling and the Control of Cell and Animal Growth

Robert T. Abraham, Pfizer Worldwide Research and Development, USA
Interplay between Glutamine Metabolism and mTOR Signaling during Autophagy

Bin Zheng, Massachusetts General Hospital, Harvard Medical School, USA
Short Talk: Cross-Talk between the LKB1-AMPK and BRAF-MEK-ERK Signaling Pathways

Matthew J. Martin, AstraZeneca, UK
Short Talk: AMP-Activated Protein Kinase in Melanoma: Biology and Therapeutic Opportunities

08:00—11:15
Non-Conventional Cell Death Pathways
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Frank Madeo, University of Graz, Austria

Junying Yuan, Harvard Medical School, USA
Mechanisms of Programmed Cell Death: From Apoptosis to Necroptosis

Michael B. Yaffe, Massachusetts Institute of Technology, USA
Mitotic Catastrophe: Mechanisms and Therapeutic Induction for Cancer Treatment

Paul R. Clarke, University of Dundee, UK
Short Talk: Controlling Apoptosis in Mitosis and during Mitotic Arrest

Peter Vandenabeele, VIB, Ghent University, Belgium
TNF-Induced Necrosis, Multiple Regulation of RIP1 Kinase Activity

Oliver Florey, Babraham Institute, UK
Short Talk: A Case for Murder: Entosis is a Cell Killing Mechanism Requiring Autophagy Proteins

Dale E. Bredesen, Buck Institute for Research on Aging, USA
Role of Cell Death Signaling in Alzheimer's Disease

09:20—09:40
Coffee Break

BC Foyer
11:15
On Own for Lunch and Recreation

15:30—16:30
Special Lecture (Joint)
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Therapeutic Exploitation of Metabolic Differences between Normal and Cancer Cells

16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Hypoxia and Metabolic Stress
Meeting has ended...abstracts no longer viewable online.

Columbia Ballroom
* Peter F. Carmeliet, University of Leuven, VIB, Belgium

Pierre Sonveaux, University of Louvain, Medical School, Belgium
Short Talk: Targeting Lactate-Fueled Respiration Selectively Kills Hypoxic Tumor Cells

Adrian L. Harris, University of Oxford, Weatherall Institute of Molecular Medicine, UK
Role of Carbonic Anhydrase 9 in Regulation of Tumour pH and Response to Antiangiogenic Therapy

Sally A. Kornbluth, Duke University Medical Center, USA
Metabolic Control of Caspases

William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
Dioxygenases as Therapeutic Targets in Cancer

17:00—19:00
Immunologic Cell Death
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Guido Kroemer, Cordeliers Research Center, France

Polly Matzinger, NIAID, National Institutes of Health, USA
Conversations between Tissues and T Cells

Matthew L. Albert, Genentech, Inc., USA
The Immunogenicity of Distinct Cell Death Modalities

Seung Hyun Han, Seoul National University, South Korea
Short Talk: Functional and Phenotypic Changes in Dendritic Cells Loaded with Irradiation-Induced Apoptotic Cancer Cells

Michel Gilliet, University Hospital of Lausanne, Switzerland
Breaking Innate Immune Tolerance to Self-Nucleic Acids Released by Dying Cells

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
20:00—23:00
Entertainment

Pacific Ballroom

WEDNESDAY, MARCH 17

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA144429-01




We gratefully acknowledge additional support for this conference from:

Celgene Corporation Cell Signaling Technology, Inc.
Seahorse Bioscience, Inc.
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Pfizer Biopharmaceuticals


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