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This meeting took place in 2010



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Adipose Tissue Biology (J3)


Organizer(s) Sheila Collins, Karsten Kristiansen and Silvia Corvera
January 24—29, 2010
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 23, 2009
Late Abstract Deadline: Oct 23, 2009
Scholarship Deadline: Sep 23, 2009
Early Registration Deadline: Nov 24, 2009

Supported by The Directors' Fund


Summary of Meeting:
The study of adipose tissue has evolved over the years from merely being a passing note in most physiology texts to now playing center stage in the etiology of most metabolic diseases. This shift was assisted by early studies exploring the molecular signals and gene expression changes that dictate the differentiated state of a cell, for which the adipocyte was a model. Such studies led to the discovery of PPARgamma as one of those key regulators of adipogenesis, and later the realization that it was the pharmacologic target of the glitazone class of anti-diabetic agents. Further seminal studies from The Jackson Laboratories on mouse genetics of obesity paved the way for the discovery of adipocyte-derived regulatory hormones (“adipokines”) such as leptin and its receptor. These in turn ushered in the current state of vigorous investigation dissecting the molecular pathways of satiety and other aspects of signaling cross-talk between adipose tissue and other organs. The updated view of adipose tissue as a bona fide endocrine organ has been further extended to include it as a potential reservoir of stem cells for tissue engineering and an integral player in inflammatory status and insulin resistance. This meeting will cover these and other topics of the adipose biology field, including the role of angiogenesis in adipose tissue expansion; the white fat-brown fat debate; the contribution of the circadian clock to the hormonal and neural signals that coordinate food intake and activity for metabolic balance; and the connections between central and peripheral signals involved in the unanticipated lipodystrophic disorders resulting from such therapeutic regimens as antipsychotics and anti-retrovirals. A series of hot-topic sessions and short talks from submitted abstracts are also planned.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 24

15:00—19:30
Registration

Longs Peak Foyer
18:30—19:30
Refreshments

Longs Peak Foyer
19:30—20:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peaks
Jeffrey M. Friedman, Rockefeller University, USA
Leptin’s Loop: Dissecting the Physiologic Systems Regulating Food Intake and Metabolism


MONDAY, JANUARY 25

07:00—08:00
Breakfast

Torreys 1-3, Shavano, Red Cloud
08:00—11:15
Circadian Control of Adiposity and Metabolism (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peaks
* Martin G. Myers, Jr., University of Michigan, USA

Joseph T. Bass, Northwestern University, USA
Clock and Per: Gene Network Controls on Metabolism/Adiposity

Julian Mercer, Rowett Research Institute, UK
Effect of Rhythms, Diet and Feeding Patterns on Hypothalamic Gene Expression

Georgios Paschos, University of Pennsylvania, USA
Short Talk: Obesity in Mice with Adipose Tissue-Specific Deletion of Bmal1

Etienne Challet, CNRS, France
Synchronization of Multiple Circadian Clocks by Feeding

Clifford J. Rosen, Maine Medical Center, USA
Short Talk: Nocturnin, a Circadian Clock Gene, Stimulates Adipogenesis by Promoting Nuclear Transport of PPARgamma

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—11:30
NIDDK Discussion of Funding Issues
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
Philip F. Smith, NIDDK, National Institutes of Health, USA

11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Torreys 1-3, Shavano, Red Cloud
13:00—22:00
Poster Viewing

Torreys 1-3, Shavano, Red Cloud
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Angiogenesis and Adipose Mass: Factors and Regulation
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Anna Krook, Karolinska Institutet, Sweden

Silvia Corvera, University of Massachusetts Medical School, USA
Adipose Tissue Angiogenesis and the Development of Insulin Resistant in Human

H. Roger Lijnen, University of Leuven, Belgium
Roles of MMPs in Development of Adipose Tissue

Zofia Zukowska, University of Minnesota, USA
Neurogenic Regulation of Angiogenesis and adipogenesis – Role of Neuropeptid Y

