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This meeting took place in 2010



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Molecular Basis for Biological Membrane Organization and Dynamics (A5)


Organizer(s) Tom A. Rapoport and Sandra L. Schmid
January 10—15, 2010
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Sep 16, 2009
Late Abstract Deadline: Oct 13, 2009
Scholarship Deadline: Sep 16, 2009
Early Registration Deadline: Nov 10, 2009

Supported by The Directors' Fund

Summary of Meeting:
Cellular membrane biology is a major area of research. Membrane proteins function as receptors, ion channels, or transporters, while the lipids provide not just a barrier between aqueous compartments, but also serve as signals. Lipids and proteins combine in as yet not fully understood ways to establish and maintain membrane organization and specific membrane domains. This meeting will address major questions in membrane biology that remain unanswered, including the structure of membrane proteins (we only know ~100 structures, but 25% of all proteins are membrane proteins!), the mechanisms driving membrane organization and curvature, mechanisms of organellar biogenesis and the transport between organelles, and how membranes undergo fusion and fission. In addition, the meeting will cover emerging techniques. A major goal of the meeting is to bring together cell biologists, biophysicists and theoretical biologists, which in the past had little interaction.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 10

15:00—19:30
Registration

Ballroom Lobby
18:30—19:30
Refreshments

Ballroom Lobby
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Tom A. Rapoport, Harvard University Medical School, USA

Randy W. Schekman, University of California at Berkeley, USA
Mechanism of Transport Vesicle Budding and Cargo Sorting


MONDAY, JANUARY 11

07:00—08:00
Breakfast

Golden Cliff/Eagles Nest
08:00—11:45
Membrane Protein Structure
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Randy W. Schekman, University of California at Berkeley, USA

Poul Nissen, Aarhus University, Denmark
Structure and Function of the P-ATPase Ion Pumps

Jue Chen, Rockefeller University, USA
Alternating Access of the Maltose Transporter

Thomas Wollert, Max Planck Institute of Biochemistry, Germany
Short Talk: Molecular Mechanism for Multivesicular Body Biogenesis by the ESCRT Complexes

Ramanujan S. Hegde, MRC Laboratory of Molecular Biology, UK
Mechanisms of Membrane Protein Insertion into the ER

Roland Beckmann, University of Munich, Germany
Lessons from EM Structures of Ribosome-Translocon Complexes

Thomas U. Schwartz, Massachusetts Institute of Technology, USA
Structural Commonalities between the Lattice Scaffolds of Vesicle Coats and the Nuclear Pore Complex

Kyle D. Brewer, University of Texas Southwestern Medical Center, USA
Short Talk: NMR Analysis of Synaptotagmin-1 on Nanodiscs

09:20—09:40
Coffee Break

Ballroom Lobby
11:45
On Own for Lunch and Recreation

11:45—13:00
Poster Setup

Superior/Wasatch/Maybird
13:00—22:00
Poster Viewing

Superior/Wasatch/Maybird
16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Membrane Curvature in Vesicle Building
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics, Germany

Harvey T. McMahon, MRC Laboratory of Molecular Biology, UK
Sculpting Clathrin-Coated Vesicles

Beverly Wendland, Johns Hopkins University, USA
A New Family of Endocytic Adaptor Proteins Coordinates Membrane and Actin Dynamics

Gregory A. Voth, University of Chicago, USA
Short Talk: Multiscale Computer Simulation of Membrane Remodelling by Proteins

Bruno Antonny, Institut de Pharmacologie Moleculaire et Cellulaire, France
Sensing Membrane Curvature with ALPS Motifs

19:00—20:00
Social Hour with Lite Bites

Superior/Wasatch/Maybird
19:30—22:00
Poster Session 1

Superior/Wasatch/Maybird

TUESDAY, JANUARY 12

07:00—08:00
Breakfast

Golden Cliff/Eagles Nest
08:00—11:15
Shaping Organelles
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Sandra L. Schmid, University of Texas Southwestern Medical Center, USA

Jodi Nunnari, University of California, Davis, USA
How Mitochondria Divide and Fuse

Robert G. Parton, University of Queensland, Australia
New Insights into Caveola Formation and Function

Gia K. Voeltz, University of Colorado, Boulder, USA
Shaping the Tubular ER

Michael Kozlov, Tel Aviv University, Israel
Theory of Membrane Shaping and Remodeling by Proteins

Yoko Shibata, Harvard Medical School/HHMI, USA
Short Talk: A Class of Dynamin-like GTPases Involved in the Generation of the Tubular ER Network

James A. McNew, Rice University, USA
Short Talk: Characterization of Atlastin-Mediated Fusion in vitro

09:20—09:40
Coffee Break

Ballroom Lobby
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Superior/Wasatch/Maybird
13:00—22:00
Poster Viewing

Superior/Wasatch/Maybird
16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Functional Organization of Membrane Domains I
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Joshua Zimmerberg, NICHD, National Institutes of Health, USA

Patricia Bassereau, Institut Curie, France
Physical Aspects of Lipid and Protein Sorting