Dong-Hoon Kim, University of Cincinnati, USA
Short Talk: Differential Adipose Tissue Remodeling Related to Angiogenesis and Inflammation in Young Obesity-Prone C57Bl/6 Mice and Obesity-Resistant FVB/N Mice

James E. Minchin, Duke University, USA
Short Talk: Real-Time Imaging of Adipose Depot Morphogenesis in Zebrafish

17:00—19:00
Molecular Programming of Hypothalamic Circuitry
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Kevin L. Grove, Novo Nordisk and Oregon National Primate Research Center, USA

Joel K. Elmquist, University of Texas Southwestern Medical Center, USA
Cellular and Molecular Mechanisms Regulating Energy Balance and Glucose Homeostasis

Richard B. Simerly, Vanderbilt University, USA
Hormonal Specification of Hypothalamic Connectivity

I. Sadaf Farooqi, University of Cambridge, UK
Mutations of Hypothalamic Circuits in Humans

Yi-Chun Loraine Tung, University of Cambridge Metabolic Research Laboratories, UK
Short Talk: Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats

19:15—20:00
Social Hour with Lite Bites

Torreys 1-3, Shavano, Red Cloud
19:30—22:00
Poster Session 1

Torreys 1-3, Shavano, Red Cloud

TUESDAY, JANUARY 26

07:00—08:00
Breakfast

Torreys 1-3, Shavano, Red Cloud
08:00—11:15
Fat (R)evolution - The Brown vs. White Fat Debate
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Sheila Collins, Sanford Burnham Prebys Medical Discovery Institute, USA

Jan Nedergaard, Stockholm University, Sweden
Human Brown Adipose Tissue presence and consequence

Saverio Cinti, University of Ancona, Italy
The Adipose Organ

Bruce M. Spiegelman, Harvard Medical School, USA
Obesity-Linked Phosphorylation of PPARgamma by cdk5 Causes Fat Cell Gene Dysregulation and Is a Direct Target of the Anti-Diabetic PPARgamma Ligand

Karsten Kristiansen, University of Copenhagen, Denmark
Single Gene Mutations that Promote Brown Adipocyte Differentiation

Marika Charalambous, Queen Mary University of London, UK
Short Talk: Impaired Thermogenesis and Persistent Hypothyroidism caused by Altered Dosage of Imprinted Genes

Yu-Hua Tseng, Joslin Diabetes Center/Harvard Medical School, USA
Short Talk: Identification of Brown Fat Progenitors in Mouse Skeletal Muscle

08:00—11:15
Nutrient Sensing in the Brain
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Roger D. Cone, University of Michigan, USA

Martin G. Myers, Jr., University of Michigan, USA
Neuromodulators of Leptin Action

Michael A. Cowley, Monash University, Australia
Melanocortins and Glucose Homeostasis

Michael Rosenbaum, Columbia University Medical College, USA
Leptin and Energy Homeostasis in Humans

Tamas L. Horvath, Yale School of Medicine, USA
Fuel Utilization by Neurons: A Determinant of “Nutrient Sensing"

Dong Kong, Tufts University School of Medicine, USA
Short Talk: Glucose Sensing by MCH Neurons Regulates Glucose Homeostasis and is Inhibited by UCP2

Hong Wang, University of Colorado Health Science Center, USA
Short Talk: Neuron-Specific Lipoprotein Lipase Deficiency Perturbs the Regulation of Energy Balance and Leads to Obesity by Modifying the Expression of the Orexigenic Neuropeptides AgRP and NPY

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Torreys 1-3, Shavano, Red Cloud
13:00—22:00
Poster Viewing

Torreys 1-3, Shavano, Red Cloud
14:30—16:30
Workshop 1: New Aspects of Adipogenesis, Lipid Droplets and Triglyceride Metabolism

Grays/Longs Peaks
* Sheila Collins, Sanford Burnham Prebys Medical Discovery Institute, USA

Cristina M. Rondinone, MedImmune, Inc., USA
Introductory 'In Memoriam' for Dean Londos

Chris E. Lowe, Horizon Discovery Ltd, UK
The ATF6alpha Pathway of the Unfolded Protein Response is Required for Adipogenesis

Ana G. Cristancho, University of Pennsylvania School of Medicine, USA
Transcription Factor 7-like 1 (TCF7L1) is required for PPARgamma2 Expression during Adipogenesis

Kai Ge, NIDDK, National Institutes of Health, USA
Epigenetic Regulation of Adipogenesis

Susanne Mandrup, University of Southern Denmark, Denmark
MED14 Tethers the Mediator to the N-Terminal Domain of PPARgamma and is Required for Full Transcriptional Activity and Adipogenesis

Charles Harris, Gladstone Institute for Cardiovascular Disease, USA
DGAT Enzymes Are Required for Triglyceride Synthesis and Lipid Droplet Formation But Not for Other Aspects of Adipogenesis

Cynthia Smas, University of Toledo, USA
Functional Analysis of FSP27 Protein Regions for Lipid Droplet Localization, Caspase-Dependent Apoptosis and Dimerization with CIDEA

Lise Madsen†, University of Copenhagen, Denmark
Transdifferentiation of White into Brown Adipose Tissue Requires Cyclooxygenases

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Insights from Model Organisms (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Karsten Kristiansen, University of Copenhagen, Denmark

Roger D. Cone, University of Michigan, USA
Biological Functions of AgRP and AgRP2 in Zebrafish

Sri Devi Narasimhan, Cell Press, USA
Identifying Phosphatases that Modulate the Insulin/IGF-1 Signaling Pathway

Sean M. Oldham, Sanford-Burnham Medical Research Institute, USA
Role of Nutrient Sensing TOR Pathway in High Fat Diet-induced Signaling Pathway and aging

Biao Wang, The Salk Institute, USA
Short Talk: Drosophila Salt Inducible Kinase (SIK) in Fat Metabolism

Christine Hausen, Institute for Genetics, University of Cologne, Germany
Short Talk: Conserved Role for Insulin Receptor Signaling in Catecholaminergic Cells in Control of Energy Homeostasis

19:15—20:15
Social Hour with Lite Bites

Torreys 1-3, Shavano, Red Cloud
19:30—22:00
Poster Session 2

Torreys 1-3, Shavano, Red Cloud

WEDNESDAY, JANUARY 27

07:00—08:00
Breakfast

Torreys 1-3, Shavano, Red Cloud
08:00—11:15
Immune Signals and Energy Homeostasis/Body Composition (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Randy J. Seeley, University of Michigan, USA

Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Obesity, Inflammation and Insulin Resistance (Basic and Clinical Issues)

Ajay Chawla, University of California, San Francisco, USA
Immune Regulation of Nutrient Metabolism and Aging

Carey N. Lumeng, University of Michigan, USA
Short Talk: MGL1 Promotes Adipose Tissue Inflammation and Insulin Resistance by Regulating 7/4hi Monocytes in Obesity

Umut Ozcan, Boston Children's Hospital, Harvard Medical School, USA
The ER Stress and Leptin Resistance

Daniel L. Marks, Oregon Health & Science University, USA
The Role of Central Melanocortin’s in Cachexia

Jose M. Garcia, Baylor College of Medicine, USA
Short Talk: The Effects of Peripheral Ghrelin Administration on the Lipid Metabolism are Primarily Mediated through Changes in Food Intake in a Model of Cachexia

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Torreys 1-3, Shavano, Red Cloud
13:00—22:00
Poster Viewing

Torreys 1-3, Shavano, Red Cloud
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Bariatric Surgery and the Treatment of Metabolic Disease
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA

John W. Newcomer, Washington University School of Medicine, USA

Francesco Rubino, Weill Cornell Medical College, USA
Resolution of Diabetes and Bariatric Surgery

Paul O'Brien, Monash University, Australia
Appetite Control and Bariatric Surgery

Randy J. Seeley, University of Michigan, USA
Bariatric Surgery: Beyond Restriction and Malabsorption

Thomas Alexander Lutz, University of Zürich, Switzerland
Short Talk: Roux-en-Y Gastric Bypass Increases Energy Expenditure Affects Taste Preference and Impairs Bone Structure Rats