Deborah A. Brown, Stony Brook University, USA
Caveolin-1-Induced Membrane Tubules in Human Breast Cancer Cells

Tobias Meyer, Stanford University Medical Center, USA
Ca2+ signaling and ER-PM junctions

Donatienne Tyteca, Université Catholique de Louvain, Belgium
Short Talk: Three Unrelated Sphingomyelin Analogs Spontaneously Cluster into Plasma Membrane Micrometric Domains

19:00—20:00
Social Hour with Lite Bites

Superior/Wasatch/Maybird
19:30—22:00
Poster Session 2

Superior/Wasatch/Maybird

WEDNESDAY, JANUARY 13

07:00—08:00
Breakfast

Golden Cliff/Eagles Nest
08:00—11:15
Functional Organization of Membrane Domains II
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Patricia Bassereau, Institut Curie, France

Phyllis I. Hanson, Washington University School of Medicine, USA
ESCRTs and Membrane Domains

Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Lipid–Protein Interactions Governing Raft Partitioning in Membranes

Sandra L. Schmid, University of Texas Southwestern Medical Center, USA
Dynamin-Mediated Membrane Fission

Sarah L. Veatch, Cornell University, USA
Short Talk: Correlation Function Analysis Corrects Artifactual Self-Clustering and Reveals Significant Co-Localization of FcepsilonRI and Lyn in Resting RBL-2H3 Mast Cells

Joshua Zimmerberg, NICHD, National Institutes of Health, USA
Membrane Morphological Transformations in Models for Exocytosis and Endocytosis

Dylan M. Owen, University of New South Wales, Australia
Short Talk: PALM Microscopy and Cluster Analysis of Raft and Non-Raft Proteins

09:20—09:40
Coffee Break

Ballroom Lobby
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Superior/Wasatch/Maybird
13:00—22:00
Poster Viewing

Superior/Wasatch/Maybird
16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Lipid Transport and Organelle Transport
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* William T. Wickner, Dartmouth Medical School, USA

* Randy W. Schekman, University of California at Berkeley, USA

Dennis R. Voelker, National Jewish Health, USA
Protein and Lipid Complexes Regulating Aminoglycerophospholipid Transport in Eukaryotes

William A. Prinz, NIDDK, National Institutes of Health, USA
Lipid-Regulated Sterol Transfer Between Closely Apposed Membranes by Oxysterol-Binding Protein Homologs

Gerrit van Meer, Utrecht University, Netherlands
Sphingolipid Dynamics and Membrane Protein Function

Tobias C. Walther, Yale University, USA
Short Talk: Mechanism of Plasma Membrane Organization by Eisosomes

19:00—20:00
Social Hour with Lite Bites

Superior/Wasatch/Maybird
19:30—22:00
Poster Session 3

Superior/Wasatch/Maybird

THURSDAY, JANUARY 14

07:00—08:00
Breakfast

Golden Cliff/Eagles Nest
08:00—11:15
Mechanisms Governing Membrane Fusion and Fission
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Michael Kozlov, Tel Aviv University, Israel

William T. Wickner, Dartmouth Medical School, USA
Mechanisms of Yeast Homotypic Vacuole Fusion

Stephen G. Sligar, University of Illinois at Urbana-Champaign, USA
Elucidating the Structure and Function of Membrane Proteins through Nanotechnology

Josep Rizo, University of Texas Southwestern Medical Center, USA
Synaptic Vesicle Fusion

Marta K. Domanska, University of Virginia, School of Medicine, USA
Short Talk: Fast Single Vesicle SNARE-Mediated Membrane Fusion Assay in Planar Supported Bilayers Reveals Details about Fusion Mechanism

Yoshinori Ohsumi, Tokyo Institute of Technology, Japan
Molecular Machinery for Autophagosome Formation

Eric G. Bend, University of Utah, USA
Short Talk: Unc18 and SNARE Interactions during Vesicle Fusion

09:20—09:40
Coffee Break

Ballroom Lobby
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:15
Membrane Dynamics in Endocytosis
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Harvey T. McMahon, MRC Laboratory of Molecular Biology, UK

Matthew N.J. Seaman, University of Cambridge, UK
Retromer-Mediated Endosome-to-Golgi Retrieval

David G. Drubin, University of California, Berkeley, USA
A Yeast Killer Toxin Screen Provides Insights into A/B Toxin Entry, Trafficking and Killing Mechanisms

Emanuele Cocucci, Immune Disease Institute, Harvard Medical School, USA
Short Talk: The First 2 Seconds in the Life of a Clathrin Coated Pit

Min Wu, National University of Singapore, Singapore
Short Talk: Synergistic Action of Clathrin and Membrane Tubulation in a Cell Free System

20:00—21:00
Social Hour with Lite Bites

Ballroom 1-2
20:00—23:00
Entertainment

Ballroom 1-2

FRIDAY, JANUARY 15

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13GM088852-01




We gratefully acknowledge additional support for this conference from:

Avanti Polar Lipids, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676