Jocelyne Magré, INSERM, France
Genetics of Congenital Generalized Lipodystrophy

19:00—20:00
Social Hour with Lite Bites

Torreys 1-3, Shavano, Red Cloud
19:30—22:00
Poster Session 3

Torreys 1-3, Shavano, Red Cloud

THURSDAY, JANUARY 28

07:00—08:00
Breakfast

Torreys 1-3, Shavano, Red Cloud
08:00—11:15
Adipose Stem Cells: Biology and Application (Bone Marrow vs. Adipose Tissue; Characteristics/Signaling that Promote their Differentiation; Plastics/Reconstructive, Tissue Engineering Aspects)
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Barbara Cannon, Stockholm University, Sweden

Hei Sook Sul, University of California, Berkeley, USA
Pref-1: Role in Adipogenesis and Mesenchymal Cell Fate

Rei Ogawa, Nippon Medical School, Japan
Application of Adipose Stem Cells for Plastic Surgery - In Particular about Cartilage Regeneration

Ormond A. MacDougald, University of Michigan, USA
Role of Wnt Signaling in the Regulation of Adipocyte Differentiation

Ez-Zoubir E. Amri, Centre National de la Recherche Scientifique, Université Nice, France
Short Talk: Human Multipotent Adipose-Derived Stem Cells Differentiate into Functional Brown Adipocytes

Daniel R. Zeve, University of Texas Southwestern Medical Center at Dallas, USA
Short Talk: Defining Developmentally Important Genes within the White Adipose Progenitor Cells

Maryam Ahmadian, The Salk Institute, USA
Short Talk: Adipose-Specific Phospholipase A2 (AdPLA) Ablation Prevents Diet-Induced and Genetic Obesity: A Novel Lipodystrophy Model

08:00—11:15
Thinking Outside of the Hypothalamus
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Daniel L. Marks, Oregon Health & Science University, USA

Marta Korbonits, Barts and The London, Queen Mary's School of Medicine and Dentistry, UK
Cross-Talk of Endocannabinoids and Ghrelin

Darren Opland, University of Michigan, USA
Short Talk: VTA Leptin Receptor Neurons Specifically Project to and Regulate CART Neurons of the Extended Central Amygdala

Alastair V. Ferguson, Queen's University, Canada
Sensory Circumventricular Organs: Integrative Control Centers Regulating Energy Balance?

Hans Rudolf Berthoud, Pennington Biomedical Research Center, USA
Hedonic, Emotional, Cognitive, and Metabolic Controls of Appetite and Energy Balance: Who is The Boss?

Lora K. Heisler, University of Aberdeen, UK
Serotonin Influences Melanocortin Pathways to Affect Energy Balance

Matthew R. Hayes, University of Pennsylvania, USA
Short Talk: Endogenous Leptin Signaling in the NTS is Required for Energy Balance Regulation

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Drug Development: Treating the Brain and Beyond (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peaks
* Michael A. Cowley, Monash University, Australia

Eduardo Dunayevich, Amgen, USA
The Combination of Bupropion and Naltrexone in the Treatment of Obesity: From Bench to Pivotal Trials

Donald J. Marsh, Merck Research Laboratories, USA
New Neuropeptide Target Systems: Neuromedin U

Michael Culler, Ipsen/Biomeasure, USA
Novel Peptide Ligands of the Melanocortin Type 4 Receptor for the Treatment of Obesity and Metabolic Disease

Lee M. Kaplan, Massachusetts General Hospital, USA
Short Talk: Roux-en-Y Bypass Stimulates BAT Activity and Central Control Thermogenesis in Mice

Alan Koncarevic, Acceleron Pharma, USA
Short Talk: Induction of a Thermogenic Program in White Adipose Tissue of HFD-Fed Mice Treated with a Soluble ActRIIB

19:15—20:15
Social Hour with Lite Bites

Torreys 1-3, Shavano, Red Cloud
20:00—23:00
Entertainment

Torreys 1-3, Shavano, Red Cloud

FRIDAY, JANUARY 29

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13DK084688-01




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